Patents Assigned to Bayer Healthcare AG
  • Substituted isoindoles and their use
    Publication number: 20080039446
    Abstract: The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I), a method for the production of these compounds, pharmaceutical compositions containing them, and methods of using them for the prevention and/or treatment of various diseases.
    Type: Application
    Filed: March 12, 2007
    Publication date: February 14, 2008
    Applicant: Bayer HealthCare AG
    Inventors: Alexander Straub, Thomas Lampe, Jens Pohlmann, Susanne Rohrig, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Anti-Demodicosis Agent
    Publication number: 20080039519
    Abstract: The present invention relates to the use of macrocyclic lactones for treating demodicosis, particularly in dogs.
    Type: Application
    Filed: October 27, 2005
    Publication date: February 14, 2008
    Applicant: BAYER HEALTHCARE AG
    Inventors: Josef Heine, Klemens Krieger
  • Process for the Preparation of a Solid, Orally Administrable Pharmaceutical Composition
    Publication number: 20080026057
    Abstract: The present invention relates to a process for the preparation of a solid, orally administrable pharmaceutical composition, comprising 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide in hydrophilized form, the pharmaceutical composition resulting from this process, and its use for the prophylaxis and/or treatment of thromboembolic diseases.
    Type: Application
    Filed: November 13, 2004
    Publication date: January 31, 2008
    Applicant: Bayer HealthCare AG
    Inventor: Klaus Benke
  • 18-Membered Nitrobenzyl- and Aminobenzyl-Substituted Cyclohexadepsipeptides for Controlling Endoparasites and a Process for Their Preparation
    Publication number: 20080026990
    Abstract: The invention relates to cyclic depsipeptides, especially 18-membered cyclohexadepsipeptides of general formula (I) and the salts thereof, wherein R1 represents nitrobenzyl or R?R?N-benzyl—wherein R? and R? independently represent hydrogen, optionally substituted C1-C4-alkyl, formyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkoxycarbonyl, or hydroxy-C1-C2-alkyl-sulfonyl-C1-C2-alkyl, or, together with the nitrogen atom to which they are bound, R? and R? form an optionally substituted monocyclic or polycyclic, optionally bridged and/or spirocyclic, saturated or unsaturated heterocycle containing between one and three other heteroatoms from the group of nitrogen, oxygen and sulphur, or R? and R? together form C3-C5-alkylene monocarbonyl or an optionally susbtituted diacyl radical of a C4-C6-dicarboxylic acid—and R2, R3 and R4 independently represent C1-C4-alkyl.
    Type: Application
    Filed: December 7, 2004
    Publication date: January 31, 2008
    Applicant: BAYER HEALTHCARE AG
    Inventors: Peter Jeschke, Achim Harder
  • Members of the capsaicin/vanilloid receptor family of proteins and uses thereof
    Patent number: 7323314
    Abstract: The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an hVR-1, hVR-2, and rVR-2 gene has been introduced or disrupted. The invention still further provides isolated hVR-1, hVR-2, and rVR-2 proteins, fusion proteins, antigenic peptides and anti-hVR-1, anti-hVR-2, and anti-rVR-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: January 29, 2008
    Assignee: Bayer HealthCare AG
    Inventor: Rory A. J. Curtis
  • Heterocyclic Derivatives
    Publication number: 20080021053
    Abstract: The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
    Type: Application
    Filed: February 15, 2005
    Publication date: January 24, 2008
    Applicant: Bayer HealthCare AG
    Inventors: Heike Gielen-Haertwig, Barbara Albrecht, Jorg Keldenich, Volkhart Li, Josef Pernerstorfer, Karl-Heinz Schlemmer, Leila Telan
  • Method and Apparatus for Continuously Controlling Denitrification in Variable Nitrogen Loads in Wastewater
    Publication number: 20080017583
    Abstract: The invention is a method and an apparatus for continuously controlling denitrification in wastewater purification in a sewage treatment plant having at least one denitrification stage under varying nitrogen loads comprising the steps a) provision of excess sludge, b) treatment of the excess sludge according to running parameters determined in advance, c) separation of the treated excess sludge into an organic fraction and an inorganic fraction, d) measurement of actual values for dissolved organic carbon (DOC) in the organic fraction, e) recirculation of the organic fraction to one of the denitrification stages, f) comparison of actual values with predetermined setpoint values for DOC fractions and, in the event of difference between actual values and setpoint values, determination of altered running parameters for treatment of the excess sludge in step b), g) repetition of steps a), to f).
    Type: Application
    Filed: June 16, 2005
    Publication date: January 24, 2008
    Applicant: Bayer Healthcare AG
    Inventors: Jurgen Kahlert, Frank Niemeyer, Matthaus Schmidt
  • Substituted 2-phenyl-3(2h)-pyridazinones
    Patent number: 7320977
    Abstract: The invention relates to substituted 2-Phenyl-3(2H)-Pyridazinones, to a method for the production thereof, and to their use as medicaments for the prophylaxis and/or treatment of diseases in humans and/or animals.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: January 22, 2008
    Assignee: Bayer Healthcare AG
    Inventors: Rudolf Schohe-Loop, Elmar Burchardt, Christiane Faeste, Claudia Hirth-Dietrich, Jörg Keldenich, Andreas Knorr, Thomas Lampe, Paul Naab, Delf Schmidt, Gunter Schmidt
  • Heteroaryl carboxamides
    Publication number: 20080009624
    Abstract: The invention relates to novel heteroaryl carboxamides, a process for their preparation, and pharmaceutical compositions containing them. These materials are useful for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
    Type: Application
    Filed: August 10, 2007
    Publication date: January 10, 2008
    Applicant: Bayer Healthcare AG
    Inventors: Martin Hendrix, Frank-Gerhard Boss, Christina Erb, Joachim Kruger, Joachim Luithle, Christoph Methfessel, Rudy Schreiber, Welf-Burkhard Wiese
  • Antiviral 4-Aminocarbonylamino-Substituted Imidazole Compounds
    Publication number: 20080004275
    Abstract: The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
    Type: Application
    Filed: March 11, 2005
    Publication date: January 3, 2008
    Applicant: Bayer HealthCare AG
    Inventors: Holger Zimmermann, David Bruckner, Dirk Heimbach, Martin Hendrix, Kerstin Henninger, Guy Hewlett, Ulrich Rosentreter, Jorg Keldenich, Dieter Lang, Martin Radtke
  • Diagnostics and Therapeutics for Diseases Associated With Kallikrein 3 (Klk3)
    Publication number: 20070298028
    Abstract: The invention provides a human KLK3 which is associated with the endocrine system and hormone disorders, cardiovascular disorders, metabolic diseases, cancer disorders, neurological disorders, urological disorders and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of endocrine system and hormone disorders, cardiovascular disorders, metabolic diseases, cancer disorders, neurological disorders, urological disorders and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK3 as well as pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: February 4, 2005
    Publication date: December 27, 2007
    Applicant: BAYER HEALTHCARE AG
    Inventors: Stefan Golz, Ulf Bruggemeier, Andreas Geerts, Holger Summer
  • Novel Uses of 2-Phenyl-Substituted Imidazotriazinone Derivatives
    Publication number: 20070299088
    Abstract: The invention relates to the use of PDE 5 inhibitors, and especially of known 2-phenyl-substituted imidazotriazinone derivatives for producing medicaments for the treatment of symptoms that can be treated by increasing cGMP levels in certain tissues, such as acute myocardial infarction and damage caused by reperfusion, various symptoms in the female and male reproductive system and urogenital tract, gastrointestinal diseases, damage caused by diabetes, and liver failure.
    Type: Application
    Filed: July 23, 2005
    Publication date: December 27, 2007
    Applicant: Bayer HealthCare AG
    Inventor: Helmut Haning
  • Diagnostics and Therapeutics for Diseases Associated with Peroxisome Proliferative Activated Receptor Delta (Ppard)
    Publication number: 20070286853
    Abstract: The invention provides a human PPARD which is associated with the cardiovascular diseases, infections, cancer, dermatological diseases, gastroenterological diseases, inflammation, hematological diseases, metabolic diseases, muscle-skeleton diseases, neurological diseases, urological diseases and reproduction diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, cancer, dermatological diseases, gastroenterological diseases, inflammation, hematological diseases, metabolic diseases, muscle-skeleton diseases, neurological diseases, urological diseases and reproduction diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PPARD as well as pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: March 20, 2005
    Publication date: December 13, 2007
    Applicant: BAYER HEALTHCARE AG
    Inventors: Stefan Golz, Ulf Bruggemeier, Andreas Geerts
  • Diagnostics And Therapeutics For Diseases Associated With Dipeptidyl-Peptidase 1 (Dpp1)
    Publication number: 20070286854
    Abstract: The invention provides a human DPP1 which is associated with the infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP1 as well as pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: April 15, 2005
    Publication date: December 13, 2007
    Applicant: BAYER HEALTHCARE AG
    Inventors: Stefan Golz, Bruggemeiere Ulf, Andeas Geerts
  • Tetrahydrobenzo(D)Azepin-2-One Derivatives and the Use Thereof for Treating Cardiovascular Diseases
    Publication number: 20070287698
    Abstract: The present application relates to novel tetrahydrobenzo[d]azepin-2-one derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, especially of dyslipidaemias, arteriosclerosis, restenosis and ischaemias.
    Type: Application
    Filed: February 1, 2005
    Publication date: December 13, 2007
    Applicant: Bayer HealthCare AG
    Inventors: Nils Griebenow, Timo Flessner, Michael Harter, Martin Raabe, Anja Buchmuller, Hilmar Bischoff, Peter Ellinghaus, Peter Kolkhof
  • Substituted Dihydroquinazolines II
    Publication number: 20070281953
    Abstract: The invention relates to substituted dihydroquinazolines and to a method for the production thereof, the use thereof for treating and/or preventing diseases and for producing drugs for treating and/or preventing diseases, in particular for the use of the inventive dihydroquinazolines in the form of antiviral agents, in particular against cytomegaloviruses.
    Type: Application
    Filed: October 28, 2004
    Publication date: December 6, 2007
    Applicant: Bayer HealthCare AG
    Inventors: Tobias Wunberg, Judith Baumeister, Mario Jeske, Peter Nell, Susanne Nikolic, Frank Sussmeier, Holger Zimmermann, Rolf Grosser, Guy Hewlett, Jorg Keldenich, Dieter Lang, Kerstin Henninger
  • Diagnostics and Therapeutics for Diseases Associated with Adrenomedullin Receptor (Amdr)
    Publication number: 20070280886
    Abstract: The invention provides a human AMDR which is associated with the cardiovascular diseases, infections, dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, dermatological diseases, endocrinological diseases, metabolic diseases, gastroenteroloigcal diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AMDR as well as pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: August 31, 2005
    Publication date: December 6, 2007
    Applicant: BAYER HEALTHCARE AG
    Inventors: Stefan Golz, Ulf Bruggemeier, Andreas Geerts
  • Isolated Photoprotein mtClytin, and Use Thereof
    Publication number: 20070275377
    Abstract: The invention relates to the photoprotein mtClytin, to its nucleotide and amino acid sequences and to the activity and use of the photoprotein mtClytin.
    Type: Application
    Filed: September 3, 2004
    Publication date: November 29, 2007
    Applicant: Bayer HealthCare AG
    Inventors: Stefan Golz, Svetlana Markova, Ludmila Burakova, Ludmila Frank, Eugene Vysotski
  • Penetration of Active Substances Into Cells and Organs
    Publication number: 20070270503
    Abstract: The invention relates to the use of certain cyclic acetals or ketals for improving the penetration of pharmaceutical agents into cells and organs.
    Type: Application
    Filed: March 25, 2004
    Publication date: November 22, 2007
    Applicant: Bayer HealthCare AG
    Inventors: Achim Harder, Iris Heep, Stefan Herrmann, Jeffry-Lynn Grunkemeyer, Jochen Kalbe, Heinz Mehlhorn, Jurgen Schmidt, Gunther Schmahl
  • Diagnostics and Therapeutics for Diseases Associated with Plasma Glutamate Carboxypeptidase (Pgcp)
    Publication number: 20070269421
    Abstract: The invention provides a human PGCP which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urologial diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urologial diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PGCP as well as pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: January 22, 2005
    Publication date: November 22, 2007
    Applicant: BAYER HEALTHCARE AG
    Inventors: Stefan Golz, Ulf Bruggemeier, Andreas Geerts, Holger Summer