Abstract: A disinfection device for disinfecting a female medical connector. The device includes an inner housing having an absorbent material that includes a disinfectant or antimicrobial agent that receives the connector. The device also includes an outer housing having an outer wall that receives the inner housing wherein the inner housing is rotatable within the outer housing. An indicator is located between the outer wall and a transparent collar that includes at least one rib. The indicator includes a first visual indicator and a second visual indicator concealed by the first visual indicator. The inner housing includes a boss element that extends through the outer wall and indicator and is attached to the collar. Rotation of the collar causes rotation of the absorbent material and causes the rib to remove sufficient portions of the indicator to expose the second visual indicator to provide visual indication that the connector is disinfected.

Abstract: A disinfection cap or device for disinfecting medical connectors. The cap includes a visual indicator that changes color after sufficient scrubbing effort and time have been expended by a clinician to disinfect the medical device, giving positive visual feedback to the treating clinician. An external housing of the cap includes a disinfection medium, such as a disinfectant sponge that is coupled to a rotating collar. The housing is oriented so that the sponge contacts the medical device to be cleaned. Collar rotation in turn rotates the disinfectant sponge against the VAD, providing scrubbing action. A visualization chamber within the cap contains two isolated fluids of distinct colors. As the collar is rotated it mixes the two isolated fluids, changing color of the resultant mixture. When the visualization chamber shows the new, mixed third color, the medical device is disinfected.

Abstract: A safety lock syringe assembly comprising a barrel including a distal end and a proximal end, one or more lugs extending outwardly from an outer surface of the barrel, and a needle extending from the distal end, and a sleeve having threads that engage the one or more lugs, the sleeve includes a sleeve locking mechanism, wherein the sleeve threadably rotates in a first direction to a first position that exposes the needle, the sleeve threadably rotates in a second direction to a second position that shields the needle, and the sleeve threadably rotates in the second direction to a third position that engages the one or more lugs to the sleeve locking mechanism to irreversibly lock the shield to the barrel.

Abstract: An injection pen, comprising a housing, a lead screw axially moveable in the housing, a dose set member for dose setting and dose correcting, threadably connected to the housing and having a first mating feature, a setback member having a second mating feature for engaging the first mating feature, a clicker that generates an audible or tactile indication during operation, the clicker being operatively connected to the dose set member, and a push button operatively connected to the setback member to cause the second mating feature to engage the first mating feature during an injection, the push button receiving the clicker, wherein the first mating feature is disengaged from the second mating feature during dose setting and dose correcting and engaged with the second mating feature during an injection.

Abstract: Integrated light interrogation modules are provided. In embodiments, the subject integrated light interrogation modules include a flow cell having a light-accessible flow channel for transporting particles in a flow stream, a focusing optical assembly integrated with the flow cell, and a connector for operably attaching a fiber optic light conveyor to the focusing optical assembly, where the focusing optical assembly is projects excitation wavelength light from the fiber optic light conveyor onto a focal spot of the flow cell when the fiber optic light conveyor is operably attached to the connector. In certain embodiments, focusing optical assemblies also include a connector for operably attaching a fiber optic light collection element for collecting fluorescent light emitted by the particles transported through the flow cell. Flow cytometers, methods and kits for practicing the invention are also provided.

Abstract: Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample.

Abstract: Provided is a medical device assembly for detection of medical device components and/or mating thereof. The medical device assembly may include a first medical device component having at least one first resonant structure, which may have a first resonant frequency spectrum. A second medical device component may have at least one second resonant structure, which may have a second resonant frequency spectrum different than the first resonant frequency spectrum. Upon mating of the first medical device component to the second medical device component, the first resonant structure(s) and the second resonant structure(s) may combine to have a third resonant frequency spectrum, which may be different than the first resonant frequency spectrum and the second resonant frequency spectrum. A system and method are also disclosed.

Abstract: A system includes a vial stabilizer base having a first body and a plurality of fingers projecting from the first body, with the plurality of fingers being annularly disposed about the first body, and a vial adapter having a second body and a plurality of arms projecting from the second body. The second body defines a passageway. The plurality of fingers of the vial stabilizer base defines a socket having a first seat configured to receive a vial and a second seat configured to receive the vial adapter.

Abstract: A cell sorting system that automatically generates a sorting strategy based on examples of target events provided by an operator. The target events can be selected using measurements ranging from traditional flow cytometry measurements to derived measurements that are computationally expensive to complex measurements such as images.

Abstract: A catheter system may include a catheter assembly. The catheter assembly may include the catheter adapter, which may include a distal end, a proximal end, an inner surface forming a lumen, the lumen extending through the distal end and the proximal end, and a side port disposed between the distal end and the proximal end. The catheter assembly may include an annular valve, which may be disposed within the lumen and aligned with the side port. The annular valve may seal a fluid pathway from the side port to the lumen. The catheter assembly may include a retainer ring disposed proximal and/or proximate the annular valve within the lumen. The catheter assembly may include a catheter extending distally from the distal end of the catheter adapter.

Abstract: The present disclosure relates to a connector for connecting a medical injection device to a container closed by a septum. The connector has a distal tip and a sleeve extending around the tip. The sleeve has an inner threaded portion. The connector includes a proximal part configured to engage the tip of the injection device. The proximal part includes an outer threaded portion configured to be removably screwed to the inner threaded portion of the sleeve, distal part configured to be connected to the container, and a hollow spike extending from the proximal part. The hollow spike has an internal volume in fluidic connection with the injection device and perforates the septum of the container when the distal part is connected to the container. The spike includes an opening in a distal end being configured to create a connection between the medical injection device and the container.

Abstract: Dried reagent strainers, such as cell strainers are provided. Aspects of the strainers include a body having an opening with a filter positioned in the opening, where the filter includes a dried reagent composition. Aspects of the invention further include methods of making and using the strainers, as well as kits containing the strainers.

Abstract: A system for accessing a patient's vascular system may have a tube with a wall that defines an exterior surface and lumen with a proximal end and a distal end, and a guidewire that is deployable, by sliding distally, from a retracted position in which the guidewire resides in the lumen, to a deployed position in which the guidewire extends beyond the distal end. The system may further have a retraction mechanism that can be actuated to retract the guidewire from the deployed position to the retracted position, or a protective shield that can be actuated to extend distally from the distal end of the tube to cover the guidewire in the deployed position.

Abstract: An intravenous catheter system may include a catheter adapter, which may be integrated. The intravenous catheter system may also include a housing coupled to a proximal end of the catheter adapter, an introducer needle having a proximal end, a distal tip, and a needle lumen extending between the proximal end of the introducer needle and the distal tip, a guidewire disposed within the housing and the needle lumen, and a guidewire advancement element. The housing may include a proximal end, a distal end, and a slot. A proximal end of the introducer needle may be secured within the housing. The guidewire advancement element may extend through the slot and be moveable along the slot in a distal direction to move the guidewire from a retracted position to an advanced position, in which the guidewire may extend beyond the distal tip.

Abstract: A dual chamber, sequential delivery syringe facilitates selective drug mixing, dosing, and administration through catheters or other vascular accessing devices (VADs), as well as post-administration flushing of catheters with a single syringe instrument. A syringe barrel incorporates an outlet, such as a Luer connector, a variable-volume, primary fluid chamber, and a secondary chamber that is pre-filled with fluid. A plunger manipulated, telescoping actuator, in conjunction with a medication stopper disposed within the barrel interior, form a valve for selectively isolating the secondary fluid chamber from fluid communication with the primary fluid chamber and/or the outlet of the syringe barrel. Valve opening is accomplished automatically by continuous advancement of the plunger.

Abstract: Disinfection cap includes housing comprising closed top, essentially cylindrical sidewall, and open bottom formed by the sidewall with opening to inner cavity within the housing for receiving tip including mating feature of needleless connector. Disinfection sponge can be configured within inner cavity, removable cover sealing opening to inner cavity to seal sponge within inner cavity prior to cap use. Inner cavity includes at least one thread on inner surface of its sidewall that does not correspond to the mating feature of needleless connector, but is sufficient to interlock with mating feature of needleless connector. Plurality of disinfection caps are disposed on strip of IV pole hanging device such that each cap can be peeled off the strip unsealed for immediate use, or separated from the strip sealed for later use.

Abstract: Aspects of the present disclosure include methods for characterizing particles of a sample in a flow stream. Methods according to certain embodiments include detecting light from a sample having cells in a flow stream, generating an image of an object in the flow stream in an interrogation region and determining whether the object in the flow stream is an aggregate based on the generated image. Systems having a processor with memory operably coupled to the processor having instructions stored thereon, which when executed by the processor, cause the processor to generate an image of an object in a flow stream and to determine whether the object is an aggregate are also described. Integrated circuit devices (e.g., field programmable gate arrays) having programming for practicing the subject methods are also provided.

Abstract: Systems and methods for imaging and image-based analysis of test devices can include a background device for a lateral flow assay test strip. In one aspect, the background device can include a test strip portion sized and shaped to guide placement, on the background device, of the lateral flow assay test strip; a background portion at least partially surrounding the test strip portion; and one or more features of the background portion. The one or more features can include line detection fiducials, position fiducials, modulation transfer function fiducials, motion blur detection fiducials, and/or RGB balanced areas for evaluation of lighting conditions.

Abstract: A system for capture of dose delivery information is provided. The system includes a medication delivery device, a dose information capture device adapted to be attached to the medication delivery device, and a target element adapted to be attached to the medication delivery device. The target element comprises a magnet or ferrous element and the target element attaches to the medication delivery device on a dose delivery mechanism of the medication delivery device. The dose information capture device includes a magnetic position sensor adapted to detect a position of the target element. As an alternative to magnetic sensing, MEMS flow sensors, and the like may also be used. Exemplary systems preferably transmit dose information in real time to remote devices for further processing.