Abstract: Embodiments of the present disclosure may allow for an efficient and accurate way or system to assess whether an individual has sepsis, including an individual who may exhibit symptoms or clinical criteria similar to inflammation. Embodiments include using a laboratory test that may be routinely ordered. Embodiments of the present invention may allow for the diagnosis of sepsis even when some cells show an abnormal size. Often, when white blood cells show a likelihood of an abnormal size, a “blast flag” in a system is triggered to warn a user that the sample may warrant further analysis. Unexpectedly, the diagnosis of sepsis status using standard deviation of monocyte volume may be more accurate when considering whether a blast flag has been triggered. Based on the sepsis status, treatment may be started quickly, thereby preventing complications, including organ failure and death, of not treating sepsis fast enough.

Abstract: An ion selective electrode (“ISE”) assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion.

Abstract: An integrated sample processing system including an analyzer and a mass spectrometer is disclosed. The integrated sample processing system can perform multiple different types of detection, thereby providing improved flexibility and better accuracy in processing samples. The detection systems in the sample processing system may include an optical detection system and a mass spectrometer.

Abstract: A centrifuge rotor includes a rotor body having a base, a sidewall, and a top. The top defines an opening that provides access to an annulus cavity inside the rotor body. A cover is removably attachable to the rotor body to seal the annulus cavity. A drive hub extends from a portion of the base of the rotor body and couples to a drive shaft of a centrifuge motor. The rotor body is sized to receive one or more sample containers in the annulus cavity, and to constrain the one or more sample containers inside the annulus cavity between the base, the sidewall, and the top when the one or more containers are advanced radially against the sidewall.

Abstract: Disclosed subject matter relates to method and system for securing data of objects in a laboratory environment. An image capturing device configured in a laboratory instrument may capture images of plurality of objects in the laboratory environment. A processor in the laboratory instrument may identify one or more objects from the images matching with predefined target objects. The processor may apply virtual masking object on or around the identified objects to prevent exposure of data associated with the identified objects and thus provides data privacy.

Abstract: A filtering device is provided to an analyzing instrument to block the passage of oversized particles that may otherwise clog the aperture of a sample analyzing device. The filtering device can be arranged to be proximate to the mixing chamber. In certain examples, the filtering device is placed at or adjacent an output port of the mixing chamber.

Abstract: A method of reducing quality problems associated with patient sample collection and delivery is provided. It is possible that the method can provide a chain of custody process to better track a sample from the initial point of sample collection to the final point of sample testing. Such a method can also include providing an alert to indicate a potential problem with the quality of the diagnostic test result when a measured parameter exceeds a threshold.

Abstract: The present disclosure relates to a beam measuring device, a sample processor including the beam measuring device, and a method of measuring a beam using the beam measuring device. The beam measuring device includes a detection unit and a light impediment unit. The light impediment unit is located between the detection unit and a light source, and is configured to generate a shadow area on the detection unit by blocking transmission of part of a beam coming from the light source. The detection unit is configured to measure the shadow area, and to determine whether the beam is divergent or inclined with respect to a predetermined optical axis based on the measurement of the shadow area. The beam measuring device may shorten the optical detection channel and ensure the detection accuracy, thereby having a compact structure. In addition, the beam measuring device may measure divergence angle and directionality, respectively.

Abstract: The present application relates to a system or method for auto gating of QC base on population analysis. The system or method is particular useful for a sample processing instrument (for example, a flow cytometer or analyzer). The method comprise the following steps: I) providing QC beads used for testing the performance index of an equipment of interest; II) setting the equipment to collect the data of the QC beads; III) analyzing the collected data and calculating the gate position of QC beads based on the collected data; and VI) adjusting the acquisition parameters of the equipment based on the calculated gate position.

Abstract: Described herein are database systems including one or more remote analytical instruments operably connected to one or more servers. The instruments can transmit rich data to the servers, and the one or more servers can compile a database of the rich data. One or more processors associated with the servers can be configured to execute a data analytics program on the database to identify a stochastic phenomenon or to process the data and present in real-time at a location of the one or more instruments comparison information about the instruments.

Abstract: Automatic substance preparation and evaluation systems and methods are provided for preparing and evaluating a fluidic substance, such as e.g. a sample with bodily fluid, in a container and/or in a dispense tip. The systems and methods can detect volumes, evaluate integrities, and check particle concentrations in the container and/or the dispense tip.

Abstract: The present disclosure relates to a liquid flow charging device for a flow cell and a flow cell comprising the liquid flow charging device. The liquid flow charging device comprises a first electrode and a second electrode. The first electrode is electrically connected to a liquid flow flowing through a flow channel assembly of the flow cell. The second electrode is located at a predetermined position on a radially outer side of the liquid flow and has a cylindrical inner peripheral surface surrounding the liquid flow. The liquid flow charging device has improved charging efficiency, stable charging performance, and enhanced safety.

Abstract: Certain types of automated medical analysis equipment are used to analyze blood or other fluids. The equipment may thus use various diluents or reagents that allow the blood or other fluids to be run through the analysis equipment for analysis and data collection. Disclosed is a diluent preparation module that combines purified water and reagent concentrate for use by this equipment. Also disclosed is a diluent preparation unit that combines more than one diluent preparation modules for redundancy and back-up purposes. Also disclosed are systems for supplying the Diluent prepared by the diluent preparation module or diluent preparation unit to one or more analytic instruments.

Abstract: A bubble detection device and a sample processing instrument are provided. The bubble detection device includes a body, a cover and a detection circuit board. The body includes a bottom wall and first and second side walls respectively extending from two sides of the bottom wall. The bottom, first and second side walls define a groove for accommodating a sample pipe of a sample processing instrument, and first and second holes are respectively provided in the first and second side walls to allow light from a light source to pass through the sample pipe. The cover includes a top portion for covering the groove and first and second side portions attached to the body. The detection circuit board includes the light source and a photoelectric sensor and is attached to the body such that they are aligned with the first and second holes respectively to sense intensity of the light passing through the sample pipe. The sample processing instrument includes the bubble detection device.

Abstract: The invention relates to a cuvette assembly for a sample processor, a flow cell for a sample processor comprising the cuvette assembly, and a sample processor comprising the cuvette assembly or the flow cell. The cuvette assembly comprises a cuvette body and a reflector. The cuvette body is in the shape of a rectangular parallelepiped and comprises a sample detection channel vertically penetrating the cuvette body. The cuvette body has long sides and short sides in a horizontal section. The reflector has a flat surface attached to a first side surface extending along one of the long sides of the cuvette body and a spherical surface that is opposite to the flat surface and has a truncated lower half. The reflector is positioned so that it is flush with a lower surface of the cuvette body and a center of sphere of the spherical surface falls into the sample detection channel, and the reflector extends along the long side and exceeds the short side.

Abstract: The disclosure relates to a substrate comprising a micro- or nanostructured periodic array comprised of a plurality of anisotropic metallic micro- or nanostructures, wherein each of the plurality of nanostructures induce an average maximum and substantially uniform plasmonic field greater than 108 across the substrate; a plurality of Raman-active linker molecules directly bound to the metallic micro- or nanostructures; and a plurality of capture molecules directly bound to the Raman-active linker molecules. The disclosure also relates to systems, devices, and methods that use the substrates to determine the concentration of various analytes.

Abstract: The present application discloses a system and a method for calculating a droplet delay time in a liquid flow of a sorting device, and a sorting device.

Abstract: In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations.

Abstract: The present disclosure relates to a nozzle for a sample processor, a carrier of a nozzle for a sample processor, a nozzle assembly for a sample processor, and a sample processor. The nozzle includes a body and an orifice. The body is adapted to be loaded and held in the carrier. The carrier can be slidably inserted into the sample processor in a detachable manner. The orifice is provided in the body and is configured to inject a sample from an injector body in a predetermined mode. An end surface of the body is adapted to abut against an end surface of the injector body along a sample injection direction. The nozzle assembly and the sample processor according to the present disclosure include the above-described nozzle and carrier. With the aid of the carrier, it is not necessary to install the nozzle to the injector body upstream of the nozzle, so that various adjustment operations when reinstalling the nozzle can be omitted, thereby simplifying the process of reinstalling the nozzle.