Abstract: One aspect of the invention provides and artificial, flexible valve indlucding: a stent defining a wall and a plurality of leaflets extending from the wall of the stent. The plurality of leaflets form a plurality of coaptation regions between two adjacent leaflets. The coaptation regions include extensions along a z-axis and adapted and are configured to form a releasable, but substantially complete seal when the leaflets are in a closed position. Another aspect of the invention provides an artificial, flexible valve including: a stent defining a wall and a plurality of leaflets extending from the wall of the stent. Each of the plurality of leaflets terminates in a commissure line. The commissure lines devi-ate from a hyperbola formed in the x-y plane by at least one deviation selected from the group consisting of: a deviation in the z-direction and one or more curves relative to the hyperbola.
Type:
Application
Filed:
September 6, 2019
Publication date:
January 2, 2020
Applicants:
Baylor College of Medicine, William Marsh Rice University
Inventors:
Henri JUSTINO, Daniel HARRINGTON, Kwonsoo CHUN
Abstract: The present invention provides methods for treating and improving the symptoms of osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of a binding agent that binds to transforming growth factor beta (TGF?).
Type:
Application
Filed:
July 1, 2019
Publication date:
December 26, 2019
Applicants:
GENZYME CORPORATION, Baylor College of Medicine
Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.
Type:
Grant
Filed:
March 22, 2019
Date of Patent:
December 24, 2019
Assignee:
BAYLOR COLLEGE OF MEDICINE
Inventors:
Bert W. O'Malley, David Michael Lonard, Jin Wang, Jianming Xu, Jianwei Chen
Abstract: One aspect of the invention provides a mobile clinic including: an intermodal container defining at least a first opening and a second opening; a partition wall located within the intermodal container, the partition wall separating the intermodal container into an anteroom and a treatment room; and an access control device programmed to prevent passage from the anteroom into the treatment room until a user's donning of personal protective equipment is verified. Another aspect of the invention provides a collapsible structure including: a rigid base; a rigid roof; one or more collapsible walls extending between the floor and the base; and an erector system comprising four cross-bars. Another aspect of the invention provides a crate including: a bottom panel; a top panel; and a plurality of walls, wherein at least two of said plurality of walls including one or more conduits.
Type:
Application
Filed:
August 28, 2019
Publication date:
December 19, 2019
Applicant:
Baylor College of Medicine
Inventors:
Sharmila Anandasabapathy, Sarah Michel, Caroline Popper
Abstract: The present disclosure concerns combination therapy for cancer that utilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor, and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.
Abstract: Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern production of immune cells that target one or more antigens of HPV16 and/or HPV18, including methods with stimulation steps that employ IL-7 and IL-15, but not IL-6 and/or IL-12. Other specific embodiments utilize stimulations in the presence of certain cells, such as costimulatory cells and certain antigen presenting cells.
Type:
Grant
Filed:
January 31, 2018
Date of Patent:
December 10, 2019
Assignee:
Baylor College of Medicine
Inventors:
Carlos A. Ramos, Cliona M. Rooney, Sandhya Sharma, Benjamin Hyun Joon Shin, Alex Salyer
Abstract: A system generates and displays a clinical metric based on continuously collected patient physiological data, wherein the clinical metric provides a predictive measure of the likelihood of the onset of a cardiorespiratory deterioration event in the patient in a predetermined time period in the future. If the clinical metric has a configured relationship with a predetermined threshold value, embodiments may generate an alarm in addition to or instead of displaying the clinical metric. The clinical metric thus allows clinical staff to take medically indicated actions to prevent or reduce the effects of the predicted deterioration.
Type:
Grant
Filed:
November 16, 2015
Date of Patent:
November 26, 2019
Assignee:
Baylor College of Medicine
Inventors:
Craig Rusin, Kenneth M. Brady, Eric Vu, Sebastian Acosta, Daniel J. Penny
Abstract: Embodiments of the disclosure concern compositions and methods for genetic engineering related to hypermethylation of sequences. In particular embodiments, there are methods and compositions to induce DNA methylation in a manner that leads to transcriptional suppression of a target gene that allows characterization of the gene and/or its expression.
Abstract: One aspect of the invention provides a phantom including a confined fluidic path defining a plurality of regions of monotonically decreasing, discrete cross-sectional dimensions with respect to an imaging plane. Another aspect of the invention provides a method of assessing imaging. The method includes: placing a phantom as described herein within an imaging system; flowing one or more fluids through the phantom; and capturing one or more images of the phantom. Another aspect of the invention provides a kit for assessing imaging. The kit includes a phantom as described herein and instructions for use.
Abstract: The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide.
Type:
Grant
Filed:
January 5, 2017
Date of Patent:
September 24, 2019
Assignee:
Baylor College of Medicine
Inventors:
David Spencer, Brent Hanks, Kevin Slawin
Abstract: One aspect of the invention provides a mobile clinic including: an intermodal container defining at least a first opening and a second opening; a partition wall located within the intermodal container, the partition wall separating the intermodal container into an anteroom and a treatment room; and an access control device programmed to prevent passage from the anteroom into the treatment room until a user's donning of personal protective equipment is verified. Another aspect of the invention provides a collapsible structure including: a rigid base; a rigid roof; one or more collapsible walls extending between the floor and the base; and an erector system comprising four cross-bars. Another aspect of the invention provides a crate including: a bottom panel; a top panel; and a plurality of walls, wherein at least two of said plurality of wails including one or more conduits.
Type:
Grant
Filed:
November 11, 2015
Date of Patent:
September 24, 2019
Assignee:
Baylor College of Medicine
Inventors:
Sharmila Anandasabapathy, Sarah Michel, Caroline Popper
Abstract: The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some embodiments, the compounds may be used to treat a disease such as, e.g., an allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease, or a cancer.
Type:
Grant
Filed:
August 16, 2017
Date of Patent:
August 20, 2019
Assignees:
Board of Regents, The University of Texas System, Baylor College of Medicine
Inventors:
John S. McMurray, Pijus Kumar Mandal, Pietro Morlacchi, Morgan Knight, David B. Corry
Abstract: The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
Type:
Grant
Filed:
August 24, 2016
Date of Patent:
August 20, 2019
Assignees:
Baylor College of Medicine, Wilson Wolf Manufacturing
Inventors:
Ann Marie Leen, Ulrike Gerdemann, Cliona M. Rooney, Juan F. Vera Valdes, John R. Wilson
Abstract: The present invention provides methods for treating and improving the symptoms of osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of a binding agent that binds to transforming growth factor beta (TGF?).
Type:
Grant
Filed:
February 8, 2017
Date of Patent:
August 13, 2019
Assignees:
GENZYME CORPORATION, Baylor College of Medicine
Abstract: Wireless treatment of arrhythmias. At least some of the example embodiments are methods including: charging a capacitor of a first microchip device abutting heart tissue, the charging by harvesting ambient energy; charging a capacitor of a second microchip device abutting the heart tissue, the charging of the capacitor of the second microchip device by harvesting ambient energy; sending a command wirelessly from a communication device outside the rib cage to the microchip devices; applying electrical energy to the heart tissue by the first microchip device responsive to the command, the electrical energy applied from the capacitor of the first microchip device; and applying electrical energy to the heart tissue by the second microchip device responsive to the command to the second microchip device, the electrical energy applied from the capacitor of the second microchip device.
Type:
Application
Filed:
August 22, 2017
Publication date:
July 25, 2019
Applicants:
WILLIAM MARSH RICE UNIVERSITY, TEXAS HEART INSTITUTE, BAYLOR COLLEGE OF MEDICINE
Inventors:
Yuxiang SUN, Aydin BABAKHANI, Mehdi RAZAVI, David BURKLAND, Brian GREET, Mathews JOHN, Hongming LYU
Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.
Type:
Application
Filed:
March 22, 2019
Publication date:
July 18, 2019
Applicant:
BAYLOR COLLEGE OF MEDICINE
Inventors:
Bert W. O'Malley, David Michael Lonard, Jin Wang, Jianming Xu, Jianwei Chen
Abstract: The present disclosure relates to a novel process for expanding T cells, such as autologous T cells, cell populations therefrom, pharmaceutical compositions comprising the said cell populations and use of the cells and compositions for treatment, particular the treatment or prophylaxis of virus infection and/or cancer, for example in immune compromised or immune competent human patients.
Type:
Grant
Filed:
April 23, 2012
Date of Patent:
July 16, 2019
Assignees:
Cell Medica Limited, Baylor College of Medicine
Inventors:
Cliona M. Rooney, Ann M. Leen, Juan F. Vera, Minhtran V. Ngo, Rainer Ludwig Knaus
Abstract: Embodiments of the disclosure concern methods and compositions that relate to increasing or decreasing the weight (including, for example, by increasing or decreasing the adipose mass) in individuals in need thereof. Such methods and compositions, in particular embodiments, concern providing an effective amount of the hormone asprosin to increase adipose mass in an individual with insufficient adipose mass and providing an antibody or inhibitor of asprosin in an individual with obesity or diabetes, for example, to reduce adipose mass.
Abstract: The present disclosure concerns hyperthermic devices for treating vascular involvements related to cancer therapies, such as surgery. In specific embodiments, the device is configured to provide therapeutic heating to destroy vessel-encasing tumors while still protecting the vessel itself. In particular embodiments, the devices utilize two opposing semi-cylindrical shells that encase the vessel in need of treatment of a tumor thereon. In other devices, a flexible substrate is guided under and around the vessel and tumor thereon.
Type:
Application
Filed:
May 12, 2017
Publication date:
June 13, 2019
Applicant:
Baylor College of Medicine
Inventors:
Stuart James Corr, Matthew James Ware, Steven A. Curley, Lam Nguyen