Abstract: An implantable fluid delivery device having a deformable casing containing a fluid reservoir, a compressible pump housing, and inlet and outlet valves for controlling the flow of metered amounts of fluid from the reservoir to a catheter when a target zone of the casing's top wall is depressed. The construction and operation of the outlet valve result in the generation of a tactile feedback signal transmitted through the target zone to inform a user that a measured amount of fluid has been discharged from the device.

Abstract: An implantable fluid delivery device for dispensing metered amounts of liquid medication when a pump assembly within its casing is operated by finger pressure applied to a central target zone of the casing's top wall. The top wall also includes an injection site spaced from the central target zone for use when a bolus of medicament is to be injected into the device and delivered directly to the patient without passing through the pump assembly. The flattened pear shape of the casing and the location of the sites for pump activation and refilling on one hand, and for bolus injection on the other, facilitate errorfree use and operation of the device. Although limited fluid backup may occur during bolus injection, a valve arrangement within the device prevents intermixing of the bolus medicament with the liquid medication in the reservoir. In a second embodiment, a supporting grid prevents possible injury to the backup-restraining valve during bolus injection.

Abstract: An implantable fluid delivery device for dispensing metered aliquots of liquid medication upon finger-pressure activation of the device by a patient. The device includes a soft, deformable needle-piercable casing having a fluid reservoir in which is located a relatively-rigid, apertured support plate that divides the reservoir into upper and lower chambers. A compressible, positive displacement pump chamber or housing is mounted upon the plate within the upper chamber and includes passages communicating with both the lower chamber and an outlet port. Force applied to a central target zone of the top wall causes compression of the pump housing and delivery through the outlet port of an amount of fluid equal to the displacement of the pump housing. The same target zone of the top wall serves as a self-sealing injection site for replenishing the fluid supply of the reservoir.

Abstract: A flexible collapsible container is filled with fluid by connecting a fluid conduit to a tubular port which communicates through one of the walls of the container to the container interior, and rupturing a sealing diaphragm that closes the bore of the tubular port. One then passes fluid through the conduit to fill the container. Thereafter, one seals either or both the tubular port and plastic wall which carries it to the other, opposed plastic wall of the container with seal line means to close off flow communication between the bore of the tubular port and a major portion of the container interior which contains the fluid. The effect of this is to block flow communication between the bore and the fluid so that the contents of the container remain sealed on disengagement of the fluid conduit from the tubular port.

Abstract: The present invention provides a sterile, unitized, economical device furnishing a fluid path between a plurality of solutions to be compounded and a receiving container. The device includes a plurality of fluid connectors and fluid lines sealingly connected to respective pump fittings which provide individual paths to a common junction block.The common junction block includes a portion for receiving fluid lines and preventing them from crimping thereby maintaining fluid flow. The block also includes an exit port for providing a sealingly sterile connection to the receiving container. Further, a closure is provided to protect the exit port from contamination when the port is not providing fluid communication to the receiving container.

Abstract: A closed tonometer for subcutaneous insertion is disclosed having a small closed equilibrating bath. Three noble metal electrodes, preferably platinum (Pt), communicate through electrical conductors to the bath at spacings exceeding 0.2 mm. Each noble metal electrode is typically exposed to the bath by embedding the noble metal in a dielectric and cutting both dielectric and electrode so that the exposed electrode is flush with and a part of the closed bath wall. The bath is contained within an oxygen permeable membrane -- preferably Silastic.RTM. a registered trademark of Dow Corning Corporation of Midland, Michigan. The bath contains a sodium chloride (NaCl) solution, preferably 0.9%, and small amounts of a hydroquinone such as a tenth of a gram of pure ascorbic acid per 30 ml of NaCl solution. One of the noble metal electrodes becomes a quinhydrone reference electrode preserving a precise voltage differential with respect to the electrolyte bath.