Abstract: The invention relates to substituted 2-Phenyl-3(2H)-Pyridazinones, to a method for the production thereof, and to their use as medicaments for the prophylaxis and/or treatment of diseases in humans and/or animals.
Type:
Grant
Filed:
April 8, 2003
Date of Patent:
January 22, 2008
Assignee:
Bayer Healthcare AG
Inventors:
Rudolf Schohe-Loop, Elmar Burchardt, Christiane Faeste, Claudia Hirth-Dietrich, Jörg Keldenich, Andreas Knorr, Thomas Lampe, Paul Naab, Delf Schmidt, Gunter Schmidt
Abstract: Disclosed herein is a process for the preparation of a compound of the formula (II): or a salt thereof, wherein X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl, and n is 0 to 3; which process comprises treating a compound of the formula (III): with a cyanide source and a catalyst selected from the group consisting of a tetraalkyl ammonium salt and a tetraalkyl phosphonium salt in an aqueous solvent or without solvent, wherein: X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl: and n is 0 to 3; and wherein the cyanide source is hydrogen cyanide, an alkali metal cyanide, an alkaline earth metal cyanide or an optionally substituted ammonium cyanide.
Type:
Grant
Filed:
July 8, 2005
Date of Patent:
January 22, 2008
Assignee:
Bayer Cropscience S.A.
Inventors:
Norman Dann, Peter Dominic Riordan, Mehul Rasikchandra Amin, Michael Mellor
Abstract: The present patent application encompasses a method of determining characteristic numbers for catalyst material by means of electrochemical measurement, the use of this method for optimization and selection of catalysts and processes.
Abstract: This invention relates to processes for the production of 3-oxo-pregnane-21,17-carbolactones of formula II as well as 3-oxo-pregn-4-ene-21,17-carbolactones of formula III by the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes of formula I In addition, the invention relates to the dichloromethane hemisolvate of 6B,7B;15?,16?-diethylene-3-oxo-17?-pregnan-5?-ol-21,17-carbolactone (IV) as such.
Abstract: A flame resistant thermoplastic molding composition having improved mechanical properties is disclosed. The composition contains polycarbonate, a graft polymer and a phosphorus compounds of formula (I): and a mixture of fluorinated polyolefins with polyalkyl (meth)acrylates.
Type:
Grant
Filed:
July 31, 2003
Date of Patent:
January 15, 2008
Assignee:
Bayer MaterialScience AG
Inventors:
Thomas Eckel, Andreas Seidel, Juan Gonzalez-Blanco, Dieter Wittmann
Abstract: The present invention relates to 5-anilino-4-heteroarylpyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
Type:
Application
Filed:
May 20, 2005
Publication date:
January 10, 2008
Applicant:
Bayer Pharmaceuticals Corporation
Inventors:
Louis Cantin, Xin Ma, Christiana Akuche, Sidney Liang
Abstract: The invention relates to novel heteroaryl carboxamides, a process for their preparation, and pharmaceutical compositions containing them. These materials are useful for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
Type:
Application
Filed:
August 10, 2007
Publication date:
January 10, 2008
Applicant:
Bayer Healthcare AG
Inventors:
Martin Hendrix, Frank-Gerhard Boss, Christina Erb, Joachim Kruger, Joachim Luithle, Christoph Methfessel, Rudy Schreiber, Welf-Burkhard Wiese
Abstract: The present invention relates to an improved process for preparing aliphatic oligocarbonate polyols by transesterifying dimethyl carbonate (DMC) with an aliphatic polyol component.
Type:
Grant
Filed:
September 15, 2004
Date of Patent:
January 8, 2008
Assignee:
Bayer MaterialScience AG
Inventors:
Steffen Hofacker, Herbert Witossek, Lothar Bäcker
Abstract: A method of dimerizing isocyanates using sulphonamide anions as a dimerization catalyst for the isocyanates and also to a process for preparing oligomeric isocyanates using such catalysts.
Abstract: An auto-calibration label for use with one or more sensing instruments. The label includes first and second encoded calibration information. The second encoded calibration information may correspond to a different instrument than the first encoded calibration information. The second encoded information may also be used to provide additional calibration information for use with the first instrument. The label may be removably attached to a sensor package including a plurality of sensors. A first conductive ink pattern is disposed on the label to define the first encoded calibration information. The first conductive ink pattern is disposed contemporaneously with or without a portion of a second conductive ink pattern defining the second encoded calibration information. An insulating layer is disposed on the first pattern. The second ink pattern is disposed on the insulating layer. The first pattern is operable with the first instrument, not the second instrument.
Abstract: This invention relates to methods of treatment of cardiovascular disorders, thromboembolic disorders, inflammation, and disorders of the central nervous system using pyrazol pyridine derivatives of formula (I) wherein R1 is a radical of the formula —O—SO2—R3 in which R3 is optionally substituted C1-6-alkyl, optionally substituted C3-8-cycloalkyl, or optionally substituted phenyl; R2 is H, optionally substituted C1-6-alkyl-CO— or optionally substituted C1-6-alkyl-SO2—; as well as salts, stereoisomers, tautomers, and hydrates thereof.
Type:
Grant
Filed:
July 5, 2005
Date of Patent:
January 8, 2008
Assignee:
Bayer Aktiengesellschaft
Inventors:
Johannes-Peter Stasch, Achim Feurer, Stefan Weigand, Elke Stahl, Dietmar Flubacher, Cristina Alonso-Alija, Frank Wunder, Dieter Lang, Klaus Dembowsky, Alexander Straub, Elisabeth Perzborn
Abstract: The invention relates to a method for producing 4-haloalkylnicotinamides having the formula (I): wherein R1 is (C1-C4)haloalky, comprising subjecting one or more 3-((C1-C4)haloalkyl-3-oxo-1-alkenylamino)nitriles of the formula (II), (III) or (IV): R1—C(O)—CH?CH—NH—CH?CH—CN??(II) R1—C(O)—CH?CH—NH—CH(ZR2)—CH2—CN??(III) R1—C(O)—CH?CH—NH—CH(Hal)—CH2—CN??(IV) where R1 is as defined above, R2 is the same or different and is (C1-C6)-alkyl and Z is the same or different and is O, S or NR1, to a ring-closing reaction and simultaneous hydrolysis in the presence of a strong acid.
Abstract: The present invention relates to a process for preparing an adhesive bond by i) applying an aqueous dispersion or solution containing a) at least one isocyanate-reactive polymer and b) at least one solid surface-deactivated polyisocyanate to a ii) substrate, iii) drying the aqueous dispersion or solution at a temperature from 20 to 95° C. to form an adhesive layer and iv) treating the adhesive layer with heat at a temperature greater than the temperature used to dry the aqueous dispersion or solution. The present invention also relates to a process for preparing a bond by combining at least one substrate with the adhesive bond of the present invention. Adhesive bonds of the present invention have a shear strength at least 10% greater than the shear strength of adhesive bonds containing a substrate having at least one adhesive layer based on an aqueous dispersion or solution composed of a) and b) dried at a temperature from 20 to 95° C.
Abstract: The present invention relates generally to a method for parallel optical decoding of a digital phase image to an intensity image by algorithmic encoding of a data page into phase image and parallel optical decoding by capturing the interference of the phase data page and its copy shifted by one or a few pixels with respect to each other.
Type:
Application
Filed:
June 21, 2007
Publication date:
January 3, 2008
Applicant:
Bayer Innovation GmbH
Inventors:
PAL KOPPA, JUDIT REMENYI, FERENC UJHELYI, GABOR ERDEI
Abstract: The invention relates to herbicidal compositions comprising an effective amount of an active ingredient combination composed of (a) at least one substituted thien-3-ylsulfonylamino(thio)carbonyltriazolin(thi)one of the formula (I) in which R1, R2 and R3 are as defined in the description, or salts of the compounds of the formula (I) and (b) one or more compounds from a second group of herbicides which comprises selected 4-HPPD inhibitors, and, if desired, additionally (c) a crop plant tolerance promoter compound. The invention further relates to the use of the compositions for controlling unwanted plant growth and to a process for producing the compositions.
Type:
Application
Filed:
February 19, 2005
Publication date:
January 3, 2008
Applicant:
Bayer Cropscience AG
Inventors:
Markus Dollinger, Hans-Joachim Santel, Rudolf Gesing, Erwin Hacker
Abstract: The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
Type:
Application
Filed:
March 11, 2005
Publication date:
January 3, 2008
Applicant:
Bayer HealthCare AG
Inventors:
Holger Zimmermann, David Bruckner, Dirk Heimbach, Martin Hendrix, Kerstin Henninger, Guy Hewlett, Ulrich Rosentreter, Jorg Keldenich, Dieter Lang, Martin Radtke
Abstract: Processes for the preparation of chlorine by catalytic gas phase oxidation of hydrogen chloride with oxygen, wherein the catalyst comprises at least one support substance and at least one catalytic metal sulfide, catalysts which comprise at least one support substance and at least one catalytic metal sulfide, and processes for making the same.
Type:
Application
Filed:
May 23, 2007
Publication date:
January 3, 2008
Applicant:
Bayer Material Science AG
Inventors:
Aurel Wolf, Oliver Schluter, Leslaw Mleczko, Stephan Schubert, Jorgen Kintrup
Abstract: A process for the preparation of the compounds of the formula (I), or salts thereof, wherein R represents a hydrogen atom or difluoromethanesulfonyl, characterized in that compounds of the formula (II), or salts thereof, wherein R has the same definition as aforementioned, and n represents 0 or 1, are reacted in the presence of hydrogen peroxide and acetic acid.
Type:
Application
Filed:
October 28, 2005
Publication date:
January 3, 2008
Applicant:
Bayer CorpScience AG
Inventors:
Koichi Araki, Yoshitaka Sato, Mark Ford
Abstract: Process for the continuous production of catalysts which are useful for the production of carbon nanotubes by decomposition of gaseous carbon compounds.
Type:
Application
Filed:
February 12, 2007
Publication date:
January 3, 2008
Applicant:
Bayer MaterialScience AG
Inventors:
Sigurd Buchholz, Volker Michele, Leslaw, Christian Munnich, Reiner Rudolf, Aurel Wolf
Abstract: The present invention relates to a process for the production of carbon nanotubes by decomposition of hydrocarbons on a heterogeneous catalyst in a fluidized bed reactor, wherein the reactor can be operated batchwise or continuously, and in the case of continuous operation discharge can take place with sifting or without sifting.
Type:
Application
Filed:
April 13, 2007
Publication date:
January 3, 2008
Applicant:
BAYER MATERIALSCIENCE AG
Inventors:
SIGURD BUCHHOLZ, MAZIAR KAKHI, VOLKER MICHELE, LESLAW MLECZKO, CHRISTIAN MUNNICH, REINER RUDOLF, AUREL WOLF