Abstract: The present invention relates to novel herbicidally active 2-bromo-6-alkoxyphenyl-substituted pyrrolidine-2,4-diones of the general formula (I) or agrochemically acceptable salts thereof and to their use for controlling broad-leaved weeds and weed grasses in crops of useful plants.

Abstract: Bispecific antibodies binding ALK-1 and BMPR-2 The present invention relates to bispecific antibodies binding human ALK-1 and human BMPR-2. Also provided are BsABs which are agonists of ALK-1/BMPR-2 signaling, and BsABs which do not trigger osteogenic signaling. Furthermore, the invention relates to pharmaceutical uses of the BsABs, in particular for the treatment of pulmonary hypertension. Also provided are methods to screen for BsABs for use in the therapy, e.g. of pulmonary hypertension.

Abstract: Compound (III) which is the crystalline form of [4-{[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2, -f] [1,2,4]triazin-7-yl]methyl}piperazin-2-one hydrochloride] which is the monohydrate, processes for its preparation, pharmaceutical compositions comprising it and its use in the control of disorders, including cancer.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to the recruiting of patients for one or more medicament studies. The subjects of the present invention are a method, a system and a computer program product for recruiting patients for one or more medicament studies with the aid of an individual identification feature that is applied to the packaging of a medicament.

Abstract: The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.

Abstract: The present disclosure relates to combinations of at least two components, component A and component B, component A being anti-CEACAM6 antibody TPP-3310 and component B being an anti-TIM-3 antibody, preferentially cobolimab, MBG-453, BMS-986258, Sym-023, LY-3321367 or INCAGN-2390.

Abstract: An animal trap system comprises a cage, a door, a switch system, a transmitter, a proximity signal sensor, and a proximity signal emitter. When the door is in a closed position, the door is configured to block the opening of the cage to prevent exit of the animal. When the door is in the open position the proximity signal emitter is at a position such that a magnitude of a proximity signal emitted by the proximity signal emitter and sensed by the proximity signal sensor is configured to maintain the transmitter in a non-transmitting mode. When the door is in the closed position the proximity signal emitter is at a position such that the magnitude of the proximity signal emitted by the proximity signal emitter and sensed by the proximity signal sensor is configured to cause the transmitter to transmit a signal that the cage is occupied.

Abstract: Described herein is a method for transferring of batch production process for a monoclonal antibody to a continuous production process for the same monoclonal antibody.

Abstract: The present invention relates to heterocyclylaminophenyloxadiazole and derivatives thereof that may be used and as fungicides.

Abstract: An aerial vehicle includes a liquid chemical tank, at least one spray unit, a plurality of sensors, a processing unit, and an output unit. The processing unit is configured to generate a spray record for an environment within which the aerial vehicle is operating, the spray record comprising: information over a time period of at least one spray condition relating to one or more of the at least one spray unit for the aerial vehicle operating within the environment over the time period, the determined air movement direction relative to the projection of the fore-aft axis onto the ground over the time period, and the determined air movement speed relative to the ground over the time period. The output unit is configured to output the spray record.

Abstract: The present disclosure generally relates to the field of model-based quality prediction of a chemical compound-and/or of a formulation thereof as the outcome of a production process comprising more than one sub-process. It further relates to a solution for root cause analysis of variations of one or more quality attributes of said product or formulation thereof.

Abstract: An aerial vehicle includes a liquid chemical tank, at least one spray unit, at least one actuator, a plurality of sensors, and a processing unit. The processing unit is configured to determine an air movement direction relative to a projection of the fore-aft axis onto the ground and determine an air movement speed relative to the ground, the determination comprising utilization of the speed of the aerial vehicle, the air movement direction relative to the aerial vehicle with respect to the fore-aft axis of the aerial vehicle and the air movement speed relative to the aerial vehicle. The processing unit is configured to control at least one flying operation of the aerial vehicle and/or control the at least one actuator.

Abstract: The present disclosure relates to product supply apparatus. It is described to provide a processing unit with a plurality of orders of a product, wherein the plurality of orders is formed from open orders and shipped orders. The processing unit is provided with a stock level of the product held in stock. The processing unit determines an open demand of the product to be received, wherein the determination comprises utilization of the shipped orders, open orders and a total forecast number of the product to be received. The processing unit determines a product supply plan, wherein the determination comprises utilization of the open orders, open demand and the stock level.

Abstract: The invention relates to a method for monitoring at least two redundant sensors, which are in particular arranged in a chemical plant or an aircraft, comprising providing a first sensor signal of a first sensor, the first sensor signal comprising at least one measured value, providing at least one further sensor signal from a further sensor, the further sensor signal comprising at least one further measured value, generating a first analysis signal from the first sensor signal, generating at least one further analysis signal from the further sensor signal, determining at least one relationship between the first sensor signal and the further sensor signal at least in dependence on the first analysis signal and the further analysis signal over a time horizon, comparing the relationship with at least one admissible range, and, depending on the result of the comparison, determining whether at least one sensor of the two redundant sensors is faulty.

Abstract: The disclosure relates to the control of plants by means of electrical energy and the mechanical removal of parts of the plants. The disclosure relates to a method and a device for the control of undesired plants by electrical and mechanical means.

Abstract: The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

Abstract: The present invention relates to protein-inhibitory substituted pyrrolopyridine derivatives of formula (I) in which A, X, R1a, R1b, R2, R3a, R3b, R4a and R4b are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to a process for preparing compounds of the formula (I) starting from compounds of the formula (II) wherein R1, R2, R3 and R3? are defined in according to the invention.

Abstract: The present disclosure relates to an RFID receiver for an asset tracking system. The RFID receiver includes a plurality of RFID antennas. The plurality of RFID antennas are configured to be associated with an object support structure. The object support structure is configured such that one or more objects of a plurality of objects can be placed on the object support structure. A plurality of RFID tags are configured to attach to the plurality of objects. Each object of the plurality of objects can have attached to it a different RFID tag of the plurality of RFID tags. The RFID receiver is configured to detect a signal transmitted from an RFID tag attached to an object of the plurality of objects when the object is supported by the object support structure.