Patents Assigned to Baylor
  • Module-Level Analysis of Peripheral Blood Leukocyte Transcriptional Profiles
    Publication number: 20070231816
    Abstract: The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining individual gene expression levels from cells obtained from one or more patients with a disease or condition; recording the expression value for each gene in a table that is divided into clusters; iteratively selecting gene expression values for one or more transcriptional modules by: selecting for the module the genes from each cluster that match in every disease or condition; removing the selected genes from the analysis; and repeating the process of gene expression value selection for genes that cluster in a sub-fraction of the diseases or conditions; and iteratively repeating the generation of modules.
    Type: Application
    Filed: December 9, 2006
    Publication date: October 4, 2007
    Applicant: BAYLOR RESEARCH INSTITUTE
    Inventors: Damien Chaussabel, Jacques Banchereau
  • Defects in periaxin associated with myelinopathies
    Patent number: 7273698
    Abstract: The present invention relates to defects in periaxin (PRX) associated with myelinopathies, including Charcot-Marie-Tooth syndrome and/or Dejerine-Sottas syndrome. Unrelated individuals having a myelinopathy from Dejerine-Sottas syndrome have recessive PRX mutations. The PRX locus maps to a region associated with a severe autosomal recessive demyelinating neuropathy and is also syntenic to the Prx location on murine chromosome 7.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: September 25, 2007
    Assignee: Baylor College of Medicine
    Inventors: James R. Lupski, Cornelius F. Boerkoel, III, Hiroshi Takashima
  • Multi-chamber container
    Publication number: 20070209951
    Abstract: A multi-chamber container of the present invention is divided into a plurality of filling chambers 11, 12 by a seal 13, and has a container body 1 with the chambers 11, 12 filled with respective solutions, and a cover 2 that covers at least one of the chambers 11, 12 of the container body 1. The cover 2 includes a pair of rigid members 21 that sandwich the seal portion 13 from the outside, and seal portions 22 provided to close the rigid members 21. In this multi-chamber container, the cover 2 is held when the filling chambers 11, 12 are not opened in therebetween, while being dropped easily when the filling chambers 11, 12 are opened in therebetween and the thickness of the seal portion 13 increases.
    Type: Application
    Filed: March 13, 2006
    Publication date: September 13, 2007
    Applicant: Baylor College of Medicine
    Inventor: Toshiya Okahisa
  • Gene or drug delivery system
    Publication number: 20070207194
    Abstract: The present invention includes compositions and methods for delivering one or more active agents in vivo by contacting a target organ or tissue with a microbubble encapsulated active agent comprising a neutrally charged lipid microbubble loaded with cationic liposomes comprising one or more active agents and selectively releasing the active agents at the target by exposing the microbubble at the target with ultrasound, wherein the active agents remain protected in the microbubble until selectively release at the target.
    Type: Application
    Filed: August 5, 2005
    Publication date: September 6, 2007
    Applicant: Baylor Research Institute
    Inventors: Paul Grayburn, Shuyuan Chen
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
    Publication number: 20070202106
    Abstract: The present invention includes compositions and methods for the treatment, diagnosis and prognosis of cancers by detecting the level of IL-13 expression in cancerous cells in the tissue microenvironment as an indicator of controlling the type of immune response mounted against the cancer.
    Type: Application
    Filed: March 17, 2007
    Publication date: August 30, 2007
    Applicant: BAYLOR RESEARCH INSTITUTE
    Inventors: Anna Palucka, Jacques Banchereau
  • P38 MAPK PATHWAY PREDICTS ENDOCRINE-RESISTANT GROWTH OF HUMAN BREAST CANCER AND PROVIDES A NOVEL DIAGNOSTIC AND TREATMENT TARGET
    Publication number: 20070202114
    Abstract: Acquired and de novo endocrine resistance are major clinical problems in the management of breast cancer patients. Though the antiestrogen tamoxifen prolongs disease-free and overall survival in the adjuvant setting, and induces remissions in over half of the patients with estrogen receptor positive metastatic disease, all patients eventually acquire tamoxifen resistance. Furthermore, many of the resistant tumors actually appear to be stimulated by tamoxifen just as they are by estrogens. The present invention provides methods of predicting endocrine resistance comprising detecting the biological activity and/or expression of p38 MAPK and/or AIB1. The invention further provides methods of reducing, reversing, or preventing endocrine resistance comprising contacting a breast or prostate tumor with a p38 MAPK pathway inhibitor.
    Type: Application
    Filed: April 29, 2007
    Publication date: August 30, 2007
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: C. Osborne, Rachel Schiff, Jiang Shou
  • METHOD FOR HIGH SPEED MICROSCOPY WITH THREE-DIMENSIONAL LASER BEAM SCANNING
    Publication number: 20070201123
    Abstract: A system and method for independently controlling the collimation and lateral positioning of a light beam comprises at least one acousto-optic deflector and a pair of counter propagating acoustic waves with offset frequencies. While the frequency offset controls the lateral positioning of the light beam, a frequency gradient across the acousto-optic deflectors controls the collimation of the light beam.
    Type: Application
    Filed: February 20, 2007
    Publication date: August 30, 2007
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Peter Saggau, Duemani Reddy, Vijay Iyer
  • RF coil for a highly uniform B1 amplitude for high field MRI
    Patent number: 7259562
    Abstract: An array coil to achieve more uniform RF excitation for high field magnetic resonance imaging. In the preferred embodiment, the array coil has a plurality of transmit-composite elements distributed around the object to be imaged. A composite element comprises up to three current loops preferably orthogonal to each another. The array coil has the capability to shape the distribution of all three orthogonal components (x, y, and z) of the RF B1 field.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: August 21, 2007
    Assignee: Baylor College of Medicine
    Inventors: Zhiyue J. Wang, Dah-Jyuu Wang
  • Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy
    Patent number: 7250405
    Abstract: The intramuscular electroporated injection of a protease-resistant growth hormone-releasing hormone (“GHRH”) cDNA into rat dams at 16 days of gestation resulted in the enhanced long-term growth of the F1 offspring. The offspring were significantly heavier by one week of age and the difference was sustained to 10 weeks of age. Consistent with their augmented growth, plasma IGF-I concentration of the F1 progeny was increased significantly. The pituitary gland of the offspring was significantly heavier, and contained an increased number of somatotropes (cells producing GH) and lactotrophs (prolactin-secreting cells), and is indicative of an alteration in cell lineages. These unique findings demonstrate that enhanced GHRH expression in pregnant dams can result in intergenerational growth promotion, by altering development of the pituitary gland in the offspring.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: July 31, 2007
    Assignee: Baylor College of Medicine
    Inventors: Ruxandra Draghia-Akli, Amir Khan
  • SPINE IRRITATION RELIEF AND DEGENERATION AVOIDANCE/REVERSAL APPARATUS AND METHOD
    Publication number: 20070173801
    Abstract: A system and a method for the relief of pain/irritation of the spine or for the prevention of degeneration of the spine. The system is designed to facilitate creep in the human spine in a way that can be self-administered and with which patients will readily comply. The apparatus comprises a base, an inclinable support surface pivotably connected to the base, said support surface capable of supporting the upper body of the person in a prone position, a support member coupled to the base and the support surface, and an actuator coupled to the support member for controlling the angle of inclination of the support surface to promote distraction of the spine. The method comprises positioning a person on the support surface and adjusting the angle of inclination thereof so that the device supports the upper body of the person and gravity causes distraction of the spine.
    Type: Application
    Filed: July 27, 2006
    Publication date: July 26, 2007
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventor: John HIPP
  • Method and apparatus for reducing preterm labor using neuromodulation
    Publication number: 20070167992
    Abstract: The present invention includes an apparatus, kit and method for providing neural stimulation to reduce preterm labor contractions and thereby reduce subsequent preterm births. The present invention includes one or more implantable electrodes adapted for electrical communication with one or more sacral nerve roots and an electrical energy generator to produce one or more electrical signals in electrical communication with the one or more implantable electrodes.
    Type: Application
    Filed: January 18, 2006
    Publication date: July 19, 2007
    Applicant: Baylor Research Institute
    Inventor: Michael Carley
  • Treating anemia in subjects by administration of plasmids encoding growth hormone releasing hormone
    Patent number: 7241744
    Abstract: The present invention pertains to compositions and methods for plasmid-mediated supplementation. The compositions and method are useful for retarding the growth of the tumor, and retarding cachexia, wasting, anemia and other effects that are commonly associated in cancer bearing animals. Overall, the embodiments of the invention can be accomplished by delivering an effective amount of a nucleic acid expression construct that encodes a GHRH or functional biological equivalent thereof into a tissue of an animal and allowing expression of the encoded. gene in the animal. For example, when such a nucleic acid sequence is delivered into the specific cells of the tissue specific constitutive expression is achieved.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: July 10, 2007
    Assignees: Baylor College of Medicine, ADViSYS, Inc.
    Inventors: Ruxandra Draghia-Akli, Robert H. Carpenter, Douglas R. Kern, Robert J. Schwartz, Glen King, Kevin Hahn, Malcolm K. Brenner
  • Modification of medical prostheses
    Patent number: 7238363
    Abstract: The incorporation of one or more therapeutic agents on metallic and non-metallic medical prostheses is provided. The therapeutic agent can be used, for example, to prevent, treat, or reduce bacterial and fungal infections associated with these implants. Additionally, the therapeutic agents can be used to effect other therapeutic benefits. Specifically, a bilayer therapeutic coating is applied in two steps. Additionally, non-antimicrobial therapeutic agents may be incorporated in this coating to treat, prevent, modify, or stimulate certain clinical bioactivities.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: July 3, 2007
    Assignee: Baylor College of Medicine
    Inventors: Mohammad D. Mansouri, Rabih O. Darouiche
  • Identification of oligoadenylate synthetase-like genes
    Patent number: 7232678
    Abstract: The present invention relates to compositions and methods for modulating conception in animals. More particularly, the composition modulates mRNA degradation during gametogenesis and early development. Yet further, the present invention relates to pharmaceutical compositions and methods for modulating diseases of the reproductive organs, such as hyperproliferative diseases.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: June 19, 2007
    Assignees: Wyeth, Baylor College of Medicine
    Inventors: Martin M. Matzuk, Yuchen Bai, Wei Yan
  • Diagnosis of systemic onset juvenile idiopathic arthritis through blood leukocyte microarray analysis
    Publication number: 20070134690
    Abstract: The present invention includes compositions, systems and methods for the early detection and consistent determination of systemic onset juvenile idiopathic arthritis (SoJIA) using microarrays.
    Type: Application
    Filed: October 6, 2006
    Publication date: June 14, 2007
    Applicant: Baylor Research Institute
    Inventors: Maria Pascual, Jacques Banchereau, Damien Chaussabel, Florence Allantaz
  • Oncohumouse
    Publication number: 20070118914
    Abstract: The present invention includes a model system and use of the same for the study, manipulation and focusing of the human immune in a mammal, e.g., a nonhuman mammal that is immune deficient with one or more human hematopoietic progenitor cells and one or more human tumor cell lines.
    Type: Application
    Filed: October 6, 2006
    Publication date: May 24, 2007
    Applicant: Baylor Research Institute
    Inventors: Jacques Banchereau, Anna Palucka
  • P38 MAPK pathway predicts endocrine-resistant growth of human breast cancer and provides a novel diagnostic and treatment target
    Patent number: 7217533
    Abstract: Acquired and de novo endocrine resistance are major clinical problems in the management of breast cancer patients. Though the antiestrogen tamoxifen prolongs disease-free and overall survival in the adjuvant setting, and induces remissions in over half of the patients with estrogen receptor positive metastatic disease, all patients eventually acquire tamoxifen resistance. Furthermore, many of the resistant tumors actually appear to be stimulated by tamoxifen just as they are by estrogens. The present invention provides methods of predicting endocrine resistance comprising detecting the biological activity and/or expression of p38 MAPK and/or AIB1. The invention further provides methods of reducing, reversing, or preventing endocrine resistance comprising contacting a breast or prostate tumor with a p38 MAPK pathway inhibitor.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: May 15, 2007
    Assignee: Baylor College of Medicine
    Inventors: C. Kent Osborne, Rachel Schiff, Jiang Shou
  • Incorporation of antimicrobial combinations onto devices to reduce infection
    Publication number: 20070093894
    Abstract: This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of the medical device, a bactericidal coating layer, wherein the bactericidal coating layer comprises a bactericidal agent; and applying to at least a portion of the surface of the medical device, a bacteriostatic coating, wherein the bacteriostatic coating layer comprises a bacteriostatic agent wherein the combination of the bactericidal and bacteriostatic agents are in an effective concentration to inhibit growth of microbial organisms relative to an uncoated medical device. The two antimicrobial agents are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat or flush medical devices prior to or after implantation in a mammal.
    Type: Application
    Filed: October 25, 2006
    Publication date: April 26, 2007
    Applicants: Baylor College of Medicine, Gov. of the USA As Represented by the Secretary of the Dept. of Health and Human Services
    Inventor: Rabih Darouiche
  • Method and machine for identifying a chemical compound
    Patent number: 7206700
    Abstract: The present invention is designed to efficiently calculate isotopic distribution in order to simulate mass spectra data for any chemical compound of interest. The simulated spectra considers the various isotopes of the compound based upon a probability calculation that takes into consideration the natural abundance of each isotope of individual elements of the compound. The probability calculation generates a relative probability associated with each isotope species of the subject compound. The simulated spectra are displayed on an x-y coordinate illustrating the calculated formula weight on the abscissa (x-axis) and the intensity of the specific species on the ordinate (y-axis). This theoretical data is then compared to experimental data taken from a mass spectrometer in order to identify the chemical compound at issue.
    Type: Grant
    Filed: July 25, 2005
    Date of Patent: April 17, 2007
    Assignee: Baylor University
    Inventors: Florin Aniel Neacsu, David Eugene Pennington
  • Micro-loading device
    Publication number: 20070080064
    Abstract: An electrophoresis gel sample loader and method for making the same is disclosed. One embodiment includes the electrophoresis gel sample loader comprising a loader having a backing material and a plurality of porous sample holders mounted on the backing material. The porous sample holders retain a sample by absorption. In addition, the electrophoresis gel sample loader further includes a mounting layer comprising a plurality of dividers. At least one divider is disposed laterally to a porous sample holder.
    Type: Application
    Filed: October 12, 2005
    Publication date: April 12, 2007
    Applicant: Baylor College of Medicine
    Inventors: Michael Swank, Gang-Yi Wu