Patents Assigned to Bayer HealthCare, LLC
  • Patent number: 11607489
    Abstract: A fluid injection system including a graphical user interface, a fluid control module operatively connected to the graphical user interface, a monitoring control module provided in at least one of the graphical user interface and the fluid control module, a fluid injector operatively connected to the graphical user interface and the fluid control module, at least one fluid path set in fluid communication with the fluid control module, and a hemodynamic monitoring system operatively connected to the fluid path set and the monitoring control module. The hemodynamic monitoring system may be configured to receive electrical signals regarding pressure waves formed in medical fluid directed through the fluid path set based on a location of the fluid path set in a patient's vasculature, to convert the electrical signals to pressure wave form information, and to send the pressure wave form information to the monitoring control module.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: March 21, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Gerald Callan, Michael Spohn
  • Patent number: 11602591
    Abstract: A fluid delivery device includes: a fluid-filled cartridge comprising an outlet; a syringe comprising a substantially cylindrical syringe barrel having an open end and a fluid dispensing end; and a plunger rod configured to be received within the open end of the syringe barrel. The plunger rod comprises: a first end having a sealing member provided in sealing engagement with an inner wall of the syringe barrel such that a first syringe chamber is provided between the first end of the plunger rod and the fluid dispensing end of the syringe barrel; a second end extending out of the open end of the syringe barrel and having a cartridge-receiving chamber having a connection mechanism positioned therein for connecting the outlet of the cartridge thereto. The plunger rod also includes a fluid channel extending from the connection mechanism to the first end of the plunger rod.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: March 14, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventor: Kevin P. Cowan
  • Patent number: 11600377
    Abstract: The present disclosure relates to automated systems and methods which assess the quality of radiology examinations and identify actionable changes to improve the quality of future exams. For each of a plurality of imaging studies, a study protocol and set of study metrics can be defined and the defined study protocol can be performed to generate data associated with the imaging study. A metrics assessment can be performed by applying at least a portion of the data associated with the result of the imaging study against the set of study metrics for the imaging study so as to generate a metrics score for the imaging study. The metrics scores can be stored in a score repository and analyzed so as to provide recommendations to improve the examination process.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: March 7, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John Volkar, Corey A. Kemper
  • Patent number: 11596735
    Abstract: A syringe includes a body and a plunger movably disposed within the body. The syringe may be used with an injector including a drive member. The drive member preferably includes at least one pin adapted to form a retractable abutting connection with an interior of a plunger to enable the drive member to retract the plunger with the body of the syringe.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: March 7, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, John Haury, Jared Neff
  • Patent number: 11598664
    Abstract: A calibration system for calibrating a pressure output of a fluid injector having a housing configured for connecting to the fluid injector; a drive member engagement portion configured for contacting a drive member of the fluid injector; a compressible member, which may have a known modulus of compression, connected at its proximal end to the drive member engagement portion, wherein the compressible member is compressed with movement of the drive member of the fluid injector between a first, uncompressed position and a second, at least partially compressed position of the fluid injector in a distal direction; and a sensor connected to the compressible member is described. The sensor is configured for measuring at least one of a force imparted by the drive member and a displacement of the drive member when the compressible member is in the second, at least partially compressed position.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: March 7, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael McDermott, Chelsea Marsh, Michael Spohn, William Barone, Robert Praniewicz, Edden Rabin, Corey Savannah, Vince Delbrugge
  • Patent number: 11597901
    Abstract: Disclosed herein is a sterilizable adapter for a cell culture vessel comprising a body, an upper connection and/or a lid, at least one port, a ventilation passage, a lower internal connection suitable for connection to a cell culture vessel and a cell retention device and/or a cell separation device as well as a device comprising said sterilizable adapter and a method for cell cultivation using said sterilizable adapter.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: March 7, 2023
    Assignees: Bayer Aktiengesellschaft, BAYER HEALTHCARE LLC
    Inventors: Annette Eidt, Wolf Kloeckner, Helmut Brod, Martin Poggel, Bernd Tscheschke
  • Patent number: 11583435
    Abstract: The present invention relates to an arrangement comprising an intrauterine system, an inserter for the intrauterine system and a package for the inserter.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: February 21, 2023
    Assignee: Bayer HealthCare LLC
    Inventors: Joonas Mikkonen, Tero Jalkanen, Mikko Virtanen, Taina Tjaeder, Karym El Sayed
  • Patent number: 11577022
    Abstract: A syringe includes a barrel having a distal end, a proximal end, and a sidewall extending therebetween along a longitudinal axis. At least one engagement member protrudes from a terminal portion of the sidewall in a proximal direction along the longitudinal axis. The at least one engagement member tapers axially in a direction from the distal end toward the proximal end. The at least one engagement member is configured for engagement with a locking mechanism of a fluid injector to releasably lock the syringe with the fluid injector. A taper of the at least one engagement member is configured to rotationally guide the syringe into alignment with the locking mechanism and axially eject the syringe upon rotation of the syringe. The locking mechanism operatively engages the at least one engagement member regardless of an orientation of the syringe about the longitudinal axis relative to the injector.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: February 14, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, Barry Tucker, Arthur Uber, III, Edward Rhinehart, James Neill, Glen Williams, Michael Spohn
  • Patent number: 11576985
    Abstract: A diagnostic contrast composition includes a carrier fluid and a non-decaying gas-evolving fluid incorporated in the carrier fluid. The gas-evolving fluid has a vapor pressure sufficient to evolve the gas from a circulatory system within a lung of a patient. The gas-evolving fluid is a composition containing a sufficient quantity of atoms with an atomic number higher than 8 to provide an increased absorption sufficient to increase a Hounsfield Unit measurement in an image in a CT imaging system. The gas-evolving fluid is selected from the group consisting of xenon gas, krypton gas, sulfur hexafluoride, a perfluorocarbon, a brominated perfluorocarbon, and combinations thereof. The carrier fluid is selected from the group consisting of water, saline, saline comprising one or more blood proteins, and saline comprising dissolved lipids.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: February 14, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventor: Arthur Uber, III
  • Patent number: 11578323
    Abstract: Aspects of this invention inter alia relate to novel systems for targeting, editing or manipulating DNA in a cell, comprising one or more heterologous vector(s) encoding a SluCas9 nuclease from Staphylococcus lugdunensis or variants thereof, and one or more guide RNAs (gRNAs), or a SluCas9 nuclease or variant thereof and one or more gRNAs.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: February 14, 2023
    Assignees: BAYER HEALTHCARE LLC, CRISPR THERAPEUTICS AG
    Inventors: Andre Cohnen, Moritz Schmidt, Wayne Coco, Ashish Gupta, Jan Tebbe, Cindy Schulenburg, Christian Pitzler, Michael Biag Gamalinda, Sabine Jach, Florian Richter, Anup Arumughan, Corinna Saalw├Ąchter
  • Patent number: 11564392
    Abstract: This disclosure relates to methods for use in inactivating viruses. The methods of inactivating viruses with N-methylglucamides is applicable to the purification process of biologically-active drugs such as protein subunits, proteins (enzymes, factors, etc.), recombinant proteins, antibodies, vaccine or gene therapeutic products. The detergents used in this method are based on multiple N-methylglucamide homologs, consisting of a hydrophilic glucose moiety and hydrophobic fatty acid tail, linked by an amide bond. Additionally, these sugar-based detergents are nonionic by nature, which do not disrupt the drug protein, plasma biologies, non-enveloped viral vaccine or adeno associated viral particles.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: January 31, 2023
    Assignee: Bayer Healthcare LLC
    Inventors: Shengjiang Liu, Allison Titong, Wensheng Wang, Nicholas Spadoni
  • Patent number: 11565035
    Abstract: Described is an injector system for implementing a split bolus injection procedure. The injector system includes a processor and a non-transitory storage medium having programming instructions stored therein that, when executed by the processor, enable the injector system to operate as a parameter generation system for use in determining parameters associated with a split bolus injection protocol via which injection of the contrast agent by the injector system is controlled. The split bolus injection protocol includes at least a loading injection and a diagnostic injection, wherein the loading injection is performed before the diagnostic injection, and wherein a pause separates the loading injection from the diagnostic injection. Also described is a method for patient imaging using a split bolus injection technique and a system having an imaging device and the injector system described above.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: January 31, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John Volkar, Corey Kemper
  • Patent number: 11555052
    Abstract: This disclosure relates to methods for the prevention of the reduction of disulfide bonds in a polypeptide expressed in a recombinant host cell, comprising, following fermentation, adding selenite and/or its salts or derivatives to a harvest solution of the recombinant host cell, wherein the disulfide bond in the polypeptide remains non-reduced.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: January 17, 2023
    Assignee: Bayer HealthCare LLC
    Inventor: Kathryn Kwant
  • Patent number: 11547793
    Abstract: An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and pivotally movable about a pivot pin relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are pivotally movable about the pivot pin in a radially inward direction to engage with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: January 10, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, Michael Spohn, Barry Tucker, James Dedig, Gregory Johnston, Michael McDermott, David Berry, Adam Steege, Keith Lipford, Chet Larrow, Mariano Mumpower, Danica Gordon
  • Patent number: 11547794
    Abstract: A plunger for use with a syringe has a plunger body with a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a plunger longitudinal axis. The plunger further has at least one resiliently deflectable retaining member having a first segment attached to the plunger body and a second segment protruding toward the distal end of the plunger body and deflectable relative to the first segment. The plunger further has at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member interacts with a piston to deflect the at least one resiliently deflectable retaining member upon rotation of the plunger relative to the piston. The plunger is engageable with the piston regardless of a rotational orientation of the piston relative to the plunger.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: January 10, 2023
    Assignee: Bayer Healthcare LLC
    Inventors: Michael Swantner, Richard Seman, Barry Tucker, Arthur Uber, III, Kevin Cowan, James Dedig, Christopher Capone, Jaroslaw Wlodarczyk
  • Publication number: 20220401394
    Abstract: The present disclosure relates to oral naproxen sodium tablets comprising roller-compacted granules, methods of preparing thereof, and methods of using thereof. The naproxen sodium tablets are formulated for and prepared by dry granulation methods, specifically roller compaction. The combination of dry granulation compatible excipients with roller compaction methods results m naproxen sodium tablets that exhibit an enhanced dissolution profile and shorter disintegration time as compared to commercially available oral naproxen sodium tablets prepared by standard wet granulation methods.
    Type: Application
    Filed: December 18, 2020
    Publication date: December 22, 2022
    Applicant: Bayer HealthCare LLC
    Inventors: Satish KAMATH, Rachan SIRIHORACHAI, Karthik Yadav JANGA
  • Patent number: 11529456
    Abstract: A fluid injector system includes a powered fluid injector, a connection port configured to receive a single-use disposable set having tubing connected to a fluid inlet port at a first end and connected to a waste outlet port at a second end, and a detector associated with the connection port and configured to generate a signal in response to a sonic, infrasonic, or ultrasonic wave emitted from the single-use disposable set during a priming operation of the single-use disposable set. In some examples, the detector is configured to generate a signal if the frequency of the wave emitted from the single-use disposable set is outside a predetermined range of frequencies corresponding to a predetermined range of frequencies of air expelled from the tubing. A method for detecting the multiple uses of a single-use disposable set connected to a fluid injector system is also provided.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: December 20, 2022
    Assignee: Bayer Healthcare LLC
    Inventors: John Volkar, Corey Kemper, Richard Dotson, Bernard Hobi
  • Patent number: 11529427
    Abstract: Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: December 20, 2022
    Assignees: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventor: Alan Richard Brooks
  • Patent number: 11517622
    Abstract: The present invention relates to pharmaceutical compositions and combinations comprising regorafenib or its hydrate, solvate, metabolite or pharmaceutically acceptable salt or a polymorph thereof and a PD-1/PD-L1(2) inhibitor for treating, preventing or managing diseases and conditions including hyperproliferative disorders such as cancer in humans and other mammals.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: December 6, 2022
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Sabine Hoff, Lars Rose, Dieter Zopf, Fabian Kiessling, Wiltrud Lederle, Dennis Doleschel
  • Patent number: D971022
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: November 29, 2022
    Assignee: Bayer Healthcare LLC
    Inventors: Mark Kansburg, Graham Hufton