Abstract: A pharmaceutical vial, container assembly, system and method. The vial can include a hollow body, a first passage, a second passage, a first temporary closure sealing the first passage, and a second temporary closure sealing the second passage. A diluent container can include a first connector to connect the diluent container and vial in fluid communication for mixing an active pharmaceutical ingredient with a diluent. An infusion set can include a second connector to connect the infusion set and vial in fluid communication, and a delivery device. The method can include the steps of connecting the diluent container to the first temporary closure of the vial, transferring a diluent from the diluent container into the vial, reconstituting an active pharmaceutical ingredient with the diluent to form a solution, connecting the delivery device to the second temporary closure, and administering the solution through the delivery device into a patient.

Abstract: An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a transfer set and junction structure that has a junction body, a first inlet port located at a first portion of the junction body, a second inlet port located at a second portion of the junction body, and an outlet port located at a third portion of the junction body. The junction structure can be configured to mix fluid received from both the first inlet port and second inlet port and to deliver the fluid to the outlet port. The junction structure can also include attachment structure located on the junction body and configured to attach the junction structure to the housing of the compounding device at a location downstream of a pump system.

Abstract: An exemplary compounding method of controlling a compounding device to prepare an admixture of at least two distinct material sources can include examining material source solutions for incompatibility of the ingredients and operating a first and a second pump to prevent one of the incompatible source solutions from entering a common flow path. The processing method can detect degradation of a fluid line by evaluating one or more of calibration error rate data, cumulative volumetric flow data, or cumulative pump operation data. The processing method can also selectively transfer a first group of source solutions using the first pump, receiving pump data from one or more sensors that sense actions of the pumps, applying fluid correction factors and calculating discrete pump movements, the pump movements being indicative of an amount of source solution displacement by a pump, and operating the pumps to selectively dispense the source solution amounts according to a preparation order.

Abstract: The present invention pertains to a flexible universal catheter securement device for use with, e.g. Foley catheters and other catheters. The flexible universal catheter securement device preferably comprises a cover attached to a base at a longitudinal articulation point. The cover has a top cover surface and a bottom cover surface and the bottom cover surface has an adhesive foam padding. The base has a top base surface and a bottom base surface and the top base surface has an adhesive foam padding. The articulation point is foldable such that the cover can be placed on the base. The base and the cover preferably have a centerline and the articulation point is offset there from. The base further comprises a catheter placement axis and the longitudinal articulation point is located parallel to the catheter placement axis. The cover preferably has less surface area than the base.

Abstract: A dialysis system with post dialysis aseptic blood return including a fluid source, a dialyzer, a pump, a venous line, an arterial line, a bridge line coupled between the venous line and the arterial line, and a fluid source line coupled between the fluid source and a fluid port of the arterial line downstream for the bridge line. Aseptic blood return after dialysis is performed by blocking the arterial line between the bridge line and the fluid port, unblocking the bridge line, unblocking the fluid source line, and operating the pump in a forward direction to produce fluid flow from the fluid source, through the dialyzer, and through the bridge line to force venous blood in the venous line toward the patient venous access and arterial blood in the arterial line toward the patient arterial access.

Abstract: A needle-free connector for accessing a patient's intravenous line includes a hollow body having a first end with a first opening, a second end with a second opening, and an inner wall defining a chamber. A hollow piston disposed in the chamber is axially collapsible to allow fluid to flow between the inner wall of the hollow body and the outer surface of the hollow piston. An inner surface of the hollow piston includes a fluted section having a radial array of axial slots. The fluted section has a first radial thickness configured to buckle in response to axial force applied to the hollow piston. The hollow piston further includes a retrograde-reducing stiffener. The retrograde-reducing stiffener has a second radial thickness that is greater than the first radial thickness.

Abstract: A needle-free connector for accessing a patient’s intravenous line includes a hollow body having a first end with a first opening, a second end with a second opening, and an inner wall defining a chamber. A hollow piston disposed in the chamber is axially collapsible to allow fluid to flow between the inner wall of the hollow body and the outer surface of the hollow piston. An inner surface of the hollow piston includes a fluted section having a radial array of axial slots. The fluted section has a first radial thickness configured to buckle in response to axial force applied to the hollow piston. The hollow piston further includes a retrograde-reducing stiffener. The retrograde-reducing stiffener has a second radial thickness that is greater than the first radial thickness.

Abstract: An exemplary compounding system and device for mixing materials can include a housing, a first material source and a second material source. A first fluid line can be operationally connected to the housing and configured to transport a first volume of fluid per unit time from the first material source to a final container. A second fluid line can be operationally connected to the housing and configured to transport a second volume of fluid per unit time from the second material source to the final container.

Abstract: A connector is configured to connect a drug container with a solution container and permit contents of the drug container to be combined with the solution container. The connector has a connector body with a first coupling for fluid connection with the drug container. The first coupling defines a first fluid passage. The connector body also has a second coupling for fluid connection with the solution container. The second coupling defines a second fluid passage. A control valve has a movable valve body that defines a third fluid passage. The valve body is positionable relative to the connector body in a first position, in which the first fluid passage is sealed from the second fluid passage. The valve body is also positionable in a second position, in which the first fluid passage is connected in fluid communication with the second fluid passage by the third fluid passage.

Abstract: An exemplary compounding system and method can include a transfer set that includes a manifold for assisting in transferring a plurality of ingredients from supply container(s) to a final container. The manifold can include a first channel in fluid communication with at least one primary ingredient, and a second channel in fluid communication with a plurality of secondary ingredients. The first channel and second channel can be in fluid isolation from each other such that the at least one primary ingredient does not mix with the plurality of secondary ingredients within the manifold. The transfer set can include a plurality of inlet lines in fluid communication with the manifold and two outlet lines configured for connection to two separate pumps and eventually being in fluid communication with the final container.

Abstract: A connector is configured to connect a drug container with a solution container and permit contents of the drug container to be combined with the solution container. The connector has a connector body with a first coupling for fluid connection with the drug container. The first coupling defines a first fluid passage. The connector body also has a second coupling for fluid connection with the solution container. The second coupling defines a second fluid passage. A control valve has a movable valve body that defines a third fluid passage. The valve body is positionable relative to the connector body in a first position, in which the first fluid passage is sealed from the second fluid passage. The valve body is also positionable in a second position, in which the first fluid passage is connected in fluid communication with the second fluid passage by the third fluid passage.

Abstract: An exemplary compounding system and method can include two pump heads for simultaneously drawing two different fluids from at least two separate input containers such that the at least two different fluids are mixed and distributed to an output container. The system can include a manifold that maintains separation of certain of the different fluids until after passing by a first pump and a second pump and/or additional pumps. A junction can be placed in the fluid line downstream of the first and second pumps and/or additional pumps such that all or some of the fluids are mixed prior to output to the output container. The method of using the system can include incorporating software that selects various fluids at certain times and sequences to ensure optimum efficiency and safety for the system, and can continue compounding actions even when an input supply container runs out or otherwise fails to supply a particular fluid/material.

Abstract: A peristaltic infusion pump with improved low flow performance. The pump includes a cam shaft having cams offset in an axial direction, pump fingers that engage a tube, each finger coupled to a respective cam, the fingers creating a pumping region and an occlusion region within the tube, a motor coupled to the cam shaft, a memory, and a controller. The controller implements cam rotation instructions received from the memory to cause the pump to position the fingers in the occlusion region prior to beginning an infusion therapy to deliver fluid to patient through the tube at a patient fluid delivery rate, rotate the cam shaft to transition the fingers from the occlusion region to the pumping region at a startup rate that is faster than a patient fluid delivery rate, and rotate the cam shaft at the patient fluid delivery rate in the pumping region.

Abstract: A connector is configured to connect a drug container with a solution container and permit contents of the drug container to be combined with the solution container. The connector has a connector body with a first coupling for fluid connection with the drug container. The first coupling defines a first fluid passage. The connector body also has a second coupling for fluid connection with the solution container. The second coupling defines a second fluid passage. A control valve has a movable valve body that defines a third fluid passage. The valve body is positionable relative to the connector body in a first position, in which the first fluid passage is sealed from the second fluid passage. The valve body is also positionable in a second position, in which the first fluid passage is connected in fluid communication with the second fluid passage by the third fluid passage.

Abstract: Infusion systems and related methods involving a catheter hub and an extension or IV administration set having a male Luer connector for fluid communication with the catheter hub. A support adaptor is provided with the extension or IV administration set and has a body with a length between first and second ends, and a body wall having a continuous wall surface in a radial direction relative to the length and which defines an exterior of the body. An internal wall of the support adaptor defines a bore with the body wall, wherein the bore has first and second openings. A tubing length is located in the bore and extends out of the second opening. The bore includes first and second bore sections. Optionally, the second bore section is angled relative to the first bore section. A support surface is located beneath the bore, elevation wise.

Abstract: A cassette with free flow prevention for use with an ambulatory pump. The cassette includes a free flow prevention clamp and a housing. The free flow prevention clamp includes a clamping section having a first side and a second side, a first elongate section extending from the first side, and a second elongate section extending from the second side. The housing supports the free flow prevention clamp and defines a channel for receiving a tube. The elongate sections extend parallel to the channel and the clamping section extends across the channel. The free flow prevention clamp is configurable within the housing in an open condition that allows fluid flow through the tube when force is applied to one of the elongate sections and in a closed condition that prevents fluid flow through the tube when the force is removed from the elongate sections.

Abstract: An ambulatory pump and a battery compartment for use in an ambulatory pump. The ambulatory pump includes a pump, a controller coupled to the pump for controlling the pump to deliver fluid to a patient, and a battery compartment electrically coupled to the pump and the controller. The battery compartment defines a cavity for alternately receiving a battery pack and a plurality of household batteries. A flex guide is positioned within the cavity. The flex guide has a compressed state and a non-compressed state where a profile of the flex guide has a height that is greater than half the insertion depth of the household batteries in the non-compressed state and that is less than half the insertion depth in the compressed state.

Abstract: A peristaltic infusion pump with improved low flow performance. The pump includes a cam shaft having cams offset in an axial direction, pump fingers that engage a tube, each finger coupled to a respective cam, the fingers creating a pumping region and an occlusion region within the tube, a motor coupled to the cam shaft, a memory, and a controller. The controller implements cam rotation instructions received from the memory to cause the pump to position the fingers in the occlusion region prior to beginning an infusion therapy to deliver fluid to patient through the tube at a patient fluid delivery rate, rotate the cam shaft to transition the fingers from the occlusion region to the pumping region at a startup rate that is faster than a patient fluid delivery rate, and rotate the cam shaft at the patient fluid delivery rate in the pumping region.