Abstract: Disclosed herein include systems, methods, compositions, and kits for determining the expression of highly expressed proteins and lowly expressed proteins. In some embodiments, primers allowing generation of separate libraries for abundant AbSeq protein profiling oligonucleotides and scarce AbSeq protein profiling oligonucleotides are provided.

Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.

Abstract: A syringe assembly includes a syringe barrel having a proximal end and a distal end, a needle hub supporting the needle and coupled to the distal end of the syringe barrel. An adapter is coupled to the hub where the needle extends from the adapter to define a length of the needle for injection as substance into the patient. The adapter has a diameter greater than a diameter of the syringe and has a distal face with a shape and dimension configured for controlling the depth of penetration of the needle into the patient and a proximal face forming a finger grip.

Abstract: A catheter priming apparatus may include a barrier forming a reservoir. Fluid may be disposed within the reservoir. A support structure may be disposed within the barrier. The support structure may include an opening extending through the support structure and a connector configured to couple the catheter priming apparatus to a catheter system. A one-way valve may be coupled to the support structure and configured to allow the fluid to flow out of the reservoir through the connector in response to compression of a portion of the barrier aligned with the opening.

Abstract: A delivery device for delivering an instrument through an intravenous catheter may include a housing, a rotary element disposed within the housing, and the instrument. In some embodiments, the rotary element may include a groove, which may extend around at least a portion of a circumference of the rotary element. In some embodiments, the instrument may be disposed within the groove and/or between the rotary element and the housing. In some embodiments, in response to rotation of the rotary element with respect to the housing, the instrument may be advanced distally through a port of the housing. In some embodiments, the instrument may include a guidewire, a probe, tubing, or a light tube.

Abstract: A biological fluid collection device that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection device of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection device of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications.

Abstract: A system and method for developing applications (Apps) for automated assessment and analysis of processed biological samples. Such samples are obtained, combined with nutrient media and incubated. The incubated samples are imaged and the image information is classified according to predetermined criteria. The classified image information is then evaluated according to Apps derived from classified historical image information in a data base. The classified historical image information is compared with the classified image information to provide guidance on further processing of the biological sample through Apps tailored to process provide sample process guidance tailored to the classifications assigned to the image information.

Abstract: A catheter system may include a luer adapter, which may include an outer surface having threading or a recess. The catheter system may also include a flow control plug, which may include a proximal end and a distal end. The proximal end of the flow control plug may include a filter element permeable to air and not to blood. The distal end of the flow control plug may include a cylinder and a taper-shaped luer tip spaced apart from the cylinder. An inner surface of the cylinder may include a protrusion engaged in a snap-fit with the recess or corresponding threading mated with the threading.

Abstract: Pinch-style clamps can be designed for use in clamping or occluding plastic tubing, such as intravenous tubing. These pinch clamps can include a soft, polymer material applied to various surfaces of the pinch clamp to prevent abrasion or irritation to the patient, increase friction between the pinch clamp and the user operating said pinch clamp, increase friction between engaged surfaces of the pinch clamp to prevent premature or unintended disengagement of the clamp, or increase friction between the outer surfaces of the tubing and the clamping surfaces of the clamp. Various features or components can be employed to prevent lateral disengagement of the pinch clamp. A pinch clamp may also be configured with rounded outer edges to enhance patient comfort.

Abstract: A catheter system may include a catheter assembly, which may include a catheter adapter and a catheter extending from a distal end of the catheter adapter. The catheter system may include a needle assembly, which may include a barrel, a needle hub slidably disposed within the barrel, and an introducer needle secured within the needle hub and extending through the catheter. The needle assembly may also include a stop surface coupled to the barrel and an activation latch. The activation latch may be slidable from a first position to a second position with respect to the barrel. In response to the activation latch being in the first position, the stop surface may contact the activation latch and depression of the activation latch may be prevented. In response to sliding of the activation latch from the first position to the second position, the stop surface may not contact the activation latch, which may depress.

Abstract: Medical devices capable of filling liquid into a syringe barrel while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel having a tapered sidewall portion for permitting air to vent from the chamber and preventing liquid from exiting the chamber, a plunger rod, and stopper. Another exemplary medical device includes a syringe barrel having a plurality of air venting grooves associated with the sidewall of the barrel, a plunger rod and stopper. Also described is a medical device including a syringe barrel, plunger rod and stopper having a porous plug. Described is a medical device including a syringe barrel having a plurality of air venting grooves associated with the sidewall of the barrel and a porous membrane disposed over the air venting grooves, a plunger rod and stopper. Methods for filling a syringe barrel with a liquid are also provided.

Abstract: A package for a needle assembly includes a tray defining a compartment in a first configuration for receiving the needle assembly. The tray can be reconfigured in a second configuration to form a holder configured to hold the needle assembly during fluid collection.

Abstract: An attachment for a catheter assembly may include a platform, which may include an upper surface and a bottom surface. The bottom surface may be configured to contact skin of a patient. At least a portion of the upper surface may be configured to support the catheter assembly. The upper surface may support the catheter assembly at an angle with respect to skin of the patient that is approximately equal to an insertion angle of a catheter of the catheter assembly. The attachment may include snap feature coupled to the upper surface of the platform. The attachment may include a blunt cannula extending distally from the snap feature. The blunt cannula and the portion of the upper surface may provide a generally straight pathway for an instrument inserted distally through the attachment into the catheter assembly.

Abstract: A needle stick prevention device (10, 110) includes a needle shield (20, 120) for selectively covering a distal end of a needle (41, 141). A needle hub (40, 140) is movably received within the needle shield (20, 120). The needle hub (40, 140) includes a proximal end (42, 142), a distal end (46, 146), a needle (41, 141) fixedly connected to the distal end of the needle hub (40, 140), and a plurality of ribs (54) or a cylinder (150) disposed between the proximal and distal ends. An actuation button movably received in a transverse opening of the needle shield (20, 120) to engage the needle shield (20, 120), the needle hub (40, 140) and a medical device. A spring (58, 158) is disposed between the needle hub (40, 140) and actuation member to automatically retract the needle (41, 141) into the needle shield (20, 120).

Abstract: A medication delivery device includes an infusion pump system having a reservoir, a fluid path connected between the reservoir and an insertion mechanism, a plunger arranged inside the reservoir, and a pump drive mechanism coupled with the reservoir. The medication delivery device further includes a processing device configured to determine a user fill volume of a fluid medication by analyzing a location of the plunger inside the reservoir when a fill of the fluid medication is completed. The processing device is configured to determine the user fill volume of the fluid medication by sensing a pressure inside the reservoir.

Abstract: Insulin injection syringes are disclosed that include two types of components, namely, durable components that that do not contact the fluid path and can be reused, and disposable or single-use components that contact the fluid path and are not reused. The durable components do not contact the fluid path so that sterility is not affected. Two different syringe components include a reusable outer sleeve containing scale markings for the syringe and a reusable syringe plunger are provided as durable components in embodiments of the present invention. Syringes manufactured according to the present invention can employ one or both of these durable components. Methods for making, using and packaging such syringes are also disclosed.

Abstract: A needle hub including a core mounting structur, first and second panels each connected to the core mounting structure with an opening formed between the first panel and the second panel, and an introducer needle fixedly attached to the core mounting structure; a first actuation lever disposed within the opening, cantilevered at a central portion thereof from the core mounting structure that has a first actuation button disposed at a proximal free end and a first needle hub latch disposed at a distal free end. A needle tip shield is rotatably connected to one of the first and second panels and rotatable from a first position in which a distal end of the introducer needle is exposed to a second position shielding the distal end of the introducer needle.

Abstract: A system for providing the collection of advanced, improved, and novel new components and elements in a single package to simplify assembly and use of the infusion set by the user, including one or more of an exemplary pushbutton-type inserter, squeeze-type inserter, contact-type inserter, skin pinching-type inserter, folding retraction-type inserter, and/or multistage-type inserter (700) having at least one reusable stage, an exemplary set (350) having an adhesion means with two or more user-selectable degrees of adhesion strength, a self-sealing tube connection means, a lens feature to view a site beneath the set, exemplary tube management and connection elements (450), insulin supply (475), adhesion concealment means (500), finger loops on the inserter and site preparation wipes or sprays (550) which can be provided as part of the inserter.

Abstract: A biological fluid separation device and a separation process that allows for efficient separation of plasma from a blood sample is disclosed. A biological fluid separation device of the present disclosure is adapted to receive a blood sample having a cellular portion or cells and a plasma portion or plasma. A biological fluid separation device of the present disclosure separates plasma from cells using a track-etched membrane and cross-flow filtration.