Patents Assigned to Bayer HealthCare, LLC
  • Publication number: 20200197599
    Abstract: Described is an injector system for implementing a split bolus injection procedure. The injector system includes a processor and a non-transitory storage medium having programming instructions stored therein that, when executed by the processor, enable the injector system to operate as a parameter generation system for use in determining parameters associated with a split bolus injection protocol via which injection of the contrast agent by the injector system is controlled. The split bolus injection protocol includes at least a loading injection and a diagnostic injection, wherein the loading injection is performed before the diagnostic injection, and wherein a pause separates the loading injection from the diagnostic injection. Also described is a method for patient imaging using a split bolus injection technique and a system having an imaging device and the injector system described above.
    Type: Application
    Filed: June 14, 2018
    Publication date: June 25, 2020
    Applicant: Bayer HealthCare LLC
    Inventors: John VOLKAR, Corey KEMPER
  • Patent number: 10688294
    Abstract: A fluid delivery system includes a first container configured for storing a first fluid therein and a second container configured for storing a second fluid therein, wherein the second fluid is different from the first fluid. The fluid delivery system further includes at least one pump configured for delivering under pressure one or both of the first and second fluids. At least one valve is provided for selectively delivering one or both of the first and second fluids to the pump. The first and second containers, the pump, and the valve are contained within a cartridge that is removably insertable into a cartridge carrier of the fluid delivery system.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: June 23, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin P. Cowan, Mark Trocki, Arthur E. Uber, III
  • Patent number: 10668221
    Abstract: A plunger cover for use with a syringe includes a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe. The central portion can, for example, be more rigid than the sealing portion. The sealing portion and the central portion are connected in an overmolding process. The sealing portion can, for example, be formed from a thermoplastic elastomer or a thermoplastic polyurethane. The central portion can, for example, be formed from polypropylene, acrylonitrile butadiene styrene, polycarbonate or copolymers thereof.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: June 2, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Joseph E. Bisegna, Jared E. Neff
  • Patent number: 10662425
    Abstract: The present application provides materials and methods for treating a patient with autosomal dominant RP, both ex vivo and in vivo; materials and methods for editing a RHO gene in a human cell; and materials and methods for editing a P23H mutation in a RHO gene in a human cell. In addition, the present application provides one or more gRNAs or sgRNAs for editing a RHO gene; one or more gRNAs or sgRNAs for editing a P23H mutation in a RHO gene; and a therapeutic comprising at least one or more gRNAs or sgRNAs for editing a P23H mutation in a RHO gene. The present application provides a therapeutic for treating a patient with autosomal dominant RP. The present application provides a kit for treating a patient with autosomal dominant RP. In addition, the present application provides a self-inactivating CRISPR-Cas system.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: May 26, 2020
    Assignees: CRISPR THERAPEUTICS AG, Bayer Healthcare LLC
    Inventors: Albena Kantardzhieva, Akiko Noma, Abraham Scaria, Ryo Takeuchi
  • Patent number: 10653684
    Abstract: This invention relates to methods of using aryl ureas to treat diseases mediated by the VEGF induced signal transduction pathway characterized by abnormal angiogenesis or hyperpermeability processes.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: May 19, 2020
    Assignee: Bayer Healthcare LLC
    Inventors: Jacques Dumas, William J. Scott, James Elting, Holia Hatoum-Makdad
  • Patent number: 10589018
    Abstract: A multi-dose disposable fluid delivery system includes at least one fluid container, a multi-use fluid path set, and a plurality of single-use fluid path sets. The at least one fluid container has a connection port configured for fluidly connecting with a first end of the multi-use fluid path set. The second end of the multi-fluid path set is configured for fluidly connecting to a fluid injection apparatus. The plurality of single-use fluid path sets is connected in sequence to define a fluid path extending from a first single-use fluid path set to a last single- use fluid path set. Each of the plurality single-use fluid path sets has a first end and a second end. The first end of the first single-use fluid path set is configured for connecting to a delivery line. The second end of the last single-use fluid path set is configured for connecting to the injection apparatus.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: March 17, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Arthur E. Uber, III, Ralph H. Schriver, Barry L. Tucker, James A. Dedig
  • Patent number: 10583256
    Abstract: A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with an end wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. A sidewall extends between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: March 10, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Dave Berry, Barry L. Tucker, Edward J. Rhinehart, Gerald W. Callan, Arthur E. Uber, III, Kevin P. Cowan, Raymond C. Hoffman, Benjamin T. Krupp, Martin J. Gibler, Michael A. Spohn
  • Patent number: 10549084
    Abstract: A medical connector for providing a sterile connection between a multi-use portion and a single-use portion of a fluid delivery system is provided. The medical connector includes a fluid inlet port configured for removable engagement with a connection port of a multi-use disposable set (MUDS) to establish a fluid connection therewith and a waste outlet port configured for removable engagement with a waste inlet port of the MUDS to establish a fluid connection therewith. A patient fluid line is connected, at a first end, to the fluid inlet port and connected, at a second end, to the waste outlet port. Fluid flow through the patient fluid line is unidirectional from the first end to the second end. The patient fluid line is configured for being disconnected from the waste outlet port for delivering fluid to a patient. A multi-fluid delivery system having the medical connector and MUDS is also provided.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: February 4, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Richard Sokolov, Benjamin James Cullen, Alison Ruth Norcott, Ernesto Hueso Monis, Kamman Law, Mark Silvio Profaca, John A. Haury, Michael Swantner
  • Patent number: 10549043
    Abstract: A syringe assembly may include a syringe having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end, and a syringe drip guard extending around at least a circumferential portion of the sidewall between the distal end and the proximal end of the syringe. The syringe drip guard may have an outer wall protruding radially outward relative to the sidewall. A channel may be defined between the outer wall of the syringe drip guard and the sidewall of the syringe. The channel may have a closed proximal end and an open distal end. The syringe drip guard may be configured to at least one of: collect, absorb, or adsorb fluid within the channel.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: February 4, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Stephen Sams, Gerald W. Callan
  • Patent number: 10543312
    Abstract: A fluid delivery system includes a pressurizing mechanism. The pressurizing mechanism includes: a substantially cylindrical body having a movable member positioned therein that divides the body into a first chamber and a second chamber; a plunger rod connected to a first side of the movable member and extending through a substantially closed first end of the body; and an elongated member connected to a second side of the movable member and extending through a substantially closed second end of the body. The plunger rod configured to operatively engage a fluid container. Fluid is dispensed from the fluid container by forming a vacuum within at least the first chamber by moving the movable member toward the second end of the body, allowing atmospheric pressure to enter the second chamber, and actuating the pressurizing mechanism to cause the moving member to move towards the first end of the body.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: January 28, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventor: Kevin P. Cowan
  • Patent number: 10546375
    Abstract: Techniques are disclosed for estimating patient radiation exposure during computerized tomography (CT) scans. More specifically, embodiments of the invention provide efficient approaches for generating a suitable patient model used to make such an estimate, to approaches for estimating patient dose by interpolating the results of multiple simulations, and to approaches for a service provider to host a dose estimation service made available to multiple CT scan providers.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: January 28, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Gregory Couch, James Couch
  • Patent number: 10546376
    Abstract: Techniques are disclosed for estimating patient radiation exposure during computerized tomography (CT) scans. More specifically, embodiments of the invention provide efficient approaches for generating a suitable patient model used to make such an estimate, to approaches for estimating patient dose by interpolating the results of multiple simulations, and to approaches for a service provider to host a dose estimation service made available to multiple CT scan providers.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: January 28, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Gregory Couch, James Couch
  • Patent number: 10537675
    Abstract: A fluid delivery device includes: a fluid-filled cartridge comprising an outlet; a syringe comprising a substantially cylindrical syringe barrel having an open end and a fluid dispensing end; and a plunger rod configured to be received within the open end of the syringe barrel. The plunger rod comprises: a first end having a sealing member provided in sealing engagement with an inner wall of the syringe barrel such that a first syringe chamber is provided between the first end of the plunger rod and the fluid dispensing end of the syringe barrel; a second end extending out of the open end of the syringe barrel and having a cartridge-receiving chamber having a connection mechanism positioned therein for connecting the outlet of the cartridge thereto. The plunger rod also includes a fluid channel extending from the connection mechanism to the first end of the plunger rod.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: January 21, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventor: Kevin P. Cowan
  • Patent number: 10522250
    Abstract: A system capable of monitoring a replaceable component is provided. The system includes a controller for controlling operation of the system; programming instructions according to which the system is configured to: accept input of a viable life for the component, calculate an accumulated amount of distress experienced by the component based on each set of previously collected use data associated with each previous use of the component, and determine, based in part on the accumulated amount of distress, a used portion of the viable life that the component has experienced as a result of the previous use(s) thereof and an unused portion of the viable life; and a feedback device configured to provide to an operator of the system an indication of at least one of the unused and used portions of the viable life of the component. Methods of monitoring a replaceable component of a system are also provided.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: December 31, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael Spohn, Michael Swantner, Edward Rhinehart
  • Patent number: 10512720
    Abstract: A syringe includes a barrel having a distal end, a proximal end, and a sidewall extending therebetween along a longitudinal axis. At least one engagement member protrudes from a terminal portion of the sidewall in a proximal direction along the longitudinal axis. The at least one engagement member tapers axially in a direction from the distal end toward the proximal end. The at least one engagement member is configured for engagement with a locking mechanism of a fluid injector to releasably lock the syringe with the fluid injector. A taper of the at least one engagement member is configured to rotationally guide the syringe into alignment with the locking mechanism and axially eject the syringe upon rotation of the syringe. The locking mechanism operatively engages the at least one engagement member regardless of an orientation of the syringe about the longitudinal axis relative to the injector.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: December 24, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin P. Cowan, Barry L. Tucker, Arthur E. Uber, III, Edward J. Rhinehart, James R. Neill, Glen P. Williams, Michael A. Spohn
  • Patent number: 10512721
    Abstract: A plunger for use with a syringe has a plunger body with a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a plunger longitudinal axis. The plunger further has at least one resiliently deflectable retaining member having a first segment attached to the plunger body and a second segment protruding toward the distal end of the plunger body and deflectable relative to the first segment. The plunger further has at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member interacts with a piston to deflect the at least one resiliently deflectable retaining member upon rotation of the plunger relative to the piston. The plunger is engagable with the piston regardless of a rotational orientation of the piston relative to the plunger.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: December 24, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael J. Swantner, Richard A. Seman, Barry L. Tucker, Arthur E. Uber, III, Kevin P. Cowan, James A. Dedig, Christopher D. Capone, Jaroslaw Wlodarczyk
  • Publication number: 20190381008
    Abstract: Methods for treatment of wAMD with an active CNV lesion of less than 50% of the total lesion size and pharmaceutical compositions for the use therein are disclosed.
    Type: Application
    Filed: June 26, 2019
    Publication date: December 19, 2019
    Applicant: Bayer HealthCare LLC
    Inventors: Oliver ZEITZ, Olaf SOWADE, Haiyan WU
  • Patent number: 10507319
    Abstract: A multi-use disposable set (MUDS) has at least one syringe having a proximal end and a distal end spaced apart from the proximal end along a longitudinal axis. The MUDS further has a plunger reciprocally movable within a syringe interior between the proximal end and the distal end. A manifold is in fluid communication with the distal end of the at least one syringe. At least one valve is in fluid communication with the syringe interior. The at least one valve is operable between a filling position for filling the syringe interior with fluid and a delivery position for delivering the fluid from the syringe interior. At least one connection port is in fluid communication with the manifold and the syringe interior when the at least one valve is in the delivery position. A multi-fluid delivery system having the medical convector and MUDS is also provided. Various features of the MUDS system are also described.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: December 17, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John A. Haury, Michael Swantner, Richard Sokolov, Benjamin James Cullen, Alison Ruth Norcott, Ernesto Hueso Monis, Kamman Law, Mark Silvio Profaca, Patrick Spence, Michael A. Spohn, Justin Angert
  • Patent number: 10507003
    Abstract: Described is an in-scan phantom for use during an imaging procedure. The phantom can include at least one measuring insert and/or at least one measured insert. The measuring insert may have radiation detecting capabilities while the measured insert may include a radioactive material. Also described is an imaging modality system that includes an imaging modality and an in-scan phantom as well as methods of using the in-scan phantom for imaging a patient or performing a scout scan.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: December 17, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Arthur E. Uber, III, Kevin P. Cowan, David M. Griffiths, Ivana Kingston, Dzmitry Liushtyk, Matthew Hoiko, Roey Flor, Robert Redmond, Henry Hernaez, Sridhar Balasubramanian
  • Patent number: D888226
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: June 23, 2020
    Assignee: Bayer Healthcare LLC
    Inventors: Linda van Roosmalen, Gerald Callan, Daniel Moore, Kent Diasabeygunawardena, Daniel Van Alphen, Engin Hassamanci