Abstract: A system comprises: a sample analyzing device reading measurements associated with a liquid sample; a display device displaying a graphical user interface (GUI) to a current user of the automated sample analyzer; processing circuitry; and a memory storing: a receiving engine which receives the measurements associated with the liquid sample from the sample analyzing device and storing the received measurements in memory; a configuration control engine which sets a configuration of a user model to correspond to the current user of the automated sample analyzer; a learning engine which detects and collect at least one pattern of interaction of the current user with the GUI; and a user interface engine which configures the GUI according to user-dependent configuration data of the configuration of the user model corresponding to the current user.

Abstract: Disclosed are dispensers (100, 200, 300) and methods for dispensing and degassing a liquid (102). The dispensers and methods may include a heater (308) and a first tube (124, 502) constructed of a first material. The first tube may include a first end (124A) operable to be connected to a source (104) of the liquid and a second end (124B). The first tube may be connected to the heater via a conductive pathway thermally connecting the heater to the first tube. The first material may have a permeability such that a portion of the gas dissolved in the liquid passes through the first material to an atmosphere upon being degassed from a portion of the liquid within the first tube (124, 502).

Abstract: An applicator assembly (100) for closing a sample container (500) with a plug (16) is proposed. The applicator assembly comprises a magazine (102) configured to store a string (10) comprising polymer-based material, an insertion device (104) configured to insert an end piece (12) of the string at least partly into an opening (502) of the sample container (500), and a drive system (106) configured to supply at least a part of the string (10) from the magazine (102) to the insertion device (104). The applicator assembly further comprises a separator (108) configured to separate the end piece (12) from the string, such that the end piece (12) forms a plug (16) closing the sample container (500).

Abstract: A luminometer (400) includes a light detector (630) configured to sense photons (135). The luminometer (400) includes an analog circuit (915a) configured to provide an analog signal (965) based on the photons (135) emitted from assay reactions over a time period and a counter circuit (915b) configured to provide a photon count (970) based on the photons (135) emitted from the assay reactions over the time period. The luminometer (400) includes a luminometer controller (905) configured to, in response to an analog signal value of the analog signal (965) being greater than a predetermined value, determine and report a measurement value of the photons (135) emitted from the assay reactions over the time period based on the analog signal value of the analog signal (965) and a linear function (1010). Optionally, the linear function (1010) is derived from a relationship between the analog signal (965) and the photon count (970).

Abstract: A pipetting device is disclosed. The pipetting device can include a piston with a stepped profile. The piston can be inserted into a barrel and can have at least two seal elements. The pipetting device can operate in a low volume dispense mode and a high volume dispense mode. The pipetting device can allow for high volumes of liquids to be transferred and also provide for the ability to transfer low volumes of liquids with high precision and accuracy without the need for two or more separate pipettor devices.

Abstract: The present disclosure relates to a device for mounting an optical element and a sample processing instrument including the device for mounting an optical element. The device for mounting the optical element includes: a frame; a mount fitted in the frame in a translatable but non-rotatable manner and having a mounting portion for accommodating the optical element; and an adjusting nut attached to the frame in a rotatable but non-translatable manner. The adjusting nut has a screw and a head located at an end of the screw for operation, and the mount has a threaded portion engaged threadedly with the screw, such that when the adjusting nut rotates, the mount translates relative to the frame. The device and the sample processing instrument according to the disclosure can allow adjustment of an optical element while preventing the latter from being off-center.

Abstract: Systems and methods for calibrating laboratory instruments. In an example, a laboratory instrument for testing patient specimens includes a testing apparatus configured to receive a cassette that includes a patient specimen or a quality control specimen. In response to determining that a quality control specimen is present, the instrument obtains a first measurement of a parameter. If the first parameter is outside an expected tolerance, the instrument ceases performing tests on all specimens, the instrument re-tests the quality control specimen to obtain a second measurement of the parameter. If the second measurement is within the expected tolerance, instrument resumes processing of the cassette. If the second measurement is outside the expected tolerance, the instrument indicates that recalibration or service is required.

Abstract: Instances of the present technology may include a method for operating a hematology analyzer. The method may include passing a control material through a hematology analyzer. The control material may include a first cell population and a second cell population. The method may also include determining a first cell population volume measurement and a second cell population volume measurement. A first value of a first cell population distribution width and a second value of a second cell population distribution width may be calculated. The method may include comparing the first value to a first reference range. The method may also include comparing the second value to a second reference range. Furthermore, the method may include classifying an operational status of the hematology analyzer based on the comparison of the first value to the first reference range and based on the comparison of the second value to the second reference range.

Abstract: Improved systems and methods for laboratory instrument calibration. A laboratory instrument retrieves a number of sets of past quality control parameters from a data structure. Each set includes a recovered value and a timestamp. The recovered value is equal to an output value adjusted by an initial calibration factor. The laboratory instrument determines that the number of sets is greater than a threshold and that each of the past quality control parameters has a timestamp that is within a time threshold. The laboratory instrument computes an updated calibration factor such that when the updated calibration factor is applied to a representative value of the recovered values, the representative value equals the expected recovered value. The instrument updates the data structure with the calibration factor such that the calibration factor is used in subsequent testing of patient specimens.

Abstract: The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.

Abstract: Environmentally-friendly, aqueous concentrated reagent compositions are provided for dilution and use in suitable hematology analyzers for analyzing blood cells including for enumeration and sizing of blood cells, determination of hemoglobin parameters and differentiation of leukocyte subpopulations in a single blood cell sample.

Abstract: A server stores a set of laboratory applications to process batches of samples. The server receives, from a first lab administrator, a selection of a subset of the laboratory applications to process the batches of samples and an admin configuration for a laboratory application in the subset. The server receives configuration(s) of batch(es) to be used for running at least a portion of the subset of laboratory applications configured according to the admin configuration. The server receives, from a first scientific device, a request to run a laboratory application form the first subset to process a batch. The server provides the laboratory application(s) that are capable of being executed using the first scientific device. The server receives, from the first scientific device, a selected laboratory application. The server transmits, to the first scientific device, a signal for executing a first part of the selected laboratory application.

Abstract: Systems and methods for characterizing immune response to infection using cellular analysis, such as a hematological cellular analyzer. In some instances, the immune response may be characterized as normal or abnormal based on one or more blood cell population parameters. In some instances, abnormal characterization may be used to identify patients with sepsis or at elevated risk of developing sepsis.

Abstract: A middleware device or software may be placed in communication with one or more testing instruments and a lab information system. As samples are collected from patients and tested with the testing instruments, test results pass through the middleware and are analyzed in context with other data, such as patient history, testing instrument history, and test results from other tests of the sample, in order to determine whether a particular result is acceptable, whether retesting is needed, whether additional sample collection or testing is needed, and whether currently ordered testing is still necessary. When the middleware determines a need for additional testing or retesting it may automatically create orders for such testing in order to reduce delays in manual review of testing results.

Abstract: The method involves drying down dye-conjugated reagents in separate locations in a reaction vessel so that the dyes don't non-specifically interact with each other during drying. This invention thus improves multiplex binding assays by eliminating erroneous results caused by dyes' being non-specifically attached to each other when dried down together.

Abstract: The disclosure relates to, among other things, an automated flow cytometric method and system for the analysis and enumeration of at least one of hematopoietic stem cells, hematopoietic progenitor cells, and T-cells.

Abstract: Assays (100) may be performed with a luminometer (400) having a chassis (405) that may include a reaction vessel chamber (610). The luminometer (400) may also include a light passage (640) that intersects the reaction vessel chamber (610). The luminometer (400) may also include a cap (415) that, when in a closed configuration, prevents light emitted by external sources from entering the reaction vessel chamber (610) and from entering the light passage (640). The cap (415) may provide access to the reaction vessel chamber (610) when in an open configuration. The luminometer (400) may also include a calibration light source (460) optically coupled to one end of the light passage (640) and a light detector (630) optically coupled to another end of the light passage (640). The light detector (630) may include a sensing element for receiving light from the light passage (640).

Abstract: Methods and systems for determining a dose of an analyte in an unknown sample on an instrument, such as a nucleic acid analyzer, immunoassay analyzer, or clinical chemistry analyzer using a reagent from a selected assay lot are described. The methods and systems use core dose-response information based on measurements of response values to a set of calibrators on a plurality of other instruments and assay lot-specific response information to calibrate the instrument.