Abstract: The invention describes two immunogenic regions of the E7 protein of human papillomavirus type 16 (HPV 16), one immunoreactive region being located downstream from nucleotide 595 and the other being located downstream from nucleotide 667 of the HPV 16 genome.

Abstract: The present invention relates to a composition containing the p40 subunit of interleukin-12, hereinafter referred to as p40/IL-12 and to methods of diagnosis and treatment of disorders associated with disregulation of the immune system.

Abstract: The invention relates to a process for preparing conjugates consisting of a specific binding partner and a carbohydrate-containing protein, conjugates which can be prepared by this process and their use in enzyme immunoassays.

Abstract: Substituted phenols of the formula I ##STR1## processes for their preparation and compositions containing substituted phenols of the formulae I and II ##STR2## for the treatment of disorders caused by cell proliferation, such as psoriasis, tumor disorders and immunological disorders, are described.

Abstract: A method and an agent for the functional determination of protein C inhibitor in body fluids are described, in which this fluid is incubated with a known amount of a plasminogen activator, fibrinogen and a sulfated carbohydrate, and the residual activity of the plasminogen activator is determined, and from this the amount of protein C inhibitor is determined.

Abstract: A disposable biosensor for measuring changes in viscosity and/or density in a test fluid includes a disposable housing surrounding a measuring chamber. A piezoelectric element is disposed in the measuring chamber and constitutes an oscillating unit. The piezoelectric element has a measuring surface adapted to be wetted with a measuring mixture comprising the test fluid and a reaction component. The reaction component is disposed inside the measuring chamber in a vicinity of and not touching the measuring surface of the piezoelectric element before any test fluid is introduced into the measuring chamber. Access is provided in the disposable housing for introducing the test fluid into the measuring chamber so that the test fluid comes into contact with the reaction component and the measuring surface of the piezoelectric element upon its introduction into the measuring chamber.

Abstract: The invention relates to artificial positive control reagents based on antibody conjugates that are used in immunochemical detection methods and to processes for the preparation of these reagents.

Abstract: The invention relates to compounds from biopolymers and effector substances which are linked with the aid of derivatives of optically active amino acids in which the amino group has been converted into a maleimido group and the carboxyl group into an active ester group, processes for the preparation thereof and the use thereof.

Abstract: Adsorbents composed of a polysaccharide support which is suitable for chromatography and is preferably based on agarose which has undergone a chemical reaction with the glycidyl ethers of nonionic polyoxyethylene detergents of the type HO--(CH.sub.2 CH.sub.2 O).sub.n --O--R to give a compound of the formula I ##STR1## where n is an integer from 2 to 30 andR is an alkyl radical having 4-20 or a phenyl radical or a phenylalkyl radical, where the alkyl radical has 1-16 carbon atoms, to a process for their preparation and to their use for removing lipoproteins from human or animal body fluids are described.

Abstract: Peptide amides of the formula I (SEQ ID NOS: 3-21)GPRP--X--NR.sub.1 --R.sub.2 Iwhere G is the amino acid glycine, P is the amino acid L-proline, R is the amino acid L-arginine, X is a proteinogenous amino acid apart from proline or a dipeptide from these amino acids including proline, N is nitrogen and R.sub.1 and R.sub.2 are identical or different and are hydrogen or a lower alkyl chain having up to 4 carbon atoms; processes for the preparation thereof and the use thereof as medicament or for diagnostic purposes are described.

Abstract: The invention relates to a latex agglutination method for the detection or determination of one partner of an antigen-antibody reaction, wherein, in order to suppress non-specific reactions, to, for example, Clq and rheumatoid factors the immunochemical reaction takes place in the presence of an immune complex which does not contain any antibody or antigen that is specific for one of the partners.

Abstract: A description is given of the possibility of using transglutaminases in a process for the preparation of an immunosuppressant.Additionally described is a pharmaceutical containing a transglutaminase and a plasminogen activator inhibitor.

Abstract: The invention relates to muteins of human erythropoietin (EPO) in the carboxyl terminal region which are prepared by means of recombinant DNA techniques. These mutants have advantageous properties in comparison with human wild-type EPO.

Abstract: Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.

Abstract: Oxidized derivatives of-fibrin and fibrin or fibrinogen degradation products or partial sequences, process for their preparation and their use as medicaments, for diagnosis or as an affinity agent are described.

Abstract: An H. saimiri-HTLV-1 or 2 X region vector is disclosed. This vector can be used to establish continuous cell lines of difficult to grow cells, such as human T-cells. It can also be used to obtain certain cell products and in methods for screening new compounds.

Abstract: A description is given of a one-component tissue adhesive containing, in aqueous solution, fibrinogen, F XIII, a thrombin inhibitor, prothrombin factors, calcium ions and, where appropriate, a plasmin inhibitor and of a process for the production thereof.This adhesive can be reconstituted from a freeze-dried form with water. It can contain all active substances in pasteurized form and is then free of the risk of transmission of hepatitis and HTLV III.

Abstract: Protective Plasmodium falciparum hybrid proteins which contain part-sequences of the malaria antigens HRPII and SERP, the preparation and use thereof.The invention relates to hybrid proteins composed of part-sequences of the malaria antigens HRPII and SERP. The HRPII sequence has already proven protective in the monkey model (EP-A2-0 315 085), where a C-terminal region of 189 amino acids has been used in the present invention in the same way as in the preceding protection experiment. SERP was identified with the aid of an antiserum against a protective protein band (EP-A1-0 283 882); the part-sequence used (amino acids (AA) 631-892 or 630-764) contains at least two T-cell epitopes (Roussilhon et al. (1990), Immunol. Letters 25, 149-154). In preferred embodiments, further T-cell epitope-containing regions of other P. falciparum proteins such as merozoite surface antigen I (MSA I or else "195 kd antigen"), amino acids from 100 to 300, are incorporated (Crisanti et al. (1988), Science 240, 324-326).

Abstract: Recombinant histidine-rich protein of Plasmodium falciparum, its preparation and use. It was possible, by screening two different Plasmodium falciparum cDNA gene banks with an antiserum against a 41 kD protein and by cross-hybridization with the insert DNA of a clone obtained therewith, to isolate a gene which codes for a Histidine-Alanine-rich protein (HRP-II). This protein protects aotus monkeys from infection with P. falciparum and is thus a suitable constituent of a malaria vaccine.

Abstract: Agents for immunochemical tests which contain polymers containing carboxyl groups and processes for carrying out such tests are described. These polymers are capable of improving the results obtained with such tests, in that they suppress non-specific reactions and increase the sensitivity of the tests.