Abstract: A stable ophthalmic pharmaceutical composition for relief, treatment, control, alleviation, or prevention of a pathological ocular condition of the eye comprises: (a) a first polymer, a viscosity of which changes with a change in a concentration of an electrolyte, such as a salt, when added to said first polymer; (b) a second polymer that is different from the first polymer and can modify the viscosity of the first polymer; and (c) an oil. In some embodiments, the composition further comprises a non-ionic surfactant. The composition can form a stable oil-in-water emulsion on storage, but separate into an oil phase and a water phase when applied in the eye. The emulsion can comprises an ophthalmic active pharmaceutical ingredient dissolved in the oil or water phase. The emulsion can provide enhanced stability to said active pharmaceutical ingredient.

Abstract: A preloaded intraocular lens injection device includes a retainer for releasably holding an IOL in an unstressed state. The retainer and IOL are removably attached to an injector body and are sealed in the same package for delivery to a surgeon. In an alternate embodiment, the retainer and IOL are coupled together and sealed in one package and the injector body is sealed in a separate package with the surgeon attaching the retainer to the injector body at the time of surgery. To deliver the IOL through the injector body, the retainer is removed from the injector body causing the IOL to release from the retainer and become located in an unstressed state in the injector body. A compressor is moved to the closed position to compress the IOL, the injector tip is inserted through a small incision in an eye and a plunger is advanced to push the IOL through and out the injector body tip and into an eye.

Abstract: A poly(nitrogen/amine) derivative of a natural wax of formula I, and ophthalmic compositions and contact lens care solutions that contain the poly(nitrogen/amine) derivative of a natural wax of formula I. The invention is also directed to a method of treating a patient with dry eyes, the method comprising instructing a patient to administer one or more eye drops of the ophthalmic composition that includes a poly(nitrogen/amine) derivative of a natural wax of formula I.

Abstract: An optical polymeric material that can substantially block the transmission of ultraviolet light as well as selected portion of violet light. The polymeric material will include monomeric units of one or more lens monomers, and monomeric units of a monomer of formula (I).

Abstract: Method for minimizing the sorption of tear lipids on frequent replacement, or extended-wear, contact lenses, the method comprising (a) contacting the contact lens selected from the group consisting of senofilcon A, lotrafilcon A, lotrafilcon B, and comfilcon A B with a lens care solution for a period of at least three hours to minimize the accumulation of tear lipids on the contact lens. The lens care solution comprises 0.5 ppm to 10 ppm ?-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-?-tris(2-hydroxyethyl) ammonium chloride; citrate, citric acid or a mixture thereof; and 0.005 wt. % to 0.05 wt. % hyaluronic acid. The method also includes (b) inserting the soaked contact lens into one's eye, and (c) repeating steps (a) and (b).

Abstract: A thin IOL capable of insertion through a small incision into the capsular bag of an eye includes haptics having free ends configured to absorb compressive forces resulting from shrinkage of the capsular bag in the weeks following surgery.

Abstract: A method of loading an IOL having an optic and a leading haptic into a cartridge, comprising folding the leading haptic radially inward relative to the optic as the IOL moves into a lumen of the cartridge, by using a proximal end feature of the cartridge.

Abstract: A system and method for creating a line recognition template that replicates an object is provided for use as a control reference during ophthalmic surgery on the object. Creation of the template first requires aligning a plurality of reference points along a central “z” axis, with anatomically measured lengths (?“z”n) between adjacent reference points. Axially-symmetric surfaces can then be traced between selected, adjacent, reference points to create the template. For the present invention, the location of reference points, and the tracing of axially-symmetric surfaces, are based on a cross sectional image of the object for surgery. Preferably, the cross sectional image is obtained using Optical Coherence Tomography (OCT) techniques.

Abstract: An ophthalmic instrument for use with a subject's eye, comprising an interferometer having a test arm in which the subject's eye is to be positioned and a reference arm, the reference arm including a mirror adapted to be positioned such that the reference arm has a predetermined length, and an ophthalmic apparatus coupled to the interferometer such that, by altering a test arm length, a length between the ophthalmic apparatus and the eye is also altered. The mirror is positioned to achieve the predetermined length and a length of the test arm is adjusted such that interference between the light reflected from the eye and the light reflected from the mirror is achieved, the ophthalmic apparatus is optically aligned with the eye.

Abstract: A hand-operable system for ejecting a fluid composition into an eye, the system including: (1) a container having a container opening and containing the fluid composition; (2) a double-acting pump mechanism securely disposed over the container opening; and (3) an actuator that is disposed over, and extends radially outward from, the pump mechanism, for actuating the pump mechanism by applying a force thereon, wherein the pump mechanism includes a passage for the fluid composition, and the passage is positively sealed off when the application of the force is discontinued.

Abstract: An intraocular lens (“IOL”) cartridge includes an upper wall and a lower wall, together defining a lumen for receiving an IOL. The proximal end of the cartridge has an open slot cut into and through the entire thickness of the upper wall so to allow the leading haptic of the IOL to extend above the upper wall. The cartridge includes a proximal-end feature to facilitate folding of the leading haptic radially inward relative to the optic as the IOL moves into the lumen.

Abstract: An aqueous contact lens solution comprising less than 100 ppm of a tertiary amine oxide of general formula wherein R1 is a C8-C18alkyl, and R2 and R3 are independently selected from a C1-C4alkyl or C1-C4hydroxyalkyl, and an antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds, hydrogen peroxide or a stabilized form of peroxide and any one mixture thereof. The solution has no anionic surfactant or less than 30 ppm of anionic surfactant. The invention is also directed to the use of the solution to clean and disinfect contact lenses, and in particular, soft, silicone, hydrogel contact lenses.

Abstract: Ophthalmic compositions that comprise 0.1 ppm to 50 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof; 0.005 wt. % to 2 wt. % of an anionic biopolymer; and 0.01 wt. % to 2 wt. % of an amphoteric surfactant of general formula I wherein R1 is R or —(CH2)n—NHC(O)R, wherein R is a C8-C30alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from C1-C4alkyl; R4 is a C2-C8alkylene optionally substituted with hydroxyl; and Y is CO2? or SO3. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.

Abstract: A method of calculating clinical performance of an ophthalmic optical correction using simulation by imaging a series of objects of different sizes by each of a plurality of eye optical systems, each of the eye optical systems including the ophthalmic optical correction, the method comprising A.) at an object distance, calculating a set of indicia of image quality, each indicium of the set of indicia corresponding to an object in the series of objects when it is imaged by a given one of the plurality of eye optical systems, B.) at the object distance, comparing the set of indicia to a threshold to determine a just-discernable object size for the given one of the plurality of eye optical systems, and C.) repeating steps A and B for each eye optical system in the plurality of eye optical systems.

Abstract: A substantially fully copolymerized UV blocking hydrogel lens demonstrating sufficient blocking of UV light to meet at least FDA Class II specifications for UV blocking formed from a reaction mixture comprising at least NVP and one other comonomer and a free-radical polymerizable, substituted or unsubstituted, Bis O-hydroxy benzophenone is provided herein.

Abstract: An optical polymeric material that can substantially block the transmission of ultraviolet light as well as selected portion of violet light. The polymeric material will include monomeric units of one or more lens monomers, and monomeric units of a monomer of formula (I).

Abstract: The present application relates to novel monomers comprising polycarbosiloxane monomers useful in certain specific embodiments in the manufacture of devices. More particularly, the present application relates to certain ethylenically unsaturated free radical polymerizable monomers comprising polycarbosiloxane monomers. Even more particularly, the present application pertains to monomers comprising polycarbosiloxane monomers which further comprise at least two ethylenically unsaturated free radical polymerizable groups.

Abstract: A contact lens disinfection system that includes a peroxide disinfection solution in combination with a lens closure. The disinfection solution comprises 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and an amino buffer component. The closure includes securing elements to position and maintain a pair of contact lenses in the disinfection solution, and a peroxide neutralization catalyst comprising platinum. In combination with the closure, the disinfection solution exhibits a pseudo first-order, half-life of hydrogen peroxide over an initial sixty minutes of neutralization from 12 minutes to 30 minutes in the lens closure.

Abstract: An ophthalmic surgical cassette for collecting aspirant fluid and/or tissue during an ophthalmic surgical procedure. The ophthalmic surgical cassette includes a rigid walled container having an interior volume for collecting aspirant fluid and/or tissue and an aspiration manifold coupled to the rigid walled container. The aspiration manifold is connected to an aspiration tube in fluidic communication with the interior volume, a first aspiration line for coupling a first surgical handpiece, a second aspiration line for coupling a second surgical handpiece, and a reflux bulb in fluidic communication with the first and second aspiration lines.

Abstract: A method of measuring an axis angle of a toric contact lens including a posterior toric central zone having a cylindrical axis, and an anterior lens surface forming a ballast that has an axis of orientation offset from the cylindrical axis at a selected rotational angle is disclosed.