Abstract: A delivery assembly includes a console including a vial containment region and a vial engagement mechanism extending from the console within the vial containment region. The engagement mechanism is configured to engage a vial assembly including a particulate material. The delivery assembly further includes a multi-port needle with a top distal port and bottom proximal port(s), the needle configured to puncture a septum of the vial assembly when the vial assembly is in the locked position, in which the top distal port is at a distance above the particulate material in the vial assembly. The ports are configured to inject a fluid into the vial assembly to mix with the particulate material upon actuation of the vial engagement mechanism in a first direction and to receive a resulting mixed fluid from the vial assembly upon actuation of the vial engagement mechanism in a second opposite direction.

Abstract: An atherectomy catheter includes a sheath and an elongate corewire. The sheath has a side wall configured to define, in a lumen and in a distal sheath portion, an entrapment boundary region having a drilling allowance region. The elongate corewire has a distal wire portion having an outer bulge portion that is proximal to an elongate drill tip portion. The elongate corewire is located in the lumen of the sheath with the outer bulge portion of the elongate corewire slidably disposed in the drilling allowance region of the sheath, and with the elongate drill tip portion of the elongate corewire distally protruding from the distal end of the sheath.

Abstract: A lymph conduction system implant includes a stent graft and a porous membrane. The stent graft has a non-porous tubular side wall. The non-porous tubular side wall has a proximal end and a distal end. The non-porous tubular side wall is configured to define a lumen having an inflow port at the proximal end and an outflow port at the distal end. All exposed surfaces of the stent graft are made of a first biocompatible material. The porous membrane is connected to the proximal end of the non-porous tubular side wall of the stent graft. The porous membrane is configured to span an entirety of a transverse area of the inflow port of the lumen of the stent graft. The porous membrane is made of a second biocompatible material.

Abstract: A biopsy apparatus includes a cannula assembly having a cannula hub and a cutting cannula. A stylet assembly has a stylet hub and a stylet. The stylet is coaxial with the cutting cannula. An operator mechanism is configured to effect axial movement of the stylet hub and the cannula hub. The operator mechanism has a head portion configured to releasably engage the stylet hub and an arm member configured to releasably engage the cannula hub. The stylet hub is configured to be rotationally movable between an engaged position and a disengaged position, wherein in the engaged position the stylet hub is releasably connected to the head portion of the operator mechanism, and in the disengaged position, the stylet hub is disconnected from the head portion of the operator mechanism to facilitate axial movement of the stylet assembly in a proximal direction independent of the operator mechanism.

Abstract: Systems and methods for tumor ablation with controlled precision of a temperature profile utilizing a tumor ablation probe device may include disposing a distal end of the tumor ablation probe device in a tissue, the distal end including a plurality of electrothermal modules (ETMs) on probe arm(s), each ETM including a first surface component electrically connected to a second surface component; supplying a first voltage of a first polarity or a second voltage of a second polarity to at least one ETM, and repeatedly alternating between the first polarity and the second polarity based on a time sequence cycle. When the first polarity is supplied, the ETM heats the first surface component and cools the second surface component, and when the second polarity is supplied, the ETM cools the first surface component and heats the second surface component. Each ETM and/or probe arm is configured for independent control.

Abstract: Devices, systems, and methods for providing per-procedure pricing for a product are disclosed. A system includes a facility monitoring system having one or more data gathering devices collecting data pertaining to use of a plurality of units of the product over a period of time. The system also includes a product provider system communicatively coupled to the facility monitoring system and including a determination device that receives the data and determines a total average number of units per procedure for the product, the determination device including a machine learning component trained to determine an expected number of units per procedure and determine a plurality of pricing tiers that establish a price is used to calculate an adjusted per-procedure price for the product over the period of time, the determination device issuing a rebate if the adjusted per-procedure price is less than an upfront cost paid.

Abstract: Sealant delivery systems, sealant applicators, and injection needle assemblies are disclosed. A sealant delivery system includes a sealant applicator that has two chambers separate from one another. Each chamber includes an output port on a distal end thereof. The sealant applicator also has a quarter turn connector disposed on a distal end of the sealant applicator adjacent to the output port of each chamber. The quarter turn connector is shaped to releasably interlock with a corresponding quarter turn connector of an injection needle assembly having input ports or a corresponding quarter turn connector of a dual chamber mixing syringe having mixing ports. When the injection needle assembly or the dual chamber mixing syringe is coupled to the sealant applicator via the quarter turn connector, the input ports or the mixing ports are aligned and sealed with the output port of each chamber of the sealant applicator.

Abstract: A sealant injection needle assembly includes a cannula assembly and a stylet assembly. The cannula assembly has a cannula hub and a cannula having a first longitudinal sealant passage and a second longitudinal sealant passage. The first longitudinal sealant passage has a first proximal sealant port and a first distal sealant port. The second longitudinal sealant passage has a second proximal sealant port and a second distal sealant port. The stylet assembly has a stylet advance hub and a stylet configured for longitudinal movement in a lumen of the cannula. The stylet has a first stage position and a second stage position. The stylet has a first exterior circumvolving channel longitudinally spaced apart from the second exterior circumvolving channel that are separately selectively and sequentially positionable in fluid communication with both of the first distal sealant port and the second distal sealant port of the cannula.

Abstract: An ultrasonic catheter includes a catheter sheath, an ultrasonic transmission member, and a catheter body. The ultrasonic transmission member extends within a lumen of the catheter sheath. The catheter body is coupled to the catheter sheath. The catheter body has a fluid inlet port and an inner cavity in fluid communication therewith. A plurality of O-ring members is disposed around and contacts a proximal portion of the ultrasonic transmission member. An O-ring housing is located in the inner cavity of the catheter body, which is configured to contain the plurality of O-ring members. A perimetrical fluid channel is defined between an outer surface of the O-ring housing and the catheter body. The O-ring housing is configured such that a heat dissipating fluid flows into the perimetrical fluid channel and across the outer surface of the O-ring housing to dissipate heat from the plurality of O-ring members.

Abstract: A bipolar electrosurgical pleura sealing device includes an electrosurgical probe assembly having a coaxial arrangement that includes an inner stylet, a first intermediate cannula, a second intermediate cannula, and an outer cannula, having appropriate insulation. A first mesh electrode connects to and extends between a distal end portion of the inner stylet and a distal end of the first intermediate cannula, and is movable between a first extended position and a first retracted position by an axial movement of the inner stylet and/or the first intermediate cannula. A second mesh electrode connects to and extends between a distal end of the second intermediate cannula and a distal end of the outer cannula, and is movable between a second extended position and a second retracted position by an axial movement of the second intermediate cannula and/or the outer cannula.

Abstract: A disposable medical vacuum drainage bag includes a flexible enclosure made of a flexible material. The flexible enclosure is configured to define an interior chamber. The flexible enclosure has a first fluid port and a second fluid port. The flexible enclosure has a collapsed state and an expanded state. A framework is located in the interior chamber. The framework has a plurality of frame structures configured to rotate in unison about separate rotational axes between a collapsed configuration and an expanded configuration, wherein the collapsed configuration facilitates the collapsed state of the flexible enclosure and the expanded configuration facilitates the expanded state of the flexible enclosure. An actuator is coupled to the framework. The actuator is configured to rotatably transition the plurality of frame structures between the collapsed configuration and the expanded configuration.

Abstract: A vascular device insertion system includes a support catheter having a hub, a flexible elongate member that extends distally from the hub, and a catheter lumen that extends through the hub and the flexible elongate member. An insertion module housing is configured to contain a motor having a hollow motor shaft. The hollow motor shaft has a proximal end, a distal end, a distal end portion, and an elongate opening that extends from the proximal end to the distal end. The distal end portion of the hollow motor shaft is configured to couple to the hub of the support catheter. The elongate opening of the hollow motor shaft and the catheter lumen of the support catheter together define a continuous passage. A motor controller is electrically coupled to the motor, and is configured to rotationally oscillate the hollow motor shaft to in turn rotationally oscillate the support catheter.

Abstract: Medical devices and methods thereof for determining bacterial infections in blood. The medical devices and methods thereof can utilize a coating including an antibody conjugated to a reporter protein configured to indicate a bacterial infection in a patient's blood by way of an antigen thereof. Exemplary medical devices include, but are not limited to, a catheter assembly, an AV fistula needle set, an extension set for either a catheter assembly or an AV fistula needle set, and a hemodialysis tubing set. The medical devices and methods thereof can utilize immunochromatographic separation of the antibody and an antigen-antibody complex to indicate a bacterial infection in a patient's blood.

Abstract: Compositions and methods related to hydrogel tissue sealants are generally described. In certain embodiments, a hydrogel forming composition is provided in dry form (e.g., as one or more powder mixtures) and comprises at least an electrophilic polymer crosslinking agent and a nucleophilic polymer such as a protein that is capable of crosslinking with the crosslinking agent. One or more solvents able to dissolve the crosslinking agent and the protein can be provided and used to dissolve the hydrogel forming composition to facilitate crosslinking.

Abstract: An introducer cannula for use in crossing pleural layers includes an elongate tubular member and a pleural access liner. The elongate tubular member has a proximal end, a distal end, and a side wall that longitudinally extends between the proximal end and the distal end. The side wall has an outer surface and an inner surface, wherein the inner surface defines a lumen. The pleural access liner is made of a swellable and bioabsorbable material that swells when hydrated. The pleural access liner has a shape of an elongate tube and the pleural access liner has an elongate opening that surrounds an outer surface portion of the outer surface of the elongate tubular member.

Abstract: A tissue handling system includes a biopsy device and a tissue storage container separate from the biopsy device. The biopsy device has a cutting cannula, a housing, and a tissue collecting device. The tissue collecting device is detachably received in the housing. The tissue collecting device is configured to receive at least one tissue sample. The tissue storage container is configured to detachably receive the tissue collecting device after the tissue collecting device is disengaged from the housing of the biopsy device to deliver the at least one tissue sample from the tissue collecting device to the tissue storage container.

Abstract: A cauterization device includes a handpiece configured to be grasped by a user. The handpiece includes a housing, a heat control circuit, and a control switch. A cannula has a cannula lumen, a cannula side wall surrounding the cannula lumen, a cannula proximal end portion, and a cannula distal end. The cannula proximal end portion is coupled to the housing of the handpiece. A stylet has a shaft portion and a distal heat conductive body. The distal heat conductive body is electrically coupled to the heat control circuit. The distal heat conductive body has a first end and a tapered portion that distally terminates at a second end. The shaft portion is located, at least in part, in the cannula lumen. The insulator member is configured to thermally separate the cannula distal end from the distal heat conductive body of the stylet.