Patents Assigned to Bayer HealthCare, LLC
  • Patent number: 12293817
    Abstract: A method is provided for authenticating, and establishing and tracking eligibility of a patient to purchase an over-the-counter (OTC) drug from a retailer, the patient using a client device or terminal and the retailer having a server. The server is configured to redirect the client device or terminal to a backend platform to authenticate the patient, access a storage to search for any information that indicates the patient is ineligible to purchase the OTC drug; and without any information that indicates the patient is ineligible, administer a questionnaire to the patient to assess the eligibility for the OTC drug. And the backend platform redirects the client device or terminal back to the server to complete the online sale of the OTC drug to the patient when the patient is eligible, or cancel the online sale of the OTC drug to the patient when the patient is ineligible.
    Type: Grant
    Filed: February 5, 2024
    Date of Patent: May 6, 2025
    Assignee: Bayer HealthCare LLC
    Inventors: Rama Penta, Jeffrey Brittain, William Hanisak, Audrey Belkin, Steven Rusche
  • Patent number: 12285587
    Abstract: A multi-fluid injector system and methods of operation thereof are presented. One embodiment of such a fluid injector system includes an automatic refill procedure for a fluid injector system comprising a fluid injector and an operably engaged syringe. The procedure includes the step of determining, using an electronic control device operably controlling the fluid injector system, whether a fluid injection procedure involving the syringe is impending. If the electronic control device determines that the fluid injection procedure is not impending, such that the automatic refill will not interfere with the fluid injection procedure, an automatic refill of the syringe is initiated.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: April 29, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael A. Riley, Ralph Schriver
  • Patent number: 12285242
    Abstract: A system and method for promoting and safeguarding the wellbeing of patients in relation to a fluid injection may obtain patient data; determine, based on the patient data, an initial risk prediction for a patient for a fluid injection to be administered to the patient, the initial risk prediction including a probability that the patient experiences at least one adverse event in response to the fluid injection; provide, to a user device, before the fluid injection is administered to the patient, the initial risk prediction; determine, after the fluid injection is started, sensor data associated with the patient; determine, based on the sensor data determined after the fluid injection is started, a current risk prediction including a probability that the patient experiences the at least one adverse event in response to the fluid injection; and provide, to the user device, the current risk prediction.
    Type: Grant
    Filed: December 20, 2023
    Date of Patent: April 29, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Johannes Anton Thüring, Arthur Uber, III, David Griffiths, Michael McDermott, Charles Lang, Linda Van Roosmalen, Barry Skirble, Adam Czibur, Daniel Moore, Vincenzo Caruso, Brandon Clarke
  • Patent number: 12274683
    Abstract: The present disclosure relates generally to topical analgesic compositions comprising nonsteroidal anti-inflammatory drugs, and more specifically to topical gel compositions of naproxen in combination with select neutralizing agents, thereby having enhanced skin permeation and skin retention properties as well as improved aesthetics upon application and drying.
    Type: Grant
    Filed: January 8, 2020
    Date of Patent: April 15, 2025
    Assignee: Bayer HealthCare LLC
    Inventor: Olufoyekemi Badejo
  • Patent number: 12263227
    Abstract: The present disclosure relates generally to novel lipid nanoparticle (LNP)-based compositions useful for, e.g., the delivery of a site-specific endonuclease or a nucleic acid molecule encoding same, into a target cell. Some embodiments of the disclosure relate to compositions and methods for editing the genome of a cell, which involve contacting the cell with an LNP composition as described herein.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: April 1, 2025
    Assignees: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventors: Christopher J. Cheng, Andrew Scharenberg, Kui Wang, Shailendra Sane
  • Patent number: 12263326
    Abstract: A fluid delivery system and method for determining whether the correct fluid is being drawn into and/or dispensed from a syringe. The system includes a syringe, a fluid injector for drawing fluid into and dispensing fluid from the syringe, one or more sensors adapted to measure a force required to draw the fluid into and/or dispense the fluid from the syringe, a processor in communication with the one or more sensors, and a non-transitory, computer-readable storage medium in operable communication with the processor. The computer-readable storage medium contains one or more programming instructions that, when executed, cause the processor to receive from the one or more sensors one or more measurements of the force required to draw the fluid into and/or dispense the fluid from the syringe and determine from the one or more measurements whether a correct fluid is being drawn into and/or dispensed from the syringe.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: April 1, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Arthur Uber, III, Michael Spohn, David Griffiths, Ralph Schriver
  • Patent number: 12263136
    Abstract: A syringe for delivery of a medical liquid to a container has a body with proximal end, a frustoconical distal end, and a cylindrical sidewall extending between the proximal end and the distal end along a longitudinal axis. The syringe includes a nozzle at a distal portion of the frustoconical distal end of the syringe, the nozzle having a throughbore providing fluid communication between an interior volume of the syringe and a medical connector configured to be connected to the nozzle. The nozzle includes a plurality of longitudinal ribs formed on an inner surface of the nozzle. The syringe is designed so that the plurality of longitudinal ribs directs a flow of a medical fluid along an inner surface of the frustoconical distal end and along an interior surface of the cylindrical sidewall of the syringe under a Coand? effect. Syringe and connector assemblies and methods for reducing a number of bubbles formed in a medical fluid during a syringe filling procedure are also described.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: April 1, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, James A. Dedig, Michael Spohn, Michael McDermott
  • Patent number: 12251544
    Abstract: An injector system for delivering a medical fluid may include at least one syringe defining a reservoir operatively connected to a piston; and at least one processor programmed or configured to, based on an air check protocol for detecting air in the reservoir, determine a baseline value comprising baseline compressibility data for the at least one syringe of the injector system, deliver the first amount of the medical fluid from the reservoir; refill the reservoir with a second amount of the medical fluid; based on the air check protocol, perform an air check pressurization sequence by gathering air check compressibility data for the at least one syringe of the injector system; and based on the air check protocol, compare the air check compressibility data with the baseline compressibility data to determine a volume of air present in the reservoir.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: March 18, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael McDermott, William Barone, Barry Iddon, John Volkar
  • Patent number: 12247201
    Abstract: The present application provides materials and methods for treating a patient with autosomal dominant RP, both ex vivo and in vivo; materials and methods for editing a RHO gene in a human cell; and materials and methods for editing a P23H mutation in a RHO gene in a human cell. In addition, the present application provides one or more gRNAs or sgRNAs for editing a RHO gene; one or more gRNAs or sgRNAs for editing a P23H mutation in a RHO gene; and a therapeutic comprising at least one or more gRNAs or sgRNAs for editing a P23H mutation in a RHO gene. The present application provides a therapeutic for treating a patient with autosomal dominant RP. The present application provides a kit for treating a patient with autosomal dominant RP. In addition, the present application provides a self-inactivating CRISPR-Cas system.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: March 11, 2025
    Assignees: CRISPR THERAPEUTICS AG, Bayer Healthcare LLC
    Inventors: Albena Kantardzhieva, Akiko Noma, Abraham Scaria, Ryo Takeuchi
  • Patent number: 12239818
    Abstract: A fluid injector system includes at least one injector for pressurizing and delivering at least one fluid from at least one fluid reservoir, at least one fluid path section providing fluid communication between a bulk fluid reservoir and a syringe connected to the at least one injector, and at least one sensor arranged along the at least one fluid path section. The at least one sensor includes an emitter configured to emit light through the at least one fluid path section, and a detector configured to receive the light emitted through the at least one fluid path section and generate an electrical signal based on at least one property of the received light.
    Type: Grant
    Filed: February 25, 2022
    Date of Patent: March 4, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Richard Morton, Christopher Scutt, Michael Spohn, Randy Lee, Mikayla Ferchaw, Kevin Cowan, Patrick Campbell, Andrew Naples, William Barone, Christopher Capone, Curtis Pastor, Charles Lang, Michael Swantner
  • Patent number: 12233230
    Abstract: A medical connector for providing a sterile connection between a multi-use portion and a single-use portion of a fluid delivery system is provided. The medical connector includes a fluid inlet port configured for removable engagement with a connection port of a multi-use disposable set (MUDS) to establish a fluid connection therewith and a waste outlet port configured for removable engagement with a waste inlet port of the MUDS to establish a fluid connection therewith. A patient fluid line is connected, at a first end, to the fluid inlet port and connected, at a second end, to the waste outlet port. Fluid flow through the patient fluid line is unidirectional from the first end to the second end. The patient fluid line is configured for being disconnected from the waste outlet port for delivering fluid to a patient. A multi-fluid delivery system having the medical connector and MUDS is also provided.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: February 25, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Richard Sokolov, Alison Ruth Von Moger, Benjamin James Cullen, Ernesto Hueso Monis, Kamman Law, Mark Silvio Profaca, John A. Haury, Michael Swantner
  • Patent number: 12233027
    Abstract: Systems and methods for distribution, storage, transport, administration and/or disposal of one or more therapeutic or diagnostic agents are disclosed. A storage device configured to connect to a delivery system for delivering the therapeutic or diagnostic agent has a housing with a chamber, a vessel having an access port positioned within the chamber. The door is movable relative to the housing between a closed position and an open position. In the closed position, the door covers an opening in the housing to enclose the chamber, and, in the open position, the door reveals the opening for accessing the access port of the vessel. The door is moveable between the closed position and the open position in response to actuation by an access mechanism of the delivery system.
    Type: Grant
    Filed: February 8, 2024
    Date of Patent: February 25, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John Volkar, Joana Oliveira Rego Brilhante, Anne Berit Eid, Ellia Hu, Hamsini Sundararaman, Ashley Cockerham, Winston Ge, Andrew Jones, Richard Miller, Joe Ting, Brian Yoo, Ryan Bayne
  • Patent number: 12215320
    Abstract: Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., Hemophilia A, employing ex vivo and/or in vivo genome editing.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: February 4, 2025
    Assignees: CRISPR Therapeutics AG, BAYER HEALTHCARE LLC
    Inventors: Alan Richard Brooks, Karen Vo
  • Patent number: 12214155
    Abstract: A system and method for correcting a volume of fluid delivered by a fluid injector during an injection procedure is described. The method included determining and compensating for a volume factor associated with compliance of the fluid injector system and correcting for the volume by one of over-driving the distance that the drive member travels in a fluid reservoir, under-driving the distance that the drive member travels in the fluid reservoir, or lengthening or shortening a fluid delivery time.
    Type: Grant
    Filed: October 24, 2022
    Date of Patent: February 4, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael Mcdermott, Michael Spohn, William Barone, Chelsea Marsh
  • Patent number: 12215316
    Abstract: The present application provides materials and methods for treating a patient with Usher Syndrome Type 2A, both ex vivo and in vivo; materials and methods for editing a USH2A gene in a human cell; materials and methods for editing an USH2A gene containing an IVS40 mutation; materials and methods for treating a patient with an USH2A gene containing an IVS40 mutation; and a method for deleting a sequence comprising an IVS40 mutation within a USH2A gene of a cell. The present application also provides one or more gRNAs or sgRNAs for editing an USH2A gene containing an IVS40 mutation. The present application provides a therapeutic for treating a patient with Usher Syndrome Type 2A. The present application also provides a kit for treating a patient with Usher Syndrome Type 2A.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: February 4, 2025
    Assignees: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventors: Albena Kantardzhieva, Akiko Noma, Abraham Scaria
  • Patent number: 12208239
    Abstract: A fluid injector system and method for preventing pressurized backflow of a second fluid into a first reservoir containing a fluid is described. The fluid injector system includes a control device programmed or configured to actuate a second drive component to pressurize and inject the second fluid through the fluid conduit, and while the second drive component is actuated, actuate a first drive component to introduce intermittent pulses of the first fluid to create a flow front interface between the first fluid and the second fluid in the fluid conduit to prevent backflow of the second fluid through the fluid conduit into the first fluid reservoir.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: January 28, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael McDermott, William Barone, John Volkar
  • Patent number: 12205715
    Abstract: A method, system, and computer program product for predictive maintenance. A method may include receiving operation data associated with one or more injection systems, wherein the operation data includes one or more operation parameters associated with one or more operations of the one or more injection systems: determining one or more prediction scores for the one or more injection systems based on the operation data, wherein the one or more prediction scores include one or more predictions of one or more operation failures or misuses for the one or more injection systems; and providing maintenance data associated with the one or more operation failures or misuses, wherein the maintenance data is based on the one or more prediction scores.
    Type: Grant
    Filed: January 21, 2022
    Date of Patent: January 21, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Ralph Schriver, Arthur Uber, III, Janele Archibald, Matthew Brewer, Amy Chaya, Christopher Fiorentini, David Griffiths, Jacob Hartmann, Joseph Hulbert, Susan Michel, Janel Petrilli, Michael Pogozelec, Barry Skirble
  • Patent number: 12203110
    Abstract: Aspects of this invention, inter alia, relate to novel systems for targeting, editing or manipulating DNA in a cell, using novel synthetic RNA-guided nucleases (sRGNs). The sRGNs are derived from wildtype or parental small type II CRISPR Cas9 endonucleases.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: January 21, 2025
    Assignees: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventors: Andre Cohnen, Moritz Schmidt, Wayne Coco, Michael Biag Gamalinda, Ashish Gupta, Christian Pitzler, Florian Richter, Jan Tebbe, Christopher Cheng, Ryo Takeuchi, Caroline W. Reiss
  • Patent number: 12201802
    Abstract: A multi-fluid injector system having a powered injector having a housing enclosing at least one reciprocally operable piston is described. The injector system includes a multi-use disposable set (MUDS) connectable to the powered fluid injector. The MUDS has at least one syringe having a proximal end and a distal end and a plunger reciprocally movable by the at least one piston element within a syringe interior between the proximal end and the distal end; a manifold in fluid communication with the distal end of the at least one syringe; at least one valve in fluid communication with the syringe interior, the at least one valve operable between a filling position for filling the syringe interior with fluid and a delivery position for delivering the fluid from the syringe interior; and at least one connection port in fluid communication with the manifold and the syringe interior when the at least one valve is in the delivery position.
    Type: Grant
    Filed: November 2, 2022
    Date of Patent: January 21, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John Haury, Michael Swantner, Richard Sokolov, Benjamin James Cullen, Alison Ruth Von Moger, Ernesto Hueso Monis, Kamman Law, Mark Silivio Profaca, Patrick Spence, Michael Spohn, Justin Angert, Brian Cain
  • Patent number: 12194271
    Abstract: A syringe manifold for a fluid injector assembly includes a middle body member defining an upper cavity and a lower cavity, the middle body member defining at least one fluid path in an upper surface of the middle body member and at least one fluid path in a lower surface of the middle body member, the middle body member defining at least two ports extending through the middle body member, the middle body member comprising an outlet for connection of the syringe manifold to at least one fluid delivery device; a lower body member received within the lower cavity of the middle body member, the lower body member comprising at least one connector for connection of the lower body member to a syringe assembly; and an upper body member received within the upper cavity of the middle body member.
    Type: Grant
    Filed: June 17, 2022
    Date of Patent: January 14, 2025
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Damian Peter Francis Savio, Peter Sprada, Eric Siu, Barry Iddon, Bipin Salunkhe, Michael Spohn, Richard Sokolov, Matthew J. Leroch, Michael McDermott, Kevin Cowan