Patents Assigned to B.G. Negev Technologies & Applications Ltd., at Ben-Gurion University
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Patent number: 12174009Abstract: A method for extending scatterometry measurements of periodic structures created on a substrate into the deep UV and soft X-ray regions of the electromagnetic spectrum is presented. The method comprises measuring the scattering of a high harmonic generated (HHG) beam, which is created by a driving laser, that is scattered from the structures on the substrate. The scattered HHG beam is measured by a spectrometer or a detector sensitive to HHG radiation. Also presented is a system for carrying out the method.Type: GrantFiled: February 24, 2019Date of Patent: December 24, 2024Assignee: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventor: Evgeny Frumker
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Patent number: 12174418Abstract: The invention relates to an on-chip optical waveguide comprising an input or output facet, the facet comprising an array of unit-cells; each unit cell is a recess that gradually narrows in the direction from the outer of the waveguide towards the interior of the waveguide.Type: GrantFiled: January 19, 2021Date of Patent: December 24, 2024Assignee: B.G. Negev Technologies and Applications LTD., at Ben-Gurion UniversityInventor: Alina Karabchevsky
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Publication number: 20240412356Abstract: The present invention relates generally to machine learning and artificial intelligence methods of cell anomaly detection. More specifically, the present invention relates to targeting intracellular anomalies via microscopy-based high-content phenotypic screening and generative neural networks for combinatorial drug screening. As can be seen from the provided description, the claimed invention represents the system and method of cell anomaly detection, which increase reliability of cell anomaly detection. More specifically, the claimed invention provides an assessment of cell inter-component (inter-organelle) organization for detecting cell anomaly.Type: ApplicationFiled: October 30, 2022Publication date: December 12, 2024Applicant: B.G. Negev Technologies & Applications Ltd., at Ben-Gurion UniversityInventors: Assaf ZARITSKY, Naor KOLET
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Patent number: 12163173Abstract: The present invention provides a composition with a cell having an orthogonal translation system, and an expression vector. The invention also provides a method of producing a protein carrying an unnatural amino acid, and a kit for use in producing a protein carrying the unnatural amino acid.Type: GrantFiled: November 9, 2017Date of Patent: December 10, 2024Assignees: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY, REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Lital Alfonta, Vincent Noireaux, Orr Schlesinger, Yonatan Chemla, Eden Ozer
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Publication number: 20240381857Abstract: The present invention provides a method for editing the genome of at least one cell of a crustacean embryo, the method including contacting a crustacean embryo or a cell thereof with an effective amount of a gene editing agent. Further provided is a crustacean including at least one cell comprising an edited genome, obtained according to the method of the invention.Type: ApplicationFiled: May 20, 2024Publication date: November 21, 2024Applicants: B. G. Negev Technologies and Applications Ltd., at Ben-Gurion University, COLORS FARM LTD.Inventors: Amir SAGI, Rivka MANOR, Eli AFLALO, Ran EPSTEEN, Marcia PIMENTA LEIBOWITZ, Rivki OFIR
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Patent number: 12149068Abstract: The present invention provides topologies of phase-controlled IGBT bridge type and GTO bridge type Fault Current Limiter (FCL), which allow the precise limitation of fault currents to the desired values and can keep these values constant despite variations (dynamic behavior) of the fault currents. According to an embodiment of the invention, the topologies enable to use a phase control approach for optimal firing angles calculation. This control approach can be used in the proposed FCL topologies and other controlled bridge topologies such as SCRs bridge, GTO bridge, and IGBT/IGCT/Mosfet bridge topologies.Type: GrantFiled: December 2, 2022Date of Patent: November 19, 2024Assignees: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY, SAMI SHAMOON COLLEGE OF ENGINEERING (R.A.)Inventors: Dmitry Baimel, Alon Kuperman
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Publication number: 20240366571Abstract: Compounds capable of interacting with the calmodulin-PIP2 binding domain of the SK4 channel to thereby interfere with the Ca2+-dependent activation of the SK4 channel and uses thereof in downregulating an activity of an SK4 channel in a subject in need thereof, are disclosed. Also disclosed is a method of identifying a candidate compound that is capable of downregulating an activity of SK4 channel, based on its interaction with the calmodulin-PIP2 binding domain of the SK4 channel.Type: ApplicationFiled: July 17, 2024Publication date: November 7, 2024Applicants: Ramot at Tel-Aviv University Ltd., B.G. Negev Technologies and Applications Ltd., at Ben-Gurion UniversityInventors: Bernard ATTALI, Shahaf Asher PERETZ, Elvira HAIMOV, Boris REDKO, Avi RAVEH, Adva YEHESKEL, Hamutal ENGEL, Yoram ETZION
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Patent number: 12126635Abstract: A framework for efficiently and automatically exploring a data network and accurately identifying network threats, which comprises a plurality of software and hardware-based agents, distributed over the data network. The agents are capable of adjusting or reconfiguring, on the fly, the behavior of the agents and their ability to collect data in a targeted manner, so as to investigate suspicious incidents and alerts and collect data that was not yet collected by the system; collecting forensic data by executing tasks defined in workflows, being distributed threat intercepting programs and reporting about the collected forensic data, back to a Central Control Unit (C&C).Type: GrantFiled: March 25, 2019Date of Patent: October 22, 2024Assignees: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY, NANYANG UNIVERSITYInventors: Yuval Elovici, Rami Puzis, Polina Zilberman, Elad Marco, Aviad Elitzur, Thambipillai Srikanthan, Anupam Chattopadhyay, Siew Kei Lam, Jawad Haj-Yahya
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Patent number: 12108759Abstract: The present invention relates to antibacterial carbon dots, having aminoguanidine functionality on their outermost surface. The invention further relates to the synthesis of said antibacterial carbon dots, and to the uses of these carbon dots for inhibiting a biofilm formation in the presence of said carbon dots and as fluorescent labeling markers for specific bacteria.Type: GrantFiled: October 31, 2019Date of Patent: October 8, 2024Assignee: B.G. NEGEV TECHNOLOGIES & APPLICATIONS, LTD., AT BEN-GURION UNIVERSITYInventors: Raz Jelinek, Sagarika Bhattacharya, Gil Otis
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Patent number: 12055758Abstract: The invention relates to an input or output facet for an on-chip optical waveguide, the facet comprising a grid of gradually expanding unit-cells such as cones or pyramids.Type: GrantFiled: December 29, 2019Date of Patent: August 6, 2024Assignee: B.G. NEGEV TECHNOLOGIES & APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventors: Alina Karabchevsky, Joseph Gurwich
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Publication number: 20240238735Abstract: Water permeable coated substrates comprising a polymeric substrate in contact with a coating comprising a plurality of particles and a cross-linked polymer are disclosed. Uses of the coated substrates, particularly for water filtration are also disclosed.Type: ApplicationFiled: May 26, 2022Publication date: July 18, 2024Applicant: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventors: Ron KASHER, Akshay MODI
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Publication number: 20240239349Abstract: A system, e.g., an autonomous vehicle, includes a sensor suite, a controller, and a computer-controllable device. The sensor suite collects user data descriptive of the present emotional state of a human user, such as a passenger of the representative autonomous vehicle. The controller executes a method to control the system. In particular, the controller identifies the user's psychological mode of experience in response to the user data. The controller also selects one or more intervening control actions or “interventions” from a list of possible interventions based on the mode of experience, and then controls an output state of the device to implement the intervention(s). In this manner the controller is able to support or modify the mode of experience of the user.Type: ApplicationFiled: January 12, 2023Publication date: July 18, 2024Applicants: GM GLOBAL TECHNOLOGY OPERATIONS LLC, B.G. Negev Technologies and Applications Ltd. at Ben-Gurion UniversityInventors: Asaf Degani, Yael Shmueli Friedland, Zahy Bnaya, Christine Ebner, Guy Cohen-Lazry, Tal Oron-Gilad
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Publication number: 20240233328Abstract: An information processing apparatus extracts a projection area of an object from an input scene containing a projection of the object, specifies each of second areas that are included in the extracted projection area of the object and that are similar to a plurality of first areas representing a feature of each of labels in a feature space, outputs a first classification result based on each of the plurality of labels indicating a state in which a distribution of combinations of the specified second areas and the first areas that are associated with the second areas is closer than a predetermined threshold; and determines whether or not an adversarial patch is included in the object by comparing the first classification result with a second classification result that is a result of classification of the objects obtained by inputting the input scene to a predetermined object detection model.Type: ApplicationFiled: December 29, 2023Publication date: July 11, 2024Applicants: Fujitsu Limited, B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., at Ben-Gurion UniversityInventors: Omer HOFMAN, Amit GILONI, Ikuya MORIKAWA, Toshiya SHIMIZU, Yuval ELOVICI, Asaf SHABTAI
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Publication number: 20240198423Abstract: A sensor is disclosed. The sensor comprises a substrate; and a gold pattern attached to the substrate, wherein the gold pattern is made from a plurality of repeating units, each unit is made from at least one line having a width of between 100 to 500 nm and a length of between 1 to 50 microns, and wherein a first distance between two neighboring units is between 50 to 1000 nm, and wherein all lines in the pattern, are originated from a monocrystalline gold, therefore, have the same crystallographic orientation with respect to the substrate.Type: ApplicationFiled: April 19, 2022Publication date: June 20, 2024Applicant: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventor: Muhammad Y. BASHOUTI
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Patent number: 12012336Abstract: Methods that expand the properties of laser-induced graphene (LIG) and the resulting LIG having the expanded properties. Methods of fabricating laser-induced graphene from materials, which range from natural, renewable precursors (such as cloth or paper) to high performance polymers (like Kevlar). With multiple lasing, however, highly conductive PEI-based LIG could be obtained using both multiple pass and defocus methods. The resulting laser-induced graphene can be used, inter alia, in electronic devices, as antifouling surfaces, in water treatment technology, in membranes, and in electronics on paper and food Such methods include fabrication of LIG in controlled atmospheres, such that, for example, superhydrophobic and superhydrophilic LIG surfaces can be obtained. Such methods further include fabricating laser-induced graphene by multiple lasing of carbon precursors. Such methods further include direct 3D printing of graphene materials from carbon precurors.Type: GrantFiled: November 1, 2021Date of Patent: June 18, 2024Assignees: William Marsh Rice University, B.G. NEGEV TECHNOLOGIES AND APPLICATIONS, LTD. AT BEN-GURION UNIVERSITYInventors: James M. Tour, Yieu Chyan, Christopher John Arnusch, Swatantra Pratap Singh, Yilun Li, Duy X. Luong, Carter Kittrell, Ruquan Ye, Jordan Miller, Ian Kinstlinger, Savannah Cofer
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Patent number: 11995568Abstract: A method and a system are provided for determining a likelihood of a metabolic pathway existing in an organism, including: calculating a feature vector for each metabolic pathway of metabolic pathways known to exist and not known to exist in the organism, wherein elements of the feature vectors are network properties of the metabolic pathways mapped to a metabolite concentration correlation network (CN); training a supervised machine learning model for classifying metabolic pathways as existing or not existing in the organism, according to the known and unknown feature vectors; determining, based on mapping to the CN, a feature vector of a proposed metabolic pathway, and feeding the feature vector of the proposed metabolic pathway to the trained SML model, to determine a likelihood of the proposed metabolic pathway existing in the organism.Type: GrantFiled: May 16, 2019Date of Patent: May 28, 2024Assignee: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventors: David Toubiana, Rami Puzis, Yuval Elovici
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Publication number: 20240158462Abstract: A polynucleotide is provided. The polynucleotide encoding a chimeric polypeptide comprising an amino acid sequence of an immune checkpoint molecule capable of binding a ligand thereof, the immune checkpoint molecule being translationally fused to another amino acid sequence of a cell signaling module such that upon binding of the immune checkpoint molecule to the ligand, the cell signaling module is activated. Also provided other configurations of the polynucleotide, cells comprising the polynucleotides and methods of using the cells expressing the polynucleotides.Type: ApplicationFiled: September 10, 2023Publication date: May 16, 2024Applicant: B.G. Negev Technologies & Applications Ltd., at Ben-Gurion UniversityInventors: Moshe ELKABETS, Angel PORGADOR
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Patent number: 11985233Abstract: A computer implemented method for encoding bits by qubits to perform information-theoretically secure quantum gate computation, according to which pairs of quantum bits consisting of a first qubit as an encoding of “0” and a second qubit as an encoding of “1” are randomly selected, such that the first and second qubits are orthogonal to each other as quantum states and are interchanged by a NOT gate. Each qubit rotating to a desired initial direction and then each rotated qubit is further rotated to its antipodal direction by applying a quantum NOT or CNOT gate to the each rotated qubit, without any knowledge about the desired direction. A unitary gate is further applied over the qubits, using an ancillary |0 qubit that creates an equally weighted superposition of the qubits.Type: GrantFiled: May 19, 2020Date of Patent: May 14, 2024Assignee: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventors: Daniel Berend, Dor Bitan, Shlomi Dolev
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Patent number: 11976099Abstract: Mutant M-CSF protein, comprising ?v?3 integrin binding motif and pharmaceutical compositions comprising same, are provided. Further, use of the composition for the treatment and or prevention of diseases associated with increased bone resorption are provided.Type: GrantFiled: August 4, 2021Date of Patent: May 7, 2024Assignees: THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD., B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventors: Niv Papo, Noam Levaot, Yuval Zur, Lior Rosenfeld
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Publication number: 20240141303Abstract: The present invention provides a recombinant protein including (a) lactate dehydrogenase (LDH); and (b) a minimal c-type cytochrome peptide. Further provided is a polynucleotide encoding the recombinant protein, a cell including the same, and methods of using same, such as for determining presence, concentration, or both, of an analyte in a liquid medium.Type: ApplicationFiled: January 4, 2024Publication date: May 2, 2024Applicant: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventors: Lital ALFONTA, Anastasya BOYARSKI