Patents Assigned to Bayer HealthCare, LLC
  • Patent number: 11141535
    Abstract: A fluid injector system for delivering a multi-phase fluid injection to a patient and methods of fluid delivery is disclosed. Methods of creating and using a multi-aspect fluid path impedance model of the injector system are used. Modeling and adjustment of factors that affect impedance and prevent or reduce backflow, reduce the likelihood of fluid flow rate spikes and provide more accurate flow rates and mixing ratios of fluids may be repeated or happen essentially continuously during an injection. The adjustments may be determined before the injection or determined and/or adjusted during the injection. The determination may include sensor feedback commonly used in injectors such as pressure and position feedback as well as other sensors. In all cases, the user can be notified of adjustments through on-screen notices and/or through the recordation of the injection data by a control device of the injector at the conclusion of the injection.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: October 12, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Arthur Uber, III, Chelsea Marsh, William Barone, Michael McDermott, Timothy Newing, Michael Spohn, Vince Delbrugge, Ralph Schriver, Kevin Cowan, Barry Tucker, Ronald Heller, David Griffiths, Matthew Schrauder
  • Patent number: 11135188
    Abstract: A tablet with an enhanced dissolution profile for a medicinally active ingredient such as aspirin and methods for making the tablet. The tablet comprises a blend of crystals of the medicinally active ingredient and a dissolution aid such as sodium or calcium carbonate or bicarbonate that coats the crystals upon co-milling. The blend is then compressed to form tablets that have an enhanced dissolution profile for the medicinally active ingredient.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: October 5, 2021
    Assignee: Bayer HealthCare LLC
    Inventors: Eric R. First, Ashish B. Patel, Guido Schmitz, Stephanie Petaway-Hickson, Hung-Huar Tong
  • Patent number: 11129934
    Abstract: A pressure jacket for use with a fluid injector includes a barrel having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end along a longitudinal axis. The pressure jacket includes at least one engagement member protruding from a terminal portion of the proximal end of the barrel in a proximal direction along the longitudinal axis. The at least one engagement member tapers axially in a direction from the distal end toward the proximal end of the barrel. The at least one engagement member engages with a locking mechanism on the fluid injector to releasably lock the pressure jacket with the fluid injector. A taper of the at least one engagement member rotationally guides the barrel into self-alignment with the locking mechanism and axially ejects the barrel upon rotation of the barrel about the longitudinal axis.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: September 28, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin P. Cowan, Barry L. Tucker, Arthur E. Uber, III, Edward J. Rhinehart, Michael A. Spohn, James R. Neill, Glen P. Williams
  • Patent number: 11118177
    Abstract: The present application provides materials and methods for treating a patient with one or more of Usher Syndrome Type 2A and ARRP, both ex vivo and in vivo; materials and methods for editing an USH2A gene containing a guanine deletion at nucleotide position c.2299. In addition, the present application provides one or more gRNAs or sgRNAs for editing an USH2A gene containing a guanine deletion at nucleotide position c.2299; a therapeutic comprising at least one or more gRNAs or sgRNAs for editing an USH2A gene containing a guanine deletion at nucleotide position c.2299; and a therapeutic for treating a patient with one or more of Usher Syndrome Type 2A and ARRP. The present application also provides a kit for treating a patient with one or more of Usher Syndrome Type 2A and ARRP.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: September 14, 2021
    Assignees: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventors: Mariacarmela Allocca, Akiko Noma, Abraham Scaria
  • Patent number: 11104718
    Abstract: Targeted Factor VIII molecules comprising a Factor VIII linked with at least one domain that specifically binds to a membrane protein on a red blood cell is provided. The disclosed targeted coagulation factors prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: August 31, 2021
    Assignee: Bayer HealthCare LLC
    Inventors: Alan Brooks, Richard Feldman, Jian-Ming Gu, Shaun Lippow, Shujun Yuan, Peter Bringmann
  • Patent number: 11103637
    Abstract: An injector system for injecting fluid includes a syringe and an injector. The syringe includes a body and a plunger movably disposed within the body. The plunger has at least one flexible leg extending toward the rearward end of the body. The injector has a housing with a front plate, a drive member at least partially disposed within the housing and operable to engage the plunger, and a syringe release assembly operable to release the syringe. The syringe assembly includes a syringe release gear that forms an enclosure for receiving the syringe when the syringe is fully seated within the housing and a plunger release tube surrounding at least a portion of the drive member. The plunger release tube has a first end rotationally engaged with the syringe release gear. Rotation of the syringe release assembly releases the at least one flexible leg from the drive member.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: August 31, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Charles Lang, Christopher Swenglish, Luis Castillo, Stephen Schulte
  • Patent number: 11107570
    Abstract: The present disclosure relates to automated systems and methods which assess the quality of radiology examinations and identify actionable changes to improve the quality of future exams. For each of a plurality of imaging studies, a study protocol and set of study metrics can be defined and the defined study protocol can be performed to generate data associated with the imaging study. A metrics assessment can be performed by applying at least a portion of the data associated with the result of the imaging study against the set of study metrics for the imaging study so as to generate a metrics score for the imaging study. The metrics scores can be stored in a score repository and analyzed so as to provide recommendations to improve the examination process.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: August 31, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John Volkar, Corey A. Kemper
  • Publication number: 20210254057
    Abstract: Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., Hemophilia A, employing ex vivo and/or in vivo genome editing.
    Type: Application
    Filed: January 11, 2019
    Publication date: August 19, 2021
    Applicants: CRISPR Therapeutics AG, BAYER HEALTHCARE LLC
    Inventors: Alan Richard Brooks, Karen VO
  • Patent number: 11090440
    Abstract: A power injector system having a power injector for enabling delivery of fluid in an injection procedure to be performed on a patient may include one or more processors; a first user interface; and a second user interface. The first user interface and the second user interface may be configured to accept a plurality of user inputs associated with control of a plurality of operations of the power injector system and display information associated with the plurality of operations. One of the first user interface and the second user interface may be proximate to the power injector and the other may be remote from the power injector. The one or more processors may be programmed and/or configured to independently control the first user interface and the second user interface based on a first user input and a next user input received from the first user interface and/or the second user interface.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: August 17, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John Volkar, Corey Kemper, Someshwar Mukherjee, Samantha Parker, Carl Benson, James Hoon Yoo, Leona Mulcahy, Michael Brooks, Richard Sokolov, Benjamin James Cullen, Alison Ruth Von Moger
  • Patent number: 11083882
    Abstract: A connector assembly may include a body and a fluid fitting, the fluid fitting configured for releasably engaging a syringe nozzle, at least one deflectable locking arm connected to the body and radially deflectable relative to the distal end, the proximal end of the at least one deflectable locking arm configured for deflecting in a radial direction relative to the distal end to releasably engage the syringe nozzle, and at least one locking element disposed on the at least one deflectable locking arm, the at least one locking element movable with movement of the at least one deflectable locking arm between a first position where the at least one locking element is released from an engagement portion of the syringe nozzle and a second position where the at least one locking element is engaged with the engagement portion of the syringe nozzle.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: August 10, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Matthew Schrauder, Brian Cain, Michael Cousley, Kevin Cowan, Michael Spohn
  • Publication number: 20210232785
    Abstract: A reader system for reading information on at least one identification tag associated with a syringe connected to a fluid injector has a detector and a background screen spaced apart from the detector such that at least one of the at least one identification tags is positioned in an optical path between the detector and the background screen when the syringe is connected to the fluid injector. The reader system further has an illumination system configured for illuminating at least a portion of the background screen. The detector is configured for detecting and decoding the at least one identification tag. Methods for reading information on at least one identification tag associated with a syringe are also described.
    Type: Application
    Filed: April 9, 2021
    Publication date: July 29, 2021
    Applicant: BAYER HEALTHCARE LLC
    Inventors: CHRISTOPHER CAPONE, JAROSLAW WLODARCZYK
  • Patent number: 11072792
    Abstract: The present application provides materials and methods for treating a patient with Usher Syndrome Type 2A, both ex vivo and in vivo; materials and methods for editing a USH2A gene in a human cell; materials and methods for editing an USH2A gene containing an IVS40 mutation; materials and methods for treating a patient with an USH2A gene containing an IVS40 mutation; and a method for deleting a sequence comprising an IVS40 mutation within a USH2A gene of a cell. The present application also provides one or more gRNAs or sgRNAs for editing an USH2A gene containing an IVS40 mutation. The present application provides a therapeutic for treating a patient with Usher Syndrome Type 2A. The present application also provides a kit for treating a patient with Usher Syndrome Type 2A.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: July 27, 2021
    Assignees: BAYER HEALTHCARE LLC, CRISPR THERAPEUTICS AG
    Inventors: Albena Kantardzhieva, Akiko Noma, Abraham Scaria
  • Patent number: 11058811
    Abstract: A configurable fluid delivery system and methods for its use are disclosed. The system may include one or more control units, fluid delivery units, fluid actuator units, and disposable units. Data sources and sensors on each of the delivery units, actuator units, and disposable units may provide data to the control unit, thereby identifying the components along with the manner in which they may be configured. The control unit may notify a user regarding the status of any one or more of the delivery, actuator, and disposable units to indicate their appropriateness for delivering a fluid according to one or more selected procedures and protocols. Also disclosed are methods by which the configurable fluid delivery system may provide data to a user to assist the user in assembling and testing a particular configuration of the fluid delivery system for a specific use.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 13, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Arthur E. Uber, III, Mark Trocki
  • Patent number: 11013857
    Abstract: A system for heating a medical fluid has at least one first fluid container for storing the fluid, a fluid injector having at least one second fluid container for receiving the fluid from the at least one first fluid container through a fluid path set, at least one heating element positioned in-line with the fluid path set between the at least one first fluid container and the at least one second fluid container of the fluid injector for heating the fluid to a pre-determined temperature as the fluid flows through at least one fluid path element, and a controller for controlling an output of the at least one heating element based on at least one of a property of the at least one heating element and a property of the fluid flowing through the at least one fluid path element.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: May 25, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Arthur E. Uber, III, Molly Bingaman, Gerald Callan, Kevin Cowan, Genevieve Jerome, Matthew Leroch, Daniel Moore, Ralph Schriver, Michael Spohn, Michael Swantner, Barry Tucker
  • Patent number: 11007118
    Abstract: A fill adapter for delivery of a medical liquid to a container has a body with a distal end, a proximal end, and a central bore extending between the distal end and the proximal end along a longitudinal axis. The central bore has an angled portion at the proximal end of the body such that a diameter of the central portion increases at the angled portion in a direction from the distal end to the proximal end. The fill adapter further has a flow controller disposed within the central bore at a distal end of the angled portion such that a gap is formed between an outer surface of the flow controller and an inner surface of the central bore. The flow controller is shaped to direct liquid flowing through the central bore to flow through the gap and along the angled portion of the central bore under a Coand? effect.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: May 18, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, James A. Dedig, Michael Spohn, Michael McDermott, Matthew McGee
  • Publication number: 20210138032
    Abstract: The present invention relates to methods of treating the manifestation of NVG including increased intraocular pressure and anterior segment neovascularization with a non-antibody VEGF antagonist.
    Type: Application
    Filed: June 12, 2018
    Publication date: May 13, 2021
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Sergio Casimiro SILVA LEAL, Oliver ZEITZ, Yuji IWAMOTO, Masato KOBAYASHI
  • Patent number: 11000255
    Abstract: Described is a system for generating simulated CT images. The system can include a CT image simulator, a phantom database, and a scanner database. The phantom database can include one or more virtual phantoms while the scanner database can include information about one or more CT scanners, including a subject CT scanner. The CT image simulator can use information about a subject patient, a virtual phantom, and scanner information about the subject CT scanner to generate a simulated CT image that closely simulates what an actual CT image would look like if performed on the subject patient using the subject CT scanner. The simulated CT image can be displayed on a display screen. Also described is a method of generating a simulated CT image and CT image simulator software that can be used to generate a simulated CT image.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: May 11, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventor: Mohammad Sedigh Ghamari
  • Publication number: 20210130824
    Abstract: Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., hemophilia A, employing ex vivo and/or in vivo genome editing.
    Type: Application
    Filed: February 15, 2019
    Publication date: May 6, 2021
    Applicants: CRISPR Therapeutics AG, BAYER Healthcare LLC
    Inventor: Alan Richard Brooks
  • Patent number: 10995328
    Abstract: The present application provides materials and methods for treating a patient with autosomal dominant CORD, both ex vivo and in vivo; materials and methods for editing a GUCY2D gene in a human cell; and materials and methods for editing a R838H, R838C, or R838S mutation in a GUCY2D gene in a human cell. The present application also provides one or more gRNAs or sgRNAs for editing a GUCY2D gene; one or more gRNAs or sgRNAs for editing a R838H, R838C, or R838S mutation in a GUCY2D gene; and a therapeutic comprising at least one or more gRNAs or sgRNAs for editing a R838H, R838C, or R838S mutation in a GUCY2D gene. The present application provides a therapeutic for treating a patient with autosomal dominant CORD. The present application also provides a kit for treating a patient with autosomal dominant CORD. In addition, the present application provides a self-inactivating CRISPR-Cas system.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: May 4, 2021
    Assignees: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventors: Ryo Takeuchi, Akiko Noma, Shuying He, Abraham Scaria
  • Patent number: D922880
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: June 22, 2021
    Assignee: Bayer Healthcare LLC
    Inventors: Shelley Markoulis, Simon Gainey, Jess Keene