Patents Assigned to Bayer Schering Pharma Aktiengesellschaft
  • [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20100217011
    Abstract: The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.
    Type: Application
    Filed: October 30, 2007
    Publication date: August 26, 2010
    Applicants: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, INEOS RAS, IHB RAS
    Inventors: Ludger Dinkelborg, Matthias Friebe, Nikolaevna Raisa Krasikowa, Yuri Belokon, Fedorovna Olga Kuznetsova, Keith Graham, Lutz Lehmann, Mathias Berndt
  • Aminodicarboxylic acid derivatives having pharmaceutical properties
    Patent number: 7781470
    Abstract: The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: August 24, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Cristina Alonso-Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Josef Pernerstorfer, Johannes-Peter Stasch, Frank Wunder, Klaus Dembowsky, Elizabeth Perzborn, Elke Stahl
  • sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS
    Publication number: 20100210643
    Abstract: The invention provides pharmacological compositions comprising a stimulator or activator of the soluble guanylate cyclase alone (sGC) or in combination with a PDE5 inhibitor for the treatment of urological disorders comprising of Benign Prostate Syndrome (BPS), Benign Prostate Hyperplasia (BPH), Benign Prostate Enlargement (BPE), Bladder Outlet Obstruction (BOO), Lower Urinary Tract Symptoms (LUTS), genitourinary disorders comprising neurogenic bladder syndrome (OAB) and (IC), urinary incontinence (UI) like mixed-, urge-, stress-, or overflow incontinence (MUI, UUI, SUI, OUI) and pelvic pain (PP).
    Type: Application
    Filed: April 29, 2008
    Publication date: August 19, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Peter Sandner, Hanna Tinel, Johannes-Peter Stasch, Dieter Neuser
  • 5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection
    Patent number: 7776896
    Abstract: This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory diseases associated with influenza A viruses, such as for example H5N1 and its mutations. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: August 17, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: William Guilford, Werner Skuballa, Daryl H. Faulds, Monica Kochanny, Wheeseong Lee, Bernd Radüchel
  • Substituted [(phenylethanoyl)amino]benzamides
    Patent number: 7776922
    Abstract: The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of inflammatory disorders such as, for example, cutaneous, respiratory tract and cardiovascular disorders such as, for example, arteriosclerosis and coronary heart disease.
    Type: Grant
    Filed: November 17, 2005
    Date of Patent: August 17, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Ulf Brüggemeier, Petros Gatsios, Mark Meininghaus, Leila Telan, Elisabeth Woltering, Martina Wuttke, Hartmut Beck, Nils Griebenow, Frank Süβmeier, Niels Svenstrup, Axel Kretschmer, Marcus Bauser, Johannes Köbberling, Wahed Moradi, Siegfried Zaiss, Claudia Hirth-Dietrich, Barbara Albrecht
  • Substituted oxazolidinones for combinational therapy
    Patent number: 7767702
    Abstract: The invention relates to combinations of A) oxazolidinones of formula (I) and B) other active ingredients, to a method for producing said combinations and to the use thereof as medicaments, in particular for the treatment and/or prophylaxis of thrombo-embolic diseases.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: August 3, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Alexander Straub, Thomas Lampe, Josef Pernerstorfer, Elisabeth Perzborn, Jens Pohlmann, Susanne Röhrig, Karl-Heinz Schlemmer
  • HETEROCYCLIC DERIVATIVES
    Publication number: 20100184788
    Abstract: The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, and heart failure development.
    Type: Application
    Filed: December 8, 2009
    Publication date: July 22, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Heike GIELEN-HAERTWIG, Barbara Albrecht, Jörg Keldenich, Volkhart Li, Josef Pernerstorfer, Karl-Heinz Schlemmer, Leila Telan
  • SUBSTITUTED OXAZOLIDINONES AND THEIR USE
    Publication number: 20100184740
    Abstract: The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
    Type: Application
    Filed: June 7, 2008
    Publication date: July 22, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Swen Allerheiligen, Marcus Bauser, Dirk Heimbach, Stefan Heitmeier, Mark Jean Gnoth, Christoph Gerdes, Georges Von Degenfeld, Susanne Röhrig, Ulrich Rester, Elke Dittrich-Wengenroth, Uwe Saatman, Adrian Tersteegen
  • PDE INHIBITORS FOR THE TREATMENT OF HEARING IMPAIRMENT
    Publication number: 20100184769
    Abstract: The invention provides pharmacological compositions comprising PDE-5 inhibitors for the treatment of hearing impairment i.e. hearing loss and tinnitus. The invention also provides methods of screening for such PDE-5 inhibitors for use in the preparation of medicaments for the treatment of hearing impairment i.e. hearing loss and tinnitus.
    Type: Application
    Filed: May 31, 2008
    Publication date: July 22, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventor: Peter SANDNER
  • SUBSTITUTED AZAQUINAZOLINES HAVING AN ANTIVIRAL ACTION
    Publication number: 20100179174
    Abstract: This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 15, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Tobias WUNBERG, Judith Baumeister, Mario Jeske, Frank Sûssmeier, Holger Zimmermann, Kerstin Henninger, Dieter Lang
  • USE OF PHENYLOXYANILINE DERIVATIVES FOR IMAGING CARDIOVASCULAR DISEASES
    Publication number: 20100178248
    Abstract: The present invention relates to the use of a specific compound, as described in detail below, having a high affinity to the peripheral benzodiazepine receptor for imaging cardiac and cardiovascular diseases for which inflammation and/or mitochondrial dysfunction and any other pathophysiological process leading to PBR activation are major contributing factor.
    Type: Application
    Filed: May 21, 2008
    Publication date: July 15, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Andrea Thiele, Claudia Bacher-Stier
  • Determination of free fractions
    Patent number: 7754496
    Abstract: The invention relates to methods for the determination of pharmacological properties of substances, such as, e.g., chemical substances. The invention also relates to methods and kits for use in the determination of the free fraction, fu, of pharmacologically active compounds in aqueous solutions and serum. The invention also relates to the above methods in which solid particles, coated with a lipophilic medium, are used.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: July 13, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Joachim Schuhmacher, Christian Kohlsdorfer
  • Preparation for the prophylaxis of restenosis
    Patent number: 7750041
    Abstract: The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water ?0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: July 6, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Ulrich Speck, Brunn Scheller
  • Heterocycles
    Patent number: 7750017
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly hyperproliferative diseases such as cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly hyperproliferative diseases such as cancer.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: July 6, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Chengzhi Zhang, Roger Smith, Jason Duquette, Qian Zhao, Jacques Dumas, Georgiy Bondar, Yingfu Li, Dongping Fan
  • SUBSTITUTED DIBENZOIC ACID DERIVATIVES AND USE THEREOF
    Publication number: 20100168240
    Abstract: The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.
    Type: Application
    Filed: March 15, 2008
    Publication date: July 1, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Michael Hahn, Eva-Maria Becker, Andreas Knorr, Dirk Schneider, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Frank Wunder, Dieter Lang
  • Pyrazolo[1,5-c]pyrimidines
    Patent number: 7745446
    Abstract: Compounds of a certain formula I in which R1, R2, R3 and R4 have the meanings indicated in the description are novel compounds expected to be useful in the therapy of (hyper)proliferative diseases and/or disorders responsive to induction of apoptosis.
    Type: Grant
    Filed: September 5, 2005
    Date of Patent: June 29, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Thomas Maier, Armin Zuelch, Thomas Ciossek, Thomas Baer, Thomas Beckers
  • Quinazoline derivatives, their preparation, their use, and medicaments comprising them
    Patent number: 7741333
    Abstract: The present invention relates to a quinazoline derivative having the general formula (A): in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: June 22, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Olaf Prien, Knut Eis, Wolfgang Schwede, Judith Guenther, Dieter Zopf, Dominic E. A. Brittain
  • Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors
    Patent number: 7737153
    Abstract: The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-Kinase.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: June 15, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Achim Feurer, Samir Bennabi, Heike Heckroth, Hartmut Schirok, Joachim Mittendorf, Raimund Kast, Johannes-Peter Stasch, Jean Mark Gnoth, Klaus Münter, Dieter Lang, Santiago Figueroa Perez, Heimo Ehmke
  • 2-heteroarylcarboxylic acid amides
    Patent number: 7732477
    Abstract: The invention relates to novel 2-heteroarylcarboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: June 8, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Martin Hendrix, Frank-Gerhard Böβ, Christina Erb, Timo Fleβner, Marja van Kampen, Joachim Luithle, Christoph Methfessel, Welf-Burkhard Wiese
  • 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17?-hydroxy steroid dehydrogenase type 1
    Patent number: 7732493
    Abstract: The invention relates to new 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula I in which R2 means a C1-C8-alkyl group, a C1-C8-alkyloxy group or a halogen atom, R13 means a hydrogen atom or a methyl group, R17 means a hydrogen atom or a fluorine atom, as well as their pharmaceutically acceptable salts, their manufacture and use as medicaments for prophylaxis and therapy of estrogen-dependent diseases that can be influenced by inhibition of 17?-hydroxy steroid dehydro-genase type 1.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: June 8, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Alexander Hillisch, Olaf Peters, Christian Gege, Wilko Regenhardt, Gabriele Moeller, Dominga Deluca, Jerzy Adamski, Walter Elger, Birgitt Schneider