Patents Assigned to AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.
  • Indazole having analgesic activity
    Patent number: 7662836
    Abstract: An indazole having analgesic activity, a method for the preparation thereof and a pharmaceutical composition containing the same; the indazole has the following general formula: where X, Ra, Rb, Rc and Rd have the meanings stated in the description.
    Type: Grant
    Filed: April 23, 2004
    Date of Patent: February 16, 2010
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
  • Use of indazole derivatives for the treatment of neuropathic pain
    Patent number: 7638534
    Abstract: Use of a compound of formula (I), wherein X is CH or N, and when X is CH, R is H, OH, a linear or branched alkyl chain having from 1 to 3 carbon atoms, a linear or branched alkoxy chain having from 1 to 3 carbon atoms, or a halogen atom, and when X is N, R is H, or an acid addition salt thereof with a pharmaceutically acceptable organic or inorganic acid, to prepare a pharmaceutical composition active in the treatment of neuropathic pain.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: December 29, 2009
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Angelo Guglielmotti, Lorenzo Polenzani, Alessandra Alisi, Nicola Cazzolla
  • Indazolamides with analgesic activity
    Patent number: 7632849
    Abstract: An indazolamide (I), wherein X, R1, R2, R3, R4, R5, R6, R7 and R8 have the meanings given in the description, and addition salts thereof with a pharmaceutically acceptable acid, a method for the preparation thereof and a pharmaceutical composition containing the same.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: December 15, 2009
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Angelo Guglielmotti, Guido Furlotti, Giuseppe Luna, Lorenzo Polenzani
  • L-(?)-moprolol L-(+)-tartrate
    Patent number: 7524886
    Abstract: L-(?)-moprolol L-(+)-tartrate salt (2:1), method for preparing it and pharmaceutical composition comprising it.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: April 28, 2009
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Mario Pinza, Caterina Maugeri, Nicola Cazzolla
  • Method for preparing a glucosamine compound and compound thus obtained
    Patent number: 7435812
    Abstract: Method for preparing a compound comprising protonated glucosamine and Cl?, Na+ and SO42? ions, in which (a) glucosamine hydrochloride and a stoichiometric excess of sodium sulphate are placed in water, (b) the mixture obtained from the preceding step (a) is heated, (c) the mixture is cooled, and (d) the solid present in the said cooled mixture is recovered by filtration. Compound comprising protonated glucosamine and Cl?, Na+ and SO42? ions and having the X-ray diffraction diagram of FIG. 1.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: October 14, 2008
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Mario Pinza, Franca Segnalini, Marcello Marchetti, Tommaso Iacoangeli, Francesco De Vita
  • Cetylpyridinium salt of an anti-inflammatory agent and pharmaceutical compositions containing it
    Patent number: 7250428
    Abstract: Cetylpyridinium salt of diclofenac.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: July 31, 2007
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Giorgio Pifferi
  • Use of microparticles having a protein and an antibody adsorbed thereon for preparing a pharmaceutical composition for intranasal administration
    Patent number: 7235522
    Abstract: Use of microparticles having a protein and an antibody adsorbed thereon for preparing a pharmaceutical composition for intranasal administration.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: June 26, 2007
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Dario Cremaschi, Cristina Porta
  • Disinfectant solution based on sodium hypochlorite, and process for preparing it
    Patent number: 7056538
    Abstract: Sodium hypochlorite disinfectant solution having a pH of between 10.1 and 10.7 and comprising from 0.021 to 5.76% (w/v) of sodium hypochlorite and, relative to the said amount of sodium hypochlorite, not more than 2% of sodium chlorate.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: June 6, 2006
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Mario Pinza, Marcello Marchetti
  • Pharmaceutical composition active in reducing production of MCP-1 protein
    Patent number: 6534534
    Abstract: The present application relates to a method of treating atherosclerosis by administering to a patient a compound of formula: and/or salts thereof with pharmaceutically acceptable organic or inorganic bases.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: March 18, 2003
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Angelo Guglielmotti, Alberto Mantovani
  • Ophthalmic solution comprising glycogen
    Patent number: 6486139
    Abstract: The present invention relates to humectant and lubricant solution for ophthalmic use based on a glycogen polysaccharide.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: November 26, 2002
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Giovanni Cavallo, Alberto Campana, Leonardo Marchitto, Mario Pinza
  • Pharmaceutical composition for injection based on paracetamol
    Patent number: 6423749
    Abstract: The invention relates to pharmaceutical compositions comprising paracetamol, ethanol, and polyethylene glycol, either in the absence or the presence of water.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: July 23, 2002
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Giovanni Cavallo, Mario Pinza
  • Aqueous pharmaceutical composition comprising an active ingredient which is highly insoluble in water
    Patent number: 6337087
    Abstract: Aqueous pharmaceutical composition comprising an active agent which is highly insoluble in water, dispersed in liposomes and method of preparation are disclosed.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: January 8, 2002
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Giovanni Cavallo, Leonardo Marchitto
  • Pharmaceutical antiviral composition comprising glycyrrhizic acid and at least one protein endowed with antiviral activity
    Patent number: 6329339
    Abstract: This invention relates to pharmaceutical compositions of and methods of treating viral infections with a synergistic combination of glycyrrhizic acid and either a lactoferrin or a lysozyme.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: December 11, 2001
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Raffaello Pompei, Mario Pinza
  • Pharmaceutical preparation comprising lyophilized liposomes encapsulating an active principle which is highly insoluble in water, and the process for preparing the said preparation
    Patent number: 6319517
    Abstract: The present invention to relates to a pharmaceutical preparation comprising lyophilized liposomes encapsulating a biologically-active principle which is highly insoluble in water and stable over time.
    Type: Grant
    Filed: November 3, 1999
    Date of Patent: November 20, 2001
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Giovanni Cavallo, Leonardo Marchitto
  • Indazole amide compounds as serotoninergic agents
    Patent number: 6197769
    Abstract: A compound having general formula (I) wherein R1, R2, R′3, R4, and R6 have the meanings stated in the description, acid addition salts thereof with pharmaceutically acceptable organic and inorganic acids an pharmaceutically acceptable quaternary salts thereof.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: March 6, 2001
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Alessandra Alisi, Mario Brufani, Nicola Cazzolla, Marilena Giannangeli, Mario Pinza
  • Pharmaceutical composition active in reducing production of MCP-1 protein
    Patent number: 6191158
    Abstract: Use of a compound having formula (I) and salts thereof with pharmaceutically acceptable organic or inorganic bases, for preparing a pharmaceutical composition active in the treatment of disorders characterized by production of MCP-1 protein.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: February 20, 2001
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Angelo Guglielmotti, Claudio Milanese
  • Antitussive composition containing dextromethorphan and benzydamine
    Patent number: 5932589
    Abstract: Oral antitussive pharmaceutical composition which allows a significant contact of its components with mucous membranes of the buccal cavity and comprises a centrally acting antitussive or a pharmaceutically acceptable salt thereof and benzydamine or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: December 24, 1996
    Date of Patent: August 3, 1999
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Depalmo Galli Angeli
  • Preparation of triazolone compounds
    Patent number: 5767275
    Abstract: Preparation of a 1,2,4-triazol-3-one compound substituted in positions 4 and 5 by an alkyl or aryl group and, optionally, in position 2 by an alkyl group, by reacting an ester a of carbamic acid N-substituted by an alkyl or aryl group with a hydrazide of an aliphatic or aromatic carboxylic acid, optionally N-substituted by an alkyl group, in the presence of a strong base.
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: June 16, 1998
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Alberto Nigro, Mauro Tomaselli
  • Serum proteins related to autoimmune disease
    Patent number: 5284750
    Abstract: A method for diagnosing a patient with an autoimmune disease using monoclonal antibodies to quantitate the amount of 680 kd, 54 kd, 44 kd or 14 kd present, wherein an elevated amount of protein compared to a patient without the disease indicates the presence of autoimmune disease.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: February 8, 1994
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A
    Inventors: Bruno Silvestrini, Yan Cheng
  • Serum proteins used to detect autoimmune disease
    Patent number: 5258312
    Abstract: A method for diagnosing a patient with an autoimmune disease comprising assaying a blood sample from a patient for increased levels of the carbohydrate moieties of one or more proteins, said increased level of one or more of said proteins indicating the presence of an autoimmune disease.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: November 2, 1993
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A
    Inventors: Bruno Silvestrini, Yan Cheng