Abstract: A medical connector assembly for establishing a fluid connection between a first medical device and a second medical device includes a multi-use connector and a plurality of single-use connectors connected in series. The multi-use connector has a proximal end opposite a distal end along a longitudinal length thereof. The plurality of single-use connectors each have a proximal end opposite a distal end along a longitudinal length thereof. The distal end of the multi-use connector is releasably connected to the proximal end of a first of the serially-connected single-use connectors. When a second of the serially-connected single-use connectors is disconnected from the first single-use connector, the first single-use connector remains connected to the multi-use medical connector as a sterility retaining cover.
Type:
Grant
Filed:
October 19, 2012
Date of Patent:
June 12, 2018
Assignee:
BAYER HEALTHCARE LLC
Inventors:
Arthur E. Uber, III, Kevin P. Cowan, James A. Dedig, David M. Griffiths, Edward J. Rhinehart, Benjamin Taggart, Mark Trocki
Abstract: The invention relates to the use of a compound of formula (I) or salts thereof for controlling coffee rust, citrus black spot, citrus scab or banana black sigatoka disease, and to corresponding methods.
Abstract: The present application relates to a novel and improved process for preparing the compound 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl-L-alanyl L-alaninate monohydrochloride of the formula (I) to novel precursors for its preparation, and to the preparation and use of crystal modification I of 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}-ethyl-L-alanyl L-alaninate monohydrochloride of the formula (I).
Type:
Application
Filed:
May 2, 2016
Publication date:
June 7, 2018
Applicant:
BAYER PHARMA AKTIENGESELLSCHAFT
Inventors:
Franz-Josef MAIS, Werner HEILMAN, Britta OLENIK, Birgit KEIL, Guido BECKER, Daniel MEIBOM, Thomas KUHLMANN
Abstract: A method for controlling a technical process with a controller that generates a correcting variable, where a controlled variable approximately constitutes or forms a step function as a function of the correcting variable, in which in a first section of a value range of the correcting variable, the controlled variable forms a first plateau with values that are virtually the same, in a second section of the value range of the correcting variable, the controlled variable has a steep transition from the first plateau to a second plateau with values that are likewise virtually the same, and in a third section of the value range of the correcting variable, the controlled variable forms the second plateau. According to this invention, the step function is approximated by an approximation function in the form of a sigmoid function. An inverse function is produced for the approximation function.
Abstract: The invention relates to preparations comprising amorphous emodepside in a polyvinylpyrrolidone matrix, pharmaceuticals comprising such preparations, and their use against endoparasites in animals or humans.
Type:
Application
Filed:
November 3, 2017
Publication date:
June 7, 2018
Applicant:
Bayer Intellectual Property GmbH
Inventors:
Venkata-Rangarao KANIKANTI, Petra LANGE, Hans-Juergen HAMANN, Peter KLEINEBUDDE
Abstract: The cotton variety ST 4946GLB2 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and cotton lint as well as to hybrid cotton plants and seeds obtained by repeatedly crossing plants of variety ST 4946GLB2 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of ST 4946GLB2 and to plants of ST 4946GLB2 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from ST 4946GLB2.
Abstract: Benzamides of the general formula (I) are described as herbicides. In this formula (I), X, Z and R are radicals such as alkyl and cycloalkyl. Q is a 5-membered heterocycle.
Type:
Grant
Filed:
June 26, 2015
Date of Patent:
June 5, 2018
Assignee:
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Inventors:
Hartmut Ahrens, Joerg Tiebes, Christian Waldraff, Hansjoerg Dietrich, Elmar Gatzweiler, Christopher Hugh Rosinger, Dirk Schmutzler
Abstract: The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
Type:
Grant
Filed:
April 28, 2017
Date of Patent:
June 5, 2018
Assignee:
BAYER PHARMA AKTIENGESELLSCHAFT
Inventors:
Marie-Pierre Collin, Peter Kolkhof, Thomas Neubauer, Chantal Fürstner, Elisabeth Pook, Matthias Beat Wittwer, Klemens Lustig, Anja Buchmüller, Hanna Tinel, Karoline Dröbner, Thomas Mondritzki, Heiko Schirmer, Axel Kretschmer, Carsten Schmeck, Pierre Wasnaire, Hana Cernecka
Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.
Type:
Grant
Filed:
November 11, 2014
Date of Patent:
June 5, 2018
Assignee:
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Inventors:
Wahed Ahmed Moradi, Thomas Himmler, Thomas Norbert Mueller, Albert Schnatterer, Guenter Schlegel
Abstract: The invention relates to benzoic acid amides of general formula (I) as herbicides. In formula (I) X, Z and R represent radicals such as alkyl and cycloalkyl. Q represents a 5-membered heterocycle.
Type:
Grant
Filed:
June 26, 2015
Date of Patent:
June 5, 2018
Assignee:
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Inventors:
Hartmut Ahrens, Jörg Tiebes, Christian Waldraff, Simon Dörner-Rieping, Ines Heinemann, Hansjörg Dietrich, Elmar Gatzweiler, Christopher Rosinger, Dirk Schmutzler
Abstract: This disclosure relates to variant Factor VIII polypeptides comprising an amino acid substitution at one or more positions within one or both of the thrombin cleavage site and the activation loop. In certain embodiments, the variant Factor VIII polypeptide comprises one or more amino acid substitutions within both the thrombin cleavage site and the activation loop. In further embodiments, the variant factor VIII polypeptide further comprises one or more amino acid substitutions within the A1-A2 domain interface and the A2-A3 domain interface. The present disclosure further relates to methods of producing and/or using such variant Factor VIII polypeptides; nucleic acids encoding the polypeptides; vectors and/or recombinant cells, tissues, or organisms containing such nucleic acids; and kits and pharmaceutical compositions containing such polypeptides and/or nucleic acids.
Type:
Application
Filed:
January 23, 2018
Publication date:
May 31, 2018
Applicant:
BAYER HEALTHCARE LLC
Inventors:
Uwe GRITZAN, Peter KRETSCHMER, Lilley LEONG, Chandra PATEL
Abstract: The present invention relates to amido-substituted cyclohexane compounds of general formula (I), in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredient.
Type:
Application
Filed:
May 2, 2016
Publication date:
May 31, 2018
Applicant:
Bayer Pharma Aktiengesellschaft
Inventors:
Knut EIS, Jens ACKERSTAFF, Sarah WAGNER, Philipp BUCHGRABER, Detlev SÜLZLE, Simon HOLTON, Eckhard BENDER, Volkhart LI, Ningshu LIU, Franziska SIEGEL, Philip LIENAU, Michaela BAIRLEIN, Franz VON NUSSBAUM, Simon Anthony HERBERT, Marcus KOPPITZ
Abstract: The invention relates to fungicidal N-cycloalkyl-N-{[ortho-(1-substituted-cycloalkyl)heteroaryl]methyl}carboxamides and their thiocarbonyl analogs of formula (I), their process of preparation, their use as fungicides, particularly in the form of fungicidal compositions, and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. A represents a carbo-linked, unsaturated or partially saturated, optionally substituted 5-membered heterocyclyl group; T represents O or S; Z1 represents an optionally substituted C3-C7-cycloalkyl; p represents 1-5; B1 represents a carbo-linked, unsaturated, monocyclic or fused bicyclic 5-, 6-, 8-, 9-, 10-membered heterocyclyl ring, wherein the dotted line between the two adjacent carbons represents a single bond, a double bond or an aromatic bond.
Type:
Application
Filed:
May 19, 2016
Publication date:
May 31, 2018
Applicant:
Bayer CropScience Aktiengesellschaft
Inventors:
Pierre CRISTAU, Philippe DESBORDES, Julie GEIST, Lionel NICOLAS, Philippe RINOLFI, Jan Peter SCHMIDT, Tomoki TSUCHIYA
Abstract: The present invention relates to aryl sulphide and aryl sulphoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests and to processes and intermediates for preparation thereof. The aryl sulphide and aryl sulphoxide derivatives have the general structure (I) in which the respective radicals are as defined in the description.
Type:
Grant
Filed:
June 16, 2014
Date of Patent:
May 29, 2018
Assignee:
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Inventors:
Bernd Alig, Silvia Cerezo-Galvez, Reiner Fischer, Adeline Koehler, Julia Johanna Hahn, Angela Becker, Kerstin Ilg, Arnd Voerste, Daniela Portz
Abstract: The present invention relates to aryl sulfoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests and to processes and intermediates for preparation thereof. The aryl sulfide and aryl sulfoxide derivatives have the general structure (I) in which the respective radicals are as defined in the description.
Type:
Grant
Filed:
June 16, 2014
Date of Patent:
May 29, 2018
Assignee:
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Inventors:
Bernd Alig, Silvia Cerezo-Galvez, Reiner Fischer, Adeline Koehler, Julia Johanna Hahn, Angela Becker, Kerstin Ilg, Arnd Voerste, Daniela Portz
Abstract: The invention relates to fungicidal N-cycloalkyl-N-{[ortho-(1-substituted-cycloalkyl)heteroaryl]methyl}carboxamides and their thiocarbonyl derivatives of formula (I), their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions, and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
Type:
Application
Filed:
May 19, 2016
Publication date:
May 24, 2018
Applicant:
Bayer CropScience Aktiengesellschaft
Inventors:
Pierre CRISTAU, Philippe DESBORDES, Julie GEIST, Lionel NICOLAS, Philippe RINOLFI, Jan Peter SCHMIDT, Tomoki TSUCHIYA
Abstract: The present invention relates to novel 1-methyl-pyrazole(thio)indanyl carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
Type:
Grant
Filed:
October 21, 2015
Date of Patent:
May 22, 2018
Assignee:
BAYER CROPSCIENCE AG
Inventors:
Pierre-Yves Coqueron, Mazen Es-Sayed, Simon Maechling, Pierre Wasnaire, Peter Dahmen, Ulrike Wachendorff-Neumann, David Bernier, Lionel Carles, Christophe Dubost, Stephane Brunet, Helene Lachaise, Jean-Pierre Vors
Abstract: This disclosure provides protease-regulated antibodies which specifically bind to tissue factor pathway inhibitor (TFPI). The antibodies are useful for treating bleeding disorders such as hemophilia.