Patents Assigned to Baxter Healthcare Corporation
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Publication number: 20130177933Abstract: The present specification discloses methods of characterizing a population of particles using a particle analyzer. Particles may be characterized by size, absolute number, whether the particle is non-proteinaceous or proteinaceous, whether a proteinaceous particle has or lacks a certain physical property, or any combination thereof.Type: ApplicationFiled: January 11, 2013Publication date: July 11, 2013Applicants: Baxter Healthcare SA, Baxter Healthcare CorporationInventors: Baxter Healthcare Corporation, Baxter Healthcare SA
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Patent number: 7882970Abstract: An anesthetic container includes a bottle having a wall defining a receptacle and a neck with a passage in fluid communication with the receptacle, a valve assembly including a flange, and a ferrule disposed over at least a portion of the flange of the valve assembly and about at least a portion of the neck of the bottle to secure the valve assembly to the bottle. One of the wall of the bottle, the flange of the valve assembly or a wall of the ferrule has at least one vent formed, at least in part, therein that permits air trapped between the ferrule and the valve assembly or the bottle to escape.Type: GrantFiled: July 2, 2008Date of Patent: February 8, 2011Assignees: Baxter Healthcare Corporation, Baxter Healthcare S.A.Inventors: Nathan Mitchell, Robert Gliniecki
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Publication number: 20100000958Abstract: An anesthetic container includes a bottle having a wall defining a receptacle and a neck with a passage in fluid communication with the receptacle, a valve assembly including a flange, and a ferrule disposed over at least a portion of the flange of the valve assembly and about at least a portion of the neck of the bottle to secure the valve assembly to the bottle. One of the wall of the bottle, the flange of the valve assembly or a wall of the ferrule has at least one vent formed, at least in part, therein that permits air trapped between the ferrule and the valve assembly or the bottle to escape.Type: ApplicationFiled: July 2, 2008Publication date: January 7, 2010Applicants: BAXTER HEALTHCARE CORPORATION, BAXTER HEALTHCARE S.A.Inventors: Nathan Mitchell, Robert Gliniecki
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Publication number: 20080085316Abstract: Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.Type: ApplicationFiled: September 21, 2007Publication date: April 10, 2008Applicant: Baxter Healthcare CorporationInventors: Zhen Qian, A. Osawa, Cary Reich, Donald Wallace, Narinder Shargill, Felix Vega
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Publication number: 20080064105Abstract: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes.Type: ApplicationFiled: October 30, 2007Publication date: March 13, 2008Applicant: Baxter Healthcare CorporationInventors: Leopold Grillberger, Manfred Reiter, Wolfgang Mundt, Friedrich Dorner
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Publication number: 20080064080Abstract: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes.Type: ApplicationFiled: October 30, 2007Publication date: March 13, 2008Applicant: Baxter Healthcare CorporationInventors: Leopold Grillberger, Manfred Reiter, Wolfgang Mundt, Friedrich Dorner
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Publication number: 20080009040Abstract: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes.Type: ApplicationFiled: September 20, 2007Publication date: January 10, 2008Applicant: Baxter Healthcare CorporationInventors: Leopold Grillberger, Manfred Reiter, Wolfgang Mundt, Friedrich Dorner
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Patent number: 7022098Abstract: Apparatuses, devices, systems and methods for detecting access disconnection are provided. The present invention includes electrical contacts in fluid and electrical communication with a fluid passing between a patient and a medical system during therapy. In this regard, the present invention can use a direct-contact measurement to detect access disconnection, such as dislodgment of an access device from the patient through which fluid can flow during therapy including, for example, medication delivery, dialysis therapy and the like.Type: GrantFiled: April 10, 2002Date of Patent: April 4, 2006Assignees: Baxter International Inc., Baxter Healthcare CorporationInventors: Ramesh Wariar, James Han, George Lamberson, Thomas P. Hartranft, Thore Falkvall
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Publication number: 20050196843Abstract: Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention relates to a method of recovering stable recombinant cell clones.Type: ApplicationFiled: May 6, 2005Publication date: September 8, 2005Applicants: Baxter Aktiengesellschaft, Baxter Healthcare CorporationInventors: Manfred Reiter, Wolfgang Mundt, Friedrich Dorner
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Publication number: 20040096461Abstract: The present invention provides multivalent chimeric conjugate vaccine molecule and methods of using the conjugate to immunize subjects against bacterial infections. A conjugate molecule of the invention comprises multiple bacterial capsular polysaccharides linked to a carrier protein. Accordingly, the conjugate molecule provides immune protection against multiple types of bacteria in a single vaccines. In particular, conjugate molecules of the invention are used to prevent or attenuate Group B Streptococcus and meningococcal infections.Type: ApplicationFiled: July 30, 2003Publication date: May 20, 2004Applicant: Baxter Healthcare CorporationInventors: Francis Michon, John Kim, Arun Sarkar, Catherine Uitz
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Publication number: 20040093080Abstract: The present invention provides a prosthetic heart valve that includes biologically active agents that retard or prevent the infiltration of fibrous tissue (“pannus”) from the host into the structure of the prosthetic valve. Preventing or decreasing the overgrowth of the prosthetic valve by pannus reduces the complications associated with the implantation and use of prosthetic heart valves.Type: ApplicationFiled: October 31, 2003Publication date: May 13, 2004Applicants: Edwards Lifesciences Corporation, Baxter Healthcare CorporationInventors: Michael N. Helmus, Crystal Cunanan, Ralph Kafesjian, Patrice Tremble
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Patent number: 6706690Abstract: Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to solubilize relatively rapidly when exposed to blood. The non-cross-linked polymer serves as a binder for holding the materials in desired geometries, such as sheets, pellets, plugs, or the like. Usually, the cross-linked polymer will be present in a particulate or fragmented form. The materials are particularly suitable for hemostasis and drug delivery.Type: GrantFiled: June 10, 1999Date of Patent: March 16, 2004Assignee: Baxter Healthcare CorporationInventors: Cary J. Reich, A. Edward Osawa, Helen Tran
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Publication number: 20030133829Abstract: The present invention provides a method for inactivating pathogens in a protein solution. The method includes adding to the protein solution either separately or together as a composition (a) a detergent; and (b) an ester of a di- or tri-carboxylic acid to make a preparation. The ester is generally present in the preparation in a concentration of from about 0.001 to about 2% (w/w). The detergent is typically present in a concentration of about 0.001 to about 2% (w/w). The preparation is incubated for a sufficient amount of time sufficient to inactivate the pathogens.Type: ApplicationFiled: December 21, 2001Publication date: July 17, 2003Applicant: Baxter Healthcare CorporationInventors: Heinz Anderle, Martin Spruth, Peter Matthiessen, Peter Turecek, Thomas Kreil, Hans-Peter Schwarz
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Patent number: 6575940Abstract: A sealant applicator suitable for dispensing a coagulable sealant, for example a two-component fibrin sealant mixed in the applicator, employs impulse clearing to remove residual coagulated or coagulating material from the dispensing pathway and mixing chamber, if present. Impulses may be generated by manual application of a clearing member such as a plunger which can enter into the dispensing pathway to engage, dislodge and discharge residuals or can generate a gas impulse to impact the residuals to similar effect. A clearing valve having a clearing port can be operated by movement of the clearing member to provide access to the dispensing pathway.Type: GrantFiled: May 20, 1999Date of Patent: June 10, 2003Assignee: Baxter Healthcare CorporationInventors: Mitchell E. Levinson, Gordon Howard Epstein
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Publication number: 20020182679Abstract: Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention relates to a method of recovering stable recombinant cell clones.Type: ApplicationFiled: June 12, 2002Publication date: December 5, 2002Applicant: Baxter Healthcare CorporationInventors: Manfred Reiter, Wolfgang Mundt, Freidrich Dorner
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Patent number: 5965086Abstract: Sterile interconnection between disassociated segments of thermostable, compressible fluid conduit tubing is achieved by arranging within the bore of the free end of each segment a conductive hollow metal tube so as to establish a connected fluid flow path from one segment to the other, through the metal tube, and then sterilizing the connection by induction heating.Type: GrantFiled: January 27, 1993Date of Patent: October 12, 1999Assignee: Baxter Healthcare CorporationInventors: Sam Rose, Glenn C. Buchanan
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Patent number: 5662144Abstract: A tubing has members located on the inside surface of a tubing. The flow through the tubing is completely occluded when the tubing is clamped due to the members filling channels around the clamped site. Reduced clamping pressure is required to fully occlude the flow through the tubing. The tubing undergoes less deformation upon clamping and returns to its pre-clamped form upon recovery.Type: GrantFiled: January 18, 1996Date of Patent: September 2, 1997Assignee: Baxter Healthcare CorporationInventors: Ying-Cheng Lo, Sanjay V. Odak, Rafael A. Castellanos
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Patent number: 5614490Abstract: This invention provides a method to therapeutically increase perfusion in a mammal comprising administering stroma-free hemoglobin at a dose ranging from the least amount effective to increase perfusion, up to a dose of about 2500 mg per kilogram of body weight.Type: GrantFiled: June 7, 1995Date of Patent: March 25, 1997Assignee: Baxter Healthcare CorporationInventor: Robert J. Przybelski
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Patent number: 5269946Abstract: Systems and methods of collecting blood cells use a first container connected to at least three transfer containers. A filtration system is provided with one transfer container, which ultimately serves as the storage container for red blood cells free of white blood cells. The two other transfer containers are connected to each other, one of which is empty and one of which contains and additive solution for storage of red blood cells. The empty transfer container is used for storage of platelet concentrate, while the container that originally contained the additive solution is ultimately used to store the platelet-poor plasma component. A portion of the additive solution may be separately passed through the filtration system after filtration of the red cells to flush additional red blood cells from the filtration device.Type: GrantFiled: May 22, 1991Date of Patent: December 14, 1993Assignee: Baxter Healthcare CorporationInventors: Richard Goldhaber, Daniel F. Bischof
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Patent number: RE36774Abstract: A combination heat exchanger and oxygenator device is provided. The device includes a generally cylindrical housing having first and second compartments with hollow heat exchange tubes and hollow gas exchange tubes disposed therein, a blood inlet, a blood outlet, a heat exchanges medium inlet, a heat exchange medium outlet, an oxygenating fluid inlet and an oxygenating fluid outlet. The housing has a central axis with the second compartment being concentric thereto. The blood flow passage is defined by blood entering the device generally axially through a path extending along the central axis of the housing and flows generally radially through the second, oxygenating compartment.Type: GrantFiled: April 24, 1997Date of Patent: July 11, 2000Assignee: Baxter Healthcare CorporationInventors: Louis C. Cosentino, Jeffrey A. Lee, Daniel A. Baker