Patents Assigned to Baylor
  • Publication number: 20250144191
    Abstract: Methods and compositions for treating multiple sclerosis using dendritic cell anti-ASGPR antibodies fused to myelin basic protein or myelin oligodendrocyte glycoprotein are provided.
    Type: Application
    Filed: January 6, 2025
    Publication date: May 8, 2025
    Applicant: BAYLOR RESEARCH INSTITUTE
    Inventors: SangKon OH, Gerard ZURAWSKI
  • Patent number: 12291558
    Abstract: An isolated human NKT cell or a plurality of cells thereof, having reduced or no detectable expression of endogenous beta-2-microglobulin (B2M); endogenous MHC class II-associated invariant chain (Ii); or both. Methods to generate the cell or cells, and methods of treatment using the cell or cells are also provided.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: May 6, 2025
    Assignee: Baylor College of Medicine
    Inventors: Leonid S. Metelitsa, Jingling Jin, Bin Liu
  • Patent number: 12286418
    Abstract: The disclosure relates, in certain aspects, to compounds that can be used to inhibit ?-lactamases, such as but not limited to OXA enzymes, such as but not limited to OXA-24, OXA-48, and/or OXA-58. In certain embodiments, these compounds can be used to inhibit activity of ?-lactamases in vitro and in vivo.
    Type: Grant
    Filed: June 20, 2020
    Date of Patent: April 29, 2025
    Assignee: Baylor College of Medicine
    Inventors: Timothy Palzkill, Doris Taylor, Justin Anglin, Nicholas Simmons, John Faver, Yong Wang, Zhuang Jin, Martin Matzuk
  • Patent number: 12288499
    Abstract: The present invention includes systems and methods for a six-primary color system for display. A six-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. The six-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Grant
    Filed: April 4, 2024
    Date of Patent: April 29, 2025
    Assignee: Baylor University
    Inventors: James M. DeFilippis, Gary B. Mandle
  • Publication number: 20250121048
    Abstract: Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers.
    Type: Application
    Filed: December 20, 2024
    Publication date: April 17, 2025
    Applicant: BAYLOR RESEARCH INSTITUTE
    Inventors: SangKon OH, Sandra ZURAWSKI, Gerard ZURAWSKI
  • Patent number: 12274723
    Abstract: Disclosed are compositions, devices, kits, and methods for treatment of Enterobacteriaceae infection. Aspects of the present disclosure are directed to bacteriophage compositions comprising one or more of ES17, ES19, HP3, HP3.1, and HP3.2. Certain aspects of the disclosure are directed to compositions comprising (a) bacteriophage ES17 or bacteriophage ES19, (b) bacteriophage HP3, and (c) bacteriophage HP3.1. Also disclosed are compositions comprising bacteriophage HP 3.2. Further disclosed are devices and kits comprising such compositions and methods for use of such compositions in treatment and prevention of pathogenic E. coli infection.
    Type: Grant
    Filed: June 24, 2024
    Date of Patent: April 15, 2025
    Assignees: Baylor College of Medicine, United States Government as Represented by the Department of Veterans Affairs
    Inventors: Anthony Maresso, Robert Ramig, Sabrina Green, Austen Terwilliger, Keiko Salazar, Justin R. Clark, Barbara Trautner
  • Publication number: 20250114549
    Abstract: A portable ventilator device suitable for emergency use, such as cardiac pulmonary resuscitation and well as ventilation in non-cardiac induced medical events. The device is connected to a display screen that receives simple inputs from an operator, including height, weight, or sex of the distressed patient, but does not require input of more complicated variables, such as tidal volume, respiratory rate, inspiratory airflow, or positive end-expiratory pressure. Based on the input height, weight, and/or sex, the device automatically correlates the input values with probably values for tidal volume, respiratory rate, inspiratory airflow, or positive end-expiratory pressure, based previous data point correlations. The device then begins delivering air from a ventilator to the patient based on the estimated, correlated values. While the device utilizes simple inputs, it still capable of operating in multiple modes with both pressure control and volume control.
    Type: Application
    Filed: December 17, 2024
    Publication date: April 10, 2025
    Applicant: Baylor University
    Inventors: Matthew R. Brantley, Raymond Curtice
  • Publication number: 20250116465
    Abstract: The disclosure provides a system and method for absorbing clean heat, storing it at ambient temperature for transport or delayed use, and regenerating with high exergetic efficiency. The system and method can capture high quality heat at high temperatures from a source such as nuclear, concentrated sunlight, or geothermal, store that energy in chemical bonds at ambient temperature, and regenerate the heat at the same or similar temperatures. By storing at ambient temperature, the process allows heat to be transmitted over great distances or held long term with minimal losses. The chemical reaction uses the Boudouard reaction with metal carbonate and catalyst to generate a higher heat than a typical Boudouard reaction. The sensible heat that is lost in conventional steam piping by heat transfer to the environment can be reduced or replaced with the present invention that transports chemical heat at ambient temperatures with little sensible heat loss.
    Type: Application
    Filed: October 3, 2024
    Publication date: April 10, 2025
    Applicant: BAYLOR UNIVERSITY
    Inventors: Alexandre Yokochi, Annette Von Jouanne, Yu Miao, Riley Choquette
  • Patent number: 12268704
    Abstract: Embodiments of the disclosure encompass methods and compositions related to modulating the Hippo pathway to inhibit fibrosis and/or inflammation in a tissue and/or organ of an individual in need thereof. In specific embodiments, the disclosure concerns modulation of LATS1, LATS2, or both, such as providing to the individual an effective amount of one or more agents that increase the levels of LATS1, LATS2, or both in the individual. In specific cases, cardiac fibrosis is treated with effective levels of vector(s) comprising LATS1, LATS2, or both.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: April 8, 2025
    Assignee: Baylor College of Medicine
    Inventor: James F. Martin
  • Publication number: 20250100984
    Abstract: Methods described herein relate to a partial reduction of esters to aldehydes or nitrogen-containing products facilitated by Group IV transition metal catalysts, using hydrosilanes as the reductant. The method allows the product to be preserved at the aldehyde oxidation level rather than over-reduction to the corresponding alcohol and can result in the formation of value-added recycled monomers. Methods described herein can be used for the direct catalytic chemical upcycling of polyester plastic waste through depolymerization transformations.
    Type: Application
    Filed: September 24, 2024
    Publication date: March 27, 2025
    Applicant: BAYLOR UNIVERSITY
    Inventors: Liela A. Romero, Rebecca A. Kehner, Weiheng Huang, Jack Russo
  • Publication number: 20250102468
    Abstract: The present disclosure provides a system and method for real-time visualization of a material during ultrasonic non-destructive testing. The system is capable of producing A-scans, B-scans, and C-scans of the test object and automatically highlighting potential foreign objects within the test object based on the scan data. The system includes a graphical user interface (GUI) capable of displaying a three-dimensional (3-D) image of a composite laminate constructed of a series of two-dimensional (2-D) cross sections. In one embodiment, the system includes an artificial intelligence module capable of highlighting foreign objects in order to provide size data, shape data, and/or depth data of the foreign object.
    Type: Application
    Filed: December 10, 2024
    Publication date: March 27, 2025
    Applicant: Baylor University
    Inventors: David A. Jack, Rifat Ara Nargis
  • Publication number: 20250092402
    Abstract: A novel network of tumorigenic prognostic factors is identified that plays a critical role in advanced pancreatic cancer (PC) pathogenesis. This interactome is interconnected through a central tumor suppressive microRNA, miR-198, which is able to both directly and indirectly modulate expression of the various members of this network to alter the molecular makeup of pancreatic tumors, with important clinical implications. When this tumor signature network is intact, miR-198 expression is reduced and patient survival is dismal; patients with higher miR-198 present an altered tumor signature network, better prognosis and increased survival. Further, according to the present disclosure, MiR-198 replacement reverses tumorigenicity in vitro and in vivo.
    Type: Application
    Filed: September 30, 2024
    Publication date: March 20, 2025
    Applicant: Baylor College of Medicine
    Inventors: Qizhi Yao, Christian Marin-Muller, Changyi Chen
  • Patent number: 12251449
    Abstract: Provided herein are compositions comprising multi domain peptide (MDP) hydrogels where the peptides that constitute the hydrogel have at least one N6-(1-iminoethyl)-lysine side chain. Also provided are hydrogels that further comprise a STING agonist, an immune checkpoint inhibitor, and/or an anti-cancer therapy. Also provided are methods of using such compositions in the treatment of cancer.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: March 18, 2025
    Assignees: William Marsh Rice University, Baylor College of Medicine, The Board of Regents of The University of Texas System
    Inventors: Jeffrey Hartgerink, Andrew G. Sikora, David Leach, Jared M. Newton, Simon Young
  • Publication number: 20250081998
    Abstract: Embodiments of the disclosure include particular amyloglucosidase (AMG) compositions formulated as a nutriceutical or medicinal food, for example. The AMG compositions are formulated at a specific dosage and/or are lacking in one or more toxins or have substantially reduced levels of toxin, such as deoxynivalenol (vomit toxin). The AMG compositions are provided to individuals in need thereof, such as an individual with or at risk for congenital sucrase isomaltase syndrome, functional bowel disorders, small bowel bacterial overgrowth, protein-calorie malnutrition (marasmus), radiochemotherapy-induced mucositis and/or short-gut syndrome.
    Type: Application
    Filed: November 26, 2024
    Publication date: March 13, 2025
    Applicant: Baylor College of Medicine
    Inventor: Antone Robert Opekun, JR.
  • Publication number: 20250073276
    Abstract: The present disclosure encompasses methods for generating cells or tissue from existing cells with one or more mutated variants of Yap. In specific embodiments, the disclosure regards treatment of existing cardiomyocytes with one or more mutated variants of Yap that causes them to divide and generate new cardiomyocytes. In specific cases, the mutated variant of Yap has serine-to-alanine substitutions at 1, 2, 3, 4, 5, 6, or more serines of Yap.
    Type: Application
    Filed: October 9, 2024
    Publication date: March 6, 2025
    Applicant: Baylor College of Medicine
    Inventors: Tanner Monroe, John P. Leach, James F. Martin
  • Publication number: 20250078712
    Abstract: The present invention includes systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Application
    Filed: November 19, 2024
    Publication date: March 6, 2025
    Applicant: Baylor University
    Inventors: Mitchell J. Bogdanowicz, James M. DeFilippis, Corey P. Carbonara, Michael F. Korpi, Gary Alan Feather, Gary B. Mandle
  • Publication number: 20250073194
    Abstract: Embodiments of the present disclosure concern the treatment and/or prevention of eye disorders, including dry eye disorders and any medical condition that has dry eye as a symptom. In specific embodiments, treatment and/or prevention may occur by administering therapeutic compositions comprising one or more RXR agonists to at least one eye of an individual.
    Type: Application
    Filed: February 1, 2023
    Publication date: March 6, 2025
    Applicant: Baylor College of Medicine
    Inventors: Stephen C. Pflugfelder, Jahan Alam
  • Patent number: 12243464
    Abstract: The present invention includes systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Grant
    Filed: January 4, 2024
    Date of Patent: March 4, 2025
    Assignee: Baylor University
    Inventors: Mitchell J. Bogdanowicz, Corey P. Carbonara, Michael F. Korpi, James M. DeFilippis, Gary B. Mandle
  • Publication number: 20250069536
    Abstract: Systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Application
    Filed: November 13, 2024
    Publication date: February 27, 2025
    Applicant: Baylor University
    Inventors: James M. DeFilippis, Gary B. Mandle
  • Publication number: 20250066796
    Abstract: Embodiments of the disclosure concern the use of expression constructs in which at least one polyA signal is embedded upstream of an expressible transcript, such as within a 5? UTR for the transcript, for example. In certain embodiments, the polyA signal is comprised within a ligand-binding aptamer, and the binding of the ligand to the aptamer, or lack thereof, dictates the outcome for the expressible transcript. In specific embodiments, absence of the ligand causes the expressed transcript having a polyA in its 5? UTR to be expressed but then degraded, whereas presence of the ligand causes inhibition of degradation upon expression of the expressible transcript. More than one ligand-binding aptamer may be present on the same expression construct.
    Type: Application
    Filed: November 14, 2024
    Publication date: February 27, 2025
    Applicant: Baylor College of Medicine
    Inventors: Laising Yen, Liming Luo, Pei-Wen Chao