Patents Assigned to Bayer
  • Sterility retaining medical connector assembly and method
    Patent number: 9993636
    Abstract: A medical connector assembly for establishing a fluid connection between a first medical device and a second medical device includes a multi-use connector and a plurality of single-use connectors connected in series. The multi-use connector has a proximal end opposite a distal end along a longitudinal length thereof. The plurality of single-use connectors each have a proximal end opposite a distal end along a longitudinal length thereof. The distal end of the multi-use connector is releasably connected to the proximal end of a first of the serially-connected single-use connectors. When a second of the serially-connected single-use connectors is disconnected from the first single-use connector, the first single-use connector remains connected to the multi-use medical connector as a sterility retaining cover.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: June 12, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Arthur E. Uber, III, Kevin P. Cowan, James A. Dedig, David M. Griffiths, Edward J. Rhinehart, Benjamin Taggart, Mark Trocki
  • METHOD FOR TREATING COFFEE RUST, CITRUS BLACK SPOT, CITRUS SCAB AND BANANA BLACK SIGATOKA DISEASES
    Publication number: 20180153169
    Abstract: The invention relates to the use of a compound of formula (I) or salts thereof for controlling coffee rust, citrus black spot, citrus scab or banana black sigatoka disease, and to corresponding methods.
    Type: Application
    Filed: May 18, 2016
    Publication date: June 7, 2018
    Applicant: Bayer CropScience Aktiengesellschaft
    Inventors: Rodolfo CECILIANO SOLIS, Gilbert LABOURDETTE, Rodrigo GUERZONI
  • PROCESS FOR THE PREPARATION OF 2-{4-[2-({[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]METHYL}SULFANYL)-3,5-DICYAN0-6-(PYRROLIDIN-1-YL)PYRIDIN-4-YL]PHENOXY}ETHYL-L-ALANYL-L-ALANINATE MONOHYDROCHLORIDE
    Publication number: 20180155336
    Abstract: The present application relates to a novel and improved process for preparing the compound 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl-L-alanyl L-alaninate monohydrochloride of the formula (I) to novel precursors for its preparation, and to the preparation and use of crystal modification I of 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}-ethyl-L-alanyl L-alaninate monohydrochloride of the formula (I).
    Type: Application
    Filed: May 2, 2016
    Publication date: June 7, 2018
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Franz-Josef MAIS, Werner HEILMAN, Britta OLENIK, Birgit KEIL, Guido BECKER, Daniel MEIBOM, Thomas KUHLMANN
  • METHOD FOR CONTROLLING TECHNICAL PROCESSES WITH LINEARIZATION
    Publication number: 20180157223
    Abstract: A method for controlling a technical process with a controller that generates a correcting variable, where a controlled variable approximately constitutes or forms a step function as a function of the correcting variable, in which in a first section of a value range of the correcting variable, the controlled variable forms a first plateau with values that are virtually the same, in a second section of the value range of the correcting variable, the controlled variable has a steep transition from the first plateau to a second plateau with values that are likewise virtually the same, and in a third section of the value range of the correcting variable, the controlled variable forms the second plateau. According to this invention, the step function is approximated by an approximation function in the form of a sigmoid function. An inverse function is produced for the approximation function.
    Type: Application
    Filed: June 13, 2016
    Publication date: June 7, 2018
    Applicant: BAYER CROPSCIENCE AG
    Inventor: Achim KÜPPER
  • 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES
    Publication number: 20180155285
    Abstract: Compounds of formula (I) as described hereinprocesses for their production and their use as anti-cancer agents.
    Type: Application
    Filed: June 14, 2016
    Publication date: June 7, 2018
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Keith GRAHAM, Ulrich KLAR, Hans BRIEM, Gerhard SIEMEISTER, Ursula MÕNNING, Jozsef BALINT
  • PREPARATIONS CONTAINING AMORPHOUS EMODEPSIDE
    Publication number: 20180153957
    Abstract: The invention relates to preparations comprising amorphous emodepside in a polyvinylpyrrolidone matrix, pharmaceuticals comprising such preparations, and their use against endoparasites in animals or humans.
    Type: Application
    Filed: November 3, 2017
    Publication date: June 7, 2018
    Applicant: Bayer Intellectual Property GmbH
    Inventors: Venkata-Rangarao KANIKANTI, Petra LANGE, Hans-Juergen HAMANN, Peter KLEINEBUDDE
  • Cotton variety ST 4946GLB2
    Patent number: 9986701
    Abstract: The cotton variety ST 4946GLB2 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and cotton lint as well as to hybrid cotton plants and seeds obtained by repeatedly crossing plants of variety ST 4946GLB2 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of ST 4946GLB2 and to plants of ST 4946GLB2 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from ST 4946GLB2.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: June 5, 2018
    Assignee: Bayer CropScience LP
    Inventor: Michael Robinson
  • Herbicidally active arylcarboxylic acid amides
    Patent number: 9988347
    Abstract: Benzamides of the general formula (I) are described as herbicides. In this formula (I), X, Z and R are radicals such as alkyl and cycloalkyl. Q is a 5-membered heterocycle.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: June 5, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Hartmut Ahrens, Joerg Tiebes, Christian Waldraff, Hansjoerg Dietrich, Elmar Gatzweiler, Christopher Hugh Rosinger, Dirk Schmutzler
  • Amide-substituted pyridinyltriazole derivatives and uses thereof
    Patent number: 9988367
    Abstract: The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: June 5, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Marie-Pierre Collin, Peter Kolkhof, Thomas Neubauer, Chantal Fürstner, Elisabeth Pook, Matthias Beat Wittwer, Klemens Lustig, Anja Buchmüller, Hanna Tinel, Karoline Dröbner, Thomas Mondritzki, Heiko Schirmer, Axel Kretschmer, Carsten Schmeck, Pierre Wasnaire, Hana Cernecka
  • Catalytic hydrogenation of nitriles
    Patent number: 9988353
    Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: June 5, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Wahed Ahmed Moradi, Thomas Himmler, Thomas Norbert Mueller, Albert Schnatterer, Guenter Schlegel
  • Herbicidally active benzoic acid amides
    Patent number: 9988359
    Abstract: The invention relates to benzoic acid amides of general formula (I) as herbicides. In formula (I) X, Z and R represent radicals such as alkyl and cycloalkyl. Q represents a 5-membered heterocycle.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: June 5, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Hartmut Ahrens, Jörg Tiebes, Christian Waldraff, Simon Dörner-Rieping, Ines Heinemann, Hansjörg Dietrich, Elmar Gatzweiler, Christopher Rosinger, Dirk Schmutzler
  • VARIANT FACTOR VIII POLYPEPTIDES AND METHODS OF THEIR PRODUCTION AND USE
    Publication number: 20180148495
    Abstract: This disclosure relates to variant Factor VIII polypeptides comprising an amino acid substitution at one or more positions within one or both of the thrombin cleavage site and the activation loop. In certain embodiments, the variant Factor VIII polypeptide comprises one or more amino acid substitutions within both the thrombin cleavage site and the activation loop. In further embodiments, the variant factor VIII polypeptide further comprises one or more amino acid substitutions within the A1-A2 domain interface and the A2-A3 domain interface. The present disclosure further relates to methods of producing and/or using such variant Factor VIII polypeptides; nucleic acids encoding the polypeptides; vectors and/or recombinant cells, tissues, or organisms containing such nucleic acids; and kits and pharmaceutical compositions containing such polypeptides and/or nucleic acids.
    Type: Application
    Filed: January 23, 2018
    Publication date: May 31, 2018
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Uwe GRITZAN, Peter KRETSCHMER, Lilley LEONG, Chandra PATEL
  • AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES
    Publication number: 20180148418
    Abstract: The present invention relates to amido-substituted cyclohexane compounds of general formula (I), in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredient.
    Type: Application
    Filed: May 2, 2016
    Publication date: May 31, 2018
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Knut EIS, Jens ACKERSTAFF, Sarah WAGNER, Philipp BUCHGRABER, Detlev SÜLZLE, Simon HOLTON, Eckhard BENDER, Volkhart LI, Ningshu LIU, Franziska SIEGEL, Philip LIENAU, Michaela BAIRLEIN, Franz VON NUSSBAUM, Simon Anthony HERBERT, Marcus KOPPITZ
  • FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}(THIO)CARBOXAMIDES
    Publication number: 20180146670
    Abstract: The invention relates to fungicidal N-cycloalkyl-N-{[ortho-(1-substituted-cycloalkyl)heteroaryl]methyl}carboxamides and their thiocarbonyl analogs of formula (I), their process of preparation, their use as fungicides, particularly in the form of fungicidal compositions, and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. A represents a carbo-linked, unsaturated or partially saturated, optionally substituted 5-membered heterocyclyl group; T represents O or S; Z1 represents an optionally substituted C3-C7-cycloalkyl; p represents 1-5; B1 represents a carbo-linked, unsaturated, monocyclic or fused bicyclic 5-, 6-, 8-, 9-, 10-membered heterocyclyl ring, wherein the dotted line between the two adjacent carbons represents a single bond, a double bond or an aromatic bond.
    Type: Application
    Filed: May 19, 2016
    Publication date: May 31, 2018
    Applicant: Bayer CropScience Aktiengesellschaft
    Inventors: Pierre CRISTAU, Philippe DESBORDES, Julie GEIST, Lionel NICOLAS, Philippe RINOLFI, Jan Peter SCHMIDT, Tomoki TSUCHIYA
  • Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides
    Patent number: 9981940
    Abstract: The present invention relates to aryl sulphide and aryl sulphoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests and to processes and intermediates for preparation thereof. The aryl sulphide and aryl sulphoxide derivatives have the general structure (I) in which the respective radicals are as defined in the description.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: May 29, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Bernd Alig, Silvia Cerezo-Galvez, Reiner Fischer, Adeline Koehler, Julia Johanna Hahn, Angela Becker, Kerstin Ilg, Arnd Voerste, Daniela Portz
  • Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides
    Patent number: 9981928
    Abstract: The present invention relates to aryl sulfoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests and to processes and intermediates for preparation thereof. The aryl sulfide and aryl sulfoxide derivatives have the general structure (I) in which the respective radicals are as defined in the description.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: May 29, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Bernd Alig, Silvia Cerezo-Galvez, Reiner Fischer, Adeline Koehler, Julia Johanna Hahn, Angela Becker, Kerstin Ilg, Arnd Voerste, Daniela Portz
  • FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}PYRAZOLE(THIO)CARBOXAMIDS
    Publication number: 20180139962
    Abstract: The invention relates to fungicidal N-cycloalkyl-N-{[ortho-(1-substituted-cycloalkyl)heteroaryl]methyl}carboxamides and their thiocarbonyl derivatives of formula (I), their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions, and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Application
    Filed: May 19, 2016
    Publication date: May 24, 2018
    Applicant: Bayer CropScience Aktiengesellschaft
    Inventors: Pierre CRISTAU, Philippe DESBORDES, Julie GEIST, Lionel NICOLAS, Philippe RINOLFI, Jan Peter SCHMIDT, Tomoki TSUCHIYA
  • Pyrazole indanyl carboxamides
    Patent number: 9975855
    Abstract: The present invention relates to novel 1-methyl-pyrazole(thio)indanyl carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: May 22, 2018
    Assignee: BAYER CROPSCIENCE AG
    Inventors: Pierre-Yves Coqueron, Mazen Es-Sayed, Simon Maechling, Pierre Wasnaire, Peter Dahmen, Ulrike Wachendorff-Neumann, David Bernier, Lionel Carles, Christophe Dubost, Stephane Brunet, Helene Lachaise, Jean-Pierre Vors
  • Thrombin/plasmin-regulated antibodies that bind TFPI
    Patent number: 9975962
    Abstract: This disclosure provides protease-regulated antibodies which specifically bind to tissue factor pathway inhibitor (TFPI). The antibodies are useful for treating bleeding disorders such as hemophilia.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 22, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Zhuozhi Wang, Ruth Winter, John Murphy
  • Insole
    Patent number: D818687
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: May 29, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Philip C. Yang, Richard Todd Avent