Abstract: A glycophospholipid polymer is disclosed. The glycophospholipid polymer comprises a reaction product of one or more glycosaminoglycans and one or more phospholipids. Also disclosed is a glycophospholipid polymeric network comprising a reaction product of one or more glycosaminoglycans, one or more phospholipids and, one or more crosslinking agents.

Abstract: The present disclosure describes compositions comprising comprising vitamin C, vitamin E, zinc, copper, and a potent vitamin B complex and pharmaceutically acceptable salts of any of the foregoing. The compositions are useful in methods for treating conditions associated with a loss of visual acuity including, for example, age-related macular degeneration.

Abstract: A packaging system for storing ophthalmic devices such as contact lenses and methods for packaging such ophthalmic devices with solutions is disclosed. The packaging system contains an unused, ophthalmic device in an aqueous packaging solution comprising tris(hydroxymethyl)aminomethane or a salt thereof; wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9.

Abstract: The present disclosure describes compositions comprising a potent vitamin B complex and pharmaceutically acceptable salts of any of the foregoing. The compositions are useful in methods for treating conditions associated with a loss of visual acuity including, for example, age-related macular degeneration.

Abstract: The present disclosure describes compositions comprising at least one very long chain fatty acid chosen from C26+ acids (5n-3), prodrugs thereof, and pharmaceutically acceptable salts of any of the foregoing. The compositions are useful in methods for treating conditions associated with a loss of visual acuity including, for example, age-related macular degeneration.

Abstract: A method of measuring an axis angle of a toric contact lens including a posterior toric central zone having a cylindrical axis, and an anterior lens surface forming a ballast that has an axis of orientation offset from the cylindrical axis at a selected rotational angle is disclosed.

Abstract: A suspension includes an ophthalmic active ingredient suspended in a formulation vehicle including a suspending agent and a non-ionic cellulose derivative. The ophthalmic active agent is present as particles having Dv90<5 ?m and Dv50<1 ?m. The suspension may be administered to a patient for treating an ophthalmic inflammatory condition.

Abstract: A packaging system for the storage of an ophthalmic device is disclosed. The packaging system comprises a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising one or more hydrophilic polymers or copolymers comprising hydrophilic units and endcapped with a hydrophobic end group and a hydrophilic end group, wherein the solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.

Abstract: A surgical needle assembly for attachment to an ultrasonic handpiece includes an elongated metal cannula having a distal end and a proximal end. A hub is insert molded onto the cannula generally towards the cannula proximal end and formed from a material having an ultimate strength at least twice a peak cyclical stress force at a joint between the elongated metal cannula and the hub when the surgical needle assembly is in use with the ultrasonic handpiece. The hub material has a stiffness sufficient to limit a motion of the elongated metal cannula to less than 1.5 times an expected peak to peak stroke length when the surgical needle assembly is in use with the ultrasonic handpiece. The hub includes structure for mating attachment to the ultrasonic handpiece.

Abstract: A phacoemulsification handpiece for ocular surgery includes a housing including a grip for holding the phacoemulsification handpiece, a needle extending from the housing for removing ocular material from an eye, and a horn connected with the needle. The phacoemulsification handpiece also includes a driving circuit configured to vibrate the horn according to a multi-harmonic driving signal, to generate non-sinusoidal ultrasonic motion of a tip of the needle.

Abstract: A device for ocular surgery includes a surgical handpiece including a power cord and an aspiration needle for removing ocular material from an eye, and co-extruded tubing. The tubing includes an aspiration tube for receiving the ocular material removed from the eye by the surgical handpiece, an irrigation tube integrally formed with the aspiration tube for supplying irrigation fluid to the surgical handpiece, and a ridge defined along at least a majority of a length of the co-extruded tubing, the ridge defining a groove for receiving the power cord of the surgical handpiece.

Abstract: A packaging system for the storage of an ophthalmic device includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising one or more crosslinked polymeric networks. The one or more crosslinked polymeric network comprises a reaction product of a first glycosaminoglycan, a second glycosaminoglycan, and a first crosslinking agent, wherein the first glycosaminoglycan is different than the second glycosaminoglycan. The aqueous packaging solution has an osmolality of at least about 180 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.

Abstract: The present invention relates to a method of and an apparatus for extending the shelf life of an initiated monomer mixture, the method comprising the prevention of premature free radical polymerisation by introducing oxygen or oxygen-containing gas into a container of the initiated monomer mixture and providing mechanical agitation to the container, wherein said introduction and agitation are performed in a temperature and pressure controlled environment.

Abstract: The disclosure generally describes methods, systems and products relating to the development and manufacture of scleral contact lenses. A number of dimensions for the scleral lens is generated based on control points and attendant curvature parameters. Any change to one or more of the curve parameters imparts an improved anterior and posterior surface of the scleral lens and associated thickness, while undesired modifications to control points and other curve parameters remain static inasmuch as the sagittal depth component is an input parameter of the present disclosure.

Abstract: A water extractable ophthalmic device is disclosed which is a polymerization product of a monomeric mixture comprising: (a) one or more cyclic lactams; (b) one or more non-bulky organosilicon-containing monomers; (c) one or more bulky siloxane monomers; and (d) a crosslinking agent mixture comprising (i) one or more first crosslinking agents containing at least two ethylenically unsaturated reactive end groups, wherein the at least two ethylenically unsaturated reactive end groups are (meth)acrylate-containing reactive end groups and (ii) one or more second crosslinking agents containing at least two ethylenically unsaturated reactive end groups wherein at least one of the ethylenically unsaturated reactive end groups is a non-(meth)acrylate reactive end group. The water extractable ophthalmic device has an equilibrium water content of at least about 50 wt. %, a contact angle of less than about 50°, and an oxygen permeability of at least about 60 Barrers.

Abstract: An intraocular lens includes a base refractive structure having anterior and posterior surfaces that are shaped for producing a first optical power and a diffractive structure formed in one of the surfaces of the base refractive structure including overlapping first and second diffractive patterns over a common aperture for producing second and third optical powers. The second optical power is an uneven division of the third optical power. The first and second diffractive patterns have respective step heights that are separately varied as a function of radial distance from the optical axis over the common aperture.

Abstract: An ophthalmic lens, comprising a central zone having at least a first power, and a peripheral zone having an add-power offset relative to the at least first power and a spatially-modulated optical parameter. In some embodiments, the central zone has a diameter in the range 2.0 to 5.0 mm. In some embodiments, the central zone is not more than 1 mm smaller than a wearer's pupil. The spatially-modulated optical parameter may include optical power, light scattering or light transmission.

Abstract: Exemplary embodiments of the present disclosure provide a method and apparatus for forming an ophthalmic lens. An exemplary method includes providing a plurality of posterior tools each having a posterior optic defining surface and a plurality of anterior tools each having an anterior optic defining surface, wherein each one of the plurality of posterior tools has a different central posterior optic defining surface including a unique conic section. The method further includes selecting one of the plurality of posterior tools and one of the plurality of anterior tools based on a criteria, and forming a posterior mold by the selected one of the plurality of posterior tools and an anterior mold by the selected one of the plurality of anterior tools, the posterior mold and the anterior mold operable to form an ophthalmic lens having the criteria.

Abstract: A shuttle, vial and injector are provided for storing and presenting an IOL to a patient. The shuttle includes operably engaged shuttle plates having a set of confronting surfaces that flex about a flexure interface between a storage configuration, with at least an optic of an IOL in a nominal state and a loading configuration, with at least an optic of an IOL in a deformed state. The vial engages the shuttle and maintains the shuttle in the storage configuration. The injector receives the shuttle from the vial and includes surfaces for flexing the portions of the shuttle plates to the loading configuration upon engagement with the injector, wherein the shuttle plates impart a predetermined curvature to at least a portion of the IOL.