Patents Assigned to Baylor
  • SYSTEM AND METHOD FOR A MULTI-PRIMARY WIDE GAMUT COLOR SYSTEM
    Publication number: 20230326386
    Abstract: The present invention includes systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Application
    Filed: June 16, 2023
    Publication date: October 12, 2023
    Applicant: Baylor University
    Inventors: James M. DeFilippis, Gary B. Mandle
  • TARGETING LIGANDS FOR TAU PATHOLOGY
    Publication number: 20230324411
    Abstract: Methods and compositions for detecting tau pathology are described. The compositions for detecting tau pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject.
    Type: Application
    Filed: February 1, 2023
    Publication date: October 12, 2023
    Applicants: Texas Children's Hospital, Baylor College of Medicine
    Inventors: Parag Parekh, Ananth Annapragada
  • Animal Motion Simulator
    Publication number: 20230320323
    Abstract: The present invention provides a mechanical apparatus that simulates animal movement with a high degree of accuracy. In at least some embodiments, the mechanical apparatus uses interlinked multiple four-bar linkages to provide nonlinear compound movement. Multiple four-bar linkages may be progressively linked to other four-bar linkages to produce such compound movement. The current invention improves the realism of the animal mannequin motion by using.
    Type: Application
    Filed: April 7, 2023
    Publication date: October 12, 2023
    Applicant: BAYLOR UNIVERSITY
    Inventor: Brian A. GARNER
  • Methods and compositions for the amplification of mRNA
    Patent number: 11781178
    Abstract: Provided herein are compositions and methods for the synthesis, amplification, and in vitro transcription of full-length cDNA, or cDNA fragments. Methods are provided for reverse transcription of RNA and amplification for in vitro transcription. Further provided are method for loading of dendritic cells with the RNA and homologous lysate for immune stimulation.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: October 10, 2023
    Assignee: Baylor College of Medicine
    Inventors: William K. Decker, Vanaja Konduri
  • System and method for a multi-primary wide gamut color system
    Patent number: 11783749
    Abstract: Systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Grant
    Filed: March 25, 2022
    Date of Patent: October 10, 2023
    Assignee: BAYLOR UNIVERSITY
    Inventors: Mitchell J. Bogdanowicz, Gary B. Mandle
  • SYSTEM AND METHOD FOR A MULTI-PRIMARY WIDE GAMUT COLOR SYSTEM
    Publication number: 20230290291
    Abstract: Systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Application
    Filed: May 10, 2023
    Publication date: September 14, 2023
    Applicant: Baylor University
    Inventors: Mitchell J. Bogdanowicz, Ph.D., Corey P. Carbonara, Ph.D., Michael F. Korpi, James M. DeFilippis, Gary B. Mandle
  • Trocars
    Patent number: 11751759
    Abstract: One aspect of the invention provides a trocar including: a central cylinder defining a central channel and having a distal end adapted and configured for insertion within a subject; one or more gas outlets located within the central cylinder proximate to the distal end of the trocar; and one or more liquid outlets located within the central cylinder on a proximal side of the one or more gas outlets. The one or more liquid outlets are adapted and configured to dispense a liquid when an endoscope is withdrawn from a fully extended position within the central channel of the trocar to a position proximate to the one or more liquid outlets. Distal advancement of the endoscope to a position adjacent to the one or more gas outlets removes liquid from a distal end of the endoscope.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: September 12, 2023
    Assignees: Baylor College of Medicine, Texas Heart Institute
    Inventors: Bryan M. Burt, Mahmood Khan, William Cohn
  • SYSTEM AND METHOD FOR A MULTI-PRIMARY WIDE GAMUT COLOR SYSTEM
    Publication number: 20230282147
    Abstract: The present invention includes systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Application
    Filed: May 11, 2023
    Publication date: September 7, 2023
    Applicant: Baylor University
    Inventors: Mitchell J. Bogdanowicz, Corey P. Carbonara, Michael F. Korpi, James M. DeFilippis, Gary B. Mandle
  • Helper-dependent adenoviral gene therapy delivery and expression system
    Patent number: 11746359
    Abstract: The present invention relates to gene therapy delivery and expression systems comprising at least one helper-dependent adenoviral vector containing a nucleic acid sequence encoding for proteoglycan 4 (PRG4) or a biologically active fragment thereof. The invention further relates to a pharmaceutical composition comprising a therapeutically effective amount of at least one helper-dependent adenoviral vector containing said nucleic acid sequence encoding for proteoglycan 4 (PRG4), or a homolog thereof from any other species, or a biologically active fragment thereof. The invention also relates to the use of the novel gene therapy delivery and expression system according to the invention for use in the prevention and/or treatment of camptodactyly-arthropathy-coxa vara-pericarditis (CACP), or a musculoskeletal disorder such as a joint disorder or joint disease.
    Type: Grant
    Filed: April 1, 2022
    Date of Patent: September 5, 2023
    Assignee: Baylor College of Medicine
    Inventors: Merry Ruan, Kilian Guse, Brendan Lee
  • Benefits of supplementation with n-acetylcysteine and glycine to improve glutathione levels
    Patent number: 11730711
    Abstract: Compositions and methods are related to utilizing glycine and N-acetylcysteine for a variety of medical conditions related to reduced levels of glycine, N-acetylcysteine, and/or glutathione, for example, muscle loss such as sarcopenia, HIV infection and other infections, organ damage such as those from diabetes and insulin resistance and diabetic nephropathy, cardiac function and failure such as preventing or improving heart failure, fatty liver, cancer prevention, and other conditions.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: August 22, 2023
    Assignees: Baylor College of Medicine, Societe de Produits Nestle S.A.
    Inventors: Stephen Kirnon, Eric Freedland, Rajagopal V. Sekhar
  • DESIGN OF 3D-PRINTED NASOPHARYNGEAL SWABS
    Publication number: 20230255606
    Abstract: Improved nasopharyngeal swabs for COVID-19 or other molecular diagnostic testing are discussed herein. Swab designs for adult use are not suitable for pediatric use. Swabs for pediatric use need to be smaller and more flexible to navigate delicate pediatric nasopharyngeal cavities. A novel use of maxillofacial CT scans to aid in the design of pediatric nasopharyngeal swabs satisfying such criteria is discussed. Further, the novel swabs are also suitable for 3D printing.
    Type: Application
    Filed: July 21, 2021
    Publication date: August 17, 2023
    Applicants: BAYLOR COLLEGE OF MEDICINE, TEXAS CHILDREN’S HOSPITAL
    Inventors: Zbigniew Starosolski, Prasad Admane, James Dunn, Brent Kaziny, Ananth Annapragada
  • SYSTEM AND METHOD FOR A MULTI-PRIMARY WIDE GAMUT COLOR SYSTEM
    Publication number: 20230260444
    Abstract: The present invention includes systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Application
    Filed: April 14, 2023
    Publication date: August 17, 2023
    Applicant: Baylor University
    Inventors: Mitchell J. Bogdanowicz, Ph.D., Corey P. Carbonara, Ph.D., Michael F. Korpi, James M. DeFilippis, Gary B. Mandle
  • CSGP4—specific chimeric antigen receptor for cancer
    Patent number: 11725061
    Abstract: Embodiments of the disclosure include methods and compositions related to chimeric antigen receptors (CAR) that target chondroitin sulfate proteoglycan-4 (CSPG4). T cells transduced with a CSPG4-specific CAR are effective for inhibition of particular cancer cells that express CSPG4. In certain embodiments, the cancer is melanoma, breast cancer, head and neck cancer, mesothelioma, glioblastoma, or renal cancer.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: August 15, 2023
    Assignees: The General Hospital Corporation, Baylor College of Medicine
    Inventors: Gianpietro Dotti, Soldano Ferrone
  • Reversing the effects of the tumor microenvironment using chimeric cytokine receptors
    Patent number: 11717538
    Abstract: The present invention concerns compositions and methods related to approaches to render ineffective Th1 T cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. In particular embodiments, tumor-specific T cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a Th1 immunostimulaotyr/activating signal. In specific embodiments, the T cells employ a chimeric antigen receptor having exodomains for IL10, IL13 and/or IL4 fused with the signal transducing endodomains for IL2 and/or IL7.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: August 8, 2023
    Assignee: Baylor College of Medicine
    Inventors: Ann Marie Leen, Juan F. Vera
  • System and method for a multi-primary wide gamut color system
    Patent number: 11721266
    Abstract: Systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.
    Type: Grant
    Filed: July 29, 2022
    Date of Patent: August 8, 2023
    Assignee: BAYLOR UNIVERSITY
    Inventors: Gary B. Mandle, James M. DeFilippis, Mitchell J. Bogdanowicz, Corey P. Carbonara, Michael F. Korpi
  • Human liver chimeric mouse with deficient P450 oxidoreductase
    Patent number: 11716974
    Abstract: The present disclosure provides a chimeric non-human animal comprising human hepatocytes, methods for preparing the chimeric non-human animal comprising human hepatocytes and methods of utilizing the chimeric non-human animal comprising human hepatocytes to screening and identifying metabolites for any type of drugs, typically small molecule drugs, which might affect human liver functions and any other bodily function.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: August 8, 2023
    Assignee: Baylor College of Medicine
    Inventors: Karl-Dimiter Bissig, Maria de las Mercedes Barzi Dieguez, Peter Francis Pankowicz
  • Vaccines against HPV and HPV-related diseases
    Patent number: 11717567
    Abstract: Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: August 8, 2023
    Assignee: Baylor Research Institute
    Inventors: SangKon Oh, Sandra Zurawski, Gerard Zurawski
  • SMART MEDBED
    Publication number: 20230240923
    Abstract: One aspect of the invention provides a self-contained patient-bed-and-headboard assembly including: a patient bed and a headboard. The patient bed includes: a central region; a head region hingedly attached to the central region; and a foot region hingedly attached to the foot region. Both the head region and the foot region can rotate between: a first position in which the head region and the foot region are substantially upright; and a second position in which the head region and the foot region are coplanar. Both the head region and the foot region each comprise one or more lateral attachment points. The headboard includes one or more complementary attachments points adapted and configured to engage with the one or more lateral attachment points of the head region and the foot region of the patient bed when in the first position.
    Type: Application
    Filed: August 30, 2021
    Publication date: August 3, 2023
    Applicant: Baylor College of Medicine
    Inventor: Sharmila Anandasabapathy
  • Systems and methods for wireless treatment of arrhythmias
    Patent number: 11712559
    Abstract: Wireless treatment of arrhythmias. At least some of the example embodiments are methods including: charging a capacitor of a first microchip device abutting heart tissue, the charging by harvesting ambient energy; charging a capacitor of a second microchip device abutting the heart tissue, the charging of the capacitor of the second microchip device by harvesting ambient energy; sending a command wirelessly from a communication device outside the rib cage to the microchip devices; applying electrical energy to the heart tissue by the first microchip device responsive to the command, the electrical energy applied from the capacitor of the first microchip device; and applying electrical energy to the heart tissue by the second microchip device responsive to the command to the second microchip device, the electrical energy applied from the capacitor of the second microchip device.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: August 1, 2023
    Assignees: William Marsh Rice University, Texas Heart Institute, Baylor College of Medicine
    Inventors: Yuxiang Sun, Aydin Babakhani, Mehdi Razavi, David Burkland, Brian Greet, Mathews John, Hongming Lyu
  • Multipoint wireless network
    Patent number: 11716136
    Abstract: Disclosed systems and methods configure a plurality of wireless access points to perform probe request handling operations including, responsive to receiving a probe request from a mobile device, relaying the probe request to a network controller, and responsive to receiving a probe response from the network controller, relaying the probe response to the mobile device. The network controller is configured to provide the mobile device with a multipoint wireless network by identifying two or more of the plurality of wireless access points as selected access points for multipoint transmission with the mobile device, coordinating the selected access points to allow simultaneous transmissions to the mobile device from each of the selected access points, and forwarding a probe response indicative of the selected access points to the selected access points.
    Type: Grant
    Filed: November 17, 2021
    Date of Patent: August 1, 2023
    Assignee: Baylor University
    Inventors: Liang Dong, Jonathan Hu, Yang Li