Abstract: An inhibitor of FXII/FXIIa for the prevention of the formation and/or stabilization of thrombi during and/or after a medical procedure performed on a human or animal subject comprising contacting blood of said human or animal subject with artificial surfaces, wherein said inhibitor of FXII/FXIIa is administered before and/or during and/or after said medical procedure.

Abstract: The invention relates to therapeutic fusion proteins in which a coagulation factor is fused to a half-life enhancing polypeptide, and in which both are connected by a linker peptide that is proteolytically cleavable. The cleavage of such linkers liberates the coagulation factor from activity-compromising steric hindrance caused by the half-life enhancing polypeptide and thereby allows the generation of fusion proteins may show relatively high molar specific activity when tested in coagulation-related assays. Furthermore, the fact that the linker is cleavable can enhance the rates of inactivation and/or elimination after proteolytic cleavage of the peptide linker compared to the rates measured for corresponding therapeutic fusion proteins linked by the non-cleavable linker having the amino acid sequence GGGGGGV.

Abstract: This application relates to neurological inflammatory diseases, such as multiple sclerosis, and to methods of administering a Factor XII inhibitor to prevent, treat, or otherwise ameliorate the effects of a neurological inflammatory disease, such as multiple sclerosis. Agents and pharmaceutical compositions comprising agents which inhibit the activity of FXII are also provided.

Abstract: The application relates to a heat exchanger and a connecting system for the heat exchanger. This subject matter includes a housing formed by a top part and a bottom part and a first connecting element and a second connecting element connected to these top and bottom parts. Specific embodiments of the subject matter are shown in which the connecting elements connect the housing top part and bottom part by a positive and/or material connection. The advantages of each embodiment over prior approaches are too numerous to include in this abstract, but will be apparent to one of ordinary skill in the art when reviewing the full specification.

Abstract: A heat exchanger assembly may include an intercooler and a housing which encloses said intercooler. The housing may be part of a charge air line. The housing may include a charge air inlet, a charge air outlet and an opening through which the intercooler can be inserted into the housing from one side. The housing may also include a recess on the side opposite the opening, into which recess the intercooler engages. The heat exchanger assembly may include an elastic seal arranged in the region of the recess between the intercooler and the housing. The seal may be configured to at least one of bridge the deformation of the housing occurring during pressure pulsations, bridge relative movements between the intercooler and the housing, and tightly connect the intercooler to the housing in all operating states preventing an undesirable bypass flow.

Abstract: A thermal transfer device for generating a thermal transfer between an energy store and a temperature-control panel for the temperature-control of the energy store. The thermal transfer device has a thermal insulation layer made of an unevenly distributed insulation material and a tolerance compensating layer made of a compressible material for compensating different material strengths of the thermal insulation layer.

Abstract: A heat exchanger may include a gas conduit flowable through by a predetermined gas and a heat conduit flowable through by a predetermined fluid compound working fluid. The heat conduit may be in thermal communication with the gas conduit. The heat exchanger may include a first section having a first section length, a second section having a second section length, and a third section having a third section length. The gas conduit may span, in a direction of flow of the gas, the first section, the second section, and the third section. The heat conduit may span, in a direction of flow of the working fluid, the third section, the first section, and the second section. The first section may include a gas inlet and the third section may include a working fluid inlet and a gas outlet. The section may include a working fluid outlet.

Abstract: A thermoelectric device may include a housing that may have a first housing element and a second housing element. The first housing element and the second housing element may each be composed of an electrically conductive material. At least two thermoelectric elements may be arranged between the first housing element and the second housing element. The at least two thermoelectric elements may be arranged at a distance from each other and may be electrically connected via at least one conductor bridge. A first electrical insulator may be arranged between the at least two thermoelectric elements and the first housing element. A second electrical insulator may be arranged between the at least two thermoelectric elements and the second housing element.

Abstract: The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.

Abstract: The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.

Abstract: A thermoelectric arrangement for use in a cooling system (4, 6) of a motor vehicle has a thermocouple (8) with a first, heat-outputting thermal element (10), a second, heat-absorbing thermal element (12) and a conductor element (14) through which current flows. At least two cooling circuits (16, 18, 20) are provided. The first thermal element (10) is arranged in at least one cooling circuit (16, 18, 20), and the second thermal element (12) is arranged in at least one heating circuit (48). The first thermal element (10) is arranged in a first connecting line (22) that is connected fluidically to the respective cooling circuits (16, 18, 20) via valve arrangements (24, 26; 28, 30; 32, 34) on the input and output sides of the first thermal element (10). A cooling system having such a thermoelectric arrangement also is described.

Abstract: The invention relates to a module for a heat pump, comprising an adsorption-desorption region, wherein in the region a bundle of pipes through which fluid can flow is arranged and a housing encloses the pipe bundle and a movable working medium in a sealing manner, wherein a supporting structure forms a mechanical support of a wall of the housing against the action of an external pressure.

Abstract: The invention relates to compositions comprising an isolated sugar for use in the treatment of von Willebrand disease and/or hemophilia A, wherein the sugar is an accessible sugar residue derived from ABO(H) blood group antigen.

Abstract: A heat exchanger for transferring heat between a gaseous first fluid and a liquid second fluid may include a plurality of hollow pipes extending transversely through a first fluid path for conducting the first fluid. The plurality of pipes may be coupled externally to a plurality of cooling fins arranged in the first fluid path. The plurality of pipes may internally define a second fluid path for conducting the second fluid. The plurality of pipes and the plurality of cooling fins may be arranged stacked on one another in a stacking direction to define a cooler block. The cooler block may include two side parts extending along two outer sides of the cooler block facing away from one another in the stacking direction. At least one tension rod may fixedly connect the two side parts and be configured to transmit a tensile force in the stacking direction.

Abstract: A heat transfer device for a motor vehicle may include a pump and a heat exchanger. The heat exchanger may have a first inlet and a first outlet for a refrigerant, and a second inlet and a second outlet for a coolant. The pump and the heat exchanger may be mounted to each other forming a common assembly.

Abstract: The present invention relates generally to a method of reducing the level of at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) in a solution comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and von Willebrand factor (VWF), the method comprising: (i) passing a feedstock comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF through a hydrophobic charge-induction chromatographic resin under conditions selected such that at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) present in the feedstock is bound to the resin; and (ii) recovering a solution comprising the at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF which passes through the resin, wherein the concentration of the at least one protein selected from the group consisting of pl

Abstract: The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.

Abstract: A combined intake and exhaust manifold (1) for a thermoelectric temperature control device includes an outer manifold case (2) that partially encases a first case interior (3), and an inner manifold case (4) provided in the first case interior (3), which partially encases a second case interior (5). The outer and the inner manifold cases (2, 4) have a joint connection side (6) for connecting a fluid line (17a, 17b). The manifold further includes at least one first flow-through opening (7a, 7b) for introducing or discharging a fluid into or out of the first case interior (3) and at least one second flow-through opening (8a, 8b) for introducing or discharging the fluid into or out of the second case interior (5) on the connection side (6).

Abstract: An adsorber structure for an adsorption heat exchanger may include directed transport structures for the transport of at least one of heat and adsorptive vapours. The transport structure may be substantially aligned with a gradient direction.

Abstract: The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.