Abstract: Methods for classifying fluorescent flow cytometer data are provided. In some instances, methods include processing the flow cytometer data with a supervised algorithm configured to cluster the fluorescent flow cytometer data into distinct populations according to the relationship of data points to relevant threshold values. In embodiments, methods include determining a measure of spillover spreading by calculating spillover spreading coefficients and combining them in a spillover spreading matrix. In some embodiments, populations of fluorescent flow cytometer data are adjusted to subtract the magnitude of spillover spreading. In embodiments, spillover spreading adjusted populations are partitioned after potential partitions are evaluated relative to the threshold values. In embodiments, partitioned populations of fluorescent flow cytometer data are classified (i.e., phenotyped) according to a hierarchy. Systems and computer-readable media for classifying fluorescent flow cytometer data are also provided.

Abstract: Devices and methods detect and mitigate pre-occlusion leak pressures within a dispense stroke of an infusion device. An infusion pump obtains pump measurements indicative of pressure, and controls its pump mechanism to pause when the pump measurements satisfy a pre-occlusion pressure threshold. Additional pump measurements are obtained during the pause and pressure-related conditions can abate during the pause. The dispense stroke is resumed by the infusion pump when the pump measurements no longer satisfy pre-occlusion pressure criteria, and can be paused again. The number and frequency of pauses, analysis of pump measurements, and resumption of a dispense stroke can be predetermined, or dynamically determined. Pauses can also be preset regardless of current pressure conditions. Pausing the pump to increase the samples or sampling rate of a measured parameter indicative of pressure (e.g., pump motor current) provides a much higher resolution for detecting an occlusion.

Abstract: A medical instrument or device, such as a catheter, has echogenic properties, in addition to or as an alternative to radiopaque properties, to facilitate detection of the medical instrument or device during medical procedures using suitable imaging methods, such as ultrasound imaging and/or x-ray imaging methods. In example embodiments, an example catheter has a relatively increased radiopacity and echogenicity to facilitate a clinician with detecting the catheter with ultrasound imaging and/or x-ray imaging methods to assist the clinician with the insertion, placement, and/or maintenance of the catheter, for example.

Abstract: A catheter system may include a catheter adapter and a catheter extending distally from the catheter adapter. The catheter system may include a needle assembly, which may include a plug, an outer housing, and an introducer needle. An outer surface of the plug may include multiple grooves, which may be in fluid communication with the introducer needle and configured to receive blood flashback. The grooves may include a first groove having a first surface-area-to-volume ratio, and a second groove having a second surface-area-to-volume ratio. The first surface-area-to-volume ratio may be less than the second surface-area-to-volume ratio. The first groove may have a greater volume than the second groove. The outer housing may seal a top of the first groove and a top of the second groove to prevent blood from flowing out the top of the first groove and the top of the second groove.

Abstract: A reader includes a first antenna, a second antenna spaced apart from the first antenna, an RFID reader circuit, and a processor. The first antenna and the second antenna are connected to the RFID reader circuit. The first antenna is configured to receive a first signal from an RFID tag. The second antenna is configured to receive a second signal from the RFID tag. The processor controls the RFID reader circuit to determine a first value of a signal parameter associated with the RFID tag based on the first signal and a second value of the signal parameter associated with the RFID tag based on the second signal, receives, from the RFID reader circuit, the first value and the second value, and determines, based on the first value and the second value, whether the RFID tag is located between the first antenna and the second antenna.

Abstract: A system for infusing a gas into a vascular access device may include a catheter interface, which may include a distal end, a proximal end, and a lumen extending between the distal end and the proximal end. The system may also include a connector disposed on an outer surface of the catheter interface. The connector may be configured to couple to a reservoir. The reservoir may include a housing, which may include an opening and an impermeable wall. The opening may be configured to couple to the connector of the catheter interface. The reservoir may also include a molecular precursor to a gaseous agent that is suspended in a hydrogel and disposed within the housing. The gaseous agent may be antimicrobial, antithrombogenic, or both antimicrobial and antithrombogenic.

Abstract: Devices, systems and methods are provided to improve pairing between first and second devices to mitigate risk that either device pairs with an unintended device by reducing transmit power to limit communication range between devices to be paired, using minimum and maximum received signal strength thresholds to reject unintended devices, and instructing user to move to another location when multiple devices are detected for pairing. The second device scanning time for detecting advertising signals from the first device is adjusted to detect multiple device co-existence. Pairing is controlled to occur when the second device is the only device that the first device detects.

Abstract: Aspects of the present disclosure include methods for adjusting sensitivity of a photodiode in a light detection system. Methods according to certain embodiments include detecting light with a light detection system having a photodiode and an amplifier, determining responsivity of the photodiode over a plurality of wavelengths of light and adjusting one or more parameters of the amplifier in response to the responsivity of the photodiode over the plurality of wavelengths of light. Systems (e.g., particle analyzers) having a light source and a light detection system that includes a photodiode and an amplifier for practicing the subject methods are also described. Non-transitory computer readable storage medium are also provided.

Abstract: Devices and methods detect an empty reservoir condition in an infusion pump using pump measurements such as motor current during aspiration. An infusion pump obtains and analyzes pump measurements indicative of pressure during aspiration and determines whether pump measurements satisfy metrics corresponding to an empty reservoir condition such as pressure threshold corresponding to a pump measurement value exceeded when the reservoir is empty, a range of pump measurement values indicating a pressure above normal operating pressure of the pump, and a designated shape of a signal waveform corresponding to the pump measurements indicating a pressure above normal operating pressure of the pump. Devices and methods can be configured to disregard one or more of the pump measurements obtained during one or more portions of the duration of the aspirate operation characterized by transient increases therein from normal operation of the pumping mechanism.

Abstract: A drug delivery device includes a reservoir for containing a medical product, a distally projecting end-piece having an outer surface and a total length measured along a longitudinal axis of said end-piece, said end-piece defining an axial passageway for the transfer of said medical product contained in said reservoir, wherein a gripping surface is provided on a portion of said outer surface, said portion being located in a distal region of said end-piece, the length of said portion representing at most 40%, preferably less than 33%, of the total length of the end-piece. An assembly includes such a drug delivery device and an adaptor intended to be mounted onto the end-piece.

Abstract: The disclosure provides a system and method to safely and efficiently store and transport process tubes in a carrier tray comprising prior to and during amplification of nucleotides in the process tubes. The process tube disclosed includes a securement region having an annular ledge, a neck, and a protrusion. The securement region of the process tube can secure the process tube in a port of the carrier tray, but still allows the process tube to adjust or float in order to align the process tube into a rigid heater well of a thermal cycler.

Abstract: A single use delivery device is disclosed having a manually deformable liquid container defining an inner chamber, the container having a distal end, a body, a proximal end, and an outlet on the distal end; a tip projecting from the outlet on the distal end of the container, the tip in fluid communication with the inner chamber of the container; a primer element for removing one or more air bubbles from the chamber, said primer element being attached to and in fluid communication with the deformable container, the container, the tip and the primer element being collapsible to minimize dead space in the delivery device; and two or more one-way valves. A method of administering a fluid to or flushing a vascular access device using a single use pre-filled delivery device as described herein is also disclosed.

Abstract: A pediatric catheter system may include a catheter adapter having a distal end, a proximal end, and a lumen extending therebetween. The lumen may include an upper surface and a lower surface with an adhesive coupled to the lower surface. The system may include a plurality of wings that extend outwardly from the catheter adapter. The plurality of wings may be configured to fold upwardly. The system may include a catheter cannula extending distally from the catheter adapter. The system may include a needle hub removably coupled to a proximal end of the catheter adapter and an introducer needle extending through the catheter tube. A proximal end of the introducer needle may be secured within the needle hub.

Abstract: Aspects of the present disclosure include a particle sorter with a droplet deflector configured to apply a known offset deflection force to a droplet stream. Particle sorters according to certain embodiments include a flow cell, a light source, e.g., laser, for irradiating an interrogation point of the flow cell, a detector for detecting light from the interrogation point, a droplet generator for producing a droplet stream from fluid exiting the flow cell and a droplet deflector configured to apply a known offset deflection force to the droplet stream. In some cases, the droplet deflector comprises first and second plates configured to be offset from one another. Methods and particle sorting modules for applying a known offset deflection force are also provided.

Abstract: An intravenous catheter device can include a safety mechanism having a slider that couples to a catheter adapter and slides relative to a barrel. A needle hub can be contained within the barrel and can be retracted once a catheter has been inserted into the patient's vasculature. The retraction of the needle hub can be triggered by the sliding of the slider. The slider may also function to guard the distal tip of the needle once the needle hub is retracted within the barrel.

Abstract: A plastic flange for a medical container, the plastic flange defining an opening, the opening being surrounded by a peripheral collar, the collar providing a support to a user's fingers, wherein the flange comprises connecting means for connecting the flange to an external surface of a tubular barrel of the medical container, and wherein the flange further comprises a remotely readable electronic component for remote identification of the medical container, the remotely readable electronic component being embedded into the plastic flange.

Abstract: In a computer; a computer readable medium for providing rapid syndrome analysis includes instructions for measuring a plurality of CUSUMs simultaneously and generating CUSUM data in response to an observed value. It also includes instructions for comparing the CUSUM data with a predetermined plurality of threshold values and instructions for generating a signal when the CUMSUM data exceeds any of the plurality of threshold values by a predetermined amount.

Abstract: Devices and methods are provided to improve accuracy of occlusion detection based on measured data in a fluid delivery device by using dead band normalization of loaded measured data to unloaded measured data. The loaded measured data and unloaded measured data are obtained during the same fluid movement operation or stroke of the fluid delivery device. The dead band normalization can be performed during an aspiration operation or a dispensing operation. An interface in the fluid delivery device that is close to the fluid driving mechanism and that can at least temporarily move under control but without moving fluid can be used to identify when to generate unloaded measured data during a fluid movement operation for dead band normalization of loaded measured data measured during that fluid movement operation.

Abstract: A packaging apparatus for small piece goods, the use of the packaging apparatus, and a method for producing a blister tube are provided. The packaging apparatus includes a packaging material guiding device for providing a shaped packaging material web suitable for receiving small piece goods, a longitudinal joining device which is arranged downstream of the packaging material guiding device and a transverse joining device which is arranged downstream of the packaging material guiding device. The transverse joining device joins the shaped packaging material web together at predetermined intervals transversely to the direction of travel to form a transverse joining area. The transverse joining device includes two joiners, a first joiner having a plurality of embossers that are individually movable transversely to the direction of travel and are arranged so that they can be extended from the first joiner and retracted into the first joiner.