Patents Assigned to Bioscience, Inc.
  • Systems, kits and methods for loading and delivering a small volume dose from a syringe
    Patent number: 11931554
    Abstract: A kit is disclosed for accurately loading a small volume dose of a medication within a syringe and for delivering the small volume dose of the medication at a treatment site. The kit generally includes a loading and delivery system in accordance herewith, a syringe, and a medication. The loading and delivery system includes a syringe delivery ring and a syringe loading guide, which may be used for example, to administer a small volume dose of a medication at the end of an ocular surgery.
    Type: Grant
    Filed: August 23, 2021
    Date of Patent: March 19, 2024
    Assignee: ICON BIOSCIENCE, INC.
    Inventor: Cathy Ann Gerlett
  • Control of insect infestation
    Patent number: 11932853
    Abstract: Provided herein are methods for using RNAi molecules targeting a proteasome beta 5 (PSMB5) gene for controlling Coleopteran insects, methods for producing RNAi molecules targeting PSMB5, and compositions comprising RNAi molecules targeting PSMB5.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: March 19, 2024
    Assignee: GreenLight Biosciences, Inc.
    Inventors: Thais Barros Rodrigues, Suresh Desai, Krishnakumar Sridharan
  • Immunoregulatory agents
    Patent number: 11932601
    Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: March 19, 2024
    Assignee: Flexus Biosciences, Inc.
    Inventors: Hilary Plake Beck, Juan Carlos Jaen, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky, James Aaron Balog, David K. Williams, Weiwei Guo
  • KDM1A inhibitors for the treatment of disease
    Patent number: 11932629
    Abstract: The present disclosure relates to compounds and methods which may be useful as inhibitors of KDM1A for the treatment or prevention of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation in cancer cells in a human or animal subject are also provided for treatment of disease such as acute myelogenous leukemia.
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: March 19, 2024
    Assignee: Imago Biosciences, Inc.
    Inventors: Amy E. Tapper, Cassandra Celatka, Michael Clare, Hugh Y. Rienhoff, Jr.
  • Treating tissue pulsed energy using high-voltage catheters
    Patent number: 11931570
    Abstract: Flexible catheters adapted to be inserted into a body to deliver high-voltage, fast (e.g., microsecond, sub-microsecond, nanosecond, picosecond, etc.) electrical energy to target tissue may include a plurality of conductive layers, that may be coaxial. These catheters and method of using them to treat tissue are configured to reduce or avoid arcing.
    Type: Grant
    Filed: January 3, 2023
    Date of Patent: March 19, 2024
    Assignee: Pulse Biosciences, Inc.
    Inventors: David J. Danitz, Kevin L. Moss, Wesley C. Joe, Christopher J. Foster, Gary L. Boseck, Xitlalic Y. Soto-Sida, Robert Maston, John P. Lunsford
  • CD73 inhibitors
    Patent number: 11931343
    Abstract: Compounds, such as compounds having Formula (I): wherein each variable is as described herein, that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: March 19, 2024
    Assignee: Arcus Biosciences, Inc.
    Inventors: Joel Beatty, Laurent Pierre Paul Debien, Samuel Lawrie Drew, Jeremy Fournier, Rebecca Louise Grange, Steven Donald Jacob, Jenna Leigh Jeffrey, Kenneth V. Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Debashis Mandal, Jay Patrick Powers, Anh Thu Tran, Rhiannon Thomas-Tran, Xuelei Yan
  • ENGINEERED MEGANUCLEASES THAT TARGET HUMAN MITOCHONDRIAL GENOMES
    Publication number: 20240084276
    Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.
    Type: Application
    Filed: November 21, 2023
    Publication date: March 14, 2024
    Applicants: Precision Biosciences, Inc., University of Miami
    Inventors: James Jefferson Smith, Ginger Tomberlin, John Morris, Wendy Shoop, Carlos T. Moraes
  • GENETICALLY-MODIFIED IMMUNE CELLS COMPRISING A MICRORNA-ADAPTED SHRNA (SHRNAMIR)
    Publication number: 20240084252
    Abstract: The present invention encompasses genetically-modified immune cells (and populations thereof) expressing a microRNA-adapted shRNA (shRNAmiR) that reduces the expression of a target endogenous protein. Methods for reducing the expression of an endogenous protein in an immune cell are also provided wherein the method comprises introducing a shRNAmiR that targets the endogenous protein. Using shRNAmiRs for knocking down the expression of a target protein allows for stable knockdown of expression of endogenous proteins in immune cells.
    Type: Application
    Filed: November 8, 2023
    Publication date: March 14, 2024
    Applicant: Precision Biosciences, Inc.
    Inventors: Aaron Martin, Jon E. Chatterton, Michelle Brenda Pires
  • SPATIALLY ENCODED BIOLOGICAL ASSAYS
    Publication number: 20240084366
    Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.
    Type: Application
    Filed: November 21, 2023
    Publication date: March 14, 2024
    Applicant: Prognosys Biosciences, Inc.
    Inventor: Mark S. Chee
  • Intracellular genomic transplant and methods of therapy
    Patent number: 11925664
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: March 12, 2024
    Assignees: INTIMA BIOSCIENCE, INC., REGENTS OF THE UNIVERSITY OF MINNESOTA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Branden Moriarity, Beau Webber, David Largaespada, Modassir Choudhry, Steven A. Rosenberg
  • Synthetic human cell mimic hydrogel particle for cytometric or coulter device
    Patent number: 11927519
    Abstract: Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.
    Type: Grant
    Filed: April 26, 2023
    Date of Patent: March 12, 2024
    Assignee: Slingshot Biosciences, Inc.
    Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
  • Methods and Compositions for Diagnosing and Treating Rare Genetic DIseases
    Publication number: 20240077471
    Abstract: Collectively, rare diseases affect approximately 350 million people worldwide, of which half are diagnosed in childhood. Even though more than 80% of rare diseases are genetic in origin and begin in utero, drug target discovery has historically been stymied due to difficulties in obtaining fetal, neonatal, and pediatric tissues for genetic study and drug discovery. Disease modeling with patient-specific hiPSCs is an ideal platform for both rapid identification and experimental validation of early life disease mechanisms. This invention combines high content genomic assays, phenotypic measurements, and machine learning (Artificial Intelligence/Machine Learning) with hiPSC disease models to identify DNA mutations causing early life diseases.
    Type: Application
    Filed: January 28, 2022
    Publication date: March 7, 2024
    Applicant: Rosebud Biosciences, Inc.
    Inventor: Kitch Wilson
  • SYSTEMS AND METHODS FOR COUNTING CELLS
    Publication number: 20240077406
    Abstract: According to at least one aspect, a system configured to count cells in a vessel is provided. The system comprises an imaging system configured to image cells in the vessel and a controller coupled to the imaging system. The controller is configured to control the imaging system to capture a focused image of the cells and estimate a number of cells in the focused image. The controller is configured to control the imaging system to capture a focused image of the cells at least in part by controlling the imaging system to capture a plurality of images of the cells in a plurality of focal planes, determining an area of at least one cell in each of the plurality of images, and selecting one image from the plurality of images as the focused image using the area of the at least one cell in the plurality of images.
    Type: Application
    Filed: November 8, 2023
    Publication date: March 7, 2024
    Applicant: Thrive Bioscience, Inc.
    Inventors: Kam Lin Wong, Melanie Scully
  • Cell culture incubators with integrated cell manipulation systems
    Patent number: 11920122
    Abstract: A cell culture incubator with an incubator cabinet has an internal chamber with a door opening from an external environment. An imager and a manipulator with a scraper are in the internal chamber. A controller is configured for controlling the manipulator to modulate the contact pressure between a scraping edge of the cell scraper and a surface of a cell culture vessel and a sensor is connected to the cell scraper that provides signal to the controller informative of a sensed pressure between a scraping edge of the cell scraper and the surface of a cell culture vessel. The controller controls the manipulator to increase or decrease the pressure between a scraping edge of the cell scraper and the surface of a cell culture vessel.
    Type: Grant
    Filed: April 12, 2022
    Date of Patent: March 5, 2024
    Assignee: Thrive Bioscience, Inc.
    Inventor: Alan Blanchard
  • Antibodies for SARS-CoV-2 and uses thereof
    Patent number: 11919944
    Abstract: The disclosure relates generally to the field of immune binding proteins and method for obtaining immune binding proteins from genomic or other sources. The disclosure also relates to anti-SARS-CoV-2 antibodies that have been obtained from subjects who became immune to this coronavirus, and to methods of using these anti-SARS-CoV-2 antibodies. Methods for neutralizing SARS-CoV-2 are disclosed, as well treatments for SARS-COV-2 using the anti-SARS-CoV-2 antibodies.
    Type: Grant
    Filed: May 9, 2021
    Date of Patent: March 5, 2024
    Assignee: Augmenta Biosciences, Inc.
    Inventors: Christopher J. Emig, Rosanna Man Wah Chau, Payam Shahi, Kim-Xuan Nguyen, Yushuan Lai, Robin Emig, John Beaber, Steven Henry, Marco Antonio Mena
  • Varin markers
    Patent number: 11920187
    Abstract: Provided herein is the identification of markers associated with THCV, THCVA, CBDV, CBDVA, CBGV, or CBGVA production in Cannabis plants and their use in selecting Cannabis plants having modified THCV, THCVA, CBDV, CBDVA, CBGV, or CBGVA activity. The markers are useful for breeding plants having modified varin activity, including elevated THCV levels, by obtaining nucleic acids, detecting one or more markers that indicate modified varin activity, and establishing plant lines having such characteristics.
    Type: Grant
    Filed: August 24, 2022
    Date of Patent: March 5, 2024
    Assignee: Phylos Bioscience, Inc.
    Inventors: Erica Bakker, Alisha Holloway, Kayla Hardwick
  • Cellular diagnostic and analysis methods
    Patent number: 11922623
    Abstract: Detection of pathological abnormalities in tissue samples and/or pluralities of cells is a highly specialized and time-consuming effort, usually performed by a select group of clinicians and technical personnel. Described herein are methods for more automatable, consistent and comprehensive cell sample analysis to deliver a rapid, reliable and detailed classification, e.g., diagnosis, of the status of cells present in a sample, particularly, but not limited to cancer diagnosis.
    Type: Grant
    Filed: July 13, 2021
    Date of Patent: March 5, 2024
    Assignee: Aquyre Biosciences, Inc.
    Inventors: Bertrand Le Conte Chrestien De Poly, Emilie Benoit A La Guillaume, Zoya I. Volynskaya
  • Automated cell culture incubator
    Patent number: 11920121
    Abstract: Aspects relate to an automated cell culture incubator and to methods for using such an incubator. In one aspect, the cell culture incubator includes an incubator cabinet having a transfer chamber and an internal chamber that are arranged to form an airlock configuration. In some embodiments, objects placed into the incubator cabinet are sterilized using ozone produced by an ozone generator. The incubator may include one or more transfer devices that move objects between the transfer chamber and the internal chamber.
    Type: Grant
    Filed: March 7, 2022
    Date of Patent: March 5, 2024
    Assignee: Thrive Bioscience, Inc.
    Inventor: Alan Blanchard
  • Antibody binding active ?-synuclein
    Patent number: 11919947
    Abstract: A monoclonal antibody that binds ?-synuclein, and that binds tau fibrils, and methods of using the monoclonal antibody, are provided. The monoclonal antibody may be hybridoma clone 2F11. Also provided is a composition comprising the monoclonal antibody 2F11 and a pharmaceutically acceptable carrier, adjuvant, vehicle or excipient. A method of reducing active ?-synuclein in a subject in need thereof is also disclosed. The method involves administering an amount of the composition comprising 2F11 to the subject. The monoclonal antibody 2F11 may also be used to determine the ?-synuclein, or tau fibril, level in a biological sample.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: March 5, 2024
    Assignee: STRESSMARQ BIOSCIENCES INC.
    Inventor: Ariel Louwrier
  • CELL INCUBATOR AND A TOOL FOR USE IN A CELL INCUBATOR
    Publication number: 20240067913
    Abstract: At least one tool removably mountable on a cell incubator mandrel or a cell incubator having at least one mandrel having an end portion, the at least one mandrel mounted on a movable transport for moving the at least one mandrel and at the least one tool removably mountable on the end portion of the at least one mandrel. The at least one tool is preferably electrically powered and controllable by signals applied to the at least one tool to perform at least one operation with respect to the incubation of cells.
    Type: Application
    Filed: November 8, 2023
    Publication date: February 29, 2024
    Applicant: THRIVE BIOSCIENCE, INC.
    Inventor: Alan BLANCHARD