Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.

Abstract: A fiber optic cassette includes a body defining a front and an opposite rear. A cable entry location, such as a multi-fiber connector, is defined on the body for a cable to enter the cassette, wherein a plurality of optical fibers from the cable extend into the cassette and form terminations at one or more single or multi-fiber connectors adjacent the front of the body. A flexible substrate is positioned between the cable entry location and the connectors adjacent the front of the body, the flexible substrate rigidly supporting the plurality of optical fibers. Each of the connectors adjacent the front of the body includes a ferrule. Dark fibers can be provided if not all fiber locations are used in the multi-fiber connectors. Multiple flexible substrates can be used with one or more multi-fiber connectors.

Abstract: A digital synchronizer is disclosed with a phase locked loop and a carrier generator. The phase locked loop is configured to produce an output signal having the same frequency as an input signal by selecting a divider ratio of a frequency divider with a control signal, the frequency divider divides the frequency of a high frequency signal by the divider ratio to provide the output signal; carrier generator is configured to generate an oversampled carrier signal by using the control signal to produce a carrier signal with a period corresponding with a contemporaneous period of the output signal.

Abstract: The present disclosure relates to microparticles or nanoparticles comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9; m+p+q=1 whereby m or p could be 0; n is about 5 to about 300; (pref.

Abstract: A mining system includes: a vessel for processing mined ore, an upper platform coupled with the vessel, a lower platform supported by the ocean floor, a number of transport cables which extend between the upper and lower platform, and a container for containing ore which container is fixedly coupled to a container transporting cable such that the container moves vertically with the container transporting cable to transport the container in a container trajectory extending between the upper and lower platform.

Abstract: A process capturing CO2 from a CO2-containing gas stream, contacting a CO2-containing gas stream with a CO2-absorbing agent in an absorption step in a vessel with maximum temperature T1 resulting in absorption of CO2. The CO2 absorbing agent comprising a polymer dissolved in an aqueous medium, the polymer, a thermoresponsive copolymer, comprising amine monomer distributed through the copolymer, subjecting the CO2-containing absorbing agent to a desorption step in a vessel with maximum temperature T2, releasing CO2, wherein T1 is below LCST of the thermoresponsive polymer at maximum CO2 loading, and T2 is above LCST of the thermoresponsive polymer at minimum CO2 loading. CO2 absorbing agent comprises amine component dissolved in the aqueous medium. Use of the specific polymer dissolved in an aqueous medium at T1, wherein amine monomer, distributed through the copolymer with an amine component, improves net CO2 sorption and high absorption speed, allowing a relatively small absorption reactor.

Abstract: A transport device includes a flexible base plate which is rolled up when not in use and is spread out flat to receive a load to be transported and is raised at least at the longitudinal sides when in use. The transport device has holes for the attachment of straps or belts at least along two longitudinal edges of the base plate. Reinforcing elements each include two plates fixed to the base plate on both sides by an eyelet and two further fastening elements associated with the holes. The eyelet borders the hole for attachment of the strap or belt. The eyelet and the two further fastening elements are disposed in a triangle.

Abstract: The invention relates to improvements of a scraping heat exchanger having an outer cylinder comprising a first wall having a smooth circle-cylindrical inner side, and an inner cylinder positioned concentrically within it. The improvements regard a simple detachable inner cylinder, a heat exchanger with lid including a fluid barrier, a heat exchanger with a tangential output, and a method and heat exchanger adapted for improved evacuation of a product chamber of a heat exchanger.

Abstract: Data carriers for inventorying by means of a communication station, whereby the communication station and each data carrier are brought into communicative connection, and each data carrier brought into communicative connection with the communication station is configured to generate a response signal that renders possible an inventorying of the data carrier and is capable of delivering a generated response signal with the use of a transmission start moment that can be selected from a plurality of transmission start moments, each data carrier tests whether another data carrier is already giving its response signal. Each data carrier is configured to discontinue the generation or delivery of its response signal if another data carrier is already providing its response signal.

Abstract: An electronic tag, e.g. for use as a tracker tag or combined tracker and data tag, with a cellular communication module is disclosed. The cellular communication module is configured to transmit an indication of a current geographical location to an external data server. The electronic tag can optionally receive tag data from an external tag reader and optionally comprises an output means configured to output the tag data. The tag's microprocessor is configured to switch off at least a transmitter part of the cellular communication module in response to first data contained in a Mode S signal of an aircraft transponder. Said transmitter part may be switched on again depending on data in signals from external source(s) as received in the tag.

Abstract: Methods, apparatus, and computer program products are provided. An example method comprises identifying an object in a source graph; defining a closure graph around the object in the source graph; building a closure set around the object based on the closure graph; identifying the anchor nodes of the closure set on the target graph; and deflating the closure set on the target graph to identify a target object in the target graph that corresponds to the object in the source graph. The object is identified by a directed way and an offset there along. An anchor node is a junction that is tagged with a junction identifier configured to uniquely identify the junction in both the source graph and a target graph.

Abstract: A lighting assembly, a light source and a luminaire are provided. The lighting assembly 100 comprises a primary thermal layer 112, a plurality of Lighting Emitting Diode assemblies 106 and a plurality of wires 102. The primary thermal layer 112 is of a thermally conductive material. The wires 102 are electrically coupled between electrodes 108, 114 of at least two different Light Emitting Diode assemblies 106. The Light Emitting Diode assemblies 106 comprise a sub-mount 110, a first and a second metal electrode 108, 114 and a Light Emitting Diode die 116. The sub-mount 110 is of a thermally conductive and electrically insulating ceramic. The sub-mount 110 has a first side which is thermally coupled to the primary thermal layer 112 and has a second side being opposite the first side. The first and the second metal electrode 108, 114 are arranged at the second side of the sub-mount 10.

Abstract: The invention relates to a monitoring arrangement for monitoring an electrical line having at least one thermogenerator and/or a device for inductively producing energy, determination means for determining at least one electrical characteristic parameter of an electrical current flowing in the electrical line and/or the temperature of the electrical line and/or the area surrounding the electrical line. An electrical connection exists or can be established between the determination means and the thermogenerator or the device for inductively producing energy, which connection can be used to operate the determination means with electrical energy produced by the thermogenerator or provided by the device for inductively producing energy; and connection means for establishing a mechanical connection to the electrical line.

Abstract: A receiver assembly comprising a first and a second receiver housing and a spout. The second receiver housing is positioned over a first sound outlet port of the first receiver housing and the spout is positioned over a second outlet port of the second receiver housing. An acoustic duct is located between the first and second receiver housing acoustically connecting the first sound outlet port to the spout and is provided with an acoustic mass.

Abstract: Apparatuses, systems, and methods for the deployment of a plurality of autonomous underwater seismic vehicles (AUVs) on or near the seabed based on acoustic communications with an underwater vehicle, such as a remotely operated vehicle. In an embodiment, the underwater vehicle is lowered from a surface vessel along with a subsea station with a plurality of AUVs. The AUVs are configured to acoustically communicate with the underwater vehicle or a second surface vessel for deployment and retrieval operations. The underwater vehicle and/or second surface vessel is configured to instruct the AUVs to leave the subsea station or underwater vehicle and to travel to their intended seabed destination. The underwater vehicle and/or second surface vessel is also configured to selectively instruct the AUVs to leave the seabed and return to a seabed location and/or a subsea station for retrieval.

Abstract: A new and distinct cultivar of Salvia plant named ‘Barsalcaram’, characterized by its upright plant habit; vigorous growth habit; freely branching habit; dark purple-colored lateral branches; early and freely flowering habit; upright inflorescences with violet blue-colored flowers; and good garden performance.