Abstract: The present invention discloses a method for the measurement of hydride using a chemiluminescent compound. The preferred chemiluminescent molecule is an acridinium compound. The source of hydride for the reduction of acridinium compound may be of chemical or biochemical origin, or the result of enzymatic catalysis. The chemical source of hydride, for example, might be metal hydrides, such as NaBH4. A biochemical source of hydride might be that derived from NADH, or NADPH, while an enzymatic source would be the class of oxidoreductases termed dehydrogenases which convert NADH or NADPH from NAD or NADP. There are numerous potential applications for acridinium compounds as chemiluminescent indicators of hydride. Any applied tests or diagnostic assays, in which hydride is either present at the onset of or generated through the course of a reaction, would benefit from the present invention.

Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Abstract: A water-resistant polyurethane geotextile composite suitable for use as a liner is made by impregnating a geotextile with a water-resistant polyurethane and allowing the polyurethane impregnated in the geotextile to cure. The water-resistant polyurethane composition is a reaction product of (a) a liquid polyisocyanate having an isocyanate content of at least 10% by weight, (b) an isocyanate-reactive component which includes (1) 20-90% by weight castor oil having a water content of less than 0.5% by weight, and (2) a polyether polyol in which at least 70% by weight of the alkylene oxide is propylene oxide, and (c) a urethane catalyst. Low molecular weight diols and triols and fillers may optionally be included.

Abstract: A compatible blend of polycarbonate resin with a vinyl (co)polymer blending partner is disclosed. The preparation of inventive blend comprise reactive blending of polycarbonate, a vinyl (co)polymer and a novel compatibilizer in the presence of a transesterification catalyst and under conditions of time and temperature designed to promote transesterification. The compatibilizer is the polymerized reaction product of at least one vinyl monomer that contains no hydroxy groups and a hydroxyl containing monomer conforming to (I) where R denotes H or C1-C4 alkyl, R1 denotes H, Cl, Br, C1-C4 alkyl, cyclohexyl, or C1-C4 alkoxy, a is 0 or 1, b is 0 or 1, c is 0 or 1, n is an integer of 0 to 4 and X is an OH group. The compatible blends of the invention are characterized by their improved properties.

Abstract: This invention relates to aryl urea compounds in combination with cytotoxic or cytostatic agents for use in treating raf kinase mediated diseases such as cancer.

Abstract: The present invention is generally directed to detectable chemiluminescent acridinium ester labels having hydrophilic modifiers; to compositions, complexes and/or conjugates which include such labels; and to processes for performing bioanalytical assays for target analytes which use such labels. Assays for folate, theophylline, and tobramycin (using such labels with hydrophilic modifiers such as nonionic polyethylene glycol and polyionic spermine disulfonate and polyionic spermine dicarboxylate) are described in detail.

Abstract: An apparatus (26) for mounting a display screen (28) to a printed circuit board (32). The display screen (28) has four edges. The apparatus (26) includes a top member (34) opposed to a bottom member (36), and first and second snap-fit members (40). The top member (34) and the bottom member (36) each form an overhang (38), wherein each overhang (38) is adapted to receive an edge (30) of the display screen (28). The first snap-fit member (40) is connected with and extended outwards from the top member (34). The second snap-fit member (40) is also connected with and extended outwards from the bottom member (36). Both the first and the second snap-fit members (40) are adapted to connect with the printed circuit board (32) for snap-fit assembly of the mounting apparatus (26) to the printed circuit board (32).

Abstract: A fluoroionophore for the fluorescent detection of potassium ions.

Abstract: A compressible and expandable sample tube holder includes a housing with a plurality of adjacent section members, movable toward and away from each other. Biasing members normally maintain the section members in an expanded condition. In the compressed condition the spacing between section members is reduced. A sample tube breakage detector for the sample tube holder includes slidable plungers having a protracted position that corresponds to a broken sample tube and a retracted position that corresponds to an unbroken sample tube in the sample tube holder. A detector compares the plunger positions before and after a centrifuge spin operation to detect any broken sample tubes in the sample tube holder. A gripper device for gripping the sample tube holder includes a lifting probe with an actuatable eccentric portion to hold the sample tube holder and a stabilizer to stabilize the sample tube holder during lifting.

Abstract: This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality which is oxidized at the nitrogen heteroatom and which are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.

Abstract: The serum transfer cup is nestable in two different size blood collection tubes such as a 13 mm diameter sample tube and a 16 mm diameter sample tube of the same axial length. The serum transfer cup includes a flange stepped down from a top edge of the cup by a distinctive axial distance that permits ultrasonic identification of the presence of the serum transfer cup regardless of which sample tube nests the serum transfer cup. The serum transfer cup has a higher elevation in the 13 mm sample tube than in the 16 mm sample tube, and the different flange heights can be detected using ultrasonic signals. Thus ultrasonic measurement of the flange position of the nested serum transfer cup identifies the presence of different serum transfer cups in the 13 mm sample tube and in the 16 mm sample tube, and also identifies the 13 mm and 16 mm sample tubes with the nested serum transfer cups.

Abstract: This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.

Abstract: A molded article, e.g., a cross car beam (3), which includes a rigid support (a) having a plurality of perforations, e.g., rigid support (12), and a rigid hollow thermoplastic member (b), e.g., an air duct (15), attached thereto is described. A portion of the thermoplastic material of rigid hollow member (b) extends through at least some of the perforations of rigid support (a), embedding the edges of the perforations therein. The thermoplastic material extending through the perforations forms an attachment element, e.g., an attachment head (24), that serves to fixedly attach rigid hollow member (b) to rigid support (a). Also described is a method of preparing the molded article of the present invention, in which the rigid hollow member (b) is fixedly attached to the rigid support (a) during the blow mold fabrication of rigid hollow member (b).

Abstract: This invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.

Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.

Abstract: This invention relates to methods of using aryl ureas to treat diseases mediated by the VEGF induced signal transduction pathway characterized by abnormal angiogenesis or hyperpermeability processes.

Abstract: Molded polyurethane articles having improved flex modulus and impact strength are produced by subjecting a polyurethane-forming reaction mixture which has been introduced into a mold to a static electric field. The static electric field must have a field strength which is less than the dielectric strength of the polyurethane being produced but sufficiently strong to align the hard segment dipoles of the polyurethane.

Abstract: This invention relates to a process for the production of composite wood products. This process comprises a) applying a binder composition to wood particles, and b) molding or compressing the wood particles treated with the binder to form a composite wood product. Suitable binder compositions comprise a polymethylene poly(phenyl isocyanate) and a solid resole resin.

Abstract: This invention relates to a process for the production of composite wood products. This process comprises a) applying a binder composition to wood particles, and b) molding or compressing the wood particles treated with the binder to form a composite wood product. Suitable binder compositions comprise a polymethylene poly(phenyl isocyanate) and a solid novolac resin.