Patents Assigned to Beckman Instruments
  • Patent number: 4372915
    Abstract: A fluorescent sulfur dioxide analyzer that includes a generator for producing a standard gas of known sulfur dioxide content. A source of ultraviolet radiation illuminates the interior of a reaction chamber in which an oxygen containing gas is passed over a deposit of sulfur. During passage, a part of the oxygen reacts with the sulfur to produce sulfur dioxide. Because the quantity of sulfur dioxide is predictable and reproducible, the resulting sulfur dioxide containing gas is suitable for use as a standard or span gas in the analyzer with which it is used, thereby eliminating the need for the storage tanks or permeation tubes.
    Type: Grant
    Filed: June 26, 1981
    Date of Patent: February 8, 1983
    Assignee: Beckman Instruments, Inc.
    Inventors: Radhakrishna M. Neti, Raymond E. Rocks
  • Patent number: 4372683
    Abstract: Photometric analysis apparatus having a cylindrical glass sample container which is rotated about its axis during optical measurement of sample in the container. Rotation of the 5 container window areas past an optical detector compensates for optical variations and imperfections in the container wall which would otherwise render the measured photometric signal sensitive to each particular rotational orientation of the container.
    Type: Grant
    Filed: September 9, 1981
    Date of Patent: February 8, 1983
    Assignee: Beckman Instruments, Inc.
    Inventor: James C. Sternberg
  • Patent number: 4370152
    Abstract: A gas dryer cartridge for removing the moisture from a sample gas stream prior to the application thereof to a metabolic measuring instrument. A dryer housing having an inlet and an outlet is partitioned into a first, gas drying chamber containing a desiccant and a second, liquid collecting chamber containing an absorbent liquid retaining element. The volume of the liquid collecting chamber is made sufficiently large that it can contain the liquid produced in the event that the desiccant is liquefied as a result of prolonged use. The liquid retaining element prevents the collected liquid from being swept up in the gas stream during the removal or replacement of the cartridge.
    Type: Grant
    Filed: June 29, 1981
    Date of Patent: January 25, 1983
    Assignee: Beckman Instruments, Inc.
    Inventor: Charles R. Luper
  • Patent number: 4369317
    Abstract: A membrane for use in the determination of calcium ion concentration in an aqueous solution, the membrane being of the type comprising a calcium ion selective component and a carrier material.
    Type: Grant
    Filed: June 29, 1981
    Date of Patent: January 18, 1983
    Assignee: Beckman Instruments, Inc.
    Inventor: John J. Hawkins
  • Patent number: 4367081
    Abstract: A filter assembly for collecting particulate matter from a stream of sample gas. A filter housing having at least an inlet section and an outlet section supports one or more removable filter elements between adjacent housing sections. At least one end of each housing section is provided with a tapered flange whereby it may be joined to the end of an adjacent housing section. Quick-release clamping means engages the flanges to provide a convenient means for fastening and unfastening the sections of the filter housing without dislodging appreciable quantities of the particulate matter collected on the filter elements. The filter assembly may be expanded as required to accommodate any desired number of filter stages.
    Type: Grant
    Filed: January 16, 1981
    Date of Patent: January 4, 1983
    Assignee: Beckman Instruments, Inc.
    Inventor: Robert N. Harvey
  • Patent number: 4367404
    Abstract: Output current hysteresis exhibited by a multiple-dynode photomultiplier detector is reduced by inactivating one or more of the dynodes by shorting to the detector anode, and operating the detector with the reduced number of active dynodes while retaining the anode as the output current supply terminal.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: January 4, 1983
    Assignee: Beckman Instruments, Inc.
    Inventor: Wilbur I. Kaye
  • Patent number: 4360151
    Abstract: A sealed bowl rotor having a transparent lid for easy visual checking of rotor contents. The lid has sealing means that automatically creates a seal which prevents the escape of liquid samples from within the rotor when the lid is placed on the rotor. The rotor design prevents the application of any possible hydraulic loading on the transparent lid. The installing/removing mechanism on the lid provides the capability for removal of the lid after the centrifugation run without disturbing the contents of the samples within the rotor.
    Type: Grant
    Filed: July 1, 1980
    Date of Patent: November 23, 1982
    Assignee: Beckman Instruments, Inc.
    Inventors: Mark J. Cowell, Thomas D. Sharples
  • Patent number: 4360150
    Abstract: A centrifuge rotor and sample containers for reorienting gradients and separating the components of a sample. The rotor contains a plurality of cylindrical recesses equally spaced about its rotational axis. The recesses are open at the top and have a concave hemispherical bottom. A cylindrical plug member is positioned in each of the recesses, and the lowermost end of the cylindrical plug member is formed in the shape of a concave hemisphere. A sample container in the shape of a hollow sphere is positioned between the hemisphere of the cylindrical plug member and the hemisphere of the recess bottom, and means are provided to retain the cylindrical plug member in the recess. The symmetry of the hemispherically shaped sample container is advantageous for minimizing any disturbance to a gradient during reorientation. In another embodiment, a centrifuge rotor is provided which is adapted for fixed angle centrifugation with hemispherical sample containers.
    Type: Grant
    Filed: June 18, 1981
    Date of Patent: November 23, 1982
    Assignee: Beckman Instruments, Inc.
    Inventors: Kenzo Ishimaru, Steven T. Nielsen
  • Patent number: 4360413
    Abstract: A creatine kinase reagent of the type comprising a buffer, creatine phosphate, adenosine diphosphate, D-glucose, hexokinase, glucose-6-phosphate dehydrogenase, a thiol compound, magnesium ion, adenosine monophosphate, and a coenzyme selected from a group consisting of nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, and mixtures thereof. The reagent is characterized in that it further comprises an effective amount of an enzyme selected from a group consisting of phosphogluconate dehydrogenase and phosphogluconate dehydrogenase (decarboxylating).An electrophoretic technique for assaying the relative distribution of creatine kinase characterized in that the above reagent is employed therein.
    Type: Grant
    Filed: July 20, 1981
    Date of Patent: November 23, 1982
    Assignee: Beckman Instruments, Inc.
    Inventor: Robert T. Y. Lee
  • Patent number: 4358425
    Abstract: A transparent tube for use in the cavity of the rotor of a high speed centrifuge. The tube is penetrable at its bottom end by a needle of a hypodermic syringe. The tube is open at the top and has a rounded bottom with an opening forming a passageway therein. A recess forming a shoulder co-axial with the passageway is provided both on the inner side and the outer side of the tube. A resilient plug having flanges at each end provides a tight fitting closure for the passageway and recesses.
    Type: Grant
    Filed: February 17, 1981
    Date of Patent: November 9, 1982
    Assignee: Beckman Instruments, Inc.
    Inventors: Jack P. Finney, Kenzo Ishimaru
  • Patent number: 4358420
    Abstract: A method for making a thin wall centrifuge tube using an injection blow molded process to achieve not only uniform thickness of the tube, but also uniform or homogeneous material properties throughout the tube structure. The unique application of this process includes the making of a preform mold which retains its molten stage on a transferrable core pin that is received at a second stage, where the final configuration mold is placed around the core pin. The blow molding stage operates in conjunction with the molten preform to create the high strength centrifuge tube with uniform material properties.
    Type: Grant
    Filed: May 26, 1981
    Date of Patent: November 9, 1982
    Assignee: Beckman Instruments, Inc.
    Inventors: Steven T. Nielsen, Robert S. Carey
  • Patent number: 4357061
    Abstract: An electro-mechanical package is disclosed which includes an LCD and an IC chip mounted on opposite sides of a PC board by common package-retaining means, which includes posts extending through the PC board and a clip member that latches onto the ends of the posts to retain the package in assembled position. The latching action is resilient and permits non-destructive disassembly.
    Type: Grant
    Filed: February 28, 1980
    Date of Patent: November 2, 1982
    Assignee: Beckman Instruments, Inc.
    Inventor: John B. Crosby
  • Patent number: 4355897
    Abstract: A light scattering photometer including a rotating segmented mirror intercepting light from a laser source and alternately directing the light into a sample zone along an optical axis in first and second opposite directions. A mask annulus coaxial with the optical axis intercepts light scattered from the sample in an incremental angle .DELTA..theta. at a selected angle .theta. with respect to the axis. As the direction of sample illumination alternates, the annulus alternately intercepts forward scatter and back scatter of light from the sample at angles .theta. and 180.degree.-.theta., respectively, and passes the forward and back scatter in alternate succession to a detector. The detector output signal is demodulated to derive near-simultaneous forward and back scatter measurements from the sample. The photometer permits measurement at small values of .theta. approaching 0.degree. and hence permits near-simultaneous scatter measurements at forward and back scatter angles spaced by an angle approaching 180.
    Type: Grant
    Filed: June 9, 1980
    Date of Patent: October 26, 1982
    Assignee: Beckman Instruments, Inc.
    Inventor: Wilbur I. Kaye
  • Patent number: 4355233
    Abstract: A method and apparatus is disclosed for selectively determining by non-dispersive infrared techniques the concentration of a gaseous constituent in a sample gas mixture while determining and discounting deleterious effects of spectrally interfering gases in the sample gas mixture.
    Type: Grant
    Filed: January 31, 1980
    Date of Patent: October 19, 1982
    Assignee: Beckman Instruments, Inc.
    Inventors: Dale F. Warnke, Carl N. Cederstrand, Charles A. Keenan
  • Patent number: 4352119
    Abstract: An electrical device consisting of a package 10 comprising a base 11 and a lid 15 and an operation element 17 contained within the package. A particle getter 19 is disposed on the lid 15 for entrapping and retaining foreign particles contained within the package 10. A method for protecting the operational element 17 of such an electrical device from the particles is disclosed wherein a polysiloxane material is partially cured with less than about 9 parts of a suitable curing agent to 100 parts of polysiloxane resin to a non-flowing, particle entrapping and retaining condition and the partially cured material is secured within the package.
    Type: Grant
    Filed: September 17, 1979
    Date of Patent: September 28, 1982
    Assignee: Beckman Instruments, Inc.
    Inventors: William H. Bardens, Gale C. Nelson
  • Patent number: 4350283
    Abstract: The present invention provides a centrifuge rotor adapted for continuous separation of specific particles from mixed populations thereof by a process of centrifugal elutriation. In the rotor, elutriation cells abut a central spindle having fluid carrying means, and thereby eliminate intermediate conduits and seals therefor, thus reducing the likelihood of leakage because of faulty aperture registration or failure of the sealing means.
    Type: Grant
    Filed: July 1, 1980
    Date of Patent: September 21, 1982
    Assignee: Beckman Instruments, Inc.
    Inventor: Armen L. Leonian
  • Patent number: 4347058
    Abstract: A polarization fluoroimmunoassay for T.sub.3 or T.sub.4 thyroid hormones where a serum sample is assayed by contacting the sample with a base to denature the thyroxine binding globulins and thereby form a solution, incubating the solution, contacting the solution with a separating agent and separating bound thyroid hormone from the serum, contacting the separating agent with bound thyroid hormone with an antibody against the thyroid hormone, incubating the separating agent-antibody combination, separating free antibody and thyroid hormone bound antibody from the separating agent, contacting the free antibody with fluorescent labelled thyroid hormone and measuring the fluorescence polarization as an indication of the thyroid hormone in the sample.
    Type: Grant
    Filed: September 15, 1980
    Date of Patent: August 31, 1982
    Assignee: Beckman Instruments, Inc.
    Inventors: Alan J. Polito, Kurtis R. Bray
  • Patent number: 4347059
    Abstract: A T.sub.3 uptake polarization fluoroimmunoassay where a sample is assayed by contacting a serum sample with T.sub.3 to form a solution, contacting the solution with a separating agent and incubating the same, separating T.sub.3 bound to the separating agent from the serum sample, contacting the T.sub.3 bound to the separating agent with an antibody against T.sub.3, incubating and separating the agent-anti-body combination, separating free anti-body and contacting the free antibody with fluorescent labeled T.sub.3 and fluorometrically measuring the fluorescence polarization.
    Type: Grant
    Filed: September 15, 1980
    Date of Patent: August 31, 1982
    Assignee: Beckman Instruments, Inc.
    Inventors: Alan J. Polito, Kurtis R. Bray
  • Patent number: 4345713
    Abstract: In accordance with the present invention, there is provided an air driven centrifuge having an access door to a rotor chamber housing a rotor seat and a rotor having a plurality of turbine flutes formed in the underside thereof. Air jet means in the rotor seat are provided for supporting and spinning the rotor on an air cushion in the chamber. Means are provided to prevent the opening of the access door when pressurized air is supplied to the air jets, and means are provided to delay for a predetermined period, the opening of the door after the supply of pressurized air to the air jets is discontinued.
    Type: Grant
    Filed: April 13, 1981
    Date of Patent: August 24, 1982
    Assignee: Beckman Instruments, Inc.
    Inventors: William S. Gutierrez, Lee Gropper, Hugh O. Brown
  • Patent number: 4344864
    Abstract: A stable blood serum conjugated bilirubin reference composition characterized in that the composition possess a pH of from about 8.2 to bout 9.2 and comprises (a) a sulfhydryl compound in an amount sufficient to enhance the stability of the conjugated bilirubin and (b) a chelating agent in an amount sufficient to bind all the metals present in the blood serum moiety of the composition. This blood serum conjugated bilirubin composition when stored in a gas impervious vial under an inert atmosphere has an excellent shelf life.
    Type: Grant
    Filed: October 30, 1980
    Date of Patent: August 17, 1982
    Assignee: Beckman Instruments, Inc.
    Inventors: Allan L. Louderback, Thomas J. Foley