Abstract: A method for making a polyaspartic ester mixture in-situ comprising the sequential steps of (a) reacting a polypropylene oxide amine with an excess amount of an ester of fumaric or maleic acid to form a mixture containing first polyaspartic ester component and excess unreacted ester of fumaric or maleic acid, and (b) adding an acyclic amine to the mixture resulting from step (a) and reacting the acyclic amine with the excess ester of fumaric or maleic acid to form a second polyaspartic ester component.

Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Abstract: The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and of select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.

Abstract: An oil pan which includes a shell of plastic material (e.g., of thermoplastic polyamide), and a support structure (e.g., of metal), having a plurality of perforations, that is fixedly attached to the exterior surfaces and/or the interior surfaces of the plastic shell, is described. More particularly, the oil pan (2) comprises: (a) a shell (11) of plastic material having interior and exterior surfaces, the interior surfaces of the shell defining a hollow interior (40); and (b) a support structure (12) in abutting relationship with and being fixedly attached to at least one of, (i) at least a portion of the exterior surfaces of the shell (11), and (ii) at least a portion of the interior surfaces of the shell (11), the support structure (12) has a plurality of perforations (20) having edges.

Abstract: A method for making an energy-absorbing foam having a density that is less than about 7 pcf that exhibits excellent strength properties and that is particularly suitable for automobile bumper applications. The invention is also directed to the energy-absorbing foam made with the method.

Abstract: The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof.

Abstract: The pot life of an isocyanate formulation is controlled by including a chain extender having (a) at least two secondary amine groups, (b) no primary amine groups, and (c) a reactivity low enough that the chain extender will not react sufficiently with isocyanate groups present in the isocyanate formulation to increase the viscosity of the isocyanate formulation to more than 2000 mPa·s within 5 seconds in the isocyanate formulation.

Abstract: The present invention is directed to a method for impregnating at least one geofabric with a liquid solidifiable polyurethane composition, conforming at least one polyurethane-impregnated geofabric to a surface (such as to the surface of a canal, ditch and/or pipe) and allowing the liquid solidifiable polyurethane composition to cure and form a polyurethane/geofabric composite. The liquid solidifiable polyurethane composition is the reaction product of COMPONENT A, COMPONENT B and COMPONENT C, as defined herein. COMPONENT C has the same equivalent weight as COMPONENT B and contains catalyst. One advantage of the present invention is that the ratio of COMPONENT B to COMPONENT C can be adjusted during processing without changing the isocyanate index. As a result, geltimes of liquid solidifiable polyurethane compositions of the present invention can be adjusted to accommodate changes in outdoor application temperature.

Abstract: A device and method for seed-train expansion of a source of mammalian cells and their use in production of proteins expressed by the cells comprising the use of a dedicated inoculation bioreactor for expanding the cells prior to the transfer to a production bioreactor is disclosed.

Abstract: This invention relates to paper sizing compositions comprised of at least one sizing agent selected from ASA, AKD and rosin where the at least one sizing agent is emulsified in water, at least one emulsion stabilizer, and from about 0.01% to about 15% by weight of at least one hydrophobic substance, based on the total weight of sizing agent present, provided that the hydrophobic substance is not highly alkoxylated. The sizing promotion efficiency of the paper sizing compositions, as determined by at least one method selected from the Cytec size testing method, the Hercules size testing method, and the Cobb size testing method, is greater than or equal to about 4. Exemplary hydrophobic substances include fatty acid esters, triglycerides, hydrocarbons, esters and/or amides derived from ASA, silicone oils, alcohols, and stearic anhydride. The invention also relates to methods for sizing paper products with these paper sizing compositions and paper or paperboard treated with these sizing compositions.

Abstract: The present invention relates to air-assisted, low pressure spray equipment having an improved spray nozzle including 1) a caulking gun having a carriage adapted to receive two or more cartridges having a nozzle, 2) a static mixer having an upstream end and a downstream end wherein a) the upstream end has an inlet port for receiving a liquid component from the nozzle of each cartridge and the upstream end is dimensioned to be reversibly connected to the cartridges of the caulking gun, and b) the downstream end has an optionally removable spray tip for introducing the mixed liquid components into an atomizing zone and the downstream end is dimensioned for reversibly connecting the static mixer to a spray section, and 3) a spray section having an upstream end and a downstream end wherein a) the upstream end of the spray section is dimensioned for being reversibly connecting to the static mixer, b) the spray section has inlet ports for receiving pressurized air and c) the downstream end of the spray section h

Abstract: A process of calendering a sheet or a film having at least one textured surface entailing passing a web of polymeric resin through a nip between a rigid roll and a resilient roll is disclosed. The inventive process comprises slowing down the cooling rate of the web by rolling its textured surface about the resilient roll. The rate of cooling is in comparison to a corresponding process where the web is rolled about said rigid roll. Products thus produced are suitable for making thermoformed articles having low gloss.

Abstract: Rigid polyurethane or polyisocyanurate foams are produced by reacting an organic polyisocyanate with an amine-based polyether polyol in the presence of a catalyst, a hydrogen-containing fluorocarbon, water and carbon dioxide.

Abstract: This invention relates to a process for the production of an optically clear, light-stable polyurethane-urea elastomer having an onset softening point of at least 130° C., processed at ambient temperature and casted in a mold at an isocyanate index of 95 to 120. This process comprises reacting: A) a liquid polyisocyanate or polyisocyanate prepolymer having an NCO group content of about 5 to about 50%, an average functionality of 2 to 3, a viscosity of less than 5,000 mPa.s at 25° C.; and B) an isocyanate-reactive component; in the presence of C) at least one organometallic catalyst. The present invention also relates to the optically clear, light-stable polyurethane-urea elastomers produced by this process.

Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Abstract: A molding composition comprising thermoplastic polyurethane is disclosed. The polyurethane is characterized in having ultimate tensile strength (UTS) and elongation at break (EAB) values after hot storage which are, each, at least 60% of the corresponding value before hot storage, glass transition temperature equal to or lower than −50° C., UTS and EAB values after hydrolytic storage which are, each, at least 80% of the corresponding value before hydrolytic storage, and Shore A hardness of 70 to 95. The polyurethane is a product of a reaction comprising an aliphatic diisocyanate, a mixture of polyols and a chain extender and contains a UV stabilizer, an antioxidant and an optional anti-hydrolysis agent.

Abstract: An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection system for reagent containers, sample and reagent aspirating and dispensing probes, a separation system for separating bound from unbound tracer or labeled reagent, a detection system and date collection/processing system. AU of the sub-units of the machine are controlled by a central processing unit to coordinate the activity of all of the subunits of the analyzer. The analyzer is specifically suited for performing heterogeneous binding assay protocols, particularly immunoassays.

Abstract: The present invention relates to polyurethanes containing secondary amide groups in the backbones of the polyurethanes, wherein the secondary amide groups (calculated as NH—CO—, MW 43) are present in an amount of 1 to 14% by weight, based on the weight of the polyurethanes, and correspond to the formula —X1—R1—NH—C(O)—R2—X2—  (I) wherein X1 and X2 are the same or different and represent the groups obtained by removing a hydrogen atom from a hydroxy group or a primary or secondary amino group and R1 and R2 are the same or different and represent linear or branched hydrocarbon groups that are optionally substituted by groups that do not contain isocyanate-reactive hydrogen atoms. The present invention also relates to one-component, thermoset compositions containing the polyurethanes with secondary amide groups in the backbone and a cross-linking component that is reactive with amide groups.