Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical 2019 compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to a method for preparing substituted imidazolyl carboxyamides of the formula (II) proceeding from compounds of the formula (I) via an intermediate of the formula (IIIa) or (IIIb) in which the structural elements specified in the formulae (I), (II), (IIIa) and (IIIb) have the definitions stated. Furthermore, the invention relates to the compounds of the formulae (IIIa) and (IIIb).

Abstract: The present invention relates to substituted dihydroimidazopyridinedione compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative, angiogenesis disorders, inflammatory diseases or diseases associated with inflammatory pain, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to the field of accompanying patients and alleviating the symptoms of a disease, particularly in patients suffering from cardiac insufficiency. The invention relates to a method and a system for monitoring the state of health of a large number of patients.

Abstract: The present invention relates to an antibody or a fragment thereof comprising at least one heterologous amino acid sequence incorporated within at least one CDR region of said antibody or fragment thereof, wherein said at least one heterologous amino acid sequence comprises an N-terminal linker sequence (Ntls), a C-Type Natriuretic Peptide (CNP) and a C-terminal linker sequence (Ctls). Optionally, at least a portion of said at least one CDR region is replaced by said at least one heterologous amino acid sequence incorporated therein. The present invention further relates to such antibody or fragment thereof for use in a method for treatment, a composition comprising such antibody or fragment thereof, a nucleic acid or a mixture of nucleic acids encoding such antibody or fragment thereof, a host cell comprising such nucleic acid or such mixture of nucleic acids and to a process for producing such antibody or fragment thereof.

Abstract: The invention relates to a device (1) and a method for determining the action of active ingredients on nematodes and other organisms in aqueous tests.

Abstract: The present invention relates to herbicidal mixtures comprising (i) 2-[(2,4-dichlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidanone, (ii) pyroxasulfone and (iii) mefenpyr-diethyl, and to herbicidal compositions comprising these mixtures. Furthermore, the present invention relates to a process for preparing these herbicidal mixtures and compositions comprising these mixtures. Furthermore, the invention relates to the use of the mixtures and compositions mentioned in the field of agriculture for controlling harmful plants.

Abstract: The present invention relates to sGC activators and sGC stimulators for use in the treatment of cognitive impairment in a mammal in need of such treatment, in particular for use in the treatment of vascular dementia.

Abstract: The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.

Abstract: A method, a device, a system and a computer program product for creating a training and/or validation dataset for a self-learning algorithm for classifying objects using supervised learning.

Abstract: A spray apparatus for a vehicle includes a processing unit with at least one image of an environment. The processing unit analyzes the at least one image to activate at least one chemical spray unit mounted on the vehicle. Air is blown by at least one air blower mounted on the vehicle into a first downward directed air flow with respect to the vehicle. Air is directed by at least one diverter mounted on the vehicle into a second downward directed air flow with respect to the vehicle. A chemical spray unit of the at least one chemical spray unit is positioned relative to one or more air blowers and is positioned relative to one or more air diverters such that ejected liquid chemical is at least partially entrained within the first downward directed air flow and is at least partially entrained within the second downward directed air flow.

Abstract: A method and a system for the detection and acquisition of resistances of harmful organisms to pest control agents. The system is configured to establish a resistance map, in which information regarding the resistance of one or more harmful organisms to one or more control agents is recorded for a field or a plurality of fields for the cultivation of cultivated plants.

Abstract: The present invention provides methods for the preparation of Compound (I): Compound (I), the use of intermediates for the preparation of said compound and its crystalline form A.

Abstract: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.

Abstract: The invention relates to a method for preparing methyl 4-[(4,5-dihydro-3-methoxy-4-methyl-5-oxo-1H-1,2,4-triazol-1-yl)carbonyl)sulfamoyl]-5-methylthiophene-3-carboxylate from 4-methoxycarbonyl-2-methylthiophene-3-sulfonyl chloride in the presence of an imidazole base substituted in the 1-position or in the presence of a mixture of bases comprising an imidazole base substituted in the 1-position (N-alkylimidazole).

Abstract: The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1-and/or TASK-3-blocking properties.

Abstract: A holding stand for a multicoupling for filling and/or emptying a chemical plant container is provided, having a mounting device for the essentially stationary fastening of the holding stand and at least one compensating device, couplable indirectly or directly to the multicoupling, for varying a position of the multicoupling in relation to the mounting device in the vertical direction and/or in the horizontal direction and/or for varying an angular position of the multicoupling in relation to the mounting device about a vertical and/or horizontal axis of rotation. It thereby becomes possible for a multicoupling to be coupled simply.

Abstract: An apparatus for weed control includes a processing unit with a least one sensor data of an environment. The processing unit analyzes at least some of the at least one sensor data to determine at least one ground property for each of a plurality of locations of the environment. The processing unit determines a power setting for activation of at least one electrode based weed control unit for each of the plurality of locations. The determination of the power setting for activation of the electrode based weed control unit comprises utilization of the at least one ground property associated with that location. An output unit outputs information useable to activate the at least one electrode based weed control unit.

Abstract: Information relating to a patient may be provided to a hand held communication device. A communication link is established between the hand held communication device and an apparatus associated with the patient comprising utilization of the information relating to the patient. The hand held communication device receives operational data associated with operation of a medical device by the patient. Receiving the operational data involves receiving compliance data over the communication link from the apparatus relating to utilization of the medical device for a medical condition of the patient.