Abstract: The present invention discloses the use of RNA inhibitory molecules, particularly siRNA molecules silencing the expression of Voltage-Dependent Ion Chanel-1 (VDAC1) for the induction of cancer stem cell differentiation and reduction of TAMS abundance and tumor angiogenesis, thereby preventing tumor invention and recurrence.

Abstract: The invention provides a nano-sized particle comprising a cross-linked polymer, wherein the polymer is selected from the group consisting of a polyacrylic acid homopolymer; polymethacrylic acid homopolymer; poly(alkylcyanoacrylate) polymer; a copolymer comprising at least two monomers selected from acrylic acid, methacrylic acid, hydroxyethyl acrylate, hydroxyethyl methacrylate, and alkyl cyanoacrylate/cyanoacrylic acid monomers; carboxymethyl cellulose; alginic acid polymer, polylactic-polyglycolic acid (PLGA), and xanthan gum; and wherein said polymer is cross-linked with a metal ion. A process for preparing such particles is also provided.

Abstract: A broadcast encryption method that allows a broadcaster to send encrypted content to a set of users such that only a subset of authorized users can decrypt the content, and to perform both temporary and permanent revocation of users. Accordingly, during a Setup stage, a Key Service generates a public key and a Master Secret Key (MSK) and sends the Public Parameters PP used to generate the public key to a broadcaster and to all users. The broadcaster uses the Public Parameters PP to create a message M, with which the broadcaster encrypts the content, and further creates a Cipher Text (CT), which is sent to all users. During a Key Gen stage, whenever a user wishes to decrypt the message M for decrypting the content, the user sends a request with his ID1 to the Key Service. The Key Service generates a corresponding secret key SKID1 and the secret key SKID1 is sent to the user ID1 via a secure data channel.

Abstract: The present invention provides conjugates comprising a sugar such as mannitol and one or more L-DOPA and/or DOPA decarboxylse inhibitors including, inter alia, L-DOPA, carbidopa, benserazide, or a combination thereof, wherein the sugar is conjugated to the carboxyl group of the L-DOPA and/or DOPA decarboxylse inhibitor/ s) via a hydroxyl group of the sugar. The present invention further provides related pharmaceutical compositions and methods of producing the conjugates, as well as methods of use for treating medical disorders responsive to dopamininergic stimulation such as movement disorders including, inter alia, Parkinson's Disease.

Abstract: The invention provides ultraviolet light absorber suitable for use as an additive in polymers, comprising particles of inorganic oxide having UV light-absorbing compound on their surface, wherein said UV light-absorbing compound is chemically bonded, either to a spacer provided on the surface of said particle, or directly to the surface of the particle. Process for preparing the additive absorber and a thermoplastic polymer (e.g., a film) comprising the absorber additive are also provided.

Abstract: Mutant M-CSF protein, comprising ?v?3 integrin binding motif and pharmaceutical compositions comprising same, are provided. Further, use of the composition for the treatment and or prevention of diseases associated with increased bone resorption are provided.

Abstract: A method of monitoring network traffic in a communication network with a sentinel module to detect malicious activity is described. A gateway sentinel module receives network traffic directed through a gateway installed for a local distribution of the network, the gateway connecting the local distribution of the network to a core of the network. Malicious activity in the local distribution is detected based on a combination of: a local machine-learning model for identifying malicious activity in the local distribution, the local machine-learning model modelling network traffic from the local distribution; and a global machine-learning model. The global machine-learning model models network traffic from a plurality of local distributions of the network based training data from a plurality of local sentinel modules executed on a respective plurality of computing nodes. The computing nodes respectively receive network traffic from the plurality of location distributions.

Abstract: A high-frequency resonant power conversion system for transferring power from an oscillator to a load or vice-versa, the system including components with at least one fluctuating parameter and is configured to control the value of a defined variable selected from: a certain current, a certain voltage, a phase difference between a certain voltage and a certain current, and a certain power; the system further including a virtual impedance creation loop which is configured to create a virtual component, the virtual component forming a basis for changing amplitude and a phase of the oscillator, thereby to compensate for a deviation from the controlled variable due to the fluctuations.

Abstract: Provided are RNA inhibitory molecules, particularly siRNA molecules silencing the expression of Voltage-Dependent Ion Chanel-1 (VDAC1) for the induction of cancer stem cell differentiation and reduction of TAMs abundance and tumor angiogenesis, thereby preventing tumor invention and recurrence.

Abstract: A system for measuring with the aid of light absorption spectrometry the concentration of one or more analytes in porewater in soil, the system comprising: one or more monitoring unit(s), each monitoring unit comprising a porewater sampler (1), an optical flow cell (2) with a tube connecting the liquid inlet port of said optical flow cell to said porewater sampler; and vacuum arrangement to enable extraction of porewater; at least one light source (5) for generating a light beam to be transmitted through said optical flow cell (2); and at least one detector (8) for obtaining spectral information from the beam exiting said optical flow cell. A method of measurement is also provided.

Abstract: Methods that expand the properties of laser-induced graphene (LIG) and the resulting LIG having the expanded properties. Methods of fabricating laser-induced graphene from materials, which range from natural, renewable precursors (such as cloth or paper) to high performance polymers (like Kevlar). With multiple lasing, however, highly conductive PEI-based LIG could be obtained using both multiple pass and defocus methods. The resulting laser-induced graphene can be used, inter alia, in electronic devices, as antifouling surfaces, in water treatment technology, in membranes, and in electronics on paper and food Such methods include fabrication of LIG in controlled atmospheres, such that, for example, superhydrophobic and superhydrophilic LIG surfaces can be obtained. Such methods further include fabricating laser-induced graphene by multiple lasing of carbon precursors. Such methods further include direct 3D printing of graphene materials from carbon precursors.

Abstract: Peptides derived from NKp44 protein, chimeric peptides, nucleotides encoding same and pharmaceutical compositions comprising same, are provided. Further, methods of extending the biological half-life of a protein of interest are provided.

Abstract: A method for testing operating software of a system consisting of a plurality of internal subsystems operating in an environment and controlled by a hardware board using electronic signals and an operating software. The signals are translated into a computer readable format by an interfacing card for each internal subsystem and simulating the internal subsystems by data acquisition modules by a simulating computer, which simulates the environmental conditions to which each module is currently exposed. A scenario based test software module generates a plurality of possible independent test scenarios using Behavioral Programming (BP) and the independent scenarios are interleaved at run time by an execution engine, to thereby automatically create a larger number of dependent and derived scenarios representing only possible combinations which are relevant to the operating conditions and states of the system.

Abstract: The present invention relates to a robot device comprising a chain comprising a plurality of fixedly connected links and a mobile actuator movable thereon configured to change a position of a link relative to a position of an adjacent link; wherein said mobile actuator comprises at least a first motor to drive it along said chain of connected links; and wherein said mobile actuator is engageable with a position-determining element in said link.

Abstract: The invention relates generally to compositions and methods for generating immunotolerant responses in a subject. Specifically, the invention relates to a composition comprising a sulfated polysaccharide and a bioactive polypeptide for generating an immunotolerant response.

Abstract: A method for providing self-stabilization of functionality security and privacy to a distributed computer system with self-stabilizing machines, according to which the system periodically and constantly recovers from cyber-attacks performed by an adversary who gained access to the system during a vulnerability window. Then a True Random Number Generator (TRNG) generates a random number from which generating a pair of public and private keys are generated. The public key of the pair is distributed among neighboring machines, to generate a common symmetric secret key. Each machine to exchanges messages with any other machine using messages that are encrypted and decrypted by their established common symmetric secret key, where all keys are generated using random numbers that were generated by the True Random Number Generator.

Abstract: A method for efficiently method for performing adaptive management of a cache with predetermined size and number of cells with different locations with respect to the top or bottom of the cache, for storing at different cells, data items to be retrieved upon request from a processor. A stream of requests for items, each of which has a temporal probability to be requested is received and the jump size is incremented on cache misses and decremented on cache hits by automatically choosing a smaller jump size and using a larger jump size when the probability of items to be requested is changed. The jump size represents the number of cells by which a current request is promoted in the cache, on its way from the bottom, in case of a cache hit, or from the outside in case of a cache miss, towards the top cell of the cache.

Abstract: Mutant M-CSF protein, comprising ?v?3 integrin binding motif and pharmaceutical compositions comprising same, are provided. Further, use of the composition for the treatment and or prevention of diseases associated with increased bone resorption are provided.

Abstract: An upconversion system, including: a glow discharge device (GDD) configured to detect signal source radiation, wherein the signal source radiation is at least one of millimeter wave (MMW) radiation and Terahertz (THz) radiation; and a photodetector configured to measure intensity changes in visible light emitted by said GDD as a result of absorption of the signal source radiation. The upconversion system optionally includes a processor operatively coupled to the photodetector. The processor is configured to analyze imagery captured by the photodetector, and to compute at least one parameter of the signal source radiation based on the imagery.

Abstract: The invention relates to a method for the preparation of a layer containing a plurality of linear carbyne chains, the method comprising (a) applying laser ablation on a piece of shungite in a liquid, followed by laser irradiation of the resultant carbon structures within the liquid in the presence of stabilizing metal nanoparticles, thereby to form a colloidal solution; and (b) subjecting at least a portion of said colloidal solution to AC voltage while the solution is allowed to dry, thereby to create a two-dimensional layer containing a plurality of carbyne chains.