Abstract: The invention relates to methods of treating antibody-mediated rejection in a subject comprising administering C1-INH to the subject according to a schedule with the following steps: (a) intravenously administering one or more iv-doses of C1-INH, (b) subcutaneously administering at least 10 sc-doses of C1-INH over several weeks, wherein each week at least one sc-dose is administered. The invention further relates to a method of treating antibody-mediated rejection in a transplant recipient comprising subcutaneously administering C1-INH over at least 10 weeks, wherein each week at least one sc-dose is administered.

Abstract: The invention pertains to a blood coagulation factor replacement product for use in the treatment or prophylaxis of bleedings of patients having an acquired coagulation factor deficiency or for use in the treatment or prophylaxis of bleedings of patients having a congenital deficiency of a coagulation factor. Said product comprises at least isolated prothrombin (Factor II) and isolated Antithrombin III (ATIII), whereby the molar ratio between ATIII to Factor II is at least 1:30. By administration of said product the patient's risk for a thromboembolic complication is reduced.

Abstract: The present invention relates to a process for purifying C1-esterase inhibitor (C1-Inh), and more in particular a Cl-Inh concentrate.

Abstract: The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.

Abstract: The present invention relates to a contact activation system inhibitor, preferably a C1INH, for use in the treatment and/or prevention of remote ischemia-reperfusion injury (IRI), comprising administering the contact activation system inhibitory to an individual.

Abstract: A battery cooling device may include a refrigeration circuit configured to communicate a refrigerant in a flow direction. The refrigeration circuit may include a plurality of refrigerant paths configured to be flowed through in parallel by the refrigerant along the flow direction. The plurality of refrigerant paths may respectively include at least one of a cooling element and a cooling element section. The at least one of the cooling element and the cooling element section may be fluidically incorporated into the respective refrigerant paths and be thermally coupled in a heat-transmitting manner to at least one battery. A plurality of valve devices may be arranged in the respective refrigerant paths and be configured to control a throughflow of the refrigerant.

Abstract: The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.

Abstract: A thermoelectric module may include a fluid-tight housing having at least one thermoelectrically active element arranged therein. The at least one thermoelectrically active element may have a coating. The housing may form an outer encapsulation and the coating may form an inner encapsulation for the at least one thermoelectrically active element.

Abstract: A heat exchanger component of a temperature control system of an electrical energy store may include a carrier material and at least two layers. The at least two layers may include a first layer composed of an electrically insulating material and a second layer that may facilitate temperature control via at least one of cooling and heating the electrical energy store.

Abstract: A heat exchanger may include a plate, a seal and a cover. The plate may have at least two receiving grooves having a respective groove base, an intermediate region disposed in a plane between a plurality of rim holes, and a ramp extending between the intermediate region and the respective groove base of the at least two receiving grooves. The seal extends in the at least two receiving grooves. The ramp may be rounded at a transition to the receiving grooves with a first radius and at a transition to the intermediate region with a second radius, and the ramp may be inclined between 20°<?<65° relative to the intermediate region or has an S-shaped progression. An inflection point of the plate may be arranged in a region from 10% to 80% of a height difference between the intermediate region and the respective groove base.

Abstract: The present invention relates generally to a method of reducing the level of at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) in a solution comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and von Willebrand factor (VWF), the method comprising: (i) passing a feedstock comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF through a hydrophobic charge-induction chromatographic resin under conditions selected such that at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) present in the feedstock is bound to the resin; and (ii) recovering a solution comprising the at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF which passes through the resin, wherein the concentration of the at least one protein selected from the group consisting of pl

Abstract: The present invention relates to a contact activation system inhibitor, preferably a C1INH, for use in the treatment and/or prevention of remote ischemia-reperfusion injury (IRI), comprising administering the contact activation system inhibitory to an individual.

Abstract: A heat exchanger may include a heat exchanger block that may have a plurality of pipes and at least one collector. The at least one collector may include at least one pipe end that may accommodate the plurality of pipes in a leakproof manner at a longitudinal end thereof. The heat exchanger may include a terminal piece that may have a duct structure. The duct structure may include a plurality of webs that may separate a plurality of ducts situated between the plurality of webs from each other. The plurality of webs may include a web width bS of 1.0 mm<bS<5.0 mm. The plurality of webs may define a ratio between the web width bS and a duct width bK may be of bS/bK<4.

Abstract: An exhaust gas system for a motor vehicle may include an exhaust gas aftertreatment device communicating fluidically with an exhaust gas evaporation device. The exhaust gas aftertreatment device and the exhaust gas evaporation device may be arranged in one or more housings. A connecting line may be provided to fluidically connect the exhaust gas aftertreatment device to the exhaust gas evaporation device. The connecting line may include a fluid inlet connected to the exhaust gas aftertreatment device and a fluid outlet connected to the exhaust gas evaporation device. An evaporation bypass line may branch off from the connection line at a branching-off point. A valve apparatus may be arranged in at least the connecting line and may be adjustable between a first position to fluidly connect the fluid inlet to the fluid outlet, and a second position to fluidly connect the fluid inlet to the evaporator bypass line.

Abstract: A motor vehicle may include an internal combustion engine and an air-conditioning system, which may include a heat exchanger and a compression refrigeration system. The heat exchanger and the compression refrigeration system may be incorporated into a coolant circuit configured to communicate a coolant flow and may have a pump. The compression refrigeration machine may be driven at least one of directly and indirectly via the internal combustion engine. An adsorption system may be incorporated into the coolant circuit and may be connected to the internal combustion engine in a heat-transferring manner. The adsorption system may be configured to receive a waste heat load from the internal combustion engine for operation. A valve device may be incorporated into the coolant circuit and be switchable between at least two position for distributing the coolant flow between the adsorption system and the compression refrigeration system.

Abstract: A charge-air cooler for a fresh-air system of an internal combustion engine may include a cooler box and an upper shell such as a flange plate. The cooler box may include a cooler box passage opening, and the flange plate may include a flange plate passage opening arranged complementary with the cooler box passage opening. An adapter element may have a first end section and a second end section. The adapter element may be connected to a rim of the cooler box that borders the cooler box passage opening. A pipe element may be detachably secured to the adapter element and have a first end section and a second end section. The first end section of the adapter element and the first end section of the pipe element may define a clip-type connection when the adapter element and the pipe element are secured to one another.

Abstract: An arrangement may include an electrical component and a heat exchanger arranged on the electrical component for controlling a temperature of the component. An electrically insulating isolation layer may be arranged at least partially between the heat exchanger and the component. The isolation layer may be connected to at least one of the component and the heat exchanger via a materially cohesive connection.

Abstract: A cooling device for a battery of a motor vehicle may include a first cooling plate and a second cooling plate bonded to the first cooling plate. The second cooling plate may include at least one depression extending in a direction away from the first cooling plate. The depression may define at least one fluid duct for a coolant flow. A first side of the first cooling plate facing away from the second cooling plate may include at least one thermoelectric element. A first side of the second cooling plate facing towards the first cooling plate may include a plurality of turbulence-generating elements.

Abstract: An assembly for an air conditioning system may include an air filter for filtering drawn-in fresh air. The air filter may be arranged in a fresh air path and may separate a raw side from a clean side of the fresh air path. A water path for discharging water separated from the fresh air may be disposed at the raw side of the air filter. The water path may include a water filter for filtering the separated water. The water filter may separate a raw side from a clean side of the water path.

Abstract: A method for the production of a heat exchanger is provided, particularly a sorption heat exchanger, in which several components of the heat exchanger have a ferrous based material, such as pipes, the pipes finishing the bottoms, and the bottoms and the pipes enclosing the housing components are coffered and then soldered. In one method, which reliably realizes the soldering of the joints with different widths, a brazing foil is introduced during the coffering of the components of the heat exchanger formed of steel or stainless steel between the joints of the components of the heat exchanger, and then the joints are filled with a low-melting solder and soldered without flux material.