Abstract: The present invention is directed to a method of treating a fungal infection comprising administering topically, to a subject in need thereof, an anti-fungal effective amount of roflumilast. Preferably, topically administered roflumilast is used to treat fungal infections, fungal growth of and/or hypersensitivity to the fungi Malassezia spp. Patients may also be suffering from seborrheic dermatitis, dandruff, dupilumab facial redness, Tinea versicolor, Pityriasis versicolor, Tinea circinata, Tinea pedis, Tinea unguium, Tinea manus, Tinea cruris, Tinea corporis, Tinea faciei, Tinea capitis, and/or Tinea incognito. Topically administered roflumilast is a quick and effective antifungal agent and presents a viable alternative to current antifungal treatments.

Abstract: A battery control system includes a plurality of battery cells that are separately controllable as units of individual cells or groups of cells. Each controllable unit may be switchably activated or deactivated in the overall battery circuit, and one or more conditions of each controllable unit may be individually measured. Various techniques are disclosed for operating the battery control system to optimize or improve system performance and longevity.

Abstract: Provided herein are compounds, compositions, formulations, kits, uses, and methods for vaccinating a subject against Neisseria meningitidis.

Abstract: A retention system for a line on a spool is disclosed. The retention system may include a base component that includes a retention receiving element within a line-side surface of the base component. The retention system may include a line engagement component that includes an engagement surface, wherein the engagement surface includes a portion that is perpendicular to the base component to engage a line, wherein the engagement surface abuts the line-side surface. The retention system may include a removable retention component that is configured to retain the line between the engagement surface and the removable retention component when the removable retention component is installed within the retention receiving element.

Abstract: Disclosed is a LIDAR apparatus for a vehicle including a light-emitting unit configured to generate and emit laser light, a light-receiving unit configured to receive reflected light based on the laser light, at least one electronic component electrically connected to the light-emitting unit and the light-receiving unit, and a case configured to accommodate the light-emitting unit, the light-receiving unit, and the electronic component therein, wherein the case is formed of a metal material, and is in contact with at least one element included in at least one of the light-emitting unit, the light-receiving unit, or the electronic component.

Abstract: Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: A gaming system includes at least one input device adapted to receive a physical item associated with a monetary value that establishes a credit balance, an input indicative of a wager drawn on the credit balance for a wagering game, and a cashout input that initiates a payout from the credit balance. In response to a wager input, a wagering game is initiated that includes the spinning and stopping of a set of bonus reels through a plurality of bonus spins populating a bonus array with bonus symbols. The bonus reels comprise a combination of symbols reducing display processing requirements and improve mapping random numbers to displayed symbols for display during bonus spins having reduced durations. When completed, an award is determined based according to values associated with less than all of the bonus symbols displayed in a bonus outcome array.

Abstract: Embodiments herein describe using visual passwords to control access to secure information. When a user attempts to access the secure information, she can provide her username to an authentication agent which identifies the visual password corresponding to the received username and selects a first set of images that contains the visual password and a second set of images that does not. The first and second sets of images are then transmitted to a user device. The user device can display the first and second sets of images to the user who selects which images have the visual password. An indication of which images the user selected is then transmitted to the authentication engine which determines whether the user selected all the images in the first set and none of the images in the second set. If so, the user is granted access to the secure information.

Abstract: Providing access to an external application includes receiving login credentials to access a client instance, wherein the login credentials are associated with a user account, causing the client instance to provide a link to an external application in the client instance, detecting a request to navigate to the external application from the link, generating a authentication record for the user account and the external application, storing information for the user account based on the authentication record, and generating a URL for the external application based on the authentication record. Providing access to the external application also includes receiving, from a remote client device hosting the external application, an authorization request comprising nonce information, determining that the user account is authorized to access the external application based on the authentication table, and providing access to the external application.

Abstract: A smart energy storage system is described. The system includes a smart energy storage unit coupled to a selected circuit of a local electric grid, and configured for being charged so as to withdraw and store energy from the local electric grid, and discharged for supplying energy to the local electric grid. The smart energy storage unit includes an energy storage cell configured for being charged so as to withdraw and store energy from the local electric grid, and discharged for supplying energy to the local grid, and a storage cell management unit for controlling the energy storage cell.

Abstract: The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of ROR1, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.

Abstract: A combination adaptive energy absorption and emergency flotation device for positioning beneath a plurality of seat pans of a seat assembly in an aircraft seating application. The device includes a plurality of fluidly coupled inflatable elastic bladders, at least one constrictor valve fluidly coupling at least two adjacent ones of the plurality of inflatable elastic bladders allowing fluid flow therethrough in response to predetermined pressure on the device from the plurality of seat pans, and a fluid supply source fluidly coupled to the plurality of inflatable elastic bladders for outputting a positive flow of fluid to the plurality of inflatable elastic bladders, wherein the adaptive energy absorption device is detached from the plurality of seat pans to allow removal from beneath the plurality of seat pans for use as an emergency flotation device.

Abstract: An integrated seal member includes an at least partially annular body defining a longitudinal axis, a radial direction, and a circumferential direction. The at least partially annular body includes a mounting portion, a sealing portion including at least one top sealing feature and at least one bottom sealing feature, and an apertured connecting portion that extends radially outwardly from the mounting portion to the sealing portion.

Abstract: A method and a gateway system of a mobile asset are described. A voltage produced by a power system of the mobile asset is monitored by a gateway system. In response to determining that a first fluctuation occurs in the voltage produced by the power system of the mobile asset over a first interval of time, the gateway system operates in a first mode. In response to determining that a value of the voltage produced by the power system of the mobile asset is less than a voltage threshold, the gateway system automatically transitions to operating in a second mode, which is different from the first mode and causes the gateway system to consume less power than when it is operating in the first mode.

Abstract: A system is used for lifting a heavy oversized structural element. At least two opposing lifts are placement adjacent opposing sides of the element. Each lift includes a base, a tower, an elevator, and an actuator. The tower extending vertically from the base, and the elevator is disposed on the tower. A support extends from the elevator outward from the tower to engage a point on the element. A guide of the elevator is configured to ride along a rail of the tower. The actuator is connected to the elevator and is configured to move with the elevator vertically along the tower. The actuator can include a strand jack disposed on the elevator. Hydraulic operation of the stand jack moves the jack and elevator along a strand extending along the tower. The arrangements of the lifts leave space below the raised element free for access to other operations.

Abstract: Techniques for implementing event proxies in a Functions-as-a-Service (FaaS) infrastructure are provided. In one set of embodiments, a computer system implementing an event proxy can receive an event emitted by an event source, where the computer system is part of a first computing cloud including the FaaS infrastructure, and where the event source is a software service running in a second computing cloud that is distinct from the first computing cloud. The computer system can translate the event from a first format understood by the event source to a second format understood by a function scheduler of the FaaS infrastructure, where the function scheduler is configured to schedule execution of functions on hosts of the FaaS infrastructure. The computer system can then make the translated event available to the function scheduler.

Abstract: A graphic session coordinator is established to enable remote virtualized graphics operations on behalf of a set of graphics request generators. A request generator submits a graphics session request to the session coordinator. A configuration operation is performed at one or more routing devices to enable graphics operation request packets from the request generator to be delivered to a first remote virtualized graphics device and to enable graphics operation response packets to be transmitted to a destination.

Abstract: In one embodiment, a method includes receiving an image associated with an object in an environment, the image being captured by sensors associated with a vehicle, generating a feature representation of the image, determining a potential ground control point associated with the object based on the feature representation of the image, determining a predetermined location reading based on the potential ground control point, calculating a differential relative to the predetermined location reading based on the potential ground control point, and determining a location of the vehicle based on the differential and the predetermined location reading based on the potential ground control point.

Abstract: An expandable intervertebral implant is provided for insertion into an intervertebral space defined by adjacent vertebrae. The expandable intervertebral implant includes a pair of outer sleeve portions and an inner core disposed between the outer sleeve portions. Movement of the inner core relative to the outer sleeve portions causes the outers sleeve portions to deflect away from each other, thereby engaging the expandable intervertebral implant with the vertebrae and adjusting the height of the intervertebral space.