Patents Assigned to Bioscience, Inc.
  • AZAINDOLE ROCK INHIBITORS
    Publication number: 20240254124
    Abstract: This invention provides rho-associated protein kinase (ROCK) inhibiting compounds for therapeutic applications as described further herein.
    Type: Application
    Filed: March 19, 2024
    Publication date: August 1, 2024
    Applicant: Avicenna Biosciences, Inc.
    Inventor: Thomas Maxwell Kaiser
  • Tissue-homing peptide conjugates and methods of use thereof
    Patent number: 12048750
    Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
    Type: Grant
    Filed: August 15, 2022
    Date of Patent: July 30, 2024
    Assignee: Blaze Bioscience, Inc.
    Inventors: Stacey J. Hansen, Claudia Jochheim, Dennis M. Miller, Natalie Winblade Nairn, Julia E. Novak, Mark R. Stroud, Valorie R. Wiss, Kelly Byrnes-Blake, Scott Presnell
  • Methods of treating breast cancer
    Patent number: 12048732
    Abstract: Compositions and formulations comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to detectable agents or active agents. Methods of detecting and treating ductal carcinoma in situ breast cancer, invasive ductal carcinoma breast cancer, lobular carcinoma in situ, invasive lobular carcinoma, and triple-negative breast cancer with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: July 30, 2024
    Assignee: Blaze Bioscience, Inc.
    Inventors: Stacey J. Hansen, Julia E. Novak
  • AZAINDOLE ROCK INHIBITORS
    Publication number: 20240246972
    Abstract: This invention provides rho-associated protein kinase (ROCK) inhibiting compounds for therapeutic applications as described further herein.
    Type: Application
    Filed: March 19, 2024
    Publication date: July 25, 2024
    Applicant: Avicenna Biosciences, Inc.
    Inventor: Thomas Maxwell Kaiser
  • CLEC12a binding polypeptides and uses thereof
    Patent number: 12043667
    Abstract: Provided herein are VHH-containing polypeptides that bind CLEC12a. Uses of the VHH-containing polypeptides are also provided.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: July 23, 2024
    Assignee: Inhibrx Biosciences, Inc.
    Inventors: Lucas Rascon, Angelica Sanabria, John C. Timmer, Brendan P. Eckelman
  • Electrical applicators with non-penetrating electrodes for applying energy to tissue surfaces
    Patent number: 12042653
    Abstract: Applicators, systems, and methods for delivering electrical energy to a target treatment region with large area surface electrodes are disclosed. In one example, a system may include a housing, a pulse generator, and a treatment applicator coupled to the pulse generator and configured to deliver sub-microsecond high-voltage electric pulses from the pulse generator. The treatment applicator may include a first and second electrodes coupled to a substrate, where the first and second electrodes are configured to provide a uniform gap between edges of the first and second electrodes.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: July 23, 2024
    Assignee: Pulse Biosciences, Inc.
    Inventors: Cameron D. Hinman, Wesley C. Joe
  • Polymorphic form of TG02 for treating cancer
    Patent number: 12043630
    Abstract: The present disclosure provides crystalline polymorphic forms of TG02 free base and TG02 acid addition salts, pharmaceutical compositions comprising crystalline polymorphic forms of TG02 free base and TG02 acid addition salts, and methods of treating cancer and other diseases in a patient with crystalline polymorphic forms of TG02 free base and TG02 acid addition salts.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: July 23, 2024
    Assignee: Cothera Bioscience, Inc.
    Inventors: Robert K. Mansfield, Tracy Parrott
  • TREATMENT OF RETINITIS PIGMENTOSA USING ENGINEERED MEGANUCLEASES
    Publication number: 20240238387
    Abstract: Disclosed are recombinant meganucleases engineered to recognize and cleave recognition sequences present in a mutant RHO P23H allele. The invention further relates to the use of such recombinant meganucleases in methods for treating retinitis pigmentosa, wherein the mutant RHO P23H allele is preferentially targeted, cleaved, and inactivated.
    Type: Application
    Filed: July 13, 2023
    Publication date: July 18, 2024
    Applicant: Precision BioSciences, Inc.
    Inventors: Victor Bartsevich, Derek Jantz, James Jefferson Smith, Michael G. Nicholson
  • ANTI-ROR1 ANTIBODY AND ROR1-TARGETING ENGINEERED CELLS
    Publication number: 20240239918
    Abstract: The present invention is directed to a monoclonal mouse or humanized ROR1 antibody, or a single-chain variable fragment (scFv). The present invention is also directed to a mouse or humanized ROR1 chimeric antigen receptor (CAR) comprising from N-terminus to C-terminus: (i) a single-chain variable fragment (scFv) of the present invention, (ii) a transmembrane domain, (iii) at least one co-stimulatory domains, and (iv) an activating domain.
    Type: Application
    Filed: February 1, 2024
    Publication date: July 18, 2024
    Applicant: Caribou Biosciences, Inc.
    Inventors: Vita Golubovskaya, Lijun Wu
  • Compositions and methods for cell-like calibration particles
    Patent number: 12038369
    Abstract: A method includes calibrating a cytometric device for analysis of a target cell, by inserting, into the cytometric device, a hydrogel particle. The hydrogel particle has at least one of a background fluorescent property or a spectral property that is substantially similar to the at least one of a background fluorescent property or a spectral property of the target cell. The method also includes measuring at least one property of the hydrogel particle using the cytometric device.
    Type: Grant
    Filed: June 26, 2023
    Date of Patent: July 16, 2024
    Assignee: Slingshot Biosciences, Inc.
    Inventors: Jeffrey Kim, Anh Tuan Nguyen, Brandon Miller
  • Methods and apparatus for forming 2-dimensional drop arrays
    Patent number: 12036556
    Abstract: Certain embodiments are directed to finite step emulsification device and/or methods that combine finite step emulsification with gradients of confinement for the formation of a 2D monolayer array of droplets with low size dispersion.
    Type: Grant
    Filed: October 10, 2022
    Date of Patent: July 16, 2024
    Assignee: Pattern Bioscience, Inc.
    Inventor: Ross Johnson
  • Immune cells having co-expressed shRNAS and logic gate systems
    Patent number: 12037407
    Abstract: Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.
    Type: Grant
    Filed: May 3, 2023
    Date of Patent: July 16, 2024
    Assignee: Arsenal Biosciences, Inc.
    Inventors: Jasper Williams, Michelle Nguyen, Anzhi Yao, Stephen Santoro, Aaron Cooper, John Gagnon, Adam Litterman, Omar Khan, Natalie Bezman, Katherine Harris, Harbani Kaur Malik Chaudhry, Nicole Allen
  • TROJAN CIRCULATING TUMOR CELLS
    Publication number: 20240226147
    Abstract: Provided herein are compositions and methods for engineering treatment resistant circulating tumor cells to generate immune stimulating or anti-cancer exosomes, which can be infused into a patient to self-home to the primary tumor and metastatic lesions. Also provided are compositions and methods for forming a population of engineered exosome-loaded dendritic cells, which can be infused into the patient to activate a systemic immune response. The compositions and methods allow for infiltration into solid tumors using “trojan” cells that are naturally adapted and mechanistically engineered to evade patients' defenses.
    Type: Application
    Filed: May 6, 2022
    Publication date: July 11, 2024
    Applicant: Astrin Biosciences Inc.
    Inventor: Jayant Parthasarathy
  • Treatment of Warts
    Publication number: 20240226213
    Abstract: Disclosed herein are compositions having standardized potencies for use in the treatment of warts. Methods of treating a common wart comprising administering one or more intralesional injections of compositions having standardized potencies to a patient in need thereof are also disclosed. Further disclosed are methods of treating a non-common wart administering one or more intralesional injections of compositions having standardized potencies to a patient in need thereof.
    Type: Application
    Filed: March 19, 2024
    Publication date: July 11, 2024
    Applicant: Nielsen BioSciences, Inc.
    Inventor: H. Stewart NIELSEN, JR.
  • CELL MAINTAINER FOR AUTOLOGOUS CELL THERAPY PRODUCTION
    Publication number: 20240228936
    Abstract: In some aspects, the invention relates to automated cell culture incubators and their methods of use. In one aspect, the disclosure provides cell culture incubators having an airlock chamber, a storage chamber and/or an internal chamber. In some aspects, the disclosure provides methods for producing autologous mammalian cell cultures.
    Type: Application
    Filed: December 13, 2023
    Publication date: July 11, 2024
    Applicant: Thrive Bioscience, Inc.
    Inventor: Alan Blanchard
  • Diagnostics for Emerging Disease
    Publication number: 20240226877
    Abstract: The present disclosure relates to enhancements in diagnostic assays for detection of analytes. The improved assays are suitable for management of infections and pandemics in humans and animal reservoirs, including but not limited to SARS-CoV-2 (CoV2), and for measurement of biomarkers of disease (both human and veterinary).
    Type: Application
    Filed: October 25, 2023
    Publication date: July 11, 2024
    Applicant: Trellis Bioscience, Inc.
    Inventors: Urs A. Ramel, Joel Blatt, Lawrence M. Kauvar, Stote Ellsworth, Ralph A. Tripp, Leslie P. Jones
  • Virus-like particle conjugates for diagnosis and treatment of tumors
    Patent number: 12029794
    Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
    Type: Grant
    Filed: December 2, 2021
    Date of Patent: July 9, 2024
    Assignees: Biosciences, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Serv.
    Inventors: Elisabet de los Pinos, John Todd Schiller, Rhonda C. Kines, John MacDougall
  • VIRUS-LIKE PARTICLE CONJUGATES FOR DIAGNOSIS AND TREATMENT OF TUMORS
    Publication number: 20240216527
    Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
    Type: Application
    Filed: March 14, 2024
    Publication date: July 4, 2024
    Applicants: Aura Biosciences, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Serv.
    Inventors: Elisabet de los Pinos, John Todd Schiller, Rhonda C. Kines, John MacDougall
  • Autoflowering markers
    Patent number: 12024712
    Abstract: Provided herein is the identification and markers and genes associated with day-neutral autoflowering in plants and their use in selecting plants, including Cannabis plants, having autoflowering activity. The markers are useful for breeding autoflowering plants by obtaining nucleic acids, detecting one or more markers that indicate autoflowering activity, and establishing plant lines having such characteristics. Also provided are methods of editing plants to establish plant lines having autoflowering allelic variations.
    Type: Grant
    Filed: February 5, 2022
    Date of Patent: July 2, 2024
    Assignee: Phylos Bioscience, Inc.
    Inventors: Erica Bakker, Alisha Holloway, Kristen Waterman
  • Methods and systems for screening using microcapillary arrays
    Patent number: 12024705
    Abstract: High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be isolated, and cells expressing the variant proteins of interest can be characterized. Also provided are systems for performing the disclosed screening methods.
    Type: Grant
    Filed: October 17, 2022
    Date of Patent: July 2, 2024
    Assignee: XCELLA Biosciences, Inc.
    Inventors: Jennifer R. Cochran, Bob Chen, Spencer Caleb Alford