Patents Assigned to AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.
  • Solid pharmaceutical composition for oral administration containing dapiprazole
    Patent number: 5234927
    Abstract: A stable solid pharmaceutical composition for oral administration comprising dapiprazole or a physiologically acceptable acid salt thereof together with a pharmaceutically acceptable inert excipient and magnesium oxide as a degradation retarding agent is disclosed.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: August 10, 1993
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Depalmo Galli Angeli, Leandro Baiocchi
  • Method of treating contact lenses
    Patent number: 5176714
    Abstract: Treatment of contact lenses by an effective amount of bendazac, 5-hydroxybendazac or a salt thereof with a physiologically acceptable base.
    Type: Grant
    Filed: October 30, 1989
    Date of Patent: January 5, 1993
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Mauro De Gregorio
  • 1-benzyl-3-hydroxymethyl-indazole compounds and derivatives
    Patent number: 5112986
    Abstract: Compounds of the formulaA--CH.sub.2 --O--CRR'--COOR'" (I)wherein A, R, R' and R'" have the meanings mentioned in the description, salts thereof with pharmaceutically acceptable bases, intermediates and processes for their preparation, and analgesic pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: May 12, 1992
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Leandro Baiocchi, Bruno Silvestrini
  • Method for inhibiting the development of tolerance in the analgesic treatment with morphine
    Patent number: 5041446
    Abstract: Method for inhibiting the development of tolerance in the analgesic treatment with morphine of a subject in need of said treatment, comprising administering systemically and contemporarily an effective analgesic dose of morphine and an amount of dapiprazole of from 1/4 to 1 part by weight to 1 part by weight of said analgesic dose of morphine.Pharmaceutical composition useful in the said method.
    Type: Grant
    Filed: June 6, 1989
    Date of Patent: August 20, 1991
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Bruno Silvestrini
  • Method of treating contact lenses
    Patent number: 5013484
    Abstract: Treatment of contact lenses by an effective amount of bendazac, 5-hydroxybendazac or a salt thereof with a physiologically acceptable base.
    Type: Grant
    Filed: November 7, 1989
    Date of Patent: May 7, 1991
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Mauro De Gregorio
  • Method of preventing myocardial infarction and acute cerebral ischaemia
    Patent number: 4906632
    Abstract: Use of trazodone for preparing pharmaceutical compositions of use in the prevention of infarction or acute cerebral ischaemia.Controlled-release pharmaceutical compositions which, in vitro, release from 1 to 20 mg/h of trazodone base.
    Type: Grant
    Filed: November 28, 1988
    Date of Patent: March 6, 1990
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.S
    Inventor: Bruno Silvestrini
  • Method of treating contact lenses
    Patent number: 4895676
    Abstract: Treatment of contact lenses by an effective amount of bendazac, 5-hydroxybendazac or a salt thereof with a physiologically acceptable base.
    Type: Grant
    Filed: January 11, 1989
    Date of Patent: January 23, 1990
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Mauro De Gregorio
  • Use of bendazac and its salts in the treatment of retinitis pigmentosa
    Patent number: 4554288
    Abstract: It was discovered that bendazac, or (1-phenylmethyl-1H-indazol -3-yl)oxy acetic acid, when administered in a form suitable to obtain therapeutic tissue concentrations, determine an improvement in retinitis pigmentosa. The lysine salt of bendazac is well adapted for this use owing to its good oral absorption.
    Type: Grant
    Filed: April 6, 1984
    Date of Patent: November 19, 1985
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Bruno Silvestrini
  • Bendazac treatment of cataract
    Patent number: 4451477
    Abstract: It was discovered that bendazac, or [(1-benzyl-1H-indazol-3-yl)oxy] acetic acid, when administered in a form suitable to obtain therapeutic tissue concentrations, determines a regression of cataract. It was demonstrated in particular, that the lysine salt of bendazac is well adapted for this use since it produces adequate tissue concentrations following both oral administration and topical application on the eye. The chemical and physical characteristics of this bendazac salt are described here together with the preparation techniques.
    Type: Grant
    Filed: June 8, 1982
    Date of Patent: May 29, 1984
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Bruno Silvestrini, Leandro Baiocchi
  • [(1-Benzyl-1H-indazol-3-yl)oxy] acetic acid salt with L. lysine
    Patent number: 4352813
    Abstract: A new salt of [(1-benzyl-1H-indazol-3-yl)oxy] acetic acid (or bendazac) with L. lysine.Following oral administrations of this compound in man, the concentrations of bendazac found in the blood are higher than those obtained after administration of bendazac as such.This discovery extends the therapeutic use of bendazac. In fact, whereas up to now bendazac could only be used topically, the L. lysine salt of bendazac makes it possible to perform therapeutic treatments with the oral route of administration as an agent with a normalizing effect on blood lipids.
    Type: Grant
    Filed: June 2, 1981
    Date of Patent: October 5, 1982
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Bruno Silvestrini, Leandro Baiocchi
  • Method of treating glaucoma with cycloalkyltriazoles
    Patent number: 4307096
    Abstract: Compounds of the general formula: ##STR1## in which alk and alk' represent the bivalent radicals: aliphatic alkyl chains; and R and R' represent the alkyl, halogen, hydrogen, alkyloxy, --OH, --CF.sub.3 or --SCH.sub.3 radicals. The compounds of the formula I are effective as antiglaucomic, antipsychotic and also as additive agents in the withdrawal treatment of various addictive conditions. Methods for their preparation are also disclosed.
    Type: Grant
    Filed: August 29, 1980
    Date of Patent: December 22, 1981
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Bruno Silvestrini, Leandro Baiocchi
  • Method of treating schizophrenia with cycloalkltriazoles
    Patent number: 4307095
    Abstract: Compounds of the general formula: ##STR1## in which alk and alk' represent the bivalent radicals aliphatic alkyl chains; and R and R' represents the alkyl, halogen, hydrogen, alkyloxy, --OH, --CF.sub.3 or --SCH.sub.3 radicals. The compounds of the formula I are, effective as antiglaucomic, antipsychotic and also as additive agents in the withdrawal treatment of various addictive conditions. Methods for their preparation are also disclosed.
    Type: Grant
    Filed: August 29, 1980
    Date of Patent: December 22, 1981
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Bruno Silvestrini, Leandro Baiocchi
  • Method with substituted 1-benzyl-1H-indazole-3-carboxylic acids for interrupting pregnancy in mammals
    Patent number: 4282237
    Abstract: This invention relates to the use of substituted 1-benzyl-1H-indazole-3-carboxylic acids to interrupt pregnancy. These compounds are described in the U.S. Pat. No. 3,895,026 assigned to the same assignee of the present patent application.
    Type: Grant
    Filed: August 8, 1978
    Date of Patent: August 4, 1981
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Bruno Silvestrini
  • Basic thio-indazoles
    Patent number: 4264618
    Abstract: Compound belonging to the class of 2-benzyl-3-(3-dimethylaminopropylthio)-2H-indazole, its sulfoxide and its sulfone and their pharmacologically acceptable salts, and process for obtaining such compounds having an antiinflammatory action in the common pathological conditions.
    Type: Grant
    Filed: December 11, 1979
    Date of Patent: April 28, 1981
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Leandro Baiocchi, Bruno Silvestrini
  • Cycloalkyltriazoles and process for obtaining same
    Patent number: 4252721
    Abstract: Compounds of the general formula: ##STR1## in which alk and alk' represent the bivalent radicals; aliphatic alkyl chains; and R and R' represent the alkyl, halogen, hydrogen, alkyloxy, --OH, --CF.sub.3 or --SCH.sub.3 radicals. Said compounds of the formula I are effective and useful as antiglaucomic and antipsychotic agents and also as additive agents in the withdrawal treatment of various addictive conditions. Methods for their preparation are also disclosed.
    Type: Grant
    Filed: March 29, 1979
    Date of Patent: February 24, 1981
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Bruno Silvestrini, Leandro Baiocchi
  • Use of trazodone and etoperidone in Parkinsonism and in other extrapyramidal syndromes characterized by tremors
    Patent number: 4162318
    Abstract: Treatment of tremors in Parkinsonism and in other extrapyramidal syndromes by administering an amount of trazodone of the formula ##STR1## AND OR OF ETOPERIDONE OF THE FORMULA: ##STR2## in the range of about 25 mg. to 100 mg. three times a day.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: July 24, 1979
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Bruno Silvestrini
  • Synthesis of hydratropic acid and some of its alkyl derivatives
    Patent number: 4154962
    Abstract: A new process by which cyclohexanone is treated, in the presence of a suitable acid or a salt of an organic base, with pyruvic acid or with one of its simple derivatives (ester or salt) to give hydratropic acid.
    Type: Grant
    Filed: November 1, 1977
    Date of Patent: May 15, 1979
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Leandro Baiocchi
  • Guaiacol p-isobutyl hydratropate
    Patent number: 4134989
    Abstract: This invention provides guaiacol p-isobutyl hydratropate as a new compound for use in human therapy as an analgesic, anti-inflammatory, antipyretic, antiseptic and expectorating agent.
    Type: Grant
    Filed: June 24, 1977
    Date of Patent: January 16, 1979
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Leandro Baiocchi, Bruno Silvestrini
  • Use of combinations of L-DOPA with trazodone and L-DOPA with etoperidone in Parkinsonism
    Patent number: 4131675
    Abstract: A combination of trazodone or etoperidone with L-DOPA is used in the treatment of Parkinsonism by oral administration to a patient.
    Type: Grant
    Filed: February 9, 1978
    Date of Patent: December 26, 1978
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Bruno Silvestrini
  • Synthesis of m-benzoyl-hydratropic acid
    Patent number: 4097522
    Abstract: A process is provided for the production of m-benzoyl-hydratropic acid which comprises heating the reaction mixture obtained from the condensation of 2-benzoyl-cyclohexanone and pyruvic acid, its esters or salts, at a temperature of 200.degree. to 230.degree. and in the presence of an acid catalyst.
    Type: Grant
    Filed: May 28, 1976
    Date of Patent: June 27, 1978
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Leandro Baiocchi