Patents Assigned to Bayer Aktiengesellschaft
  • Patent number: 10820591
    Abstract: The present invention relates to the use of a compound of the general formula (I) in which M and D have the meanings given in the description for controlling animal pests, in particular nematodes.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: November 3, 2020
    Assignees: Bayer Aktiengesellschaft, Bayer CropScience Aktiengesellschaft
    Inventors: Martin Füßlein, Heinz-Jürgen Wroblowsky, Susanne Kübbeler, Dominik Hager, Nina Kausch-Busies, Roland Andree, Johannes-Rudolf Jansen, Hans-Georg Schwarz, Daniela Portz, Kerstin Ilg, Olga Malsam, Sascha Eilmus, Peter Lösel, Stefan Herrmann, Angela Becker, Arnd Voerste, Ulrich Görgens, Anton Lishchynskyi, Andreas Turberg
  • Publication number: 20200339567
    Abstract: The present application relates to novel substituted imidazopyridine amides of the formula (I), to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular, neurological and central nervous as well as metabolic disorders.
    Type: Application
    Filed: October 18, 2018
    Publication date: October 29, 2020
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Daniel MEIBOM, Jutta MEYER, Karl COLLINS, Nuria ORTEGA HERNANDEZ, Jan STAMPFUSS, Frank WUNDER, Till FREUDENBERGER, Thomas MONDRITZKI, Nina Alexandra SCHEERER, Kirsten LEINEWEBER, Jens SCHAMBERGER, Alexander STRAUB, Kersten Matthias GERICKE, Walter KROH, Mario LOBELL, Klaus MÜNTER
  • Publication number: 20200337590
    Abstract: The present invention relates to the treatment of cardiac insufficiency. A sensor for measuring the tissue fluid content in the region of the rib cage is implanted in a person suffering from cardiac insufficiency. If the tissue fluid content does not get back to normal within a defined period of time and under treatment with the available standard therapy, treatment with a V1a/V2 vasopessin receptor antagonist is recommended. Dosage of the V1a/V2 vasopressin receptor antagonist and duration of the treatment with the V1a/V2 vasopressin receptor antagonist can be determined on the basis of the acquired sensor data.
    Type: Application
    Filed: January 10, 2019
    Publication date: October 29, 2020
    Applicant: Bayer Aktiengesellschaft
    Inventors: Frank KRAMER, Wilfried DINH, Daniel FORLER, Hubert TRÜBEL
  • Publication number: 20200337289
    Abstract: A pest monitoring system and associated method includes pest monitoring devices for placement at a site and generating a signal upon detection of a pest, and a pesticide dispensing unit including a reservoir housing a diluent and a pesticide module housing a pesticide. A computer device remotely disposed to the pest monitoring devices receives generated signals therefrom, analyzes environmental and historical factor data for the site to determine an amount and placement location of the pest monitoring devices for monitoring the site, and directs deployment of the pest control monitoring devices according to the analysis. The computer device also receives data from the pesticide dispensing unit including an amount or rate of the pesticide substance dispensed from the pesticide module, to form treatment having a concentration of the pesticide substance in the diluent, the treatment being dispensed from the pesticide dispensing unit to treat a detected pest at the site.
    Type: Application
    Filed: April 12, 2018
    Publication date: October 29, 2020
    Applicant: Bayer Aktiengesellschaft
    Inventors: Byron REID, Volker GUTSMANN, Gaelle FAGES, Michael ZIMMERMANN, Chris PIENAAR, Peter JARDINE
  • Patent number: 10815215
    Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: October 27, 2020
    Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGELLSCHAFT, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Stefan Nikolaus Gradl, Duy Nguyen, Knut Eis, Judith Günther, Timo Stellfeld, Andreas Janzer, Sven Christian, Thomas Müller, Sherif El Sheikh, Han Jie Zhou, Changjia Zhao, David B. Sykes, Steven James Ferrara, Kery Liu, Michael Kröber, Claudia Merz, Michael Niehues, Martina Schäfer, Katja Zimmermann, Carl Friedrich Nising
  • Publication number: 20200329982
    Abstract: A system, a method and a computer program product for automated detection and recognition of adverse events for monitoring the state of health of an individual
    Type: Application
    Filed: November 19, 2018
    Publication date: October 22, 2020
    Applicant: Bayer Aktiengesellschaft
    Inventors: Ulf HENGSTMANN, Christian Johannes MÜLLER, Georg BERNS, Sabine GENT
  • Publication number: 20200289509
    Abstract: The present invention covers 2-hetarylpyrimidine-4-carboxamide compounds of general formula (I): in which X, Y, Z, R1, R2 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: November 16, 2017
    Publication date: September 17, 2020
    Applicants: Bayer Aktiengesellschaft, Deutsches Krebsforschungszentrum, Bayer Pharma Aktiengesellschaft, Deutsches Krebsforschungszentrum
    Inventors: Julien LEFRANC, Norbert SCHMEES, Ulrike RÖHN, Ludwig ZORN, Judith GÜNTHER, Ilona GUTCHER, Lars RÖSE, Benjamin BADER, Detlef STÖCKIGT, Michael PLATTEN
  • Patent number: 10772332
    Abstract: The invention relates to novel compounds of the formula (I) in which R1, R2, R3, R4, A1, A2, X and n have the definitions given above, to the use thereof as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for preparation thereof.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: September 15, 2020
    Assignees: BAYER AKTIENGESELLSCHAFT, BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Marc Mosrin, Ruediger Fischer, Dominik Hager, Laura Hoffmeister, Kerstin Ilg, Nina Kausch-Busies, David Wilcke, Matthieu Willot, Sascha Eilmus, Ulrich Goergens, Andreas Turberg
  • Patent number: 10765116
    Abstract: The invention relates to compounds of the formula (Ia) or (Ib), in which Aa, Ab, Ac, Ad, R1, R10 R11, R12, R13, R14, R15, R16, R17, Q, R4, R5, R6 and have the meanings indicated in the claims, and to agrochemical formulations containing the compounds according to formula (Ia) or (Ib) for use as acaricides and/or insecticides for combating animal pests, primarily arthropods and in particular insects and arachnids. 2-[3-(alkylsulfonyl)-2H-indazol-2-yl]-3H-imidazo[4,5-b]pyridine derivatives and similar compounds are particularly preferable.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: September 8, 2020
    Assignees: BAYER CROPSCIENCE AKTIENGESELLSCHAFT, BAYER AKTIENGESELLSCHAFT
    Inventors: Nina Kausch-Busies, Rüdiger Fischer, Laura Hoffmeister, David Wilcke, Dominik Hager, Matthieu Willot, Marc Mosrin, Kerstin Ilg, Ulrich Görgens, Andreas Turberg
  • Publication number: 20200247783
    Abstract: The present invention provides 6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives of formula (I): The present invention provides 6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives of formula (I):
    Type: Application
    Filed: August 2, 2018
    Publication date: August 6, 2020
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Manuel Ellermann, Stefan Nikolaus Gradl, Charlotte Christine Kopitz, Martin Lange, Adrian Tersteegen, Philip Lienau, Detlev Sülzle, Timothy Lewis, Heidi Greulich, Xiaoyun Wu, Matthew Meyerson
  • Publication number: 20200237648
    Abstract: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal, pulmonary and ophthalmic disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.
    Type: Application
    Filed: July 19, 2019
    Publication date: July 30, 2020
    Applicants: BAYER PHARMA AKTIENGESELLSCHAFT, BAYER AKTIENGESELLSCHAFT
    Inventors: ANKE STROYER, Carmen LOBBACK, Peter SERNO, Kia LOVIS, Philipp RUBENBAUER, Helko SCHIRMER, Danja GROßBACH, Tia JACOBS, Britta OLENIK, Julia Küsel, Donald BIERER
  • Publication number: 20200236938
    Abstract: The present invention relates to novel active compound combinations comprising at least one known compound of the formula (I) and at least one further active compound, which combinations are highly suitable for controlling animal and microbial pests such as unwanted insects and/or unwanted acarids and/or unwanted nematodes.
    Type: Application
    Filed: October 12, 2018
    Publication date: July 30, 2020
    Applicant: Bayer Aktiengesellschaft
    Inventors: Silvia CEREZO-GALVEZ, Christian MARIENHAGEN, Holger WECKWERT, Wolfgang THIELERT, Marita JOHN
  • Publication number: 20200237331
    Abstract: The present invention is concerned with the radiological identification of chronic thromboembolic pulmonary hypertension (CTEPH). The invention relates to a method, a computer system and a computer program product for automatically identifying signs of the presence of CTEPH in a person.
    Type: Application
    Filed: April 26, 2018
    Publication date: July 30, 2020
    Applicant: Bayer Aktiengesellschaft
    Inventors: Karym EL SAYED, Simon Alexander TEAL, Eva-Maria QUAST, Soeren HOERNIG, Mitesh DAFTARDAR, Matthias MÜHLENDYCK, Hans-Peter PODHAISKY, Barbara HINZMANN, Oliver SIEGLER, Levent KILIC
  • Patent number: 10722501
    Abstract: The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones of formula (I), to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: July 28, 2020
    Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Nicole Biber, Damian Brockschnieder, Kersten Matthias Gericke, Florian Kölling, Klemens Lustig, Jörg Meding, Heinrich Meier, Thomas Neubauer, Martina Schäfer, Andreas Timmermann, Dmitry Zubov, Carsten Terjung, Niels Lindner, Volker Badock, Dieter Moosmayer, Hideki Miyatake Ondozabal, Stephen Moore, Alexander Schulz
  • Publication number: 20200230136
    Abstract: The invention relates to selective adrenoreceptor ?2C receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (PAD) and/or critical limb ischemia (CLI).
    Type: Application
    Filed: April 19, 2018
    Publication date: July 23, 2020
    Applicant: Bayer Aktiengesellschaft
    Inventors: Eva Maria BECKER-PELSTER, Christiane OTTO, Carsten SCHMECK, Hanna TINEL, Chantal FÜRSTNER
  • Publication number: 20200229421
    Abstract: An apparatus for weed control includes a processing unit that receives at least one image of an environment. The processing unit analyses the at least one image to determine at least one vegetation control technology from a plurality of vegetation control technologies to be used for weed control for at least a first part of the environment. An output unit outputs information that is useable to activate the at least one vegetation control technology.
    Type: Application
    Filed: July 2, 2018
    Publication date: July 23, 2020
    Applicant: Bayer Aktiengesellschaft
    Inventors: Hinnerk BAßFELD, Thomas ARIANS, Pascal DAY, Virginie GIRAUD, James HADLOW
  • Publication number: 20200214281
    Abstract: The present invention relates to an apparatus for weed control. It is described to provide (210) a processing unit with at least one image of an environment. The processing unit analyses (220) the at least one image to determine at least one location within the environment for activation of at least one mulch application unit. The at least one mulch application unit is configured to apply at least one mulch to the at least one location for weed control. An output unit outputs (230) information that is useable to activate the at least one mulch application unit.
    Type: Application
    Filed: July 2, 2018
    Publication date: July 9, 2020
    Applicant: Bayer Aktiengesellschaft
    Inventors: Rainhard KOCH, Jerry OUTRAM
  • Publication number: 20200205394
    Abstract: An apparatus for weed control includes a processing unit that receives at least one image of an environment. The processing unit analyses the at least one image to determine at least one mode of operation of a vegetation control technology from a plurality of modes of operation of the vegetation control technology to be used for weed control for at least a first part of the environment. An output unit outputs information that is useable to activate the vegetation control technology in the at least one mode of operation.
    Type: Application
    Filed: July 2, 2018
    Publication date: July 2, 2020
    Applicant: Bayer Aktiengesellschaft
    Inventors: Pascal DAY, Thomas ARIANS, Virginie GIRAUD, James HADLOW, Hinnerk BAßFELD
  • Patent number: 10696940
    Abstract: The invention provides a method for the continuous, microbe-reduced production and/or processing of a biopharmaceutical, biological macromolecular product from a heterogeneous cell culture-fluid mixture, comprising the steps of: (a) providing a particle-free fluid from a heterogeneous cell culture-fluid mixture containing the product, in the form of a product stream, (b) at least one filtration, providing a filtrate, (c) at least two chromatography steps for purifying the product, (d) at least one virus depletion, (e) at least one ultrafiltration and/or at least one diafiltration of the product stream of steps (b), (c) and/or (d), characterized in that the at least two chromatography steps from (c) comprise a purification via at least two chromatography columns and/or membrane adsorbers in each case and that the process is carried out in a closed and modular manner The invention further provides a corresponding modular system for carrying out said method.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: June 30, 2020
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Benjamin Maiser, Peter Schwan, Martin Lobedann, Volker Möhrle
  • Publication number: 20200199837
    Abstract: An apparatus and a method for increasing the movement speed of the rail vehicle while carrying out measures for controlling weeds on track systems. A rail vehicle equipped with an apparatus for increasing the movement speed of the rail vehicle while carrying out measures for controlling weeds on track systems.
    Type: Application
    Filed: May 11, 2018
    Publication date: June 25, 2020
    Applicant: Bayer Aktiengesellschaft
    Inventor: Hinnerk BASSFELD