Abstract: The invention relates to novel bicyclic indoline sulfonamide derivatives of general formula (I), methods for the production thereof, and the use thereof in medicaments, especially as potent PPAR delta agonists for preventing and/or treating cardiovascular diseases, particularly dyslipidemia, arteriosclerosis, and coronary heart diseases.

Abstract: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G?, and G? represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.

Abstract: Reagents that regulate human asparagine-hydroxylase and reagents which bind to human asparagine-hydroxylase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to cardiovascular disorders, anaemia, cancer, inflammatory diseases, fibrotic disorders, and CNS disorders.

Abstract: The present invention relates to new hydrophilicized blocked polyisocyanates, a process for preparing them and their use.

Abstract: A combination static mixer and heat exchanger having heat exchanger tubes (1) which are provided over their circumference with fins (2a, 2b) which have a static mixing effect.

Abstract: The present invention relates to cytostatics which have a tumour-specific action as a result of linkage to ?v?3 integrin antagonists via preferred linking units. The preferred linking units guarantee serum stability of the conjugate of cytostatic and ?v?3 integrin antagonist and at the same time the desired intracellular action in tumour cells as a result of their enzymatic or hydrolytic cleavability with release of the cytostatic.

Abstract: A thermoplastic molding composition having good flame resistance, melt flowability, resistance to chemicals and creep is disclosed. The composition contains A) at least one member having weight average molecular weight (Mw) of 25,000 to 35,000 g/mol, selected from the group consisting of aromatic polycarbonate and polyestercarbonate B) ABS graft polymer produced by the mass polymerization process and characterized in (i) having a butadiene content of 8 to 15% in relation to the weight of the graft polymer, (ii) having an acrylic acid derivative content of 15 to 30% in relation to the total weight of the acrylic derivative and styrene monomer, and (iii) containing styrene monomer-acrylic acid derivative copolymer having a weight average molecular weight of 5·104 to 14·104 g/mol. The composition may further contain one or more of halogen-free phosphorus compounds, fluorinated polyolefin, a polymer containing acrylate monomer and an inorganic material in particulate form.

Abstract: The invention relates to methods for the determination of pharmacological properties of substances, such as, e.g., chemical substances. The invention also relates to methods and kits for use in the determination of the free fraction, fu, of pharmaco-logically active compounds in aqueous solutions and serum. The invention also relates to the above methods in which solid particles, coated with a lipophilic medium, are used.

Abstract: Nucleic acid molecules are described encoding a starch granule-bound protein as well as methods and recombinant DNA molecules for the production of transgenic plant cells and plants synthesizing a modified starch with modified viscosity properties and a modified phosphate content. Moreover, the plant cells and plants resulting from those methods as well as the starch obtainable therefrom are described.

Abstract: The invention relates to compounds of formula (I), wherein A1, A2, R1, R2, R3, R4, R5, and Y have the meaning indicated in the description, methods and intermediate compounds for the production thereof, and the use thereof for controlling pests.

Abstract: The present invention relates to an aqueous herbicidal composition based on a suspension concentrate comprising a herbicidally active compound of the formula (I), a safener of the formula (II) and optionally a herbicidally active compound of the formula (III) In these formulae, R1, R2, R3 and R4 independently of one another are methyl or ethyl; R5 is isopropyl or cyclopropyl; R6 is hydrogen or chlorine; Q is cyclohexane-1,3-dion-2-yl, isoxazol-4-yl or pyrazol4yl; and R7, R8 and R9 are hydrogen, halogen or various organic radicals.

Abstract: Polyammonium-Polysiloxane compounds in which siloxane and alkylene oxide substructures are joined with each other through ammonium structures, useful as wash resistant softners.

Abstract: This invention relates to a compound of Formula (I): (I) and its use in treating hyper-proliferative disorders and diseases associated with angiogenesis.

Abstract: The invention relates to a formulation having a plurality of phases containing active ingredients. Said formulation is characterised in that: it contains a first, innermost, finely distributed phase (I) consisting of active ingredients or an active ingredient solution, preferably some of the phase particles being surrounded by a barrier sheath (M); the formulation has a second, intermediate phase (II) that serves as a dispersant for the first, inner phase (I) and can also be dissolved in the active ingredient; and the formulation has a third, outer phase (III) that serves as a dispersant for the second intermediate phase and can, in turn, be dissolved in the active ingredient and/or can be in the form of solid particles that can, in turn, be surrounded by a barrier sheath. In this way, a plurality of biological active ingredients can be produced in the different phases in different concentrations and with a respectively controlled release rate in a single formulation.

Abstract: The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.

Abstract: The invention provides a human LTB4 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of LTB4 as well as pharmaceutical compositions comprising such compounds.

Abstract: The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ?in which W, X, Y, Z, A, B, D and G are each as defined in the disclosure, and (b) specified agonists or antagonists of nicotinic acetylcholine receptors.

Abstract: The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a optical sensor which incorporates said compound for the detection of lithium ions. Additionally, the present invention provides a method of detecting lithium ions which comprises placing the novel optical sensor into communication with a biological fluid. Once the novel compound of the present invention encounters a lithium ion(s), a fluorescence is generated, the intensity of which is measured and allows for the determination of lithium ion concentration. The present invention provides a medical professional with the ability to selectively determine lithium ion concentration in a biological fluid thereby facilitating the treatment of various diseases, such as manic-depressive illness.

Abstract: Homopolymers suitable for storage of information provided optically are disclosed.

Abstract: Polymeric material suitable for the preparation of optical recording media for volume data storage is disclosed. The molecular structure of the material contains a main chain derived from any of poly(meth)acrylate, poly(meth)acrylamide, polysiloxane, polyurea, polyurethane, polyester, polystyrene and cellulose, and the side chains contain a) azobenzene dye, b) form anisotropic grouping, and c) at least one monomer selected from the group consisting of where R=H or methyl, R? and R? independently denote CnH2n+1 or CnH2n-OH and R?? denotes —CnH2N—OH.