Patents Assigned to Bioscience, Inc.
  • Publication number: 20250154485
    Abstract: Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non-palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases.
    Type: Application
    Filed: January 17, 2025
    Publication date: May 15, 2025
    Applicant: Precision Biosciences, Inc.
    Inventors: James Jefferson Smith, Derek Jantz
  • Patent number: 12297411
    Abstract: In some aspects, the invention relates to selectively permeable cell culture vessel storage containers and their methods of use. In some embodiments, the containers comprise a gas-permeable membrane that is selectively impermeable to water vapor.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: May 13, 2025
    Assignee: Thrive Bioscience, Inc.
    Inventor: Alan Blanchard
  • Publication number: 20250145606
    Abstract: The present disclosure is directed to compounds having a structure according to Formula I, and compositions containing those compounds. Methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.
    Type: Application
    Filed: November 1, 2024
    Publication date: May 8, 2025
    Applicant: Arcus Biosciences, Inc.
    Inventors: Srijita Bhowmik, Karen Yir Jing Chen, Jeremy Fournier, Jenna Leigh Jeffrey, Manjunath Lamani, Manmohan Reddy Leleti, Guillaume Mata, Hyunyoung Moon, Pradeep Nareddy, Srinivas Paladugu, Zhang Wang, Xuelei Yan, Monika Yadav, Jiang Zhu
  • Publication number: 20250145933
    Abstract: A method and apparatus for measuring cells and cell confluence includes an imager for imaging a z-stack of bright field images and a processor for selecting a best focus bright field image at a z position of f microns in the z-stack of images. In the manner described herein, the processor selects a bright image n microns lower in the z-stack than the best focus bright field image and a dark image m microns higher in the stack than the best focus bright field image. The processor applies edge detection to the dark image to obtain an edge image and subtracts the edge image from the dark image and the processor applies an adaptive threshold to the bright image to create a mask and uses the adaptive thresholded image as seeds to evaluate the edge image to find cell candidates.
    Type: Application
    Filed: January 19, 2023
    Publication date: May 8, 2025
    Applicant: Thrive Bioscience, Inc.
    Inventors: Alan BLANCHARD, Kenneth CHAPMAN, Frank EVANS
  • Publication number: 20250146016
    Abstract: The present disclosure relates to circular, non-viral DNA vectors, compositions including one or more of the disclosed vectors, and methods for delivering and/or expressing one or more therapeutic genes (e.g., proteins) in mammals, e.g., human patients. In some embodiments, the present disclosure is directed to circular, non-viral DNA vectors, such as circular non-viral DNA vectors including at least two inverted repeat sequences, where the at least two inverted repeat sequences are separated by a non-repeated nucleotide sequence which is not part of the at least two inverted repeat sequences. In some embodiments, the disclosed circular, non-viral DNA vectors do not include a “DD element.” In some embodiments, the disclosed circular, non-viral DNA vectors do not include a “DD element,” but include at least a portion of a bacterial origin of replication.
    Type: Application
    Filed: January 10, 2025
    Publication date: May 8, 2025
    Applicant: Rampart Bioscience, Inc.
    Inventors: Jeffrey S. Bartlett, Ming Yan
  • Publication number: 20250146015
    Abstract: The present disclosure relates to circular, non-viral DNA vectors, compositions including one or more of the disclosed vectors, and methods for delivering and/or expressing one or more therapeutic genes (e.g., proteins) in mammals, e.g., human patients. In some embodiments, the present disclosure is directed to circular, non-viral DNA vectors, such as circular non-viral DNA vectors including at least two inverted repeat sequences, where the at least two inverted repeat sequences are separated by a non-repeated nucleotide sequence which is not part of the at least two inverted repeat sequences. In some embodiments, the disclosed circular, non-viral DNA vectors do not include a “DD element.” In some embodiments, the disclosed circular, non-viral DNA vectors do not include a “DD element,” but include at least a portion of a bacterial origin of replication.
    Type: Application
    Filed: January 9, 2025
    Publication date: May 8, 2025
    Applicant: Rampart Bioscience, Inc.
    Inventors: Jeffrey S. Bartlett, Ming Yan
  • Patent number: 12291548
    Abstract: Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: May 6, 2025
    Assignee: Sperovie Biosciences, Inc.
    Inventors: Radhakrishnan P. Iyer, Geeta Meher, Sreerupa Challa, Shenghua Zhou
  • Publication number: 20250137075
    Abstract: Provided herein is the identification of the causal gene KR associated with THCV, THCVA, CBDV, CBDVA, CBGV, CBGVA, CBCV, or CBCVA production in Cannabis plants. Also included are isolated cells, nucleic acids, transgenic Cannabis plants; methods of editing, and methods of using marker assisted selection to select and establish plant lines having modified THCV, THCVA, CBDV, CBDVA, CBGV, CBGVA, CBCV, or CBCVA activity.
    Type: Application
    Filed: August 4, 2022
    Publication date: May 1, 2025
    Applicant: Phylos Bioscience, Inc.
    Inventors: Erica Bakker, Alisha Holloway, Annie Poczynek
  • Publication number: 20250134950
    Abstract: The invention provides non-hormonal vitamin D conjugated to apelin proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. In some embodiments, the vitamin D targeting groups are coupled to the apelin proteins via the third carbon on the vitamin D backbone.
    Type: Application
    Filed: July 23, 2024
    Publication date: May 1, 2025
    Applicant: Extend Biosciences, Inc.
    Inventors: Tarik Soliman, Laura M. Hales, Daniel B. Hall, Christopher So, Howard P. Sard, Vishnumurthy Hegde
  • Publication number: 20250136681
    Abstract: Provided herein are VHH-containing polypeptides that bind NKp46. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: August 29, 2022
    Publication date: May 1, 2025
    Applicant: Inhibrx Biosciences, Inc.
    Inventors: John C. Timmer, Brendan P. Eckelman, Rajay A. Pandit, William Crago, Florian Sulzmaier, Heather Kinkead, Nadja Kern
  • Patent number: 12286427
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Grant
    Filed: July 19, 2024
    Date of Patent: April 29, 2025
    Assignee: Kumquat Biosciences Inc.
    Inventors: Yi Liu, Pingda Ren, Liansheng Li, Zhimin Zhu, Xiuwen Zhu
  • Patent number: 12285761
    Abstract: A compact sorting flow cytometer system includes a fluidics system having a flow cell and a deflection chamber in communication with the flow cell and a droplet deposition unit (DDU) system in communication with the deflection chamber. The defection chamber receives drops in a stream of a sample biological fluid with one or more biological cells or particles and selectively deflect the drops in the stream. The DDU system is in communication with the deflection chamber to receive the selectively deflected drops into one or more containers. The DDU system includes a case forming a portion of a containment chamber. When closed, one or more doors seal and close off the containment chamber from an external environment. Air can be evacuated from the containment chamber by one or more fans in one or more tunnels. Air can be conditioned by a thermoelectric cooling array between the containment chamber and an air conditioning chamber that is moved by one or more fans.
    Type: Grant
    Filed: February 4, 2022
    Date of Patent: April 29, 2025
    Assignee: Cytek Biosciences, Inc.
    Inventors: Glen Krueger, David Vrane, Kuncheng Wang, Qiuta Gu
  • Patent number: 12286433
    Abstract: This invention provides rho-associated protein kinase (ROCK) inhibiting compounds for therapeutic applications as described further herein.
    Type: Grant
    Filed: October 14, 2024
    Date of Patent: April 29, 2025
    Assignee: Avicenna Biosciences, Inc.
    Inventor: Thomas Maxwell Kaiser
  • Publication number: 20250127811
    Abstract: The application relates to the field of oncology, cancer immunotherapy, molecular biology and recombinant nucleic acid technology. In particular, the invention relates to genetically-modified eukaryotic cells comprising modulated TGF Beta signaling. The application further relates to the use of such genetically-modified eukaryotic cells for treating a disease, including cancer, in a subject.
    Type: Application
    Filed: January 28, 2022
    Publication date: April 24, 2025
    Applicant: Precision BioSciences, Inc.
    Inventor: Aaron Martin
  • Publication number: 20250127104
    Abstract: Provided herein is the identification of genetic markers associated with modified cannabinoids relating to levels or ratios of one or more of tetrahydrocannabinol (THC), cannabidiol (CBD), cannabigerol (CBG), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromene (CBC), or cannabigerovarin (CBGV). The markers are useful for breeding plants having modified cannabinoids by obtaining nucleic acids, detecting one or more markers that indicate modified cannabinoids, and establishing plant lines having such characteristics.
    Type: Application
    Filed: September 28, 2022
    Publication date: April 24, 2025
    Applicant: Phylos Bioscience, Inc.
    Inventors: Erica Bakker, Alisha Holloway
  • Patent number: 12281355
    Abstract: Methods for imaging an analyte in a sample include contacting the biological sample with a binding agent, where the binding agent includes a binding moiety that binds to the analyte and a first nucleotide sequence, contacting the biological sample with a catalytic agent, where the catalytic agent includes a second nucleotide sequence linked to an enzyme, and where the second nucleotide sequence hybridizes to the first nucleotide sequence, contacting the biological sample with a localization agent, where the localization agent includes a substrate complementary to the enzyme and a third nucleotide sequence linked to the substrate, and contacting the biological sample with a labeling agent, where the labeling agent includes a fourth nucleotide sequence linked to an optical label, where the fourth nucleotide sequence hybridizes to the third nucleotide sequence.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: April 22, 2025
    Assignee: Akoya Biosciences, Inc.
    Inventor: Grady Carlson
  • Patent number: 12281136
    Abstract: Crystalline forms of the compound of Formula (I), which modulates the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compound and methods for preparing the crystalline forms, are described herein. The use of such crystalline form of Formula (I) and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.
    Type: Grant
    Filed: April 7, 2023
    Date of Patent: April 22, 2025
    Assignee: Arcus Biosciences, Inc.
    Inventors: Andrew M. K. Pennell, Eric F Connor, Stephen Edmund Gottschling, Jim Dimetrios Colomvakos, Mohammed Asadullah Khan
  • Patent number: 12281115
    Abstract: This invention provides rho-associated protein kinase (ROCK) inhibiting compounds for therapeutic applications as described further herein.
    Type: Grant
    Filed: October 14, 2024
    Date of Patent: April 22, 2025
    Assignee: Avicenna Biosciences, Inc.
    Inventor: Thomas Maxwell Kaiser
  • Publication number: 20250121039
    Abstract: Disclosed are recombinant meganucleases engineered to recognize and cleave recognition sequences present in a mutant RHO P23H allele. The invention further relates to the use of such recombinant meganucleases in methods for treating retinitis pigmentosa, wherein the mutant RHO P23H allele is preferentially targeted, cleaved, and inactivated.
    Type: Application
    Filed: December 19, 2024
    Publication date: April 17, 2025
    Applicant: Precision BioSciences, Inc.
    Inventors: Victor Bartsevich, Derek Jantz, J. Jefferson Smith, Michael G. Nicholson
  • Publication number: 20250121012
    Abstract: A treatment compound and its use in the prevention and treatment diseases are disclosed. The compound comprises one or more materials selected from an algal biomass/supernatant (including both algae and bacteria), a bacterial biomass, and isolated and purified compound(s) as well as specific active sites or structures on those compounds. The bacteria are selected from the group consisting of Algoriphagus sp., Bosea sp., Brevundimonas sp., Desulfovibrio sp., Microbacterium sp., Sphingomonas sp., and Variovorax sp. The disclosed inventive compound and method of treatment find particular application in the treatment of disease in poultry, particularly in the prevention and treatment of coccidiosis.
    Type: Application
    Filed: December 19, 2024
    Publication date: April 17, 2025
    Applicant: Zivo Bioscience, Inc.
    Inventors: Amy E. Steffek, William P. Pfund, Andrew A. Dahl