Abstract: The present invention provides iRNA agent including at least one monomer having the structure shown in formula (I?) wherein: A and B are each independently for each occurrence O, N(RN) or S; X is H, a protecting group, a phosphate group, a phosphodiester group, an activated phosphate group, an activated phosphite group, a phosphoramidite, a solid support, —P(Z?)(Z?)O-nucleoside, —P(Z?)(Z?)O-oligonucleotide, a lipid, a PEG, a steroid, a polymer, —P(Z?)(Z?)O-L6-Q?-L7-OP(Z??)(Z??)O-oligonucleotide, a nucleotide, or an oligonucleotide; Y is H, a protecting group, a phosphate group, a phosphodiester group, an activated phosphate group, an activated phosphite group, a phosphoramidite, a solid support, —P(Z?)(Z?)O-nucleoside, —P(Z?)(Z?)O-oligonucleotide, a lipid, a PEG, a steroid, a lipophile, a polymer, —P(Z?)(Z?)O-L6-Q?-L7-OP(Z??)(Z??)O-oligonucleotide, a nucleotide, or an oligonucleotide; R is folate, a folate analog a folate mimic or a folate receptor binding ligand; L6 and L7 are each independently for e

Abstract: The present disclosure describes a system and method for securing medical devices to the tissue of a patient using one or more anchors. Anchors can be independent from or integral to the medical device deployed within the patient. Such anchors are configured to engage and maintain contact with the tissue using a tissue-penetrating point and bendable shaft.

Abstract: A variety of methods and arrangements are described for selectively reducing intake manifold pressure in a skip fire engine control system. In some embodiments, a throttle is adjusted to generate a manifold vacuum, which is used for various applications, including but not limited to purging a fuel vapor canister, reducing pressure within a brake vacuum booster reservoir and/or venting gas from a crankcase interior. An engine firing fraction is increased to help maintain a desired torque level. Other techniques for reducing the intake manifold pressure are also described, such as applications involving a return to idle.

Abstract: A LED driving device adapted to driving N LED strings connected in series is provided. N is a positive integer greater than 1. The LED driving device includes (N?1) switch units, a current source, a detection unit and a control unit. The ith switch unit electrically connects to the (i+1) LED string in parallel or to the ith LED string in parallel, and 0<i?(N?1). The current source supplies a driving current to drive the N LED strings. The detection unit outputs a detection signal according to a voltage of the current source, a first reference voltage and a second reference voltage. The control unit outputs a plurality of first control signals according to the detection signal to dynamically control an amount of the (N?1) switch units turned on.

Abstract: Methods for producing implantable bone compositions suitable for attaching stem cells thereto, characterized in that bone particles are contacted with an albumin comprising solution. Said bone particles can be mineralized and/or lyophilized bone particles of animal or human origin. Preferably the non-immunogenic albumin comprising solution is lyophilized onto said bone particles. The invention further concerns bone compositions suitable for usin in graft implantation obtainable by said methods.

Abstract: Systems, computer implemented methods, and computer readable medium having program products are provided to customize by a user weather-risk products and to provide a customized weather-risk product to be purchased by user. Embodiments of a system include a tract-user computer having a display to display graphical user interfaces to a user and an input to receive user selections, the tract-user computer being connected to a communications network to receive graphical user interfaces and transmit user selections to a weather-risk product issuer computer. Embodiments of a system can also include a database to associate user selections with actuarial data, location data, and basis weather data and a weather-risk product issuer computer to transmit graphical user interfaces to the tract-user computer, receive user selections, and process user selections to generate virtual weather data and to generate weather-risk products.

Abstract: Solid state lighting (“SSL”) devices with improved contacts and associated methods of manufacturing are disclosed herein. In one embodiment, an SSL device includes an SSL structure having a first semiconductor material, a second semiconductor material spaced apart from the first semiconductor material, and an active region between the first and second semiconductor materials. The SSL device also includes a first contact on the first semiconductor material and a second contact on the second semiconductor material, where the first and second contacts define the current flow path through the SSL structure. The first or second contact is configured to provide a current density profile in the SSL structure based on a target current density profile.

Abstract: A computing multi-magnet device and method for solving complex computational problems is provided. Embodiments include a first magnet, a second magnet, and an interconnect between and interconnecting the first and second magnets, the interconnect configured to allow the first and second magnets to communicate via a voltage or current applied to the first and second magnet and conducted by the interconnect. The scalability of computing multi-magnet device provides solutions to algorithms that have exponentially increasing complexity.

Abstract: The current invention relates to a sunlight readable full color active matrix liquid crystal display devices. By means of a novel Directional Light Guiding (DLG) film structure, both the internal backlight and the external sunlight can be used synergistically for lighting the display so as to deliver superior readability and color quality. A seamless transition between indoor and outdoor applications makes the vivid true color display an ideal solution to portable electronics.

Abstract: A substrate processing system including a load port module configured to hold at least one substrate container for storing and transporting substrates, a substrate processing chamber, an isolatable transfer chamber capable of holding an isolated atmosphere therein configured to couple the substrate processing chamber and the load port module, and a substrate transport mounted at least partially within the transfer chamber having a drive section fixed to the transfer chamber and having a SCARA arm configured to support at least one substrate, the SCARA arm being configured to transport the at least one substrate between the at least one substrate container and the processing chamber with but one touch of the at least one substrate, wherein the SCARA arm comprises a first arm link, a second arm link, and at least one end effector serially pivotally coupled to each other, where the first and second arm links have unequal lengths.

Abstract: A semiconductor chip package is fabricated including providing a compliant layer over a contact bearing face of a semiconductor chip, with a bottom surface of the compliant layer adjacent that chip face, a top surface facing away from the bottom surface, and at least one sloping surface extending between the top and bottom surfaces. Bond ribbons can be formed atop the compliant layer, each bond ribbon electrically coupling one of the contacts with an associated conductive terminal at the top surface of the compliant layer. A bond ribbon can include a strip extending along the sloping surface. The strip may have a substantially constant thickness in a direction away from the sloping surface.

Abstract: The present invention is directed to the compound 2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, its use as an inhibitor of stearoyl CoA desaturase and to pharmaceutical compositions containing this compound.

Abstract: An incrementally-sized dishware system and method for weight management gradually modifies food portion consumption behavior to provide healthier eating habits. The incrementally-sized dishware system and method includes a plurality of incrementally-sized plates having successively differentiated plate surface areas. Each of the incrementally-sized plate surface areas is successively different by an increment to modify food portion delivery to a user. When utilizing the incrementally-sized dishware system and method a user selects a starting plate surface area based on a combination of weight management factors, and over time successively shifts to plates having smaller/larger plate surface areas. Interval changes between the dishes of the incrementally-sized dishware system and method adjust the amount of food consumed and rate of weight loss over time.

Abstract: The present invention relates to separation of desired target products from biological, plant, and waste-type material, wherein the desired target products include renewable fuels such as ethanol, biobutanol, and biodiesel, wherein the separation is conducted with a cross-flow filtration system having the ability to separate desired products from both non-viscous and viscous medium.

Abstract: Method and system for treating a patient using a compressible, pressure-attenuating device. According to one embodiment, the system is used to treat urinary tract disorders and comprises an access device, a delivery device, a pressure-attenuating device, and a removal device. The access device may be used to create a passageway to an anatomical structure, such as the patient's bladder. The delivery device may be inserted through the passageway created by the access device and may be used to deliver the pressure-attenuating device to the anatomical structure. The removal device may be inserted through the passageway created by the access device and may be used to view the bladder and/or to capture, to deflate and to remove the pressure-attenuating device.

Abstract: A portable electronic device includes a main body and a heat dissipation module with a tiltedly installed centrifugal fan inside thereof. The main body includes an upper housing wall and a lower housing wall. The heat dissipation module includes a centrifugal fan, a heat dissipation fin array and a heat pipe. The centrifugal fan includes an impeller, a radial air outlet, an upper axial air inlet and a lower axial air inlet, wherein the centrifugal fan has a first side that is in contact with the upper housing wall and an opposite second side that is in contact with the lower housing wall. The heat dissipation fin array is located at the radial air outlet of the centrifugal fan. The heat pipe has a first end connected with the heat dissipation fin array and a second opposite end connected with a heat source.

Abstract: A novel catalytic reactor is provided for controlling the contact of a limiting reactant with a catalyst surface. A first flow vessel defines an interior surface and an exterior surface, and the interior surface has a catalyst deposited on at least a portion thereof. A second flow vessel is positioned within the first flow vessel and the second flow vessel defines a porous surface designed to deliver a fluid uniformly to at least a portion of the interior surface of the first flow vessel.

Abstract: A system for removing selenium from a solid feed stream includes a selenium dissolver configured to selectively dissolve elemental selenium from the solid feed stream and to produce a selenium rich solution and a crystallizer coupled to the selenium dissolver and configured to receive the selenium rich solution from the dissolver, to add an acid to the selenium rich solution, to remove purified selenium from the selenium rich solution, and to remove sulfur dioxide from the selenium rich solution.

Abstract: An improved outer layer of plating comprising a binary metal alloy of gold and palladium is employed on connector contacts. The binary metal alloy is plated on at least the contact surface of the contacts. Intermediate plating layers can be applied between the outer layer of gold and palladium and the conductive base of the contacts. The binary metal alloy of gold and palladium may be configured to have a mostly gold or a mostly silver appearance, depending upon the relative concentration of gold and palladium in the binary metal alloy.

Abstract: Systems and methods are provided which perform a file level restore by utilizing existing operating system components (e.g., file system drivers) that are natively installed on the target computing device. These components can be used to mount and/or interpret a secondary copy of the file system. For instance, the system can instantiate an interface object (e.g., a device node such as a pseudo device, device file or special file) on the target client which includes file system metadata corresponding to the backed up version of the file system. The interface provides a mechanism for the operating system to mount the secondary copy and perform file level access on the secondary copy, e.g., to restore one or more selected files.