Patents Assigned to Bioscience, Inc.
  • Nucleic acid constructs and methods of use
    Patent number: 10266883
    Abstract: The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: April 23, 2019
    Assignee: Prognosys Biosciences, Inc.
    Inventor: Mark S. Chee
  • Nucleic acid constructs and methods of use
    Patent number: 10266884
    Abstract: The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: April 23, 2019
    Assignee: Prognosys Biosciences, Inc.
    Inventor: Mark S. Chee
  • MEASURING METHOD FOR AMPLICON LENGTH
    Publication number: 20190112642
    Abstract: A measuring method for amplicon length is provided. A qPCR master mix, a forward primer, a reverse primer, a hybridization probe, a double-stranded DNA binding dye, and nucleic acid samples are added into reaction wells for qPCR reaction, and the fluorescence intensity of each of a hybridization probe and a double-stranded DNA binding dye varying with cycle number is respectively measured. Afterwards, amplicon length is obtained by applying a calculating method.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Applicant: Quark Biosciences, Inc.
    Inventors: Chung-Fan Chiou, Cheng-Wey Wei, Yu Chang, Chang-Wei Huang
  • Optical detection system for flow cytometer, flow cytometer system and methods of use
    Patent number: 10261080
    Abstract: An optical engine its use in a bench top flow cytometer, the optical engine having a set of lasers, each focused horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same excitation plane of a flow cell, a set of optics that separate fluorescence of a same wavelength range into different locations in a focal plane of collection optics according to the different lasers by which the fluorescent light is excited; and a detector that selectively detects light from the different locations thereby distinguishing between fluorescence emitted within the same wavelength range as excited by the different lasers.
    Type: Grant
    Filed: July 15, 2017
    Date of Patent: April 16, 2019
    Assignee: ACEA Biosciences, Inc.
    Inventors: Nan Li, Lingbo Kong, Jian Wu, Ting Cheng, Yangde Qin, Xiaobo Wang
  • Prescription decision support system and method using comprehensive multiplex drug monitoring
    Patent number: 10262112
    Abstract: A decision support system and method for optimizing medication dosages includes comprehensive patient databases correlating medications and exposure values across data models having pharmacokinetic and pharmacodynamic dimensions. The system determines distinctions between expected and detected medications and exposure values for a patient, and further distinguishes between non-compliant patients from compliant patients having high metabolizing characteristics with respect to certain expected but undetected medications. The system links to and reconciles the patient medical record accordingly. Graphical user interfaces display recommended dosages and projected exposure ranges for the expected and detected medications. In an embodiment, the interface presents certain alternative treatment options determined as being available with respect to the expected but undetected medications.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: April 16, 2019
    Assignee: Precera Bioscience, Inc.
    Inventor: Timothy P. Ryan
  • Antibody specific for CD22 and methods of use thereof
    Patent number: 10259871
    Abstract: The present disclosure provides antibodies specific for an epitope present on CD22. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: April 16, 2019
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Robert George Edward Holgate, Francis Joseph Carr
  • Combination therapy with glutaminase inhibitors and immuno-oncology agents
    Patent number: 10258619
    Abstract: The invention relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases with a combination of a glutaminase inhibitor and an immuno-oncology therapeutic agent, such as an inhibitor of arginase, CTLA-4, indoleamine 2,3-dioxygenase, and/or PD-1/PD-L1.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: April 16, 2019
    Assignee: Calithera Biosciences, Inc.
    Inventors: Susan M. Molineaux, Matthew I. Gross, Susan D. Bromley, Francesco Parlati, Mark K. Bennett
  • Nicotinic receptor non-competitive antagonists
    Patent number: 10258582
    Abstract: The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: April 16, 2019
    Assignee: Catalyst BioSciences, Inc.
    Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Ronald Joseph Heemstra, Jason Speake, Daniel Yohannes, Matt S. Melvin, Yunde Xiao
  • Multiple section trocar
    Patent number: 10251673
    Abstract: A medical device insertion system, and a method of using the system, to mate trocars inside a patient during a medical procedure, the system including a first trocar having a first end to insert into a patient, and a second end at which a first user control is provided, and a second trocar having a first end to insert into a patient, and a second end at which a second user control is provided, wherein the respective first ends of the first and second trocars are formed so as to mate to one another inside the patient to form a continuous path between the respective second ends.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: April 9, 2019
    Assignee: Arkis Biosciences Inc.
    Inventors: Chad Seaver, James Alexander Killeffer, Chris Arnott
  • Hand-held micro-raman based detection instrument and method of detection
    Patent number: 10253346
    Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: April 9, 2019
    Assignees: Seraph Biosciences, Inc., Wayne State University
    Inventors: Gregory William Auner, Charles Shanley, Michelle Brusatori, Tara Twomey, David Sant
  • CD20 BINDING MOLECULES AND USES THEREOF
    Publication number: 20190100597
    Abstract: This disclosure provides pentameric and hexameric CD20 binding molecules and methods of using such molecules to direct complement-mediated, T-cell-mediated, or both complement-mediated and T-cell-mediated killing of CD20-expressing cells.
    Type: Application
    Filed: March 4, 2015
    Publication date: April 4, 2019
    Applicant: IGM Biosciences, Inc.
    Inventors: Bruce Keyt, Omar Duramad, Beatrice Tien-Yi Wang, Ramesh Baliga, Fen Zhang
  • Implantable bio-pressure transponder
    Patent number: 10244954
    Abstract: An implantable subcutaneous device to measure internal body pressure and wirelessly transmit information corresponding to the measured internal body pressure, including a pressure sensor to sense pressure of a particular region of a body of a patient and output a pressure signal corresponding to the sensed pressure, an encoder to receive the pressure signal and encode a signal to produce a sensor information signal to be transmitted to an ex vivo receiver, a transceiver to receive the sensor information signal from the encoder and transmit the sensor information signal to the ex vivo receiver, and a biocompatible housing in which to enclose the pressure sensor, encoder, and transceiver.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: April 2, 2019
    Assignee: Arkis Biosciences Inc.
    Inventors: Chad E. Seaver, James A. Killeffer, James C. Arnott
  • PHOTOLABILE COMPOSITIONS AS A STABILIZATION PLATFORM
    Publication number: 20190091346
    Abstract: A photodegradable polymeric system is presented that can be employed to entrap and stabilize bioactive therapeutics such as proteins and vaccines from environmental stressors. This system would obviate the need for refrigeration and would decrease transportation and storage costs of temperature-sensitive therapeutics. By using a photosensitive release system, users can administer temperature-sensitive compounds at their discretion. This photodegradable system will also permit the potential to stabilize temperature-sensitive therapeutics in a liquid suspension, eliminating the need for reconstitution.
    Type: Application
    Filed: November 29, 2018
    Publication date: March 28, 2019
    Applicant: Nanoly Bioscience, Inc.
    Inventors: Balaji V. Sridhar, Mark W. Tibbitt, Oyvind Hatlevik, Jacob W. Heaps, John Janczy
  • HUMAN MILK COMPOSITIONS AND METHODS OF MAKING AND USING SAME
    Publication number: 20190090501
    Abstract: The disclosure features human milk fortifier compositions, standardized human milk, and methods of making and using same. In one embodiment, a pasteurized human milk composition includes a human protein constituent of about 35-85 mg/mL; a human fat constituent of about 60-110 mg/mL; and a human carbohydrate constituent of about 60-140 mg/mL.
    Type: Application
    Filed: November 14, 2018
    Publication date: March 28, 2019
    Applicant: Prolacta Bioscience, Inc.
    Inventors: Elena M. Medo, Martin L. Lee, David J. Rechtman, Joseph Fournell
  • Systems and methods for detection of cells using engineered transduction particles
    Patent number: 10240212
    Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: March 26, 2019
    Assignee: GeneWeave Biosciences, Inc.
    Inventors: Diego Ariel Rey, Shaunak Roy, Leonardo Maestri Teixeira, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor H. Yee, Werner Frei
  • VIRUS-LIKE PARTICLE CONJUGATES FOR DIAGNOSIS AND TREATMENT OF TUMORS
    Publication number: 20190083647
    Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
    Type: Application
    Filed: September 26, 2018
    Publication date: March 21, 2019
    Applicants: Aura Biosciences, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Ser.
    Inventors: Elisabet de los Pinos, John Todd Schiller, Rhonda C. Kines, John MacDougall
  • Optical engine for flow cytometer, flow cytometer system and methods of use
    Patent number: 10234392
    Abstract: An optical engine for use in a bench top flow cytometer, the optical engine comprising a set of lasers; a different set of beam shaping optics for each laser, wherein each set comprises two lenses to adjustably focus light horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same plane; collection optics for collecting fluorescence from the flow cell; filtration optics that filter the collected fluorescence from the flow cell into different detection channels according to wavelength ranges; and a detector for each detection channel that converts the filtered fluorescence to electrical signals, wherein electrical signals are processed so that the fluorescence from each laser at the different vertical positions is distinguished at the same detector.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: March 19, 2019
    Assignee: ACEA Biosciences, Inc.
    Inventors: Nan Li, Ye Chen, Hyunsun Chung, Zengqiang Li, Xiaobo Wang
  • Multiplexed method for the identification and quantitation of minor alleles and polymorphisms
    Patent number: 10233489
    Abstract: Provided herein are products and processes for detecting the presence or absence of minor nucleic acid species in a sample containing a mixture of minor nucleic acid species and one or more major nucleic acid species, where the amount (frequency or copy number) of the minor nucleic acid species is less than that of the major nucleic acid species. Certain methods include amplifying the mixture and extending the resulting amplicons using chain terminating reagents and extension primers that specifically hybridize to the amplicons, where a chain terminating reagent specific for the major nucleic acid species has a concentration that is less than a chain terminating reagent that is specific for a minor nucleic acid species.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: March 19, 2019
    Assignee: Agena Bioscience, Inc.
    Inventor: Anders Olof Herman Nygren
  • Site specific chemically modified nanopore devices
    Patent number: 10234415
    Abstract: Provided are site specific chemically modified nanopore devices and methods for manufacturing and using them. Site specific chemically modified nanopore devices can be used for analyte sensing and analysis, for example.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: March 19, 2019
    Assignee: Electronic BioSciences, Inc.
    Inventors: Eric N. Ervin, John J. Watkins, Geoffrey A. Barrall
  • METHODS AND COMPOSITIONS FOR ATTENUATING GENE EXPRESSION MODULATING ANTI-VIRAL TRANSFER VECTOR IMMUNE RESPONSES
    Publication number: 20190076458
    Abstract: Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
    Type: Application
    Filed: August 9, 2018
    Publication date: March 14, 2019
    Applicant: Selecta Biosciences, Inc.
    Inventor: Takashi Kei Kishimoto