Patents Assigned to Bio-Lab, Inc.
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Publication number: 20220356089Abstract: Disclosed herein is a liquid pod comprising a liquid composition comprising at least two of a Solvent A, a Solvent B, an Active, a Modifier, and an Adjuvant, wherein the water treatment liquid composition is disposed within a packet comprising a water-soluble polymer film.Type: ApplicationFiled: August 4, 2020Publication date: November 10, 2022Applicant: BIO-LAB, INC.Inventors: Curtis SAYRE, Anjelica SWANSON, John WEBER, Jordan WOOTEN
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Publication number: 20220298037Abstract: Disclosed herein is a composition for the treatment of a recirculating water system, comprising: trichloro-s-triazentrione (TCCA) in an amount of from about 75% to about 98% by mass of the composition; an inorganic salt present in an amount of from about 2% to about 25% by mass of the composition; and an auxiliary agent in a total amount of from about 0% to about 10% by mass of the composition. Also disclosed herein is a formed object comprising the composition, a process for preparing the formed object, and a method of using the formed object.Type: ApplicationFiled: August 18, 2020Publication date: September 22, 2022Applicant: BIO-LAB, INC.Inventors: Curtis SAYRE, Jeffrey GAULDING, Brian TRENCK, Al YEOMAN
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Patent number: 11366061Abstract: An approach is described that combines distinct properties of a specialized porous nitrocellulose film (PNC) with quantum nanoparticles to create an improved assay and detection sensitivity, permitting the development of a camera-based imaging system for fluorescent detection of macromolecules in microarray format. The two properties of PNC that facilitate the approach are an extraordinarily high binding capacity and a newly observed internal scattering of light. Quantum nanoparticles complement these PNC properties by providing a higher level of emitted light than the fluorescent dyes in common microarray use. Overall, the approach allows for instrument cost savings, reduced imaging time, and the ability to remotely image.Type: GrantFiled: January 23, 2014Date of Patent: June 21, 2022Assignee: Grace Bio-Labs, Inc.Inventors: Jennipher Lyn Grudzien, Michael Albert Shultz, Florian Gene Bell, Charles M. McGrath
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Patent number: 10739339Abstract: Methods and systems are provided for imaging a microarray of a microarray assembly. The microarray assembly may be configured as a protein microarray and may be used to visualize protein expression levels in sample for disease detection and/or diagnosis. In one example, the microarray assembly may comprise a laser pointed in a first direction, a camera positioned parallel to and vertically below the laser, a first dichroic mirror vertically aligned with the laser for reflecting light emitted from the laser, a second mirror vertically aligned with the camera and horizontally aligned with the first dichroic mirror, and a chip coated in a nitrocellulose film and including an array of wells containing one or more biomolecules.Type: GrantFiled: September 27, 2016Date of Patent: August 11, 2020Assignee: Grace Bio-Labs, Inc.Inventors: Florian Gene Bell, Jacob Burrel Wells, Donna Kay Barton, Jennipher Lyn Grudzien
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Patent number: 9981264Abstract: Methods and systems are provided for a lateral flow test device. In one example a lateral flow test device may include a housing comprising an upper first portion and a lower second portion, the lower second portion further including a planar surface, a nitrocellulose matrix strip, the strip disposed on the planar surface, and one or more ligand regions included in the strip, the ligand regions comprising one or more ligands. The strip may be formed from a liquid polymer mixture dispensed onto the planar surface via a dispensing device positioned vertically above the planar surface.Type: GrantFiled: November 3, 2015Date of Patent: May 29, 2018Assignee: Grace Bio-Labs, Inc.Inventors: Charles Greef, Joshua Snider, Steven Weaver, Jennipher Grudzien
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Patent number: 9839212Abstract: Horizontally layered tablets, methods of making the horizontally layered tablets, and tableting equipment capable of producing the horizontally layered tablets are described. The horizontally layered tablets can be produced by simultaneously feeding a segregated flow of different compositions that form the respective layers of the tablet.Type: GrantFiled: April 16, 2015Date of Patent: December 12, 2017Assignee: Bio-Lab, Inc.Inventors: Alan Yeoman, Curtis Sayre, Edward Santorella
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Patent number: 9815719Abstract: A system for dispensing water treatment compositions into a pool, spa, or other body of water is disclosed, which system provides a visible cue that the water treatment is properly dispersing and also provides a visible cue when the desired amount of water treatment has been dispensed. The system comprises a dispenser and the water treatment composition contained within the body of the dispenser, which dispenser and which system provides a readily visual cue that when the water treatment dose has been fully, or in some cases mostly or partially dispersed. For example, the dispenser sinks when fully dosed and resurfaces when empty, and in particular embodiments the water treatment generates visible gas bubbles and/or a color stream as the treatment dissolves.Type: GrantFiled: April 1, 2013Date of Patent: November 14, 2017Assignee: Bio-Lab, Inc.Inventors: Curtis Sayre, Zach Hansen, David Rouse, Anna Florine McLeroy
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Publication number: 20140206580Abstract: An approach is described that combines distinct properties of a specialized porous nitrocellulose film (PNC) with quantum nanoparticles to create an improved assay and detection sensitivity, permitting the development of a camera-based imaging system for fluorescent detection of macromolecules in microarray format. The two properties of PNC that facilitate the approach are an extraordinarily high binding capacity and a newly observed internal scattering of light. Quantum nanoparticles complement these PNC properties by providing a higher level of emitted light than the fluorescent dyes in common microarray use. Overall, the approach allows for instrument cost savings, reduced imaging time, and the ability to remotely image.Type: ApplicationFiled: January 23, 2014Publication date: July 24, 2014Applicant: Grace Bio-Labs, Inc.Inventors: Jennipher Lyn Grudzien, Michael Albert Shultz, Florian Gene Bell, Charles M. McGrath
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Patent number: 8287822Abstract: A reaction surface array diagnostic apparatus and method of making the same includes a substrate carrying a plurality of reaction surfaces, a plate and a gasket, each having a plurality of through bores, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the gasket and the plate are sealingly affixed to the substrate to form a stack. Clamp members engage opposite side edges of a stack to compress the gasket. A plurality of side-by-side disposed clamped stacks of plates, gaskets and substrates are mounted in a tray in the standard footprint of a microtitre plate. Alternately, the plate and the gasket are combined into a single plate formed of a flexible material having an adhesive on one surface.Type: GrantFiled: May 14, 2010Date of Patent: October 16, 2012Assignee: Grace Bio-Labs, Inc.Inventors: Jennipher Grudzien, Charles M. McGrath
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Patent number: 8034306Abstract: A reaction surface array diagnostic apparatus includes a substrate carrying a plurality of reaction surfaces and, a plate having a plurality of wells, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the plate and the substrate are sealingly affixed to each other in a frame. The plate is formed of a flexible material which may have an adhesive on one surface. Interlocking latch members are formed on the plate and the frame for releasably latching the plate and the frame in a position for sealing attachment to the substrate.Type: GrantFiled: September 28, 2005Date of Patent: October 11, 2011Assignee: Grace Bio-Labs, Inc.Inventors: Jennipher Grudzien, Charles McGrath
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Publication number: 20100267590Abstract: A reaction surface array diagnostic apparatus and method of making the same includes a substrate carrying a plurality of reaction surfaces, a plate and a gasket, each having a plurality of through bores, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the gasket and the plate are sealingly affixed to the substrate to form a stack. Clamp members engage opposite side edges of a stack to compress the gasket. A plurality of side-by-side disposed clamped stacks of plates, gaskets and substrates are mounted in a tray in the standard footprint of a microtitre plate. Alternately, the plate and the gasket are combined into a single plate formed of a flexible material having an adhesive on one surface.Type: ApplicationFiled: May 14, 2010Publication date: October 21, 2010Applicant: GRACE BIO-LABS, INC.Inventors: Jennipher Grudzien, Charles M. McGrath
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Patent number: 7736594Abstract: A reaction surface array diagnostic apparatus and method of making the same includes a substrate carrying a plurality of reaction surfaces and a gasket having a plurality of through bores, each alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the gasket is sealingly affixed to the substrate. In one aspect, the gasket and the substrate are mounted in a support. In another aspect, a plate having a plurality of through bores is mountable on the gasket and substrate. Clamp members engage opposite side edges of the plate, the gasket and the substrate.Type: GrantFiled: January 22, 2003Date of Patent: June 15, 2010Assignee: Grace Bio-Labs, Inc.Inventors: Jennipher Grudzien, Charles M. NcGrath
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Patent number: 7731909Abstract: A reaction surface array diagnostic apparatus and method of making the same includes a substrate carrying a plurality of reaction surfaces, a plate and a gasket, each having a plurality of through bores, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the gasket and the plate are sealingly affixed to the substrate to form a stack. Clamp members engage opposite side edges of a stack to compress the gasket. A plurality of side-by-side disposed clamped stacks of plates, gaskets and substrates are mounted in a tray in the standard footprint of a microtiter plate. Alternately, the plate and the gasket are combined into a single plate formed of a flexible material having an adhesive on one surface.Type: GrantFiled: February 20, 2004Date of Patent: June 8, 2010Assignee: Grace Bio-Labs, Inc.Inventors: Jennipher Grudzien, Charles M. McGrath
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Patent number: 7452122Abstract: The feeder apparatus including a chamber formed of at least one upstanding wall, a water outlet in the wall, a drain in the wall, the chamber having a bottom, inlets for water jets in the bottom for creating turbulence inside the chamber to create particle suspension and/or to increase chemicals solubility, or a perforated plate inside of the chamber and spaced from the bottom of the chamber to permit water to flow underneath and up through perforations in the plate and into the chamber.Type: GrantFiled: September 10, 2004Date of Patent: November 18, 2008Assignee: Bio-Lab, Inc.Inventor: Shawn H Lin
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Patent number: 7419589Abstract: A water purification apparatus connected to a water system includes a hopper for holding chemical tablets on a perforated bed and an underlying basin. A spray head is detachably connected to the perforated bed and sprays water onto the tablets and parallel to the perforated bed. The basin receives the water through the perforated bed. Because the hopper allows for the use of different spray head designs, the rate at which water is introduced to the tablets, and thus the chemical output, may be modified by replacing one spray head for another having a different number of spray nozzles or having spray nozzles of a different size or shape. Consequently, the hopper of the present invention may be used for delivering the proper concentration of a variety of water treatment chemicals.Type: GrantFiled: August 19, 2004Date of Patent: September 2, 2008Assignee: Bio-Lab, Inc.Inventors: Paul Eserkaln, Cuahutemoc H. Acevedo
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Patent number: 7364669Abstract: Stable compositions of calcium hypochlorite containing selected hydrated inorganic salts having a sufficiently high enthalpy and the ability to provide water release to sufficiently quench reactions and reduce the potential for conflagration.Type: GrantFiled: June 4, 2007Date of Patent: April 29, 2008Assignee: BIO-Lab, Inc.Inventor: John P. Garris
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Patent number: 7063979Abstract: The invention describes a process for preparing a microtiter-microarray device that includes a bottomless microtiter plate attached to the first side of one or more substrates with microarrays of materials attached thereto. The microtiter plate and the one or more substrates are attached through one or more gaskets. Preferably, the microtiter plate is attached to one face of the one or more gaskets by an irreversible water-tight seal, and the first side of the one or more substrates is attached to the opposite face of the one or more gaskets by a reversible, water-tight seal.Type: GrantFiled: June 13, 2002Date of Patent: June 20, 2006Assignees: Grace Bio Labs., Inc., President and Fellows of Harvard CollegeInventors: Gavin MacBeath, Jennipher Grudzien
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Patent number: 6387415Abstract: Metal-containing biocides for treating swimming pool water, spas, cooling towers, or other industrial applications without staining are disclosed. The biocidal compositions include a source of metal and a polymeric sequestering agent. The polymeric sequestering agent may be a water-soluble anionic or cationic polymer. Conventional sequestering agents may also be included in the composition.Type: GrantFiled: April 1, 1998Date of Patent: May 14, 2002Assignee: Bio-Lab, Inc.Inventor: John P. Garris
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Patent number: 6068791Abstract: Disclosed are trichloroisocyanuric acid compositions that have improved algicidal and/or fungicidal properties yet are relatively safe and non-corrosive. The compositions preferably contain between about 50% and about 95% TCCA, between about 0.5% and about 7% glycoluril, between about 2% and about 40% alum, and between about 2% and about 40% borax. The compositions generate substantially less chlorine gas than would be expected from the teachings of the prior art, especially when wet. The inventive compositions are therefore less toxic and less corrosive.Type: GrantFiled: March 30, 1999Date of Patent: May 30, 2000Assignee: Bio-Lab, Inc.Inventors: Thomas M. Lachocki, Presley K. Mitchell, Oscar T. Ragin
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Patent number: 5908580Abstract: Disclosed are trichloroisocyanuric acid compositions that have improved algicidal and/or fungicidal properties yet are relatively safe and non-corrosive. The compositions preferably contain between about 50% and about 95% TCCA, between about 0.5% and about 7% glycoluril, between about 2% and about 40% alum, and between about 2% and about 40% borax. The compositions generate substantially less chlorine gas than would be expected from the teachings of the prior art, especially when wet. The inventive compositions are therefore less toxic and less corrosive.Type: GrantFiled: April 2, 1997Date of Patent: June 1, 1999Assignee: Bio-Lab, Inc.Inventors: Thomas M. Lachocki, Presley K. Mitchell, Oscar T. Ragin