Abstract: A device for protecting an injection apparatus for injecting a product, the said apparatus comprising a needle and a piston connected to an actuating rod surmounted by a piston head, the said device comprising: a support sleeve, a protective sleeve for protecting the needle, first retaining means for holding the protective sleeve in its standby configuration in a first position, second retaining means for holding the protective sleeve in its standby configuration in a second position, an intermediate collar comprising collaboration means for collaborating with the piston head, and deactivation means for deactivating the first and second retaining means. The second retaining means being able to be deactivated by the deactivation means of the intermediate collar by the release of the pressure of the piston head on the collaboration means of the intermediate collar to allow the protective sleeve to deploy under the action of pushing means.

Abstract: A spray or injection device that includes a casing or a pusher that includes at least one tab configured to move radially between a first radial position in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The tab includes an opening. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position then to penetrate the opening thereby allowing the tab to return to the first radial position. The pusher or the casing, respectively, further includes at least one stop region against which the tab abuts when the tab is brought into the second radial position by the projection. The stop region occurring just before the projection being opposite the opening.

Abstract: This device comprises: a body housing a hollow injection needle and a container containing the injectable product; the needle is connected to the body but able to move relative to the latter between an injection position and a retracted position; a plunger that slides in the body and is displaceable relative to the latter to perform the injection; the container is able to move relative to the plunger between a position that enables the injection to be performed and a retracted position; an arrangement for keeping the needle and the plunger in injection position, which arrangement can be released to free the needle and the plunger to move to the retracted position.

Abstract: The present invention relates to a shield (1) for covering at least part of a needle (2) and needle hub (6) of a needle assembly, said shield (1) having an open proximal end (1a), a closed distal end (lb) and a longitudinal wall (4) extending from said proximal end (1a) to said distal end (1b) and defining an interior cavity (5) for receiving at least part of the needle (2) and needle hub (6), characterized in that it comprises a first bulge (8) defined on said wall (4) and extending into said interior cavity (5), said first bulge (8) being designed to be able to, resiliently and releasably, engage a part of said needle assembly to secure said shield (3) thereto, said first bulge (8) further being circumferentially non-continuous about said interior cavity (5). The invention also relates to a needle assembly and to an injection device, each comprising such a shield.

Abstract: A method for surface marking a solid substrate (1), according to which, during an exposure sequence, said substrate is exposed to coherent monochromatic light (2) in order to strip said substrate over an indented surface (3), wherein the exposure conditions, including duration, are set in order to restrict said indented surface to simple abrasion designed for the bonding of a printing medium, and the exposure sequence is followed by a sequence of projecting in discrete form, during which particles (6) of said printing medium, the deposition of which subsequently defines a printed element (4), are projected in targeted fashion into the indented surface (3, 31).

Abstract: This connecting device applies to a sealed connection device in which, firstly, each chamber, respectively a stationary chamber “A” and a transportable chamber “B” has at least one access opening equipped with a door (2, 3) cooperating with a flange (4, 5) with the interposition of sealing elements (12, 14), one (2) of the two doors being articulated to its flange (4), and secondly, the two doors (2, 3) have an element to lock their respective flanges (4, 5) and complementary connecting elements which allow them to be connected thereby forming, through contact of sealing elements (12, 16), an internal space “C” isolating their faces (17, 18) opposite each other from the external medium.

Abstract: A bag comprising an envelope closed at one end by an end wall and delimiting a mouth at the other end, containing a charge capable of passing, for example under gravity, through said mouth, when said bag is in the inverted position, said envelope being shaped on itself at said mouth in order to close said bag. At the opposite end to the end wall, the envelope is shaped on itself, in particular folded, to determine, without discontinuity: an outer sleeve which is above the mouth when the bag is in the inverted position; at least one inner closure fold; a neck inside which the inner closure fold is located; and at least one outer closure fold closing said neck.

Abstract: A sealed connection device in which, two chambers (“A” and “B”), each has an access opening equipped with a door (2, 3) cooperating with a flange (4, 5) with the interposition of sealing means (12, 14), one (2) of the two doors being articulated with its flange (4). The detection device comprises two grooves (30, 35), formed in the external face of the flange (4) of chamber (A), a seal (36) placed in the groove (35), a network of ducts (31, 32, 33) formed in flange (4) and connecting the inner groove (30) to a coupling (34), a vacuum pump (38) the intake (37) of which is connected to the said coupling, and a sensor (44) measuring the strength of the partial vacuum in the pneumatic circuit leading to the groove (30) and reacting on alarm means (47, 48) if ever the partial vacuum does not reach an appropriate value.

Abstract: A method for surface marking a solid substrate (1), according to which, during an exposures sequence, said substrate is exposed to coherent monochromatic light (2) in order to strip said substrate over an indented surface (3), wherein the exposure conditions, including duration, are set in order to restrict said indented surface to simple abrasion designed for the bonding of a printing medium, and the exposure sequence is followed by a sequence of projecting in discrete form, during which particles (6) of said printing medium, the deposition of which subsequently defines a printing element (4), are projected in targeted fashion into the indented surface (3, 31). A device for marking a surface of a substrate is also provided.

Abstract: A lockable safety shield assembly for a prefillable syringe is provided. The design of the lockable safety shield assembly enhances pharmaceutical manufacturers' ease of assembling the various components as part of its filling or processing of the prefillable syringes in normal practice, while at the same time minimizes difficulties in mating parts made from different materials. A tube is placed around the outside surface of the syringe barrel and affixed thereto. A collar is provided on the tube adjacent the distal end of the syringe barrel. A safety shield is axially slidable over the tube between a retracted position, wherein the distal end of the piercing element associated with the prefillable syringe is exposed, and an extended position, wherein the safety shield is locked to the collar to protectively cover the distal end of the piercing element. The safety shield includes locking structure configured so that the shield can be easily fitted over the tube.

Abstract: A transfer set for transferring fluid from a first container, such as a conventional sealed vial, to. a second container, such as a conventional syringe having a luer connector without a needle canula. The transfer set includes a tubular housing member having a proximate end adapted to be attached to the first container open end, a tubular transfer member located within the tubular housing member, a piercing member telescopically supported in the tubular transfer member, and a cap or closure which in the preferred embodiments releasably retains the distal end of the piercing member prior to removal of the cap. The cap includes a central portion having a tubular connector portion which receives and releasably retains the distal end of the piercing member.

Abstract: A medical device is provided which includes a shield system and a syringe which is coupled to the shield system. The shield system includes a syringe holder and a shield which is slidably coupled to the holder. A spring resiliently urges the shield from a retracted position to an extended position. Stop members are provided on the holder and shield for maintaining the shield in the retracted position. The syringe is slidably coupled to the holder, and extends within the shield. Axial movement of the syringe with respect to the holder causes disengagement of the stop members, allowing the spring to move the shield to the extended position. Detents are provided on the holder for maintaining the shield in the extended position.

Abstract: A sealed connection device in which, two chambers (“A” and “B”), each has an access opening equipped with a door (2, 3) cooperating with a flange (4, 5) with the interposition of sealing means (12, 14), one (2) of the two doors being articulated with its flange (4). The detection device comprises two grooves (30, 35), formed in the external face of the flange (4) of chamber (A), a seal (36) placed in the groove (35), a network of ducts (31, 32, 33) formed in flange (4) and connecting the inner groove (30) to a coupling (34), a vacuum pump (38) the intake (37) of which is connected to the said coupling, and a sensor (44) measuring the strength of the partial vacuum in the pneumatic circuit leading to the groove (30) and reacting on alarm means (47, 48) if ever the partial vacuum does not reach an appropriate value.

Abstract: Device (10) for achieving communication, via a coupling means, between a first chamber (1) and a second chamber (2). The coupling means comprises, on the same side as the first chamber (1), a first shut-off member (41), and, on the same side as the second chamber (2), a second shut-off member (4) comprising a second flange (52) forming a seat for a second removable shutter element (72). The coupling means further comprises means of sealed connection between two flanges (51) and (52). The second chamber (2) being defined by the inside of a flexible and sealed bag (15), the border of the mouth of which is connected in a sealed way to the second flange (52). When the coupling, means is in an uncoupled position, the flexible bag (15) comprises a band (15d) extending the bag (15) continuously beyond the second flange (52), defining a closed (15f) and sealed, but openable envelope (12) for protecting the second shut-off member (42).

Abstract: A transfer set assembly for transferring fluids between a first container, such as a conventional medical vial, having a sealed open end and a second container such as a conventional IV infusion bag. The transfer set includes a collar having a proximate tubular end portion for securement to the container, a needle cannula and holder assembly, which is telescopically received in a distal tubular portion of the collar, and a closure including a tubular body portion having an open proximate end which is telescopically received over the needle cannula and holder assembly and the distal tubular portion of the collar, a closed distal end portion and an inner tubular portion which is integral with the closed distal end. The inner tubular portion includes a free end having spiral camming surfaces which mate with spiral camping surfaces on the inside surface of the tubular distal portion of the needle cannula holder.

Abstract: Leaktight confinement appliance (1), intended to cooperate with an independent receptacle (3) containing a substance (4), having its own means (8) for transfer into and/or out of the receptacle, and with an independent means (71) for delivery of a material. The appliance includes a handling chamber (2) defined by a wall (13) of flexible material substantially leaktight with respect to the external environment. A pouch is formed within the wall of the handling chamber (2) for retaining an interconnection device. The handling chamber (2) is arranged to connect at least the transfer means (8) of the receptacle (3) to the delivery means (71) through the interconnection device.

Abstract: Leaktight confinement appliance (1), intended to cooperate at least with one independent receptacle (3) containing a substance (4), having its own means (8) for transfer into and/or out of the said receptacle, and with at least one independent means (71) for delivery of a material, the said appliance comprising a handling chamber (2), defined by a wall (13) of flexible material substantially leaktight with respect to the external environment, arranged to connect at least the transfer means (8) of the receptacle (3) to the delivery means (71), inside the handling chamber (2). This appliance comprises a means for leaktight assembly (50) between the handling chamber (2) and the transfer means (8) of the receptacle (3), and a means (70) for leaktight connection between the handling chamber (2) and the delivery means (71).

Abstract: Leaktight confinement appliance (1), intended to cooperate at least with one independent receptacle (3) containing a substance (4), having its own means (8) for transfer into and/or out of the said receptacle, and with at least one independent means (71) for delivery of a material, the said appliance comprising a handling chamber (2), defined by a wall (13) of flexible material substantially leaktight with respect to the external environment, arranged to connect at least the transfer means (8) of the receptacle (3) to the delivery means (71), inside the handling chamber (2).

Abstract: A bottle having a sterility seal and a method for producing same are disclosed. The bottle, which can be configured to retain a medicament in powder or tablet form, features a protective cap configured to engage a transfer assembly associated with the bottle. The cap includes one or more raised ridges on an interior surface engageable with a portion of the transfer assembly. A band or layer configuration of a sealing material such as silicone is applied to the transfer assembly prior to insertion of the cap thereover. As the cap comes into surface contact with the sealing material, the ridges cause the material to “roll up” into a toroidal O-ring configuration, thereby forming a seal between the cap and the bottle adapted to the dimensional variations of those components.