Abstract: A polynucleotide is provided. The polynucleotide encoding a chimeric polypeptide comprising an amino acid sequence of an immune checkpoint molecule capable of binding a ligand thereof, the immune checkpoint molecule being translationally fused to another amino acid sequence of a cell signaling module such that upon binding of the immune checkpoint molecule to the ligand, the cell signaling module is activated. Also provided other configurations of the polynucleotide, cells comprising the polynucleotides and methods of using the cells expressing the polynucleotides.

Abstract: A computer implemented method for encoding bits by qubits to perform information-theoretically secure quantum gate computation, according to which pairs of quantum bits consisting of a first qubit as an encoding of “0” and a second qubit as an encoding of “1” are randomly selected, such that the first and second qubits are orthogonal to each other as quantum states and are interchanged by a NOT gate. Each qubit rotating to a desired initial direction and then each rotated qubit is further rotated to its antipodal direction by applying a quantum NOT or CNOT gate to the each rotated qubit, without any knowledge about the desired direction. A unitary gate is further applied over the qubits, using an ancillary |0 qubit that creates an equally weighted superposition of the qubits.

Abstract: Mutant M-CSF protein, comprising ?v?3 integrin binding motif and pharmaceutical compositions comprising same, are provided. Further, use of the composition for the treatment and or prevention of diseases associated with increased bone resorption are provided.

Abstract: The present invention provides a recombinant protein including (a) lactate dehydrogenase (LDH); and (b) a minimal c-type cytochrome peptide. Further provided is a polynucleotide encoding the recombinant protein, a cell including the same, and methods of using same, such as for determining presence, concentration, or both, of an analyte in a liquid medium.

Abstract: An electrochemical method of determining the presence and optionally the concentration of at least two analytes in a test sample which contains a mixture of analytes, wherein the analytes differ from one another in electrical charge and/or size, comprising the steps of: applying variable voltage, fixed voltage, current or impedance across an array of working electrodes consisting of electrodes coated with films of varying thickness and optionally a bare electrode, when the array is in contact with the test sample; measuring the current flowing or the impedance between each of the film-coated working electrodes and a counter electrode, or the potential between each of the film-coated working electrodes and a reference electrode, to obtain a raw data set consisting of a plurality of electrochemical signals; preprocessing the raw data set; and applying chemometric method (s) to the processed data, to qualitatively or quantitively characterize the at least two analytes of interest; wherein the working electrodes

Abstract: A mixed-signal controller for controlling a multiphase average-current-mode voltage regulator having an output connected to a load, which comprises a digital voltage-sampling ADC for converting the output voltage signal from analog to digital representation; a digital current-sampling ADC, for converting the inductor current from analog to digital representation; a digital compensator for generating a current reference signal, based on a digital voltage error signal and for generating a duty-ratio command signal, based on a digital current error signal; a multiphase Digital Pulse Width Modulator (DPWM), for generating a pulse-width-modulated signal (per-phase), to thereby control the per-phase currents and output voltage supplied to the load; an analog front-end, in which single-ended signals are used for steady-state control via ADC measurement and the single-ended output voltage is used for transient detection and output voltage extremum detection during transient; a Transient Suppression Unit (TSU), for ge

Abstract: An integrated system and method for personalized stratification and prediction of neurodegenerative disease state and progression rate. Homogenous patient clusters are identified among heterogeneous patient data. Each patient cluster is characterized by specific disease factors that are used to predict disease progression state and rate for patients assigned to a particular patient cluster in accordance with his disease profile.

Abstract: Peptides derived from NKp44 protein, chimeric peptides, nucleotides encoding same and pharmaceutical compositions comprising same, are provided. Further, methods of extending the biological half-life of a protein of interest are provided.

Abstract: A security assessment system is configured to provide a duplicated environment which duplicates an assessment target system comprising a plurality of physical components. The security assessment system includes a duplicated environment design circuitry and a duplicated environment construction circuitry. The duplicated environment design circuitry is configured to select a duplication level based on constraints specified by a user in order to design the duplicated environment to produce a designed result indicative of a duplicated environment design. The duplication level is indicative of any one of a simulation sub-module, an emulation sub-module, and a physical sub-module which are for reproducing the physical components of the assessment target system. The duplicated environment construction circuitry is configured to construct the duplicated environment based on the designed result. The duplicated environment includes components which are duplicated by one of the duplication level.

Abstract: This invention provides an electrochemical system for manufacturing methanol from methane in good yields and without admixtures of methanol oxidation products. A fuel cell for methane or methanol utilization is also provided.

Abstract: The invention provides ultraviolet light absorber suitable for use as an additive in polymers, comprising particles of inorganic oxide having UV light-absorbing compound on their surface, wherein said UV light-absorbing compound is chemically bonded, either to a spacer provided on the surface of said particle, or directly to the surface of the particle. Process for preparing the additive absorber and a thermoplastic polymer (e.g., a film) comprising the absorber additive are also provided.

Abstract: An automated interactive optimization method of short keyword queries for improving information retrieval from opaque (black box) search engines is disclosed. The method requires collecting data from several fact-checking websites, for creating dataset used for evaluation; estimating the relevance of posts/query results retrieved from a search engine to a given input document, by calculating the mean relevance error (MRE), based on estimating the minimal distance between words comprising both the retrieved posts and the input document; labeling a subset of claims for evaluation, by choosing a number of claims that gained the maximal and the minimal mean relevance error (MRE); and finding the most appropriate queries in order to retrieve the maximal number of relevant posts using an opaque search engine, by performing an interactive greedy search for the best word that should be added to the input query, for maximizing the corresponding posts retrieved by the search engine.

Abstract: The invention provides a process for preparing an electrode, comprising: electrodeposition of metallic ruthenium/ruthenium oxide (Ru(0)/RuO2) coating onto a progressively etched nickel surface; and partial electrochemical oxidation of said metallic ruthenium to ruthenium oxide. The electrode produced and a pseudo-capacitor based on the electrode are also disclosed.

Abstract: A security assessment system is configured to provide a duplicated environment which duplicates an assessment target system comprising a plurality of physical components. The security assessment system includes a duplicated environment design circuitry and a duplicated environment construction circuitry. The duplicated environment design circuitry is configured to select a duplication level based on constraints specified by a user and effects associated with the physical components in order to design the duplicated environment to produce a designed result indicative of a duplicated environment design. The duplication level is indicative of any one of a simulation sub-module, an emulation sub-module, and a physical sub-module which are for reproducing the physical components of the assessment target system. The duplicated environment construction circuitry is configured to construct the duplicated environment based on the designed result.

Abstract: A method for creating a one-way function from a computation problem instances with a predefined success criteria, based on mutual hiding of the success criteria, comprising the steps of selecting at least a first and a second original computation tasks, each having an original corresponding success criterion; applying a function (such as a bitwise XOR operation) over both original corresponding success criteria, to form a single combined success criterion for a mutual computation task being a combination of the at least a first and a second original computation tasks; outputting the original computation tasks along with the combined success criterion, while excluding the original corresponding success criteria.

Abstract: The present invention relates to a system and method for determining sleep quality parameters according to audio analyses, comprising: obtaining an audio recorded signal comprising sleep sounds of a subject; segmenting the signal into epochs; generating a feature vector for each epoch, wherein each of said feature vectors comprises one or more feature parameters that are associated with a particular characteristic of the signal and that are calculated according to the epoch signal or according to a signal generated from the epoch signal; inputting the generated feature vectors into a machine learning classifier and applying a preformed classifying model on the feature vectors that outputs a probabilities vector for each epoch, wherein each of the probabilities vectors comprises the probabilities of the epoch being each of the sleep quality parameters; inputting the probabilities vectors for each epoch into a machine learning time series model and applying a preformed sleep quality time series pattern function

Abstract: The knowledge generation apparatus (2000) obtains a plural pieces of attack result information (100), which includes a configuration of an attack performed on the computer environment, a configuration of the computer environment attacked, and a result of the attack. By comparing the obtained attack result information (100), the knowledge generation apparatus (2000) detects environment conditions, which is regarding the configuration of the computer environment that are necessary for the success of the attack. The knowledge generation apparatus (2000) performs selection on the detected environment conditions based on a selection rule (200), and generates the knowledge information (300) that includes the selected environment conditions. The selection rule represents a rule for determining whether to include the environment condition in the knowledge information (300), with respect to a feature of a set of attacks that are affected by the environment condition.

Abstract: Provided herein is a method and system for the estimation of apnea-hypopnea index (AHI), as an indicator for Obstructive sleep apnea (OSA) severity, by combining speech descriptors from three separate and distinct speech signal domains. These domains include the acoustic short-term features (STF) of continuous speech, the long-term features (LTF) of continuous speech, and features of sustained vowels (SVF). Combining these speech descriptors may provide the ability to estimate the severity of OSA using statistical learning and speech analysis approaches.

Abstract: The present invention relates to transgenic grape cells, compositions comprising such cells or extracts or fractions thereof, and methods of use thereof for inhibiting or reducing the incidence of cytokine release syndrome or cytokine storm in a subject. Disclosed herein are also methods for preventing, treating, reducing the incidence, suppressing or inhibiting a coronavirus infection or a symptom thereof.

Abstract: The present invention is directed to a composition including a Tryptophol derivative, a 4-Ethyl-Phenol derivative, or a combination thereof, and a method of using same, such as for treating a subject in need of modulation of blood coagulation.