Abstract: Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
Type:
Grant
Filed:
October 25, 2005
Date of Patent:
March 20, 2007
Assignee:
Bayer Aktiengesellschaft
Inventors:
Jürgen Stoltefuss, Michael Lörges, Gunter Schmidt, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
Abstract: The present invention relates to a compound of the formula (I) The compound according to the invention is suitable for the preparation of herbicidal active substances such as sulfonylureas.
Type:
Grant
Filed:
March 7, 2005
Date of Patent:
March 13, 2007
Assignee:
Bayer CropScience GmbH
Inventors:
Klaus Lorenz, Hans-Joachim Ressel, Lothar Willms
Abstract: The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I), a method for the production of these compounds, pharmaceutical compositions containing them, and methods of using them for the prevention and/or treatment of various diseases.
Type:
Grant
Filed:
July 17, 2002
Date of Patent:
March 13, 2007
Assignee:
Bayer Healthcare AG
Inventors:
Alexander Straub, Thomas Lampe, Jens Pohlmann, Susanne Rohrig, Elisabeth Perzborn, Karl-Heinz Schlemmer
Abstract: An electrochromic device which carries a coating comprising at least one UV absorber and nanoparticles is effectively protected against destruction by UV light.
Type:
Grant
Filed:
February 1, 2000
Date of Patent:
March 13, 2007
Assignee:
Bayer Aktiengesellschaft
Inventors:
Horst Berneth, Werner Hoheisel, Ralf Neigl, Hermann Womelsdorf
Abstract: The invention relates to novel triazolopyrimidines of the formula in which R1, R2, R3 and X have the meanings given in the disclosure, and acid addition salts thereof, to a plurality of processes for preparing these novel substances, and to their use for controlling unwanted microorganisms. The invention further relates to novel amines and carbamates of the formulae indicated in the description and to processes for preparing these intermediates.
Type:
Grant
Filed:
April 16, 2002
Date of Patent:
March 13, 2007
Assignee:
Bayer Cropscience AG
Inventors:
Olaf Gebauer, Jörg Nico Greul, Ulrich Heinemann, Hans-Ludwig Elbe, Bernd-Wieland Krüger, Ralf Dunkel, Arnd Voerste, Ronald Ebbert, Astrid Mauler-Machnik, Ulrike Wachendorff-Neumann, Karl-Heinz Kuck, Yoshinori Kitagawa
Abstract: The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360–386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and of select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.
Type:
Grant
Filed:
June 4, 2002
Date of Patent:
March 13, 2007
Assignees:
The Wistar Institute, Bayer Corporation
Abstract: 3-Amino-2-thiomethylbenzoylpyrazoles of the formula (I) and their use as herbicides are described. In this formula (I) R1 to R9 are various radicals.
Type:
Grant
Filed:
April 1, 2005
Date of Patent:
March 13, 2007
Assignee:
Bayer CropScience GmbH
Inventors:
Monika Schmitt, Andreas van Almsick, Lothar Willms, Thomas Auler, Heinz Kehne, Martin Hills, Dieter Feucht
Abstract: Novel suspension concentrates comprising a) at least one active compound, solid at room temperature, from the group of the azoles and/or the strobilurins, b) at least one penetration enhancer from the group of the alkanolethoxylates, c) at least one dispersant from the group of the polymers of methyl 2-methyl-2-propenoate and ?-(2-methyl-1-oxo-2-propenyl)-?-methoxypoly(oxy-1,2-ethanediyl), the tristyrylphenolethoxylates and/or the propylene oxide/ethylene oxide block copolymers having molecular weights between 8000 and 10 000, d) water and also e) additives, if appropriate, a process for preparing the novel suspension concentrates and their use for applying the active compounds comprised therein to plants and/or their habitat.
Abstract: The invention provides a human AdipoR2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AdipoR2 as well as pharmaceutical compositions comprising such compounds.
Type:
Application
Filed:
September 16, 2004
Publication date:
March 8, 2007
Applicant:
Bayer Healthcare AG
Inventors:
Stefan Golz, Ulf Bruggemeier, Andreas Geerts
Abstract: The present invention relates to solid water-dispersible formulation comprising one or more herbicidally active compounds from the group of the sulfonamides of the formula (I) and their salts, one or more safeners, one or more solvents, one or more carrier materials selected from carriers having low and/or high absorbency, one or more customary auxiliaries and additives, selected from emulsifiers, antifoams, wetting agents and dispersants; where the safeners and solvents are in a particular ratio, and these two components together are also in a particular ratio to the carriers having high absorbency used. The formulations according to the invention are suitable for use in crop protection.
Type:
Application
Filed:
September 6, 2006
Publication date:
March 8, 2007
Applicant:
BAYER CROPSCIENCE GMBH
Inventors:
Hans-Peter Krause, Gerhard Schnabel, Ralph Grohs
Abstract: The invention provides a human PAR2 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, neurological disorders, urological disorders, hematological diseases and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, neurological disorders, urological disorders, hematological diseases and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PAR2 as well as pharmaceutical compositions comprising such compounds.
Type:
Application
Filed:
February 26, 2004
Publication date:
March 8, 2007
Applicant:
Bayer Healthcare AG
Inventors:
Stefan Golz, Ulf Bruggemeier, Holger Summer
Abstract: The present invention relates to storage-stable solid water-dispersible formulations comprising one or more herbicidally active compounds from the group of the sulfonamides and their salts, one or more carrier materials and one or more wetting agents from the group of the naphthalenesulfonic acids and the group of the sulfosuccinic acid derivatives and also the salts of these groups. The formulations according to the invention are suitable for use in crop protection.
Type:
Application
Filed:
September 8, 2006
Publication date:
March 8, 2007
Applicant:
BAYER CROPSCIENCE GMBH
Inventors:
Gerhard Schnabel, Hans-Peter Krause, Ralph Grohs
Abstract: The use of active compound combinations comprising prothioconazole and tebuconazole for dressing seed against attack by phytopathogenic fungi.
Abstract: The present invention relates to solid water-dispersible formulation comprising one or more herbicidally active compounds from the group of the sulfonamides and their salts, one or more safeners, one or more solvents, one or more carrier materials selected from carriers having low and/or high absorbency, one or more customary auxiliaries and additives, selected from emulsifiers, antifoams, wetting agents and dispersants; where the safeners and solvents are in a particular ratio, and these two components together are also in a particular ratio to the carriers having high absorbency used. The formulations according to the invention are suitable for use in crop protection.
Type:
Application
Filed:
September 6, 2006
Publication date:
March 8, 2007
Applicant:
BAYER CROPSCIENCE GMBH
Inventors:
Hans-Peter Krause, Gerhard Schnabel, Ralph Grohs
Abstract: Novel bacterial insecticidal proteins and equivalents thereof were isolated. These proteins and the DNA sequences encoding them are useful to make insecticidal compositions or transgenic plants to protect plants from damage by insects, particularly coleopteran insects.
Type:
Application
Filed:
August 10, 2006
Publication date:
March 8, 2007
Applicant:
Bayer BioScience N.V.
Inventors:
Annemie Boets, Greta Arnaut, Jeroen Van Rie, Nicole Damme
Abstract: This invention relates to novel triazolopyrimidines of the formula in which R1, R2, R3, R4and X have the meanings given in the disclosure, to a plurality of processes for preparing these novel substances, and to their use for controlling unwanted microorganisms. This invention further relates to novel intermediates of the formulae and processes for their preparation and additionally relates to novel amines and carbamates of the formulae given in the disclosure and processes for their preparation.
Type:
Grant
Filed:
April 18, 2002
Date of Patent:
March 6, 2007
Assignee:
Bayer Cropscience LP
Inventors:
Olaf Gebauer, Jörg Nico Greul, Ulrich Heinemann, Hans-Ludwig Elbe, Bernd-Wieland Krüger, Fritz Maurer, Ralf Dunkel, Arnd Voerste, Ronald Ebbert, Ulrike Wachendorff-Neumann, Yoshinori Kitagawa, Astrid Mauler-Machnik, Karl-Heinz Kuck
Abstract: The invention relates to novel substituted iminoazines of the general formula (I) in which R1, R2, R3, R4, Z1, Z2 and Z3 are each as defined in the disclosure, to a plurality of processes for their preparation, and to their use as herbicides.
Type:
Grant
Filed:
May 8, 2001
Date of Patent:
March 6, 2007
Assignee:
Bayer Aktiengesellschaft
Inventors:
Klaus-Helmut Müller, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
Abstract: Novel ?1-pyrrolines of the Formula (I) in which R1, R2, R3 and Het have the meanings given in the description, a plurality of processes for preparing these compounds and their use for controlling pests, and also novel intermediates and processes for their preparation.
Type:
Grant
Filed:
January 31, 2002
Date of Patent:
March 6, 2007
Assignee:
Bayer Cropscience AG
Inventors:
Andrew Plant, Rüdiger Fischer, Thomas Seitz, Christoph Erdelen, Andreas Turberg, Olaf Hansen
Abstract: The present invention relates to a process for the preparation of di- and polyamines of the diphenylmethane series, and to the preparation of di- and poly-isocyanates of the diphenylmethane series from these di- and poly-amines. The di- and poly-amines of the diphenylmethane series are prepared by the reaction of aniline and formaldehyde in the presence of hydrochloric acid. In with the present invention, the hydrochloric acid employed contains less than 0.001 wt. % of metal ions which are divalent and/or more than divalent.
Type:
Grant
Filed:
October 25, 2005
Date of Patent:
March 6, 2007
Assignee:
Bayer MaterialScience AG
Inventors:
Heinz-Herbert Müller, Stefan Wershofen, Stefan Grabowski
Abstract: A thermoplastic molding compositions having improved stress cracking resistance is disclosed. The composition contains A) 40 to 99.5 parts by weight of at least one branched resin selected from a first group consisting of aromatic polycarbonate and polyestercarbonate and B) 0.5 to 60 parts by weight of graft polymer containing a grafting shell and a grafting base, said grafting base being other than polybutadiene rubber. The structure of the branched resin contains at least one residue of a branching agent selected from among tri-functional phenolic monomer and tetra-functional phenolic monomer.
Type:
Grant
Filed:
December 1, 2003
Date of Patent:
March 6, 2007
Assignee:
Bayer Aktiengesellschaft
Inventors:
Andreas Seidel, Thomas Eckel, Holger Warth