Patents Assigned to Baylor
  • Method for synthesis of N-homocysteine thiolactonyl retinamide
    Patent number: 6054595
    Abstract: The present invention describes a method of organic synthesis for N-homocysteine thiolactonyl retinamide, a compound that has anticancer and antiatherogenic properties.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: April 25, 2000
    Assignee: Baylor University
    Inventors: Michal Kazimir, F. Ray Wilson, II
  • Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
    Patent number: 6048695
    Abstract: The invention relates to novel chemically modified nucleic acids with enhanced lability towards solid supports, such as glass. These modified nucleic acids can be readily affixed to solid supports, for instance, a glass surface, without first derivatizing the glass surface. High-density microarrays based on these modified nucleic acids as well as methods for preparing these microarrays are also useful.
    Type: Grant
    Filed: May 4, 1998
    Date of Patent: April 11, 2000
    Assignee: Baylor College of Medicine
    Inventors: Allan Bradley, Wei Wen Cai
  • Monoclonal antibody for diagnostic and therapeutic use in ovarian cancer
    Patent number: 6048528
    Abstract: A method for the diagnosis and treatment of ovarian cancer. Tissue and body fluid samples are assayed for an antigen which specifically binds an anti-OSE antigen to diagnose ovarian cancer. Therapeutic agents coupled to anti-OSE antibodies, such as PS1 are specifically directed to ovarian cancer tissues.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: April 11, 2000
    Assignee: Baylor College of Medicine
    Inventor: Bonita S. Dunbar
  • Tyramine compounds and their neuronal effects
    Patent number: 6043283
    Abstract: The present invention describes, inter alia, methods for using tyramine compounds to inhibit the toxic effects of neurotoxins, to treat and diagnose neurodegenerative diseases and disorders, and to identify compounds that inhibit the toxic effects of neurotoxins.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: March 28, 2000
    Assignee: Baylor College of Medicine
    Inventor: Dana J. Giulian
  • Nucleic acid transporter systems and methods of use
    Patent number: 6033884
    Abstract: Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.
    Type: Grant
    Filed: December 14, 1993
    Date of Patent: March 7, 2000
    Assignee: Baylor College of Medicine
    Inventors: Savio L. C. Woo, Louis C. Smith, Richard J. Cristiano, Stephen Gottchalk, Jim Sparrow
  • Sulfonylurea receptor trangenic rodents
    Patent number: 6031150
    Abstract: The present invention is directed to a method of detecting persistent hyperinsulinemic hypoglycemia of infancy comprising obtaining a sample comprising patient nucleic acids from a patient tissue sample; amplifying sulfonylurea receptor specific nucleic acids from said patient nucleic acids to produce a test fragment; obtaining a sample comprising control nucleic acids from a control tissue sample; amplifying control nucleic acids encoding wild type sulfonylurea receptor to produce a control fragment; comparing the test fragment with the control fragment to detect the presence of a sequence difference in the test fragment, wherein a difference in said test fragment indicates persistent hyperinsulinemic hypoglycemia of infancy. A diagnostic kit and primers for the detection of persistent hyperinsulinemic hypoglycemia of infancy are also within the scope of the present invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 29, 2000
    Assignee: Baylor College Of Medicine
    Inventors: Joseph Bryan, Lydia Aguilar Bryan, Daniel Nelson
  • Methods and composition for identifying group a streptococcus
    Patent number: 6030835
    Abstract: Methods and compositions are provided for identifying a group A Streptococcus in any of a variety of physiological samples, such as blood, saliva, throat swabs, cerebrospinal fluid, brocheolar lavage material, and biopsy material. The positions used include an extracellular cysteine protease or a fragment thereof, obtainable from S. pyogenes and containing at least one conserved epitope, or nucleic acid encoding the cysteine protease or fragment thereof. The compositions also find use in eliciting a protective immune response against a group A streptococcus infection.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: February 29, 2000
    Assignee: Baylor College of Medicine
    Inventors: James M. Musser, Vivek Kapur
  • Myocardial perfusion imaging during coronary vasodilation with selective adenosine A.sub.2 receptor agonists
    Patent number: 6026317
    Abstract: Potent pharmacological coronary vasodilators, of the family of compounds represented by the known compound CGS-21680, as an adjunct in the detection of coronary artery disease form the basis of this application.
    Type: Grant
    Filed: February 6, 1998
    Date of Patent: February 15, 2000
    Assignee: Baylor College of Medicine
    Inventor: Mario S. Verani
  • Systems for surface-enhanced affinity capture for desorption and detection of analytes
    Patent number: 6020208
    Abstract: This invention is directed to systems containing probes for presenting an analyte to an energy source for desorption in methods of analytic detection, such as mass spectrometry. The probes have an immobilized affinity reagent which binds the analyte on their presenting surface.
    Type: Grant
    Filed: November 27, 1995
    Date of Patent: February 1, 2000
    Assignee: Baylor College of Medicine
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Mutation detection by competitive oligonucleotide priming
    Patent number: 6015675
    Abstract: The present invention relates to a process for the rapid and simple detection of mutations in DNA and differences between DNA sequences. This competitive oligonucleotide priming system can be used for the detection of any differences between DNA sequences for which a DNA sequence is known.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: January 18, 2000
    Assignee: Baylor College of Medicine
    Inventors: Charles Thomas Caskey, Richard A. L. Gibbs
  • Assay for detecting apoptotic cells
    Patent number: 6013438
    Abstract: The invention relates to the detection of apoptotic cells using a novel assay that employs ligation of DNA fragments in situ to selectively label apoptotic cells. The assay may be used in combination with known in situ methodologies to simultaneously detect apoptotic cells and specific biomolecules present in the apoptotic cell.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: January 11, 2000
    Assignee: Baylor College of Medicine
    Inventors: Vladimir Didenko, Peter Hornsby
  • Laminates of glass or metal and poly(alkylene dicarboxylates) and syntheses thereof
    Patent number: 6011133
    Abstract: Poly(alkylene dicarboxylate) polymers and copolymers having tetraalkyl- or trialkylammonium ion end groups and methods of synthesis, thereof. The methylene-containing copolymers, in general, adhere to glass and metals, including aluminum, iron, and copper. Poly(methylene-co-ethylene terephthalate) is a clear film useful in the protection of metals or glass from corrosion or scratching. Glass may be bound to glass or to metal using the polymers of the present invention or metal to metal seals may be made.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: January 4, 2000
    Assignee: Baylor University
    Inventors: A. G. Pinkus, Rajan Hariharan
  • Nucleic acid transporter system and methods of use
    Patent number: 5994109
    Abstract: Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.
    Type: Grant
    Filed: June 3, 1995
    Date of Patent: November 30, 1999
    Assignee: Baylor College of Medicine
    Inventors: Savio L. C. Woo, Louis C. Smith, Richard J. Cristiano, Stephen Gottchalk, Jim Sparrow
  • Gene therapy for muscular dystrophy
    Patent number: 5985846
    Abstract: A gene transfer vector comprising adenovirus inverted terminal repeats, recombinant adenovirus particles containing the same, a method for producing the same and a method of use of the same to introduce and express a foreign gene in eukaryotic cells, and to treat muscular dystrophy, is disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 16, 1999
    Assignees: Baylor College of Medicine, Howard Hughes Medical Institute
    Inventors: Stefan Kochanek, C. Thomas Caskey, Kohnosuke Mitani, Paula R. Clemens
  • Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
    Patent number: 5981225
    Abstract: A gene transfer vector comprising adenovirus inverted terminal repeats, at least one adenovirus packaging signal, and an adenoviral VAI gene and/or VAII gene; recombinant adenovirus particles containing the same; a method for producing the same and a method of use of the same to introduce and express a foreign gene in adenovirus target cells, is disclosed.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: November 9, 1999
    Assignee: Baylor College of Medicine
    Inventors: Stefan Kochanek, Gudrun Schiedner
  • Monoclonal antibodies specific for human interleukin-5
    Patent number: 5976821
    Abstract: Monoclonal antibodies which specifically bind to human interleukin-5 (IL-5) are described. The antibodies can be used in assays for IL-5, to purify IL-5, or to characterize IL-5.
    Type: Grant
    Filed: October 24, 1995
    Date of Patent: November 2, 1999
    Assignee: Baylor College of Medicine
    Inventors: David P. Huston, Richard R. Dickason, Marilyn M. Huston
  • Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor
    Patent number: 5968989
    Abstract: In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid receptors, employing high affinity, high specificity ligands for such receptors. In one aspect of the present invention, there are provided ligands which are more selective for the retinoid X receptor than is retinoic acid (i.e., rexoids). In another aspect of the present invention, alternative ligands (other than retinoic acid) have been discovered which are capable of inducing retinoic acid receptor mediated processes. In yet another aspect, methods have been developed for the preparation of such retinoid receptor ligands from readily available compounds.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 19, 1999
    Assignees: The Salk Institute for Biological Studies, Baylor College of Medicine, Ligand Pharmaceuticals, Inc.
    Inventors: Ronald M. Evans, David J. Mangelsdorf, Richard A. Heyman, Marcus F. Boehm, Gregor Eichele, Christina Thaller
  • Polynucleotides encoding urogenital sinus derived growth inhibitory factor and vectors
    Patent number: 5958735
    Abstract: Urogenital sinus derived growth inhibitory factor is a protein having growth-inhibitory and antiprotease properties. The present invention relates to amino acid and nucleotide sequences for urogenital sinus derived growth inhibitory factor.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: September 28, 1999
    Assignee: Baylor College of Medicine
    Inventor: David R. Rowley
  • Specific expression vectors and methods of use
    Patent number: 5958764
    Abstract: Gene therapy by using specific expression vectors within the epidermis or epidermal cells. These vectors incorporate regulatory sequences of tissue and differentiation-specific genes.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: September 28, 1999
    Assignee: Baylor College of Medicine
    Inventors: Dennis R. Roop, Joseph A. Rothnagel, David A. Greenhalgh
  • Detection of brain hematoma
    Patent number: 5954053
    Abstract: Systems are shown that utilize differential measurement of radiation that has migrated through migration paths between two source-detector pairs placed on the head in a manner that each path is localized in a portion of one hemisphere of the brain. Various spectrophotometer systems are also shown for in vivo examination of tissue of a human by measuring changes in electromagnetic radiation scattered and absorbed in a migration path in the tissue. Generally, the spectrophotometer systems comprise a light source for introducing the radiation into the tissue, a detector for detecting radiation that has migrated in the tissue, a processor for processing signals of the detected radiation to create processed data, and a system for determining physiological or pathophysiological changes in the tissue of interest such as bleeding or tumor.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 21, 1999
    Assignees: Non-Invasive Technology, Inc., Baylor College of Medicine
    Inventors: Britton Chance, Claudia Robertson