Patents Assigned to Bayer Aktiengesellschaft
  • Apparatus for weed control
    Patent number: 11560680
    Abstract: An apparatus for weed control includes a processing unit that receives at least one image of an environment. The processing unit analyses the at least one image to determine at least one vegetation control technology from a plurality of vegetation control technologies to be used for weed control for at least a first part of the environment. An output unit outputs information that is useable to activate the at least one vegetation control technology.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: January 24, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hinnerk Baßfeld, Thomas Arians, Pascal Day, Virginie Giraud, James Hadlow
  • ANALOGUES OF 3-(5-METHYL-1,3-THIAZOL-2-YL)-N-{(1R)-1-[2-(TRIFLUORO-METHYL)PYRIMIDIN-5-YL]ETHYL}BENZAMIDE
    Publication number: 20230013419
    Abstract: The present invention covers P2X3 inhibitor compounds of general formula (I) in which R1 and R2 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: June 25, 2020
    Publication date: January 19, 2023
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Antje ROTTMANN, Oliver Martin FISCHER, Kai THEDE, Simon Anthony HERBERT, Ursula GANZER, Andrea ROTGERI, Elisabeth POOK
  • DIHYDROOXADIAZINONES
    Publication number: 20230017200
    Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: July 11, 2022
    Publication date: January 19, 2023
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Manuel ELLERMANN, Stefan Nikolaus GRADL, Charlotte Christine KOPITZ, Martin LANGE, Adrian TERSTEEGEN, Philip LIENAU, Christa HEGELE-HARTUNG, Detlev SÜLZLE, Timothy A. LEWIS, Heidi GREULICH, Xiaoyun WU, Matthew MEYERSON, Alex BURGIN
  • Apparatus for radiopharmaceutical quantification of a body part
    Patent number: 11553888
    Abstract: An apparatus for radiopharmaceutical quantification of a body part includes a processor configured to receive at least one gamma image of a body part acquired by at least one gamma camera configured to detect gamma and/or X-rays. The at least one gamma image comprises spectral energy data that includes data resulting from decay of at least one radiopharmaceutical. The processor is configured to determine an activity of the at least one radiopharmaceutical at a plurality of spatial positions in the body part and determines a spatial distribution of the at least one radiopharmaceutical in the body part. The determination for a spatial position of the plurality of spatial positions comprises correlating a generated synthetic spectrum to an experimental spectrum generated from the spectral energy data for at least one position in the at least one gamma image that corresponds to that spatial position.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: January 17, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Cecilia Hindorf, Erik Larsson, Gustav Brolin, Tomas Ohlsson
  • METHOD FOR CREATING A RENAL INJURY MODEL TO SCREEN MOLECULES FOR THE TREATMENT OF RENAL INJURY
    Publication number: 20230001023
    Abstract: The present invention is related to short-term renal injury models and methods for creating these models. The models and methods can be used for identifying, testing or characterizing candidate molecules with respect to their suitability to treat renal injury. The methods comprise a step of inducing, in a test subject, renal injury by administering subcutaneously a bolus of a renal injury inducer, in a dosage sufficiently high to induce renal injury. Different types of readout for renal injury are provided such as albumin creatinine ratio (ACR) determined in a urine sample taken from the subject, or the development of transcutaneous fluorescence after injection of a fluorescent molecule. Based on the readout the degree of renal injury and/or alteration of GFR can be determined.
    Type: Application
    Filed: July 8, 2022
    Publication date: January 5, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Simone Romoli, Tobias Bauch, Karoline Dröbner
  • Active compound combinations having insecticidal/acaricidal properties
    Patent number: 11540517
    Abstract: The present invention relates to novel active compound combinations comprising at least one known compound of the formula (I) and at least one further active compound, which combinations are highly suitable for controlling animal and microbial pests such as unwanted insects and/or unwanted acarids and/or unwanted nematodes.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: January 3, 2023
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Silvia Cerezo-Galvez, Christian Marienhagen, Holger Weckwert, Wolfgang Thielert, Marita John
  • PYRIMIDINEDIONE DERIVATIVES
    Publication number: 20220411381
    Abstract: The present invention covers pyrimidinedione derivatives of general formula (I): (I), in which R1, R2, R4, R5 and X are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: September 25, 2020
    Publication date: December 29, 2022
    Applicant: Bayer Aktiengesellschaft
    Inventors: Lea Aurelie BOUCHE, Stefan KAULFUSS, Katja ZIMMERMANN, Hartmut REHWINKEL, Roland NEUHAUS, Roman HILLIG, Duy NGUYEN, Judith GÜNTHER, Adelaide Clara FARIA ALVARES DE LEMOS
  • Heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides
    Patent number: 11528907
    Abstract: The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements Y, Q1, Q2, R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: December 20, 2022
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Alexander Arlt, Werner Hallenbach, Hans-Georg Schwarz, Martin Fuesslein, Heinz-Juergen Wroblowsky, Estella Buscato Arsequell, Marc Linka, Kerstin Ilg, Arunas Jonas Damijonaitis, Ulrich Ebbinghaus-Kintscher, Ulrich Goergens, Yolanda Cancho Grande, Peter Jeschke, Joachim Telser, Iring Heisler, Andreas Turberg
  • DIHYDROOXADIAZINONES
    Publication number: 20220396554
    Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I) in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: July 14, 2022
    Publication date: December 15, 2022
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Manuel ELLERMANN, Stefan Nikolaus GRADL, Charlotte Christine KOPITZ, Martin LANGE, Adrian TERSTEEGEN, Philip LIENAU, Christa HEGELE-HARTUNG, Detlev SÜLZLE, Timothy A. LEWIS, Heidi GREULICH, Xiaoyun WU, Matthew MEYERSON, Alex BURGIN
  • 2-phenylpyrimidine-4-carboxamides as AHR inhibitors
    Patent number: 11524944
    Abstract: The present invention covers 2-phenylpyrimidine-4-carboxamide compounds of general formula (I): (I) 5 in which X, Y, Z, R1, R2, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: December 13, 2022
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Deutsches Krebsforschungszentrum
    Inventors: Julien Lefranc, Norbert Schmees, Ulrike Röhn, Ludwig Zorn, Judith Günther, Ilona Gutcher, Lars Röse, Benjamin Bader, Detlef Stöckigt, Michael Platten
  • ADRENOMEDULLIN-ANALOGUES FOR LONG-TERM STABILIZATION AND THEIR USE
    Publication number: 20220387608
    Abstract: The invention relates to stabilized Adrenomedullin derivatives and use thereof. In particular, the invention relates to novel, biologically active, stabilized Adrenomedullin (ADM) compounds. The invention further relates to the compounds for use in a method for the treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, and to medicaments comprising the compounds for treatment and/or prevention of cardiovascular, edematous and/or inflammatory disorders.
    Type: Application
    Filed: June 12, 2020
    Publication date: December 8, 2022
    Applicant: Bayer Aktiengesellschaft
    Inventors: Johannes KÖBBERLING, Donald BIERER, Ingo FLAMME, Bernd RIEDL, Lucas Hudson HOFMEISTER, Annette BECK-SICKINGER, Sylvia ELS-HEINDL, Jan-Patrick FISCHER, Eva-Maria JÜLKE
  • 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES
    Publication number: 20220378762
    Abstract: Compounds of formula (I) for use in the treatment or prophylaxis of a disease, which is a hyperproliferative disease and/or a disorder responsive to induction of cell death, selected from a haematological tumour, a solid tumour and/or metastases thereof, said tumour harbouring a mutant EGFR with exon 19 or 21 mutations, and their use as pharmaceuticals.
    Type: Application
    Filed: April 22, 2020
    Publication date: December 1, 2022
    Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Franziska SIEGEL, Daniel KORR, Jens SCHRÖDER, Stephan SIEGEL, Heidi GREULICH, Bethany KAPLAN, Matthew MEYERSON
  • 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides
    Patent number: 11505553
    Abstract: The invention relates to novel compounds of the formula (I) in which R1, Ra, Rb, Rc, R3, R4, A1, A2 and n have the definitions given above, to agrochemical formulations comprising the compounds of formula (I) and to their use as acaricides and/or insecticides for controlling animal pests, particularly arthropods and especially insects and arachnids.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: November 22, 2022
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Marc Mosrin, Ruediger Fischer, Dominik Hager, Laura Hoffmeister, Nina Kausch-Busies, David Wilcke, Matthieu Willot, Kerstin Ilg, Daniela Portz, Ulrich Goergens, Sascha Eilmus, Andreas Turberg
  • PREDICTION OF RESIDUES OF PLANT PROTECTION AGENTS IN HARVESTED PRODUCTS
    Publication number: 20220366273
    Abstract: The present invention is concerned with the predicting of crop protection product residues in plants or parts of plants intended for human and/or animal consumption, preferably in fruit and/or vegetables. The present invention provides a method, a device, a system and a computer program product for prediction of crop protection product residues.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 17, 2022
    Applicant: Bayer Aktiengesellschaft
    Inventors: Kai WIRTZ, Rolf Christian BECKER, Linus GOERLITZ, Dirk SCHAEFER, Fabian WEYSSER
  • Macrocyclic indole derivatives
    Patent number: 11492358
    Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I) in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: November 8, 2022
    Assignees: The Broad Institute, Inc., Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Sarah Anna Liesa Johannes, Philipp Buchgraber, Ulrich Klar, Clara Christ, Kai Thede, Joachim Kuhnke, Manfred Moewes, Knut Eis, Amaury Ernesto Fernandez-Montalvan, Nicolas Werbeck, Ursula Mönning, Philip Lienau, Ulrike Sack, Arne Scholz, Michael H. Serrano-Wu, Christopher Lemke, David McKinney, Mark Fitzgerald, Christopher Nasveschuk, Kiel Lazarski, Steven James Ferrara, Laura Furst, Guo Wei, Patrick Ryan McCarren
  • Weed control at high speed
    Patent number: 11492770
    Abstract: An apparatus and a method for increasing the movement speed of the rail vehicle while carrying out measures for controlling weeds on track systems. A rail vehicle equipped with an apparatus for increasing the movement speed of the rail vehicle while carrying out measures for controlling weeds on track systems.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: November 8, 2022
    Assignee: Bayer Aktiengesellschaft
    Inventor: Hinnerk Bassfeld
  • Process for preparing substituted imidazole derivatives
    Patent number: 11479565
    Abstract: The present invention relates to a process for preparing substituted imidazole derivatives of the formula (II) from compounds of the formula (I) via intermediates of the formula (IVa) or (IVb) in which the structural elements shown in the formulae (I), (II), (IVa) and (IVb) have the meanings given in the description. Furthermore, the invention relates to the intermediates of the formulae (IVa) and (IVb).
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: October 25, 2022
    Assignee: Bayer Aktiengesellschaft
    Inventors: Matthieu Willot, Ruediger Fischer, Dominik Hager, Laura Hoffmeister, Marc Mosrin, David Wilcke
  • 2-amino-5-oxyalkyl-pyrimidine derivatives and their use for controlling undesired plant growth
    Patent number: 11477982
    Abstract: What are described are compounds of the general formula (I) and agrochemically acceptable salts thereof and their preparation and their use in the crop protection sector.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 25, 2022
    Assignees: BAYER CROPSCIENCE AKTIENGESELLSCHAFT, BAYER AKTIENGESELLSCHAFT
    Inventors: Harald Jakobi, Estella Buscato Arsequell, Klemens Minn, Uwe Doeller, Hansjoerg Dietrich, Elmar Gatzweiler, Anu Bheemaiah Machettira, Christopher Hugh Rosinger, Dirk Schmutzler
  • Antibody drug conjugates (ADCS) having enzymatically cleavable groups
    Patent number: 11478554
    Abstract: The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: October 25, 2022
    Assignees: BAYER PHARMA AKTIENGESELLSCHAFT, BAYER AKTIENGESELLSCHAFT
    Inventors: Hans-Georg Lerchen, Anne-Sophie Rebstock, Beatrix Stelte-Ludwig, Dennis Kirchhoff, Lisa Dietz, Christoph Mahlert, Simone Greven, Stephan Märsch, Sandra Berndt, Anette Sommer, Stefanie Hammer
  • Macrocyclic chlorine substituted indole derivatives
    Patent number: 11478451
    Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: October 25, 2022
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc.
    Inventors: Kai Thede, Anne Mengel, Clara Christ, Joachim Kuhnke, Sarah Anna Liesa Johannes, Philipp Buchgraber, Ulrich Klar, Ulrike Rauh, Stefan Kaulfuss, Amaury Ernesto Fernandez-Montalvan, Nicolas Werbeck, Ursula Moenning, Katrin Nowak-Reppel, Chris Lemke, Michael H. Serrano-Wu, David McKinney, Mark Fitzgerald, Christopher Nasveschuk, Kiel Lazarski, Steven J. Ferrara, Laura Furst, Guo Wei, Patrick R. McCarren, Rebecca Ann Harvey, Daniel Payne, Thomas Pesnot, Craig Wilson