Patents Assigned to Ben-Gurion University of the Negev
  • Biosensor and method of detection of a DNA sequence
    Patent number: 7947836
    Abstract: The invention relates biosensor comprising a conductive or semi-conductive support and an intercalator polymer, wherein the intercalator polymer comprises monomer units of formula (I) wherein P is an electropolymerizable moiety selected among the group consisting in pyrrole, acetylene, phenol, aniline, thiophene, carbazole and azulene; Sp is a spacer, and Im is an intercalator. The invention also relates to a method for the detection of a DNA sequence with the biosensor, comprising the steps of: hybridizing the DNA sequence with a DNA probe for forming a dsDNA incubating the biosensor with the dsDNA for anchoring the dsDNA to the intercalator detecting the quantity of dsDNA on the biosensor.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: May 24, 2011
    Assignees: Universite Joseph Fourier - Grenoble 1, Ben-Gurion University of the Negev Research and Development Authority, Centre National de la Recherche Scientifique - CNRS
    Inventors: Serge A. Cosnier, Robert S. Marks, Elena R. Ionescu
  • Amphiphilic derivatives for the production of vesicles, micelles and complexants, and precursors thereof
    Patent number: 7939562
    Abstract: Amphiphilic derivatives composed of at least one fatty acid chain are derived from natural vegetable oils such as vernonia oil, lesquerella oil and castor oil, in which the several reactive groups such as epoxy, hydroxy and double bonds can be modified to polar and ionic groups. The head group of the amphiphilic derivative may be in the main fatty acid chain or in a side chain. The amphiphiles are useful for the formation of vesicles and micelles and for use as complexants and surfactants.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: May 10, 2011
    Assignee: Ben-Gurion University of The Negev Research and Development Authority
    Inventors: Sarina Grinberg, Charles Linder, Zeev Wiesman, Eliahu Heldman, Victoria Kolot
  • COMPOSITIONS COMPRISING RED MICROALGAE POLYSACCHARIDES AND METALS
    Publication number: 20110070159
    Abstract: Provided is a composition which contains a red microalga polysaccharide and a heavy metal, which is used as a cosmetic, diagnostic, or pharmaceutical formulation. The pharmaceutical formulation may be employed topically or for treating nutritional and other disorders.
    Type: Application
    Filed: May 21, 2009
    Publication date: March 24, 2011
    Applicant: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Shosh Arad
  • Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting
    Patent number: 7887833
    Abstract: An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: February 15, 2011
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Eliahu Heldman, Charles Linder, Sarina Grinberg, Victoria Kolot, Eleonora Shaubi
  • INSULIN-LIKE GENE OF PRAWNS AND USES THEREOF
    Publication number: 20110010784
    Abstract: Nucleic acid molecules encoding an insulin-like factor of the androgenic gland of the freshwater prawn Macrobrachium rosenbergii (M. rosenbergii) are disclosed. Also disclosed are methods of silencing the expression of the insulin-like factor gene in decapod crustaceans order, particularly in M. rosenbergii, useful for producing male monosex populations.
    Type: Application
    Filed: February 4, 2009
    Publication date: January 13, 2011
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Amir Sagi, Tomer Ventura
  • Cells containing a nanopatch sensor in their membrane
    Patent number: 7855073
    Abstract: The present invention provides isolated cells comprising nanopatch sensors integrated into the cell membrane thereof, wherein said sensors are provided in the form of perturbation-sensitive constructs, and wherein said perturbation-sensitive constructs respond to perturbations of the cell membrane by means of a detectable change in one or more physical or chemical properties associated with said construct.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: December 21, 2010
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Raz Jelinek
  • Fragments of NKp44 and NKp46 for targeting viral-infected and tumor cells
    Patent number: 7825085
    Abstract: The present invention relates generally to peptides derived from the natural cytotoxicity receptors on natural killer (NK) cells and to antibodies against peptide epitopes on these receptors. In particular, the present invention identifies an essential epitope in the proximal domain of NKp46 and NKp44 receptors present on NK cells, as a crucial element for the binding to viral-infected cells. The present invention provides peptides that are derived from the amino acid sequence of NKp46 receptor, capable of specific targeting of viral-infected cells and tumor cells and monoclonal antibodies which recognize a specific domain of NKp46. The present invention further provides hyperglycosylated peptides that are derived from the NKp44 receptor, capable of specific targeting of viral-infected cells.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: November 2, 2010
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Ofer Mandelboim, Angel Porgador
  • NANOWIRES, METHOD OF FABRICATION THE SAME AND USES THEREOF
    Publication number: 20100272993
    Abstract: A method of forming a nanowire structure is disclosed. The method comprises applying on a surface of carrier liquid a layer of a liquid composition which comprises a surfactant and a plurality of nanostructures each having a core and a shell, and heating at least one of the carrier liquid and the liquid composition to a temperature selected such that the nanostructures are segregated from the surfactant and assemble into a nanowire structure on the surface.
    Type: Application
    Filed: April 8, 2010
    Publication date: October 28, 2010
    Applicant: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Roman VOLINSKY, Raz Jelinek
  • AMETHOD OF TREATING NEURODEGENERATIVE DISEASES
    Publication number: 20100272787
    Abstract: This invention provides compositions and methods for treating a subject suffering from a disease or disorder of the nervous system, associated with an inflammatory response. This invention further provides a pharmaceutical composition comprising, inter alia, an agent which increases brain levels of interferon-?; and an agent which reduces the number of brain T regulatory (Treg) cells, and optionally further comprising an agent which suppresses neurotoxic inflammatory brain responses.
    Type: Application
    Filed: December 18, 2008
    Publication date: October 28, 2010
    Applicant: Ben Gurion University of the Negev
    Inventor: Alon Monsonego
  • TELOMERASE ACTIVATING COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20100267667
    Abstract: The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.
    Type: Application
    Filed: June 4, 2008
    Publication date: October 21, 2010
    Applicant: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Aviv Gazit, Shimon Slavin, Esther Priel, Sara Yitzchak
  • Method for the preparation of dispersions of carbon nanotubes
    Patent number: 7812083
    Abstract: The invention provides a method for the preparation of a suspension of de-agglomerated carbon nanotubes, comprising mixing agglomerated carbon nanotubes with a block copolymer. Further, a powder of de-agglomerated carbon nanotubes is provided, that can be easily redispersed to obtain a suspension of untangled carbon nanotubes. The invention also relates to the use of the provided materials in the preparation of composites, and in electronics.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: October 12, 2010
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventor: Rachel Yerushalmi-Rozen
  • TRI-ARYL COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME
    Publication number: 20100256382
    Abstract: The present invention relates to a novel class of tri-aryl compounds, compositions comprising the same and processes for the preparation thereof.
    Type: Application
    Filed: June 3, 2008
    Publication date: October 7, 2010
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITKY
    Inventors: Esther Priel, Aviv Gazit, Shimon Slavin, Sara Yitzchak
  • Alginate Biomaterials for the Treatment of Hepatic Disorders
    Publication number: 20100247652
    Abstract: The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.
    Type: Application
    Filed: November 27, 2008
    Publication date: September 30, 2010
    Applicants: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD., BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Yaron Ilan, Gadi Lalazar, Eyal Shteyer, Ami Ben-Yaakov, Smadar Cohen, Tsiona Elkayam
  • Polydiacetylene-containing solid colorimetric and/or fluorescent detector, method for its preparation and uses thereof
    Patent number: 7794968
    Abstract: The invention provides a colorimetric and/or fluorescent detector, which is a solid organic matrix, most preferably in the form of a gel, comprising polydiacetylene(s) and one or more lipids. Processes for preparing the detector and methods for using the same, including for the detection of microorganism suspected to be present in food products, are also provided.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: September 14, 2010
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Raz Jelinek
  • INJECTABLE CROSS-LINKED POLYMERIC PREPARATIONS AND USES THEREOF
    Publication number: 20100190741
    Abstract: A therapeutic composition for treatment of a body tissue which includes an aqueous solution of a cross-linked polymer being capable of: (i) maintaining a liquid state in storage at room temperature for at least 24 hours; and (ii) assuming a gel state following deposition within the body tissue. The therapeutic composition can be effectively administered into a damaged body tissue via injection or catheterization, thereby treating the damaged body tissue.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 29, 2010
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Smadar Cohen, Jonathan Leor
  • INJECTABLE CROSS-LINKED POLYMERIC PREPARATIONS AND USES THEREOF
    Publication number: 20100179102
    Abstract: A therapeutic composition for treatment of a body tissue which includes an aqueous solution of a cross-linked polymer being capable of: (i) maintaining a liquid state in storage at room temperature for at least 24 hours; and (ii) assuming a gel state following deposition within the body tissue. The therapeutic composition can be effectively administered into a damaged body tissue via injection or catheterization, thereby treating the damaged body tissue.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 15, 2010
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV
    Inventors: Smadar Cohen, Jonathan Leor
  • INJECTABLE CROSS-LINKED POLYMERIC PREPARATIONS AND USES THEREOF
    Publication number: 20100173867
    Abstract: A therapeutic composition for treatment of a body tissue which includes an aqueous solution of a cross-linked polymer being capable of: (i) maintaining a liquid state in storage at room temperature for at least 24 hours; and (ii) assuming a gel state following deposition within the body tissue. The therapeutic composition can be effectively administered into a damaged body tissue via injection or catheterization, thereby treating the damaged body tissue.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 8, 2010
    Applicant: Ben-Gurion University of the Negev Research and Development Authority.
    Inventors: Smadar Cohen, Jonathan Leor
  • Highly conductive ordered ion exchange membranes
    Patent number: 7740967
    Abstract: Process for producing ion exchange membranes. A matrix material that comprises a polymeric component chosen from the group consisting of monomeric and oligomeric polymer precursors and cross-linkable polymers is provided. Ion cation or anion exchange particles, or proton or hydroxyl or ion conducting particles, or cation or anion exchange polymers, or proton or hydroxyl or ion conducting polymers are introduced in the matrix. The particles are mixed or the polymer is dissolved with the matrix. The resulting mixture is formed into membrane configuration. The particles or the domains of the polymer formed by polymer-matrix phase separation upon solvent evaporation or cooling, are ordered by an electric field.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: June 22, 2010
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Yoram Oren, Viatcheslav Freger, Ora Kedem, Charles Linder, Eliyahu Korin
  • MICRO-CONCENTRATORS FOR SOLAR CELLS
    Publication number: 20100147375
    Abstract: A solar cell system comprises a solar cell comprising a grid and a photo-sensitive area, wherein the grid includes a conductor, and an optical micro-structure positioned between the conductors, wherein the micro-structure covers at least a portion of the conductors.
    Type: Application
    Filed: February 18, 2008
    Publication date: June 17, 2010
    Applicants: Ben Gurion University of the Negev Research and Development Authority, Naftali P. Eisenberg
    Inventors: Omer Korech, Jeffrey Gordon, Ivgeny Katz, Daniel Feuermann, Naftali P. Eisenberg
  • Hydrogel functionalized with a polymerizable moiety and their uses as biosensors or bioreactors
    Patent number: 7737240
    Abstract: The present invention relates to a new hydrogel functionalized with a polymerizable moiety, the polymerized hydrogels, films and gels comprising the same and their use for cells, proteins, DNA or other molecules encapsulation, including use as biosensors or bioreactors.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: June 15, 2010
    Assignees: Universite Joseph Fourier-Grenoble 1, Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Robert Marks, Serge Cosnier, Boris Polyak, Elena Rodica Ionescu, Khalil Abu-Rabeah