Patents Assigned to Behringwerke Aktiengesellschaft
  • Expression vectors for the synthesis of proteins in the fission yeast schizosaccharomyces pombe
    Patent number: 5663061
    Abstract: Particularly suitable expression vectors for the synthesis of proteins in the fission yeast Schizosaccharomyces pombe (S. pombe) are described. These expression vectors are (in addition to other advantageous elements, equipped with a strong homologous promoter and terminator).
    Type: Grant
    Filed: January 12, 1995
    Date of Patent: September 2, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventor: Michael Broker
  • Use of lymphocytes transformed with herpesvirus saimiri in a process for replicating viruses of the HIV type which cause immune deficiency
    Patent number: 5656475
    Abstract: A process is disclosed for replicating viruses of the HIV type which cause immune deficiency, in which process lymphocytes are employed which have been transformed with herpesvirus saimiri.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: August 12, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Sigrid Nick, Helmut Fickenscher, Brigitte Biesinger-Zwosta, Gerhard Jahn, Bernhard Fleckenstein
  • Fluorogenic compounds and their use
    Patent number: 5648229
    Abstract: The invention relates to fluorogenic compounds for the detection of hydrolyzing enzymes and the use of the fluorogenic compounds.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 15, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventor: Klaus Habenstein
  • Granulocyte-binding antibody constructs, their preparation and use
    Patent number: 5645817
    Abstract: The present invention describes granulocyte-binding antibody constructs, which were derived from the monoclonal mouse antibody MAk BW 250/183 (EP-A1-0 388 914), as well as a process for their preparation and their use.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 8, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Gerhard Seemann, Klaus Bosslet
  • Use of pairs of leucine zipper peptides in immunoassay methods
    Patent number: 5643731
    Abstract: The invention relates to a method of using a pair of leucine zipper peptides for in vitro diagnosis, in particular, for the immunochemical detection and determination of an analyte in a biological liquid. In one method, the first leucine zipper peptide is immobilized by attaching it to a solid support, the second leucine zipper peptide is coupled to a specific binding partner for the analyte, the two peptides are brought into contact, the sample of the biological liquid is brought into contact with the immobilized first peptide and the specific binding partner for the analyte, and the amount of analyte bound to the binding partner is determined. The leucine zipper peptides are preferably v-fos and c-jun.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 1, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Klaus Bosslet, Peter Hermentin, Hans Harald Sedlacek, Bernhard Auerbach, Peter Pfleiderer, Rolf Muller
  • Monoclonal antibodies against Mycoplasma pneumoniae, hybridomas producing these, methods for the preparation thereof, and the use thereof
    Patent number: 5641638
    Abstract: The invention relates to monoclonal antibodies and fragments thereof which are specific for Mycoplasma pneumoniae P2 protein and have a cross-reactivity of 1% or less with five other species of the genus Mycoplasma and other pathogen species of the concomitant flora, and to methods for the preparation of the monoclonal antibodies according to the invention. The invention furthermore relates to hybridomas which produce the antibodies according to the invention, and to methods for the preparation thereof. Finally, the invention relates to the use of the monoclonal antibodies according to the invention for detecting Mycoplasma pneumoniae in a sample.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: June 24, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Wolfgang Bredt, Bernhard Gerstenecker, Enno Jacobs, Wilhelm Schuy
  • Monoclonal antibodies against tumor-associated antigens
    Patent number: 5639621
    Abstract: The invention relates to monoclonal antibodies against a tumor-associated antigen which is mainly derived from tumors from the group of carcinomas of the breast, ovaries and prostate, as well as adenocarcinomas of the lung, which additionally react with polymorphic epithelial mucin (PEM), to the preparation and use thereof and to the use of the epitope defined by the antibody for diagnosis and therapy.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 17, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Klaus Bosslet, Peter Pfleiderer, Gerhard Seemann
  • Cell-free receptor binding assays, the production and use thereof
    Patent number: 5639597
    Abstract: The invention relates to cell-free receptor binding assays which permit the binding behavior of receptor proteins in the cell membrane toward natural or artificial ligands to be investigated. This entails the particular receptor being linked to a suitable carrier molecule, preferably the heavy chain of an immunoglobulin, and being bound via the carrier, with retention of its biological property, to a suitable solid phase.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: June 17, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Leander Lauffer, Gerd Zettlmeissl, Patricia Oquendo
  • Monoclonal antibodies against tumor-associated antigens, a process for the preparation thereof and the use thereof
    Patent number: 5639622
    Abstract: The invention relates to monoclonal antibodies (MAbs) and fragments thereof which bind to defined tumor-associated antigens, principally of small cell lung carcinoma (SCLC), of melanoma, of neuroblastoma and other tumors of neuroectodermal origin, to hybridoma cell lines for the preparation thereof, and to the antigens which can be defined and/or isolated with the aid of these antibodies or antibody fragments. The antibodies, antibody fragments and antigens can be used as diagnostic. aid, active substance or active substance carrier.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 17, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Klaus Bosslet, Bernhard Auerbach, Helmut Peters
  • Process for the detection of complexed cathepsin G and .alpha.-1-antichymotrypsin
    Patent number: 5631136
    Abstract: The present invention relates to a process for determining complexes of .alpha.-1-antichymotrypsin and cathepsin G in a sample comprising adsorbing the cathepsin G portion of the complex to a solid phase coated with non-specific binding protein or gelatin, and detecting the .alpha.-1 portion of the complex with a detectably labelled anti-.alpha.-1-antichymotrypsin antibody. A diagnostic kit comprising the solid phase coated with non-specific binding protein or gelatin and the labelled anti-.alpha.-1-antichymotrypsin antibody is also provided.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: May 20, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Klaus Havemann, Hans-Heinrich Heidtmann
  • Use of HVP-16 E6 and E7-gene derived peptides to diagnose HPV-16-associated invasive cervical cancer
    Patent number: 5629161
    Abstract: The present invention relates to the use of human paillomavirus 16 (HPV-16) E7-gene derived peptides for the diagnostic identification of HPV-16-associated invasive cervical cancer.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: May 13, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Martin Muller, Lutz Gissmann
  • Apparatus for quanitative evaluation of agglutination reactions
    Patent number: 5628963
    Abstract: In the method for quantitative evaluation of agglutination reactions between a reagent and a biological fluid to be examined, the reagent and the biological fluid are intimately mixed by a horizontal circular movement. The agglutinates formed in the mixture while the circular movement is maintained are optically imaged thereafter on a ground glass plate, and the image is evaluated using an electronic evaluation device.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 13, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Paul Meller, Susanne Scheuermann, Matthias Zimmermann
  • Amidinophenylalanine derivatives, a process for the preparation thereof, use thereof and agents containing these as anticoagulants
    Patent number: 5627283
    Abstract: Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 6, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Werner St uber, Gerhard Dickneite, Rainer Koschinsky, Cenek Kolar
  • Prodrugs for enzyme mediated activation
    Patent number: 5621002
    Abstract: Enzymatically clearable prodrugs with reduced Michaelis-Menten constant (Km) are described.
    Type: Grant
    Filed: September 9, 1994
    Date of Patent: April 15, 1997
    Assignees: Behringwerke Aktiengesellschaft, Laboratoires Hoechst S/A
    Inventors: Klaus Bosslet, J org Czech, Dieter Hoffmann, Andrea Vasella, Roland Hoos, Fran.cedilla.ois Tillequin, Jean-Claude Florent, Michel Azoulay, Claude Monneret, Jean-Claude Jacquesy, Jean-Pierre Gesson, Michel Koch
  • Human papilloma virus Type 57, a method for preparing expression products thereof
    Patent number: 5618694
    Abstract: The invention describes the isolation for the first time of human papilloma virus (HPV) 57, the partial characterization of its genome and its cloning in pUC 19. This opens up a way of diagnosing those tumors (oral, genital and cutaneous tumors) which are associated with HPV 57.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 8, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Ethel-Michele de Villiers, Anja Hirsch-Behnam, Harald zur Hausen
  • Mutants of human antithrombin III
    Patent number: 5618713
    Abstract: Mutants of AT III which have been advantageously modified at one or more potential glycosylation sites or at the Arg393 position are described. As a rule, combination of the mutations enhances the advantageous modifications.
    Type: Grant
    Filed: December 18, 1992
    Date of Patent: April 8, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Gerd Zettlmeissl, Hermann E. Karges, Achim Becker
  • Agent for the determination of peroxidase activity, a process for its preparation and its use
    Patent number: 5610026
    Abstract: An agent for the detection of peroxidase or of pseudoperoxidase activity, and its preparation and its use are described. The agent contains a tetraalkylbenzidine, a peroxide and buffer substances. The agent according to the invention has, as a peroxidase substrate, the advantage over previous tetraalkylbenzidine-containing substrates that it generates higher color signals.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: March 11, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Hans E. Pauly, Herbert Schwarz
  • Peptide amides, processes for the preparation thereof and agents containing these as fibrin/thrombin clotting inhibitors
    Patent number: 5607858
    Abstract: Peptide amides of the formula I (SEQ ID NOS: 3-21)GPRP--X--NR.sub.1 --R.sub.2 Iwhere G is the amino acid glycine, P is the amino acid L-proline, R is the amino acid L-arginine, X is a proteinogenous amino acid apart from proline or a dipeptide from these amino acids including proline, N is nitrogen and R.sub.1 and R.sub.2 are identical or different and are hydrogen or a lower alkyl chain having up to 4 carbon atoms; processes for the preparation thereof and the use thereof as medicament or for diagnostic purposes are described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 4, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Werner Stuber, Karl Fickenscher
  • Method for the determination of the plasminogen activator activity in samples containing alpha-2-antiplasmin
    Patent number: 5607837
    Abstract: The disclosed invention provides a method for determining the plasminogen activator (PA) activity in a biological fluid. The method involves the use of proteolytically-degraded plasminogen and effectively eliminates the influence of alpha-2-antiplasmin on the determination of PA activity.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: March 4, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Thomas Stief, Norbert Heimburger
  • Apparatus for spraying a mixture of two components
    Patent number: 5605255
    Abstract: The invention relates to an apparatus containing two syringes whose outlets terminate in a spray head with spray nozzle (atomizer). This apparatus is suitable for spraying, and where appropriate applying to a surface, two liquids as mixture. These liquids are preferably the components of an adhesive system, especially of a tissue adhesive.
    Type: Grant
    Filed: June 26, 1995
    Date of Patent: February 25, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Guillermo Reidel, Dietmar Weitzel, Hans Grothoff