Abstract: The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.
Type:
Application
Filed:
August 26, 2005
Publication date:
January 5, 2006
Applicant:
Bayer Pharmaceuticals Corporation
Inventors:
Clark Pan, James Whelan, Kevin Clairmont
Abstract: Process for the preparation of 2-aminomethylpyridine derivative of general formula (I) or a salt thereof, formula (I) in which:-n represents 0, 1, 2 or 3,-X is halogen atom,-each Y may be the same or different and may be a halogen atom, a halogenoalkyl, an alkoxycarbonyl or an alkylsulphonyl.
Abstract: The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.
Type:
Application
Filed:
August 26, 2005
Publication date:
January 5, 2006
Applicant:
Bayer Pharmaceuticals Corporation
Inventors:
Clark Pan, James Whelan, Kevin Clairmont
Abstract: The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.
Type:
Application
Filed:
August 26, 2005
Publication date:
January 5, 2006
Applicant:
Bayer Pharmaceuticals Corporation
Inventors:
Clark Pan, James Whelan, Kevin Clairmont
Abstract: This invention relates to a compound of Formula I (I) and its use in treating hyper-proliferative disorders and diseases associated with angiogenesis.
Type:
Application
Filed:
November 10, 2003
Publication date:
January 5, 2006
Applicant:
Bayer Pharmaceuticals Corporation
Inventors:
Gaetan Ladouceur, Brian Bear, Cheng Bi, David Brittelli, Michael Burke, Gang Chen, James Cook, Jacques Dumas, Robert Sibley, Michael Turner
Abstract: A low gloss thermoplastic molding composition comprising a grafted acrylate rubber (ASA) and a process for its preparation are disclosed. The composition contains an effective amount of a gloss-reducing agent that is the reaction product of (i) compound having two or more maleic anhydride groups per molecule and (ii) compound having two or more terminal primary amine groups per molecule. The incorporation of the gloss reducing agent in the inventive composition may be by blending the reaction product or, in the alternative, blending the reactants (i) and (ii) in the molten ASA under process conditions designed to bring about the in situ formation of the inventive gloss reducing agent.
Abstract: The invention relates to a process for the preparation of carboxamides, in particular peptides, from an acid component in the form of a compound containing at least one carboxyl group and an amine component in the form of a compound containing at least one primary or secondary amino group, and its use.
Type:
Grant
Filed:
March 27, 2002
Date of Patent:
January 3, 2006
Assignee:
Bayer Aktiengesellschaft
Inventors:
Joachim Rudolph, Günther Jung, Bernd Thern
Abstract: This invention relates to methods for treating cardiovascular disorder selected from heart failure, thromboembolic disorders, venous diseases, and fibrotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) in which the several variables are as defined in the specification and claims.
Type:
Application
Filed:
August 22, 2005
Publication date:
December 29, 2005
Applicant:
Bayer Aktiengesellschaft
Inventors:
Michael Harter, Michael Hahn, Claudia Hirth-Dietrich, Andreas Knorr, Elke Stahl, Johannes-Peter Stasch, Frank Wunder
Abstract: The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.
Type:
Application
Filed:
August 26, 2005
Publication date:
December 29, 2005
Applicant:
Bayer Pharmaceuticals Corporation
Inventors:
Clark Pan, James Whelan, Kevin Clairmont
Abstract: The robot alignment system is used for establishing a predetermined alignment position between a movable robot member and an article that is processed by the robot. The system includes a laser transmitter that emits a focused laser beam and a target against which the focused laser beam is directed. The laser transmitter is preferably supported by the robot and the target is supported by the article that is processed by the robot. A signaling device cooperates with the target to produce a detectable signal when the focused laser beam is received at a predetermined location on the target. The detectable signal signifies establishment of a predetermined alignment position between the robot and the article that is processed by the robot.
Abstract: A description is given of pyridinylisoxazoles of the formula (I) or salts thereof. In this formula (I) Q is one of the radicals Q1, Q2 or Q3; R1, R2 and R3 are various radicals, and n is 0 to 2.
Type:
Application
Filed:
June 17, 2005
Publication date:
December 22, 2005
Applicant:
Bayer CropScience GmbH
Inventors:
Andreas Almsick, Lothar Willms, Thomas Auler, Martin Hills, Heinz Kehne, Dieter Feucht, Dorothee Hoischen
Abstract: A description is given of derivatives of benzoylcyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I) R1 and R2 are different radicals and Het is a saturated heterocyclic group comprising oxygen atoms and carbon atoms.
Type:
Application
Filed:
June 17, 2005
Publication date:
December 22, 2005
Applicant:
Bayer CropScience GmbH
Inventors:
Andreas Van Almsick, Lothar Willms, Thomas Auler, Christopher Rosinger, Heinz Kehne, Martin Hills, Dieter Feucht
Abstract: A description is given of benzoylpyrazoles of the formula (I) and of their use as herbicides. In this formula (I) R1, R2, R6, R7 and R8 are different radicals and Het is a saturated heterocyclic group including oxygen atoms and carbon atoms.
Type:
Application
Filed:
June 17, 2005
Publication date:
December 22, 2005
Applicant:
Bayer CropScience GmbH
Inventors:
Andreas van Almsick, Lothar Willms, Thomas Auler, Christopher Rosinger, Heinz Kehne, Martin Hills, Dieter Feucht
Abstract: The present invention relates to novel solventless reactive systems curable at room temperature, based on blocked polyisocyanates, primary amines, compounds with oxirane groups, and 2,3-dimethyl-3,4,5,6-tetrahydropyrimidine, and to processes for the preparation of these solventless reactive systems curable at room temperature.
Type:
Grant
Filed:
July 17, 2000
Date of Patent:
December 20, 2005
Assignee:
Bayer Aktiengesellschaft
Inventors:
Jörg Tillack, Wolfgang Puetz, Lutz Schmalstieg
Abstract: The present invention relates to a method for preparing oligomeric aliphatic diols, polycarbonatediols based thereon and NCO-terminated prepolymers obtainable therefrom. The inventive compounds may find use in the preparation of polyurethanes.
Abstract: The invention relates to new blocked polyurethane prepolymers, a process for their production and reactive systems produced therefrom that harden at room temperature, and their use.
Type:
Grant
Filed:
November 10, 2003
Date of Patent:
December 20, 2005
Assignee:
Bayer Aktiengesellschaft
Inventors:
Kamelia Detig-Karlou, Joachim Simon, Malte Homann, Thomas Stingl, Jörg Tillack
Abstract: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G?, and G? represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
Type:
Application
Filed:
March 10, 2005
Publication date:
December 15, 2005
Applicant:
Bayer Pharmaceuticals Corporation
Inventors:
Julie Dixon, Dhanapalan Nagarathnam, Lei Zhang, Chunguang Wang, Lin Yi, Yuanwei Chen, Jianqing Chen, Brian Bear, Michael Brands, Alexander Hillisch, Donald Bierer, Ming Wang, Wenlang Fu, Martin Hentemann, Ann-Marie Bullion, Manoj Patel
Abstract: The present invention relates to a process for the manufacture of diisocyanates by phosgenation of the corresponding diamines in which the vaporous diamines, optionally rarefied with an inert gas or with the vapors of an inert solvent, and phosgene are heated separately to temperatures of about 200° C. to about 600° C. and mixed and reacted in a tube reactor characterized in that a number n?2 of nozzles directed parallel to the axis of the tube reactor are arranged in the tube reactor, the diamine-containing stream being fed into the tube reactor through the n nozzles and the phosgene stream being fed into the tube reactor through the remaining free space.
Type:
Grant
Filed:
February 17, 2004
Date of Patent:
December 13, 2005
Assignee:
Bayer Aktiengesellschaft
Inventors:
Klaus Biskup, Peter Keldenich, Peter Fuhrmann, Christian Six
Abstract: The present invention relates to novel compounds of the formula (I) in which W, X, Y, Z, G, A, B, Q1, Q2 and D are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.
Type:
Grant
Filed:
April 5, 2001
Date of Patent:
December 13, 2005
Assignee:
Bayer Aktiengesellschaft
Inventors:
Reiner Fischer, Alan Graff, Axel Trautwein, Astrid Ullmann, Udo Schneider, Ralf Wischnat, Mark Wilhelm Drewes, Christoph Erdelen, Dieter Feucht
Abstract: The invention relates to a process for reducing the monomeric aziridine content in a polyaziridine forming reaction mixture by adding to the polyaziridine forming reaction mixture an excess of a carbodiimide scavenger wherein the excess is based on the equivalent ratio of scavenger to monomeric aziridine, and to a product obtained by this process and to a coating composition containing the product obtained by the process.
Type:
Grant
Filed:
October 31, 2002
Date of Patent:
December 13, 2005
Assignee:
Bayer MaterialScience LLC
Inventors:
Lanny D. Venham, Myron W. Shaffer, Karsten Danielmeier, Karen M. Henderson